Applications are invited for a Research Fellow to join the Schiavo Lab at the UK DRI at UCL for the project: Neurobiology of synaptic tau and its propagation in Alzheimer’s disease. In Alzheimer’s disease (AD), pathological conformations of the microtubule-associate protein tau spread in the brain via neuronal connections, likely to be synaptic. However, the mechanism of tau release from synapses has not yet been characterised. Understanding how pathological tau reaches the synapse, accumulates in vesicles, is released, and eventually is taken up by postsynaptic cells, is a hot topic in AD research. We believe that by identifying the molecular mechanisms controlling tau release and spreading, we could revolutionise the treatment of AD. The findings are likely to be relevant also for other human brain disorders characterised by protein aggregation and spreading. Ref: 1881579, Closing date: 7 Feb 2022
Apply to centreThe UK DRI runs a Cross-Centre Postdoctoral Programme, designed to simultaneously fund exciting emerging science and to foster intra-UK DRI collaboration through support of a postdoctoral position based across two UK DRI Centres. This is an exciting opportunity to work on a research project to establish a synergistic collaboration between Prof David Sharp’s laboratory (based at the UK DRI Care Research & Technology Centre) and Dr Marc Aurel Busche’s laboratory (based at the UK DRI at UCL). You’ll examine the effects of traumatic brain injury on neuronal circuit and neurovascular function in vivo, recording neuronal activity and vascular dynamics using state of the art two-photon and electrophysiological (Neuropixels) methods and linking this to available human datasets. This is fantastic chance to work independently on a high impact, state-of-the-art collaborative and cross-species project in a stimulating and vibrant research environment. Ref: 1881887, Closing date: 14 February 2022
Apply to centreWe are looking for a Postdoctoral Research Fellow with experience with in-vivo two-photon microscopy, optogenetics, stereotaxic surgeries and animal behaviour to join the Opazo lab at the UK DRI at Edinburgh. The role aims to investigate the synaptic and neuronal compensatory mechanisms that may underlie cognitive reserve in Alzheimer’s disease mouse models using state-of-the-art in-vivo two photon imaging and optogenetics. In order to be successful in this role, the applicant should have experience in in-vivo two-photon imaging microscopy, optogenetics, stereotaxic surgeries, animal behaviour and programming (Matlab). Knowledge and background experience in synaptic biology and dementia in general is an asset. Ref: 2827, Closing date: 14 February 2022
Apply to centreApplications are invited for a Senior Research Associate position at the UK Dementia Research Institute (UK DRI), at the University of Cambridge, Department of Clinical Neurosciences. The post is within a collaboration between the laboratories of Professor Sir David Klenerman at the UK DRI and Professor Maria Grazia Spillantini in the Department of Clinical Neurosciences. The project aims to study how protein homeostasis is disrupted in human derived IPSC neurons leading to the formation of increased numbers of tau aggregates and how aggregates spread from neuron to neuron by super-resolution imaging of the aggregates formed in and secreted by the neurons. Ref: ZE29745, Closing date: 28 January 2022
Apply to centreThe laboratory of Dr Raffaella Nativio at the UK DRI at Imperial is seeking a highly motivated postdoctoral scientist to lead one or more projects investigating basic mechanisms of epigenetic regulation and their involvement in aging and age-related neurodegeneration. The successful candidate will be familiar with the biology of epigenetic regulation and proficient in using genomic/epigenomic approaches (ChIP-seq, RNA-seq, ATAC-seq, CUT&RUN, CUT&Tag, HiC or HiChIP), gene editing tools (CRISPR/Cas9 or CRISPRi/CRISPRa), and induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs) culture systems. Ref: MED02721, Closing date: 2 February 2022
Apply to centreThe UK DRI is seeking a Director of Innovation and Business to cover a period of maternity leave. The Director of Innovation and Business is a critical role within the UK DRI HQ team, responsible for leading our Innovation and Business team and overseeing our Technology Transfer (TT) policies and procedures. This is an exciting opportunity, and you’ll be involved in a variety of key areas including managing our TT activities, educating our research community on TT potential, negotiating and managing licences and other partnerships, and building a valuable TT and IP portfolio across our host universities to fully exploit discoveries emerging from our world-class research activities. You will have experience of designing and delivering a broad-based TT strategy within a biomedical operation, coupled with experience of identifying, protecting, and managing IP and out-licensing university discoveries and negotiating licenses, terms, awards and other contracts between academia and industry. Ref: 1881214, Closing date: 23 January 2022
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