UK DRI Director, Prof Bart De Strooper, is looking for two highly motivated and ambitious single cell bioinformatics post doctoral fellows to join the UK DRI lab at UCL. The project will focus on understanding early cellular changes happening during the onset of Alzheimer's disease using techniques such as single cell transcriptomics. It will form an integral part of a larger initiative to work towards a complete spatial and temporal cellular atlas of Alzheimer's disease.This is an excellent opportunity to work on high impact, state of the art projects in a stimulating and social international research environment, undertaking world-class science under the guidance of a leader in Alzheimer’s biology. The posts are available immediately and are funded by the UK DRI for 5 years in the first instance. Closing date: 6th May.
Apply to centreIn this unique post, UK DRI Director and Chief Scientific Officer, Professor Bart De Strooper, is looking for a first-rate scientist to help him build, manage and oversee the day-to-day operations of his new UK DRI group at UCL. This is a major science position, perhaps well-suited to an experienced and successful post-doctoral researcher or junior faculty scientist, with extensive understanding of neurodegeneration, who relishes the chance to work closely with an accomplished academic investigator and be directly involved in top-flight science. Closing date: 5th May.
Apply to centreA postdoctoral Research Fellow position (12 months) is available to study a potential drug target for Alzheimer’s disease in induced pluripotent stem cell derived neurons. The fellow will be based in the Centre for Discovery Brain Sciences and UK Dementia Research Institute (UK DRI) at the University of Edinburgh, working with Prof Tara Spires-Jones. UK DRI at Edinburgh are looking for an enthusiastic scientist with an interest in synaptic integrity and resilience. Experience with human stem cell derived neurons is essential and experience with primary astrocyte culture, western blotting, immunohistochemistry, and confocal microscopy image analysis are highly desirable. The post holder will use stem cell derived neurons and proprietary reagents from a collaborating pharmaceutical company to test whether modulating a potential drug target can prevent or reverse synapse degeneration. Vacancy ref no: 047373. Closing date: 22.04.2019
Apply to centreThe Busche lab (buschelab.com), at the UK Dementia Research Institute at UCL, is looking for a highly self-motivated individual to combine in vivo electrophysiology and imaging with behavioural studies in models of Alzheimer’s disease and related disorders. The planned research projects are targeted to elucidate the cellular mechanisms that underlie memory and other cognitive impairments in these disorders. The post holder will perform in vivo electrophysiology and/or multiphoton imaging in behaving mice, process and analyse the electrophysiological and imaging datasets; evaluate and communicate results, publish results in peer reviewed journals and present findings at scientific conferences.
Apply to centreThe Single Cell Genomics laboratory at the UK DRI will investigate the molecular and cellular basis of fundamental brain functions that are affected in dementing illnesses (e.g. the formation, encoding and recall of memory), charting the yet uncharacterised cellular changes that support healthy ageing and those which lead to pathology. We are now looking for a Research Technician who will be in charge of preparing samples from human and rodent brain tissue, prepare single cell DNA and RNA libraries, perform in situ RNA hybridization, and image tissue sections. The successful applicant will work on lab-lead projects and will take part in several collaborative projects. The successful candidate will have Honours degree (minimum 2:1) or equivalent in Neuroscience, Biology or a related discipline. Applicants must have a substantial laboratory experience, particularly in molecular biology techniques (e.g. PCR) and biochemistry (e.g. RNA and DNA isolation), in microscopy (e.g. imaging of fluorescently labelled histology sections). Analytical skills to resolve problems that require the use of basic scientific, mathematical, or technical principles and proficiency with computer programs (e.g. Office package) are essentials. Good inter-personal skills with an ability to work co-operatively in a multidisciplinary setting are also required. Previous lab experience with rodents (e.g. maintaining a mouse colony, preparation of sections for histology) and knowledge of neuroscience are desirable.
Apply to centreWe're seeking a Director of Innovation and Business to join the UK DRI as a senior member of the HQ at UCL. The role will oversee all aspects of our innovation and technology transfer (TT) activities in order to support our growing research community. They will be responsible for establishing our TT policies and procedures, managing our TT activities, educating our research community on TT potential and negotiating and managing licences and other partnerships. In addition to generally building a valuable TT, the Director will grow an intellectual property portfolio across our seven centres in order to fully exploit discoveries emerging from our world-class research activities.
Download job overview Apply to roleWe are seeking to appoint two postdoctoral research associates in neuroscience to Professor Lawrence Rajendran's newly established lab in the UK Dementia Research Institute (DRI) at King's College London. The UK DRI at King's sits within the Department of Basic and Clinical Neuroscience. Neurodegenerative diseases are complex diseases whose aetiologies cannot be pinned to a few genes. In the case of late onset Alzheimer's disease (AD), the identity of the risk genes is still not known. The lab uses state of the art high-throughput screening methods and cell biological tools to identify genes involved in AD and other neurodegenerative diseases and in parallel, also characterise the mechanism by which they regulate this process ). By combining functional genomics with computational tools and validation in animal models, we intend to understand the complex molecular network that underlie AD. Recently, we identified a nutrient sensing pathway in neurons and in microglia, whose dysfunction is causally related to Alzheimer's disease (Paolicelli et al, Neuron, 2017). This is an exciting project which links genetics, life-style and neuroinflammation to Alzheimer's disease. The postdoctoral candidate will focus on studying how nutrient sensing pathways in neurons and microglia contribute to amyloid formation and clearance and synaptic function. Candidates should have their PhDs in Neuroscience, Molecular or Cell Biology, or Animal Genetics or an equivalent area. Only candidates who have experience with mice work need apply. Candidates should be able to demonstrate a track record of independent productive research, have strong organisational, written, and verbal skills and be able to work both independently and as part of a laboratory team. The role will involve cell/molecular biology and biochemical techniques and animal experiments.
Apply to centreUK DRI Fellows will lead an internationally competitive research programme with up to £1.5m in funding support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. Use reference: 046510 on Edinburgh vacancy page. Round closing date: 3rd July 2019
Download role profile Apply to centreUK DRI Fellows will lead an internationally competitive research programme with up to £1.5m in funding support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. Two positions currently open at either lecturer, senior lecturer or reader level.
Download role profile Apply to centreUK DRI Professors will direct internationally competitive research with up to £3m programme support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. Use reference: 046501 on Edinburgh vacancy page. Round closing date: 3rd July 2019
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