Studies are increasingly highlighting the important role of immune, vascular and metabolic factors in the development of neurodegenerative diseases but the interplay between these components in disease progression is poorly understood. The UK DRI at The University of Edinburgh will broaden out the traditional view of neurodegenerative disease as a disorder of misfolded proteins to encompass the multicellular environment surrounding degenerating neurons.
The research team lead by Professor Giles Hardingham will examine the complex interactions between cells of the brain, immune system and blood vessels that make up the ‘neurogliovascular unit’. They bring together strengths in metabolism, inflammation, blood vessel biology and stem cell medicine to explore how interactions at the neurogliovascular unit control the trajectory of neurodegenerative diseases leading to dementia.
By describing interactions at the neurogliovascular unit that help to maintain cognitive function for several decades in a healthy, ageing brain, the team aim to identify biological regulators that can inform the development of new therapies.
UK DRI at The University of Edinburgh will be located on the BioQuarter, Edinburgh's new multidisciplinary research institute and teaching hospital with access to superb multimodal neuroimaging and clinical research facilities.
Applications are invited for a full-time research assistant within the UK DRI at the University of Edinburgh. You will liaise with all UK DRI lab groups based in Chancellor’s Building at the Edinburgh BioQuarter and contribute to the management of all UK DRI rodent colonies. It is expected that the successful applicant will hold or be able to gain a Home Office Personal Licence, be experienced in all aspects of rodent colony management and logistics, be knowledgeable about rodent welfare, and will have experience of genotyping strategies. The main purpose of the role will be to assist with the management of the rodent colonies of UK DRI group lines which will include: planning, organisation and maintenance of breeding, crossing, experimental request form approval, budget guidance/management for each individual group, external import and export organisation and approval, liaison with named vet surgeons and other senior animal technical staff, liaison with users of the animal facility within each lab group; set up genotyping for the lab groups.Ref: 049051, Closing date: 2 SeptemberApply to centre