UK DRI Group Leaders or Associated Members are invited to apply to the UK DRI-Animal Models Programme (UK DRI-AMP) at the Mary Lyon Centre, MRC Harwell (MLC) for the generation of new genome edited mouse models to address novel research question. New point mutation(s), knockouts, targeted insertional transgenic models (e.g. lines expressing recombinases, fluorescent tags) will be generated by CRISPR-Cas9 gene-editing or targeted insertional transgenesis. Cross-site/multi-PI projects, tool-development for hypothesis testing and novel research questions from PIs without a track-record in mouse research are particularly encouraged.
All new mouse lines will be deposited at the MLC European Mutant Mouse Archive (EMMA) node and will be freely available to all UK DRI PIs immediately. A moratorium on open distribution to external researchers can be requested by the lead PI of the original application until date of first publication.
The programme will provide a novel line(s) of fully genetically validated mice (breeding pairs to found a colony at the PI and Co-I institutions) and archiving of these at the MLC. Funds for animal work at the PIs Institution will not be provide.
Clinical, translational and basic research projects will be considered. Applications will be assessed for feasibility by Mary Lyon Centre researchers, and for scientific merit, novelty and long-term utility and expected impact by a scientific panel composed of UK DRI, MRC-Harwell and external scientists. PIs without a previous track-record in animal research are encouraged to informally discuss their application with Dr. Wiseman (firstname.lastname@example.org) in the first instance.
Applications are restricted to UK DRI Group Leaders or a recognised UK DRI Associated Member. Up to four awards will be made in 2020. This RFP will be repeated in 2021 and 2022 in the first instances.