UK DRI is seeking a Research Assistant / Bioinformatician to support a range of collaborative studies across the McColl and Priller labs. You will be joining research-intensive labs investigating neuroimmune mechanisms involved in brain health, ageing, vascular and degenerative brain diseases. This is an exciting role that will be integral to our labs and involve implementing and advancing computational methods which we use routinely as part of a multi-modal approach to addressing our scientific questions. While the role will primarily support ongoing and planned studies of the labs, there will be scope for professional development, and intellectual contributions to research design and analysis will be highly valued. You will hold a minimum of BSc or equivalent qualification and/or experience in bioinformatics, or a related computational discipline.You will have experience in bioinformatics and statistical analysis of large -omics datasets, excellent computer and programming skills (e.g. R, Python) and ability to develop and implement computational solutions using coding best practices, good knowledge of bioinformatics tools and methods used in genomics/transcriptomics research and ability to work collaboratively in an interdisciplinary team and under own initiative. Ref: 10059, Closing date: 10 April 2024
Apply to centreUK DRI is seeking a Research Assistant to join the FTD Fluid Biomarker Lab within the UK DRI Biomarker Factory at UCL Department of School of Life & Medical Sciences. The group is part of Professor Jonathan Rohrer’s team at the Dementia Research Centre and focuses on the discovery and development of fluid biomarkers for frontotemporal dementia, specifically in genetic FTD. We are part of the GENetic FTD Initiative (GENFI), a multicentre cohort study recruiting participants carrying mutations accounting for FTD. The project will be focused on the development of new methodologies to measure fluid biomarkers in blood and cerebrospinal fluid samples from FTD participants. We are seeking an energetic and proactive individual who is passionate about the study of biomarkers for neurodegenerative diseases and understands the impact of this research in people living with dementia. Your main responsibilities will be to assist with the extractions of extracellular vesicles (EV) from plasma samples using a SEC set up with further characterisation of EV populations as well as to validate and develop immunoassays (both commercially available and home brew) for the measurement of proteins related to the lysosomal dysfunction. This is a unique opportunity to work in a vibrant research environment and at the cutting edge of disease-related neuroscience both within the UK DRI and the DRC at UCL Queen Square Institute of Neurology as well as through collaboration with external laboratories. You should have an Honours degree (min 2:1) in Neuroscience, Developmental Biology, Molecular Biology, or a related discipline and experience performing immunoassays. Knowledge in Biochemistry/Molecular Biology is also a requirement, as is excellent time management, and the ability to be meticulous and accurate in all aspects of work. Experience with extracellular vesicles purification and characterisation techniques and statistical analysis skills are desirable. Ref: B02-06710, Closing date: 14 April 2024
Apply to centreUK DRI is seeking two Research Technicians to join the Care Research and Technology Centre at Imperial College London. The role will offer a unique opportunity to contribute to a project that is both highly technical and positive in impact, working alongside dedicated software developers, data scientists, design engineers, clinical researchers, and healthcare professionals. You will have an influential role in the planning, deployment, and operation of the NHS extension of Minder. This is excellent opportunity, for the right candidate(s), to develop a career within the emerging field of IoT and AI enabled smart homes and dementia care within a rich learning environment and a supportive team. You will be responsible for the research delivery, patient monitoring and providing planned and technical troubleshooting in support of the research participants and the research team to optimise data quality. To perform the role effectively, you will have excellent interpersonal skills, be a confident communicator and ideally have knowledge of clinical research within a governance and ethical framework. Moreover, the post holder will be well organised with a strong desire to deliver excellent work and you will act as an ambassador for the UK DRI Care Research and Technology Centre. Ref: MED04471, Closing date: 17 April 2024
Apply to centreUK DRI is seeking a Scientific Project Manager to join the Care Research and Technology Centre at Imperial College London. This is an excellent opportunity to develop a career in applied clinical research management, within the emerging field of Digitally Enabled Care remote monitoring technologies and cutting-edge data management applied to clinical research. The role will offer a unique opportunity to contribute to two projects that are both highly technical and with significant social impact. The post holder will work alongside dedicated software developers, clinical researchers, data scientists, healthcare professionals and designers. You will have an influential role in the planning, deployment and operation of the NHS extension of Minder, a project with the potential to deliver positive impact to individuals and broader society and coordination of the Biomarker Repository Work Package TBI reporter. You will be responsible for the development and implementation of the CR&T product “Minder platform” into the NHS systems. In addition, you will be expected to coordinate and deliver the biomarker repository, across collaborating sites, supporting the teams, managing external agencies whilst overseeing milestones, budgets and writing reports. You will closely monitor activities for their strategic management, regular report research outcomes, and support efforts to maximise their impact, lead the running of the two studies, making sure that research activities are conducted as per protocol. We expect you to have relevant clinical research management experience from working in academia and/or industry. You will need to demonstrate an ability to coordinate research projects and understand clinical research practices (i.e. information governance and GDPR). We also expect you to have excellent organisational skills and ability to manage own workload as well as manage multidisciplinary team. This role would require the ability to quickly establish strong and effective working relationships with a wide range of people and at all levels. Ref: MED04469, 15 April 2024
Apply to centreUK DRI is seeking a Scientific Project Manager to join the Care Research and Technology Centre at the Imperial College London. The Scientific Project Manager will be responsible for the development and implementation of systems within CR&T to ensure projects are planned, monitored and tracked. You will work with the CR&T Management team and across the Centre with the seven group leaders and their teams to ensure the smooth running of their work packages. In addition the post holder will be expected to devise, plan and execute cross Centre work packages, diligently supporting the teams, managing external agencies and consultants whilst overseeing milestones, budgets and writing reports. You will also provide the Director with comprehensive administrative and management support. You will have responsibility for ensuring close monitoring of activities for their strategic management, regular reporting of research outcomes, and supporting efforts to maximise their impact. You will also work closely with the Centre and Research Commercialisation Manager to fulfil these objectives. You will hold a degree or equivalent qualification / experience, have research experience or PhD in a relevant area, project or portfolio management experience, proven success in a similar post, and research coordination / monitoring experience. Ref: MED04510, Closing date: 20 April 2024
Apply to centreUK DRI is seeking a Data Engineer (Health Technology) to join the Care Research and Technology Centre at Imperial College London. This is a rare opportunity to join a multi-functional team building a unique health technology platform that supports the care of people affected by dementia and other conditions. We are seeking a data and machine learning engineer motivated by the chance to address exciting technical challenges while working on Minder, a project with the potential to deliver positive impact to individuals and broader society. You will have an influential role in designing, deploying, managing and using infrastructure for data analysis as the platform is rolled out in a growing number of care settings. You will be working alongside dedicated software developers, clinical researchers, data scientists, healthcare professionals and designers. We use an agile development methodology, following industry-standard software and data engineering processes for version control, build automation and continuous delivery. The role is multifaceted and will inevitably evolve as Minder becomes an increasingly intelligent platform, but you can expect to be working on infrastructure and code for data management, analysis and visualisation, alongside supporting the development and overseeing the deployment of machine learning models. On a day-to-day basis you’ll be interfacing with our existing software engineering and data science teams: deploying tools to ensure that up-to-date data is made available to data scientists in useful formats, assisting them to develop and deploy their machine learning models, and providing tools for exploratory data analysis and visualisation. This will involve responsibility for building the relevant cloud infrastructure i.e. planning, implementation, QA and maintenance and will require knowledge of Python, SQL, cloud data warehouses, workflow orchestration tools and distributed compute frameworks with Kubernetes and/or Azure. You will have degree level qualification in data science, software engineering or related discipline, or equivalent professional experience, significant experience of data engineering including workflow management platforms, data warehousing solutions and data transformation tools, knowledge on how to use of cloud-native infrastructure and development of machine learning algorithms/pipelines. Ref: MED04506, Closing date 17 April 2024
Apply to centreUK DRI is seeking an enthusiastic Research Associate to join the Connor-Robson’s Lab within School of Medicine at Cardiff University. Dr Connor-Robson’s group centres on the use of cutting-edge induced pluripotent stem cell (iPSC) models to study the molecular mechanisms underlying neurodegenerative diseases with particular focus on endocytic dysfunction. The group studies neurons, microglia and astrocytes both in mono and coculture settings. The lab aims to translate the complex genetic landscape of Alzheimer’s disease into a better understanding of cellular and molecular changes that occur during disease. We hope to translate our findings into better drug targets and therapeutic strategies. The successful candidate will work with our novel Alzheimer’s disease high endocytic polygenic risk iPSC lines and use them to investigate disease mechanisms. The project will also include collaboration with Prof Steve Finkbeiner’s (UCSF) group to develop novel image analysis techniques. The successful candidate will work together with others in the lab to collect experimental data and to analyse the data. They will be highly independent and will drive the project to its fruitful completion. You will hold a postgraduate degree at PhD level (or nearing completion / submission) in a related subject area or relevant industrial experience, have established expertise and proven portfolio of research and/or relevant industrial experience within neurodegeneration and induced pluripotent stem cell models, knowledge of current status of research in specialist field (as described above), proven ability to publish in national/international journals or other research outputs and knowledge and understanding of competitive research funding to be able to develop applications to funding bodies. Ref: 17562BR, Closing date: March 31 2024
Apply to centreUK DRI is seeking an Edmond and Lily Safra Research Fellow to join the department of Brain Sciences at Imperial College London. You will belong to a cohort of up to five Fellows recruited during the 2023-24 academic year. The Fellowships may be held for 3 years in the first instance. You may spend up to 12 months visiting other research institutions and/ or in industry, the maximum time spent at any one institution or company being 6 months. Research space will be provided at Imperial, consistent with needs, along with a non-renewable research start-up fund of £30,000. You will have access to specific additional support for specialised equipment that they might need. Additional funds may also be available on a project-by-project basis from other internal funds, including e.g., those of the NIHR Biomedical Research Centre or the UKRI Impact Acceleration Account (IAA) scheme administered by the College. You will lead and grow a scientific programme of the highest quality in Parkinson’s disease research towards international excellence in the chosen area, publish research papers in peer-reviewed journals, attend and present work at international conferences and obtain external research funding. For this role you have to have achieved a PhD or equivalent higher research degree in a relevant field, have previous research and publication record with evidence of potential for international excellence and leadership in the chosen area of science and you will now be building on existing post-doctoral or equivalent research training. Ref: MED03955, Closing date: 9 April 2024
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