UK DRI at Imperial College London

• Specialisms at Imperial College London
• Neuroinflammation and neurodegeneration
• Epigenomic influences on risks and progression of dementia
• Roles of the microbiome in cognition and neurodegeneration
• Circadian neurobiology and mechanisms of neurodegeneration
• Neurotechnologies for targeted neuronal and glial modulation

• Read more about Imperial College London

  UK DRI at Imperial College London has innovation as its theme. This draws on the university’s unique strengths and focus on science, engineering, medicine and business. Led by Professor Paul Matthews, the research team will bring novel, cutting edge approaches and research tools to the study of dementia to discover new disease mechanisms and therapeutic targets. They will initially focus on the earliest pre-symptomatic stages of Alzheimer’s disease, addressing what determines the transition to neurodegeneration, but will investigate mechanisms that are likely shared across many of the dementias.

  With access to large, well characterized longitudinal cohorts the team will explore causes of individual variation in dementia within populations, looking at changes that occur across the lifespan and specifically addressing metabolic factors, the relationship with microorganisms in gut (the microbiome) and the role of sleep. The team will use a range of resources including Dementias Platform UK and the MRC-NIHR National Phenome Centre.

  UK DRI at Imperial College London will be located at the White City campus Hammersmith, London, in the Sir Michael Uren Biomedical Engineering Research Hub due to be completed in 2019, alongside Imperial’s translation and innovation ‘I-HUB’.

Apply for latest jobs at Imperial College London

• Junior Research Technician in Molecular and Cellular Neuropathology, UK DRI at Imperial

  Applications are invited for an enthusiastic research technician in the lab of Prof Paul Matthews. based at the UK Dementia Research Institute at Imperial, providing support for an exciting new portfolio of molecular and cellular neurodegenerative disease research. Candidates should be curious, dynamic and keen to be part of the larger UK Dementia Research Institute for its ambitions to develop the foundations for better treatments of people with dementia. A good qualification/equivalent experience in relevant laboratory sciences (e.g. biology or biomedical related sciences) is required with experience of laboratory-based research, and practical experience of either histology or genomics methodologies. Ref: MED01307, Closing date: 10 July

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• Research Technicians (x3) in Molecular and Cellular Neuropathology, UK DRI at Imperial

  Applications are invited for experienced research technicians in the lab of Prof Paul Matthews. based at the UK Dementia Research Institute at Imperial and providing support for an exciting new portfolio of molecular and cellular neurodegenerative disease research. Initiatives include the UK DRI Brain Atlas, a project intended to develop a comprehensive multi-omics atlas of the brain cellular neuropathology of Alzheimer’s disease as a resource for researchers world-wide. This research area is evolving rapidly, and successful candidates will be given opportunities to train in new methods and develop new competencies with a wide range of “cutting edge” methods. Candidates should be curious, dynamic and keen to be part of the larger UK DRI for its ambitions to develop the foundations for better treatments of people with dementia. Ref: MED01278, Closing date - extended: 10 July

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• Edmond and Lily Safra Research Fellows (x4) in Advanced Technologies/Bioinformatics, UK DRI at Imperial & UK DRI Care Research & Technology Centre

  With generous support from the Edmond J. Safra Foundation and in conjunction with the UK DRI at Imperial and the UK DRI Centre for Care Research and Technology, four new Edmond and Lily Safra Fellows are being sought. These are career development posts. They are seeking early career researchers ready to take the first steps towards setting up independent research programmes. They are looking for accomplished investigators who are willing to take risks to pursue important objectives. They intend to appoint 2 Fellows with research programmes using advanced technologies or data science to improve early disease detection, monitoring or care of people with neurodegenerative diseases. An additional 2 Fellows will be recruited to address a broader range of interests in bioinformatics (including, e.g. specialisations in systems/computational neuroscience, ‘omics or population studies), translational molecular cell studies or advanced neuroimaging specifically for the diagnosis, monitoring and treatment of Parkinson’s disease. Ref: MED01244, Closing date: 21 July

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