From brain vasculature to microglia: elucidating the interactions within the brain and with the body which control the trajectory of neurodegenerative disorders.
Studies are increasingly highlighting the important role of immune, vascular and metabolic factors in the development of neurodegenerative diseases but the interplay between these components in disease progression is poorly understood. The UK DRI at Edinburgh broadens out the traditional view of neurodegenerative disease as a disorder of misfolded proteins to encompass the multicellular environment surrounding degenerating neurons.
The research team lead by Professor Giles Hardingham examines the complex interactions between cells of the brain, immune system and blood vessels that make up the ‘neurogliovascular unit’. They bring together strengths in metabolism, inflammation, blood vessel biology and stem cell medicine to explore how interactions at the neurogliovascular unit control the trajectory of neurodegenerative diseases leading to dementia.
By describing interactions at the neurogliovascular unit that help to maintain cognitive function for several decades in a healthy, ageing brain, the team aim to identify biological regulators that can inform the development of new therapies.
UK DRI at The University of Edinburgh is located on the BioQuarter, Edinburgh's new multidisciplinary research institute and teaching hospital with access to superb multimodal neuroimaging and clinical research facilities.
We are looking for a Postdoctoral Research Fellow with experience with in-vivo two-photon microscopy, optogenetics, stereotaxic surgeries and animal behaviour to join the Opazo lab at the UK DRI at Edinburgh. The role aims to investigate the synaptic and neuronal compensatory mechanisms that may underlie cognitive reserve in Alzheimer’s disease mouse models using state-of-the-art in-vivo two photon imaging and optogenetics. In order to be successful in this role, the applicant should have experience in in-vivo two-photon imaging microscopy, optogenetics, stereotaxic surgeries, animal behaviour and programming (Matlab). Knowledge and background experience in synaptic biology and dementia in general is an asset. Ref: 2827, Closing date: 14 February 2022Apply to centre