From sleep to the microbiome: bringing new approaches and research tools to the study of dementia to discover new disease mechanisms and therapeutic targets.
UK DRI at Imperial College London has innovation as its theme. This draws on the university’s unique strengths and focus on science, engineering, medicine and business. Led by Professor Paul Matthews, the research team brings novel, cutting edge approaches and research tools to the study of dementia to discover new disease mechanisms and therapeutic targets. They will initially focus on the earliest pre-symptomatic stages of Alzheimer’s disease, addressing what determines the transition to neurodegeneration, but will investigate mechanisms that are likely shared across many of the dementias.
With access to large, well characterised longitudinal cohorts the team will explore causes of individual variation in dementia within populations, looking at changes that occur across the lifespan and specifically addressing metabolic factors, the relationship with microorganisms in gut (the microbiome) and the role of sleep. The team will use a range of resources including Dementias Platform UK and the MRC-NIHR National Phenome Centre.
UK DRI at Imperial College London will be located at the White City campus Hammersmith, London, in the Sir Michael Uren Biomedical Engineering Research Hub due to be completed in 2019, alongside Imperial’s translation and innovation ‘I-HUB’.
UK DRI is seeking a Research Associate in Computational Genomics to join the Neuroepigenomics Lab of Dr Alexi Nott in the Department of Brain Sciences within Imperial College London. In this post you will work on analysis and visualisation for large scale ‘omics datasets an lead computational projects exploring the transcriptome, epigenome and 3D chromatin architecture of brain cell types. You will work collaboratively as part of a multidisciplinary research team, demonstrating an aptitude for an organised, methodical approach to your work. For appointment as Research Associate, you will hold a PhD (or equivalent) in Computational Biology, Mathematics or a closely related discipline, or equivalent research or industrial experience. You will have strong programming skills in R, Python, or other coding languages (e.g., C++, Matlab), and experience within a High-Performance Computing environment. Ref: MED04379, Closing date: 23 February, 2024Apply to centre
UK DRI is seeking an Edmond and Lily Safra Research Fellow to join the department of Brain Sciences at Imperial College London. You will belong to a cohort of up to five Fellows recruited during the 2023-24 academic year. The Fellowships may be held for 3 years in the first instance. You may spend up to 12 months visiting other research institutions and/ or in industry, the maximum time spent at any one institution or company being 6 months. Research space will be provided at Imperial, consistent with needs, along with a non-renewable research start-up fund of £30,000. You will have access to specific additional support for specialised equipment that they might need. Additional funds may also be available on a project-by-project basis from other internal funds, including e.g., those of the NIHR Biomedical Research Centre or the UKRI Impact Acceleration Account (IAA) scheme administered by the College. You will lead and grow a scientific programme of the highest quality in Parkinson’s disease research towards international excellence in the chosen area, publish research papers in peer-reviewed journals, attend and present work at international conferences and obtain external research funding. For this role you have to have achieved a PhD or equivalent higher research degree in a relevant field, have previous research and publication record with evidence of potential for international excellence and leadership in the chosen area of science and you will now be building on existing post-doctoral or equivalent research training. Ref: MED03955, Closing date: 9 April 2024Apply to centre