2019 Eisai / UK DRI Research Programme on Dementia
REQUEST FOR PROPOSALS (RFP)
UK DRI and Eisai, one of the world's leading research-based pharmaceutical companies (eisai.co.uk), have joined forces to launch a post-doctoral research programme on dementia.
This new programme invites novel research projects in the field of neurodegeneration that may ultimately lead to transformative medicines for dementia patients. This programme’s particular disease focus areas are: Alzheimer’s disease, Parkinson’s disease (and related synucleinopathies) and frontotemporal dementia.
All UK DRI group leaders (at Fellow and Professor level including Ser Cymru and Sir Henry Dale Fellows) are invited to submit proposals. Although any dementia-relevant project will be considered, the following themes are of particular interest:
Removal of aggressive factors (beyond beta amyloid) underpinning neurodegenerative diseases, such as: aberrant protein misfolding, aggregation and clearance (including autophagy); mitochondrial dysfunction (including mitophagy); lipid homeostasis.
Synaptic health and function.
Neuronal regeneration and repair.
Immunodementia/neuroinflammation (microglial and astrocyte biology).
The overriding aim of the programme is to better understand the underlying biology that may lead to:
The identification of new molecular targets, pathways and/or mechanisms for therapeutic intervention.
Innovative drug methodologies to target the above (such as mechanisms for improved brain delivery, novel chemical or biological entities, cellular or genetic approaches).
The development of novel in vitro or in vivo model systems (including cutting edge screening platforms/technologies) translatable to human biological processes, with which to investigate modulation of the above.
The development of biomarkers for patient selection/stratification or pharmacodynamic assessment of new therapeutics.
This programme will be an active collaboration between the UK DRI Centres and Eisai, who will play an ongoing, active role in the projects and will seek to work with the PIs in adding value wherever possible. For further details see Annex 1.
Awards of up to £221,000 (direct costs) will be provided to support a new three-year post- doctoral position, including salary (plus employer costs) and up to £10,000 per annum for reagents or other expenses (Awards will be made by UK DRI and will be subject to established UKDRI-university overheads).
Up to three awards will be made for this cycle. (This RFP will be repeated in 2020.)
The applicant must satisfy the selection committee that they have ready access to all necessary research facilities, samples, reagents and equipment, and have all necessary regulatory approvals such that the work can start promptly.
Proposals will be assessed and funding decisions made by a joint UK DRI and Eisai committee. Successful applicants and their supported post-doctoral researcher will be required to attend an annual one-day workshop to discuss the ongoing work.