Applications are invited for a full-time research assistant within the UK DRI at the University of Edinburgh. You will liaise with all UK DRI lab groups based in Chancellor’s Building at the Edinburgh BioQuarter and contribute to the management of all UK DRI rodent colonies. It is expected that the successful applicant will hold or be able to gain a Home Office Personal Licence, be experienced in all aspects of rodent colony management and logistics, be knowledgeable about rodent welfare, and will have experience of genotyping strategies. The main purpose of the role will be to assist with the management of the rodent colonies of UK DRI group lines which will include: planning, organisation and maintenance of breeding, crossing, experimental request form approval, budget guidance/management for each individual group, external import and export organisation and approval, liaison with named vet surgeons and other senior animal technical staff, liaison with users of the animal facility within each lab group; set up genotyping for the lab groups.Ref: 049051, Closing date: 2 September
Apply to centreWe are seeking to appoint two energetic and dynamic research associates willing to carry out an interesting and challenging project of Structural Biology in the lab of Prof Annalisa Pastore at the UK DRI at King's within the Maurice Wohl Clinical Neuroscience Institute. The post-holders will develop a project in Structural Biology of neurodegeneration research as part of a wider network of centres. The roles will involve an integrated biological approach based on molecular biology, protein biochemistry, enzymology, spectroscopic, synthetic biology, crystallography and/or NMR and/or cryo-EM methodologies. The project seeks to address key questions regarding the structure, interactions and aggregation of proteins involved in dementia and neurodegeneration using an integrated structural approach. Ref: 018407, Closing date: 17 September
Apply to centreA postdoctoral Research Associate position is now available at the UK DRI at Cambridge, based at the Addenbrookes Campus as a part of a multidisciplinary project in the group of Prof David Klenerman FMedSCi FRS. The applicant will use a custom built single molecule fluorescence microscope to image and characterise individual aggregates in neurones and glial cells derived from iPSCs of human subjects, the supernatant above these cells and in aggregates present in human samples such as serum and CSF. The aim of the project is to determine the molecular processes that lead to the initiation and spreading of neurodegenerative diseases, with a particular focus on Alzheimer's disease, by charactering the heterogeneous and low concentration of protein aggregates that are formed during the onset and development of disease using a suite of ultra-sensitive biophysical methods developed in the Klenerman group, based on single molecule fluorescence imaging. Applicants should have a PhD in single molecule fluorescence or microscopy and a biophysical background and interest in performing multi-disciplinary research in a team. This is an ideal opportunity for physically trained scientist to apply imaging methods to tackle a major biomedical problem. Ref: ZE20360, Closing date: 22 September
Apply to centreApplications are open for a Centre Senior Adminstrator to support the UK DRI at UCL, one of seven centres of the UK Dementia Research Institute. The successful candidate will provide administrative and day-to-day operational support to the Centre Manager and research groups. Duties will include assisting with planning and organising Centre events, seminars and lab tours, servicing various Centre meetings and committees, financial administration of Centre research grants, assisting with recruitment and appraisal processes and acting as a first point of contact for staff, students and visitors, updating and maintaining the Centre's webpages, distributing Centre communications, and maintaining and managing the Centre's various mailing lists. Ref: 1818872, Closing date: 2 September
Apply to centreApplications are invited for a Research Associate at the UK Dementia Research Institute at Cambridge, to join Dr Will McEwan's lab. The group examines the process of protein aggregation, central to numerous neurodegenerative diseases, and has a particular interest in intracellular ‘intrinsic’ immune mechanisms that can be used to modulate protein aggregation. The successful candidate will examine the aggregation of tau, a pathological signature of several diseases including Alzheimer’s disease, in the context of its cellular and immunological environment. Applicants should have a PhD, or be in the final stages of their doctoral studies, with a proven track record in molecular biology and knowledge in the field of neurodegeneration or immunology. Ref: ZE20232, Closing date: 4 September
Apply to centreApplications are invited for a Science Review Manager, based at the UK Dementia Research Institute Headquarters at UCL. This is a new role, created to deliver the UK DRI’s portfolio of research initiatives and programmes. The successful candidate will establish transparent and fair assessment mechanisms for our competitive internal financial award opportunities and manage the application, review and reporting processes for our various funded programmes. Responsibilities will include coordinating peer review activities, providing constructive advice and guidance to applicants & designing metrics to assess the success of the different strategic initiatives. We're looking for someone with a PhD in Neuroscience (or a cognate area), coupled with project management skills and an understanding of how to utilise communication channels to target audiences. Ref: 1819553, Closing date: 25 August
Apply to centreThe UK DRI at UCL are looking to appoint a new Group Leader (Senior/Principal Fellow), who will lead an internationally competitive research programme, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will receive extensive support from the UK DRI, including up to £1.5 million start-up funding over a five-year period, appointment based on the MRC tenure-track route, access to shared equipment and technology across a national institute and membership of a community of world-leading scientists. You are also entitled to the full range of UCL staff benefits and development opportunities. You will have substantial postdoctoral experience, a proven track record of internationally competitive scientific research relevant to the UK DRI and a commitment to, appreciation and understanding of the mission of the UK DRI. You’ll be experienced in planning and developing projects or programmes of research and have a wide knowledge of techniques and methodologies related to research in neurodegeneration. You’ll propose an exciting and innovative programme of research that demonstrably interfaces and compliments the UK DRI’s current portfolio and science strategy, and evidence that you have the potential to lead, inspire and develop a research group into an excellent team. Rolling deadline.
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