Studies are increasingly highlighting the important role of immune, vascular and metabolic factors in the development of neurodegenerative diseases but the interplay between these components in disease progression is poorly understood. The UK DRI at The University of Edinburgh will broaden out the traditional view of neurodegenerative disease as a disorder of misfolded proteins to encompass the multicellular environment surrounding degenerating neurons.
The research team lead by Professor Giles Hardingham will examine the complex interactions between cells of the brain, immune system and blood vessels that make up the ‘neurogliovascular unit’. They bring together strengths in metabolism, inflammation, blood vessel biology and stem cell medicine to explore how interactions at the neurogliovascular unit control the trajectory of neurodegenerative diseases leading to dementia.
By describing interactions at the neurogliovascular unit that help to maintain cognitive function for several decades in a healthy, ageing brain, the team aim to identify biological regulators that can inform the development of new therapies.
UK DRI at The University of Edinburgh will be located on the BioQuarter, Edinburgh's new multidisciplinary research institute and teaching hospital with access to superb multimodal neuroimaging and clinical research facilities.
A postdoctoral Research Fellow position (12 months) is available to study a potential drug target for Alzheimer’s disease in induced pluripotent stem cell derived neurons. The fellow will be based in the Centre for Discovery Brain Sciences and UK Dementia Research Institute (UK DRI) at the University of Edinburgh, working with Prof Tara Spires-Jones. UK DRI at Edinburgh are looking for an enthusiastic scientist with an interest in synaptic integrity and resilience. Experience with human stem cell derived neurons is essential and experience with primary astrocyte culture, western blotting, immunohistochemistry, and confocal microscopy image analysis are highly desirable. The post holder will use stem cell derived neurons and proprietary reagents from a collaborating pharmaceutical company to test whether modulating a potential drug target can prevent or reverse synapse degeneration. Vacancy ref no: 047373. Closing date: 22.04.2019Apply to centre
UK DRI Fellows will lead an internationally competitive research programme with up to £1.5m in funding support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. Use reference: 046510 on Edinburgh vacancy page. Round closing date: 3rd July 2019Download role profile Apply to centre
UK DRI Professors will direct internationally competitive research with up to £3m programme support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working. Use reference: 046501 on Edinburgh vacancy page. Round closing date: 3rd July 2019Download role profile Apply to centre