UK DRI at Imperial College London has innovation as its theme. This draws on the university’s unique strengths and focus on science, engineering, medicine and business. Led by Professor Paul Matthews, the research team will bring novel, cutting edge approaches and research tools to the study of dementia to discover new disease mechanisms and therapeutic targets. They will initially focus on the earliest pre-symptomatic stages of Alzheimer’s disease, addressing what determines the transition to neurodegeneration, but will investigate mechanisms that are likely shared across many of the dementias.
With access to large, well characterized longitudinal cohorts the team will explore causes of individual variation in dementia within populations, looking at changes that occur across the lifespan and specifically addressing metabolic factors, the relationship with microorganisms in gut (the microbiome) and the role of sleep. The team will use a range of resources including Dementias Platform UK and the MRC-NIHR National Phenome Centre.
UK DRI at Imperial College London will be located at the White City campus Hammersmith, London, in the Sir Michael Uren Biomedical Engineering Research Hub due to be completed in 2019, alongside Imperial’s translation and innovation ‘I-HUB’.
The UK Dementia Research Institute (UK DRI) at Imperial College London is seeking a Scientific Project Manager interested in taking on a challenging role to support the creation of a comprehensive molecular cell atlas of Alzheimer’s disease in the brain through a UK DRI Multi-‘omics Atlas Project (MAP). Dementias represent one of the greatest medical and economic challenges facing our society today.Apply to centre
The UK DRI is seeking outstanding post-doctoral researchers interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. The ideal candidate will be ambitious, with the passion to tackle big problems and a readiness to try out high-risk, high-payoff projects. Exceptional experience in viral vector technologies (AAVs, LVs), in vivo and ex vivo live imaging, stereotaxic surgery, in vivo micro-dialysis, mouse behaviour will be considered as an advantage. Experience in circadian and sleep research is also an advantage, but it is not strictly required. (Second round of applications will be assessed after the first round closing 3 Jan 2019)Apply to centre
UK DRI Fellows will lead an internationally competitive research programme with up to £1.5m in funding support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working.Download role profile Apply to centre
UK DRI Professors will direct internationally competitive research with up to £3m programme support, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will draw on the knowledge and expertise of other colleagues both within and outside of the UK DRI through collaborative inputs and team working.Download role profile Apply to centre