UK DRI at The University of Cambridge

From biological to physical sciences: working across disciplines to boost our understanding of the processes underlying the earliest stages of neurodegeneration and ageing.

• Specialisms at Cambridge
• Molecular and cellular biological approaches to understanding disease mechanisms
• Proteostasis, translational control at the synapse, myelin/axon interactions in neuronal health and disease
• Biomechanics of brain ageing and its role in disease processes and therapy
• Inter-disciplinary science, including biophysics and chemistry

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  The UK DRI at The University of Cambridge focuses on the mechanistic processes involved in the earliest stages of neurodegenerative disease to identify therapeutic targets with the greatest potential to prevent dementia. These processes include the spreading of misfolded tau protein, the cold shock protein response in the repair of synapses and autophagy as a protective cellular response, all of which are relevant to several different types of dementia.

  The team uses cellular and molecular approaches to better characterise these important processes with a strong emphasis on identifying molecular targets that can be rapidly translated into new dementia treatments for those in the early stages.

  UK DRI at The University of Cambridge, embraces biological and physical sciences in the newly refurbished Island Research Building on the Cambridge Biomedical Campus.