Applications are invited for an enthusiastic research technician in the lab of Prof Paul Matthews. based at the UK Dementia Research Institute at Imperial, providing support for an exciting new portfolio of molecular and cellular neurodegenerative disease research. Candidates should be curious, dynamic and keen to be part of the larger UK Dementia Research Institute for its ambitions to develop the foundations for better treatments of people with dementia. A good qualification/equivalent experience in relevant laboratory sciences (e.g. biology or biomedical related sciences) is required with experience of laboratory-based research, and practical experience of either histology or genomics methodologies. Ref: MED01307, Closing date: 10 July
Apply to centreApplications are invited for a Research Technician to support the research of Dr Anny Devoy, as part of the larger research group of Dr Marc-David Ruepp. The post is within the KCL Institute of Psychiatry, Psychology & Neuroscience (IoPPN), although it is based entirely at the UK Dementia Research Institute at KCL. A part-time post (50% full-time equivalent), the successful candidate will carry out general and specialised technical duties, working closely with Dr Anny Devoy to support an MND Association funded project. The successful candidate will also have the opportunity to utilise the breadth and depth of expertise and technologies available across the collaborating groups, and the UK DRI at KCL. Ref: 015648, Closing date: 30 June
Apply to centreApplications are invited for a Research Fellow in the lab of Dr Frances Wiseman. The post is within the UCL Queen Square Institute of Neurology although it is based entirely at the UK Dementia Research Institute at UCL. People with Down Syndrome (DS) are at much greater risk of developing early onset Alzheimer’s disease (AD) than the general population. In this Alzheimer’s Research UK funded project we will test if cysteine cathepsins have a major and therapeutically tractable role in AD in DS due to their ability to; 1) alter APP/Aß processing, 2) affect cell death and 3) modulate neuroinflammation. The successful candidate will build hypotheses, design experiments and generate and analyse data, and will have the opportunity to utilise the breadth and depth of expertise and technologies available across the UK DRI. Ref: 1814245, Closing date: 25 July
Apply to centreApplications are invited for a Senior Research Technician in the lab of Prof John Hardy, co-line managed by Prof Henry Houlden. The post is within the UCL Queen Square Institute of Neurology although it is based entirely at the UK Dementia Research Institute at UCL. The successful candidate will provide senior technical support to run the Next Generation Sequencing Long-Read Sequencing (NG-LRS) machines and the NGS Illumina machines based in the lab, working closely with researchers in cutting edge research areas that will lead to important discoveries and publications. Depending on the person profile, there is the opportunity to do a part-time postgraduate degree such as a PhD. The successful candidate will also have the opportunity to utilise the breadth and depth of expertise and technologies available across the collaborating groups, and the UK DRI at UCL. Ref: 1813721, Closing date: 12 July
Apply to centreApplications are invited for experienced research technicians in the lab of Prof Paul Matthews. based at the UK Dementia Research Institute at Imperial and providing support for an exciting new portfolio of molecular and cellular neurodegenerative disease research. Initiatives include the UK DRI Brain Atlas, a project intended to develop a comprehensive multi-omics atlas of the brain cellular neuropathology of Alzheimer’s disease as a resource for researchers world-wide. This research area is evolving rapidly, and successful candidates will be given opportunities to train in new methods and develop new competencies with a wide range of “cutting edge” methods. Candidates should be curious, dynamic and keen to be part of the larger UK DRI for its ambitions to develop the foundations for better treatments of people with dementia. Ref: MED01278, Closing date - extended: 10 July
Apply to centreApplications are invited for a fully-funded PhD studentship in the group of Dr Soyon Hong, UK DRI at UCL, UCL Queen Square Institute of Neurology, to start 1 Oct 2019. Microglia are active participants in brain wiring – sculpting and refining neural circuits and influencing synaptic development and function. Microglia mediate synapse pruning via complement signalling (C1q, CR3/C3) in the developing brain and when this process is reactivated in the adult brain, synapses are lost. Complement components are induced during normal ageing but the molecular mechanisms that govern how and which synapses are targeted are poorly understood. Understanding what regulates complement signalling in the adult brain is crucial to learning how microglia and neurons communicate with each other to maintain proper brain function. This studentship will aim to provide mechanistic insight into local signals that regulate microglia-synapse pruning to aid foundational knowledge of brain physiology. Applicants who have or expect to obtain a 1st or upper 2nd class honours degree in biochemistry, molecular biology, neuroscience, biomedical sciences or related disciplines. Closing date: 5 July
Apply to centreApplications are invited for a Research Associate position on Building Systems for Privacy-Preserving Data Analytics, Machine Learning, and behavioural interaction systems, as part of the newly funded £20M new Care Research & Technology Centre at Imperial College. The appointed researcher will lead the design, implementation, and analysis of the systems and algorithms which help in the data collection, analysis, and user interactions in experiments and trials. They will develop apps and use the data collection infrastructure upon the existing protocols in the Databox Project (www.databoxproject.uk), with a focus on data analytics, privacy and security. They will engage with the other team members in design and conduct of experiments assessing the interaction of users with exemplar apps and data from mobile sensors, IoT devices, or personal health data. Ref: ENG00832, Closing date: 26 June
Apply to centreWith generous support from the Edmond J. Safra Foundation and in conjunction with the UK DRI at Imperial and the UK DRI Centre for Care Research and Technology, four new Edmond and Lily Safra Fellows are being sought. These are career development posts. They are seeking early career researchers ready to take the first steps towards setting up independent research programmes. They are looking for accomplished investigators who are willing to take risks to pursue important objectives. They intend to appoint 2 Fellows with research programmes using advanced technologies or data science to improve early disease detection, monitoring or care of people with neurodegenerative diseases. An additional 2 Fellows will be recruited to address a broader range of interests in bioinformatics (including, e.g. specialisations in systems/computational neuroscience, ‘omics or population studies), translational molecular cell studies or advanced neuroimaging specifically for the diagnosis, monitoring and treatment of Parkinson’s disease. Ref: MED01244, Closing date: 21 July
Apply to centreUK DRI Fellows will lead an internationally competitive research programme with up to £1.5m in funding support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. Use reference: 046510 on Edinburgh vacancy page. Round closing date: 3rd July 2019
Download role profile Apply to centreUK DRI Professors will direct internationally competitive research with up to £3m programme support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. Use reference: 046501 on Edinburgh vacancy page. Round closing date: 3rd July 2019
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