Studies are increasingly highlighting the important role of immune, vascular and metabolic factors in the development of neurodegenerative diseases but the interplay between these components in disease progression is poorly understood. The UK DRI at The University of Edinburgh will broaden out the traditional view of neurodegenerative disease as a disorder of misfolded proteins to encompass the multicellular environment surrounding degenerating neurons.
The research team lead by Professor Giles Hardingham will examine the complex interactions between cells of the brain, immune system and blood vessels that make up the ‘neurogliovascular unit’. They bring together strengths in metabolism, inflammation, blood vessel biology and stem cell medicine to explore how interactions at the neurogliovascular unit control the trajectory of neurodegenerative diseases leading to dementia.
By describing interactions at the neurogliovascular unit that help to maintain cognitive function for several decades in a healthy, ageing brain, the team aim to identify biological regulators that can inform the development of new therapies.
UK DRI at The University of Edinburgh will be located on the BioQuarter, Edinburgh's new multidisciplinary research institute and teaching hospital with access to superb multimodal neuroimaging and clinical research facilities.
A clinical research fellow is required to work on studies of Small Vessel Diseases in stroke and dementia. The post is funded by the Medical Research Council as part of clinical research on vascular causes of dementia in the UK Dementia Research Institute (DRI) at the University of Edinburgh. The clinical fellow will be part of Professor Wardlaw’s team working on mechanistic studies and clinical trials of cerebral Small Vessel Diseases, and be responsible for patient recruitment while gaining skills in a wide range of clinical research, brain MRI, trials and experimental medicine methods. The work provides a suitable basis for undertaking a PhD. The environment is world-leading in clinical research in cerebrovascular diseases and dementia. The newly formed UK DRI brings together basic, clinical and social science into one organisation to lead research into prevention of all causes of dementia at a global level. We also have exceptional international collaborative networks in stroke and small vessel diseases through Fondation Leducq, EU Horizon 2020, Stroke Association and BHF-funded research. Candidates should have a good medical degree, full registration with the GMC, MRCP or equivalent qualification or experience, a clear interest in small vessel diseases in stroke and dementia and clinical research. You should have excellent organisational skills, good oral and written communication skills, and be able to work flexibly in a large multi-disciplinary international team.Apply to centre
UK DRI Fellows will lead an internationally competitive research programme with up to £1.5m in funding support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working.Download role profile Apply to centre
UK DRI Professors will direct internationally competitive research with up to £3m programme support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working.Download role profile Apply to centre