The UK DRI at UCL is offering an exciting opportunity to join the Bartels lab as a Research Technician. The Bartels lab specialises to fill the gap for scientific research on synuclein multimers and lipidomics associated with Parkinson’s Disease. The lab is dedicated to understanding the biochemical nature of α-synuclein in healthy and diseased patients. The postholder will provide experimental support for the research project, which will comprise of the analysis of human postmortem brain material and various cell culture models including iPSC-derived and primary human neurons as well as structural in vitro assays using recombinant protein. The native brain tissue and the in vitro models will be used to study α-synuclein multimers and lipid composition in different Synucleinopathies. In vitro, aggregation assays, electron microscopy, CD spectroscopy, and FCS will be used to elucidate context-dependent folding. Technical assistance is required with histopathology techniques, biochemical analysis such as crosslinking and Western Blot, RNA and DNA analysis and cell culture, as well as protein expression and purification. Ref: B02-06769, Closing date: Thursday 25 April 2024
Apply to centreThe Opazo Lab at the UK DRI at Edinburgh is seeking a Postdoctoral Research Fellow with experience with in-vivo two-photon microscopy, optogenetics, stereotaxic surgeries and animal behaviour. The purpose of the role is to investigate the synaptic and neuronal compensatory mechanisms that preserve cognitive function in Alzheimer’s disease mouse models. The project will involve the visualization and optogenetic manipulations of synapses (e.g. dendritic spines) and neuronal ensembles using in-vivo two-photon imaging in the primary visual cortex; as well as AAV-mediated genetic manipulations and animal behaviour. The ideal candidate will have prior experience with in-vivo two-photon imaging microscopy, optogenetics, stereotaxic surgeries and animal behaviour. Some experience with transcriptomics/proteomics, in-utero electroporation, molecular biology and programming (Matlab), would be desirable. Ref: 10199, Closing date: 7 May 2024
Apply to centreThe Opazo Lab at the UK DRI at Edinburgh is seeking a Research Assistant to provide support for ongoing experiments using immunohistochemistry, confocal and two-photon microscopy, stereotaxic surgeries and AAV-mediated genetic manipulations. The primary purpose of the position is to provide research support for ongoing experiments on synaptic compensation and repair in Alzheimer’s disease models. The projects in the lab involve AAV-mediated genetic manipulations, as well as the visualization of synapses (e.g. dendritic spines) using in-vitro and in-vivo two-photon microscopy. The ideal candidate will have prior experience in stereotaxic surgeries, two-photon microscopy and management of transgenic mouse lines colonies, as well as the ability to conduct own research and associated administrative activities. Ref: 10202, Closing date: 7 May 2024
Apply to centreThe Hasel Lab at the UK DRI at Edinburgh is seeking a Research Assistant to help explore how astrocytes at the borders of the brain contribute to brain function and dysfunction in disease. The candidate will establish, carry out and optimise experimental protocols and perform laboratory organisational activities such as stock checks and ordering, medium and reagent prep and lab maintenance. The post-holder will contribute to data collection for original research through assisting with sample preparation, RNA in situ hybridization, immunohistochemistry, microscopy and data analysis. The job is in a new research group that combines wet lab work with computational tools and is a great opportunity to learn new skills in molecular biology, histology or help with the generation and analysis of single cell RNA-sequencing and spatial transcriptomics data. A B.Sc. (or equivalent qualification) or higher degree in Biology, Biochemistry, Neuroscience or related field is essential. Ref: 10029, Closing date: Wed 26 April 2024
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