UK DRI is seeking a Research Fellow to join the Wiseman Lab in Department of School of Life & Medical Sciences in UCL. We are looking for a highly motivated Research Fellow to undertake a proteomic-neuropathology project as part of an international collaborative project (Wiseman Lab, UCL, Ryan, Fox and Lashley, UCL, UK DRI Biomarkers Factory, Strydom Lab, KCL, and Poiter Lab, ICM, Paris). You will analyse amyloid-β proteomic data from cases of AD-AD and determine the relationship between a novel amyloid-β species and cerebral amyloid angiopathy (CAA) load, as well as test a newly developed anti-amyloid-β antibody for its specificity for cerebral amyloid angiopathy (CAA), in cases of DS-AD, FAD and sporadic EOAD. Also, you will coordinate this work with related work being undertaken in the group of Marie-Claude Potier (ICM, Paris), Andre Strydom (KCL) and the UK DRI Biomarkers Factory, in addition to communicating research findings to collaborative partners and study participants. You will have (or be close to obtaining) a PhD in Neuroscience or a cognate area, as well as experience in immunohistochemistry and immunofluorescence methods, including on human post-mortem brain material. Experience in applying specialist skills and techniques in a laboratory setting and an understanding of the legal requirements for working with human post-mortem tissue under UK law is also required for this role. Ref: B02-06151, Closing date: 10 December 2023
Apply to centreUK DRI is seeking 2 Research Associates in Neuroinflammation/ Complement Biology to join Prof Paul Morgan's lab in the UK DRI at Cardiff University School of Medicine.These posts will join a new programme of research supported by LifeArc that explores the role of neuroinflammation in Alzheimer’s disease (AD). The work focuses on the development of new therapeutic approaches to treatment of AD and other dementias through targeting the complement system, a known driver of neuroinflammation and neurodegeneration. The appointees will join a team developing and testing novel brain-penetrant complement-blocking drugs using in vitro and in vivo systems. The ultimate aim of the work is to develop brain-penetrant drugs that modulate complement dysregulation in the brain in AD that are ready for progression to human trials. You will hold a Postgraduate degree at PhD level (or nearing completion / submission) in a related subject area or relevant industrial experience, and an established expertise and proven portfolio of research and/or relevant industrial experience within Immunology and Inflammation biology, Neuroscience and dementia research or Drug development and testing. You will have knowledge of current status of research in neuroimmunology, neurodegeneration and dementia therapies, proven ability to publish in national journals and/or present at relevant conferences, and knowledge and understanding of process of obtaining competitive research funding, including contributing to development of applications to funding bodies. Ref: 17537BR, Closing date: 3 December 2023
Apply to centreUK DRI is seeking a Research Associate in Neuroinflammation/ Complement Biology to join the lab of Prof Paul Morgan in the UK DRI at Cardiff University School of Medicine. This post will join an ongoing programme of research that explores the roles of neuroinflammation in dementias. The work focusses on roles of the complement system, a known driver of neuroinflammation and neurodegeneration, and spans genetics, in vitro modelling, in vivo modelling and human studies to address three key questions: 1. When, where and why is complement dysregulated in the brain? 2. Does complement dysregulation drive neurodegeneration at different stages of disease? 3. Can inhibiting complement in the brain reduce disease? The ultimate aim of the work is to identify therapeutic strategies to modulate complement dysregulation in dementias. You will hold a Postgraduate degree at PhD level (or nearing completion / submission) in a related subject area or experience in immunology, neuroimmunology and/or dementia models, and have an established expertise and proven portfolio of research and/or relevant industrial experience within Immunology and Inflammation biology or Neuroscience and dementia research. You will have knowledge of current status of research in neuroimmunology and neurodegeneration, proven ability to publish in national/international journals and/or present at relevant conferences and knowledge and understanding of competitive research funding and process of developing applications to funding bodies. Ref: 17382BR, Closing date: 3 December 2023
Apply to centreUK DRI is seeking two Research Associates in Neuroinflammation/ Complement Biology to join the lab of Prof Paul Morgan in the UK DRI at Cardiff University School of Medicine. These posts will join an ongoing programme of research that explores the roles of neuroinflammation in dementias. The work focusses on roles of the complement system, a known driver of neuroinflammation and neurodegeneration, and spans genetics, in vitro modelling, in vivo modelling and human studies to address three key questions: 1. When, where and why is complement dysregulated in the brain? 2. Does complement dysregulation drive neurodegeneration at different stages of disease? 3. Can inhibiting complement in the brain reduce disease? The ultimate aim of the work is to identify therapeutic strategies to modulate complement dysregulation in dementias. You will hold a Postgraduate degree at PhD level (or nearing completion / submission) in a related subject area or experience in immunology, neuroimmunology and/or dementia models, and an established expertise and proven portfolio of research and/or relevant industrial experience within Immunology and Inflammation biology or Neuroscience and dementia research. You will have knowledge of current status of research in neuroimmunology and neurodegeneration, a proven ability to publish in national/international journals and/or present at relevant conferences and knowledge and understanding of competitive research funding and process of developing applications to funding bodies. Ref: 17381BR, Closing date: 3 December 2023
Apply to centreUK DRI is seeking an Edmond and Lily Safra Research Fellow to join the department of Brain Sciences at Imperial College London. You will belong to a cohort of up to five Fellows recruited during the 2023-24 academic year. The Fellowships may be held for 3 years in the first instance. You may spend up to 12 months visiting other research institutions and/ or in industry, the maximum time spent at any one institution or company being 6 months. Research space will be provided at Imperial, consistent with needs, along with a non-renewable research start-up fund of £30,000. You will have access to specific additional support for specialised equipment that they might need. Additional funds may also be available on a project-by-project basis from other internal funds, including e.g., those of the NIHR Biomedical Research Centre or the UKRI Impact Acceleration Account (IAA) scheme administered by the College. You will lead and grow a scientific programme of the highest quality in Parkinson’s disease research towards international excellence in the chosen area, publish research papers in peer-reviewed journals, attend and present work at international conferences and obtain external research funding. For this role you have to have achieved a PhD or equivalent higher research degree in a relevant field, have previous research and publication record with evidence of potential for international excellence and leadership in the chosen area of science and you will now be building on existing post-doctoral or equivalent research training. Ref: MED03955, Closing date: 9 April 2024
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