​UK DRI at UCL

• Specialisms at UCL
• Mechanistic understanding of dysfunction in cells and neural systems
• Gene expression and biological pathways in single cells related to the progression of Alzheimer’s disease
• New biomarkers to monitor disease progression
• Deficits in axonal transport in early neurodegeneration
• Wnt signalling in synapses to discover new targets for future dementia therapies

• Read more about UCL

  Research from UK DRI at UCL will cover the journey from the patient to the laboratory and back to the patient with improved diagnosis, biomarkers and candidate therapies to put to the test. Led by Professor Bart de Strooper, UK DRI Director, the team will address the key unanswered mechanistic questions that link genetic and lifecourse factors to dysfunction in molecular pathways, in cells and in neural systems during the progression of the dementias. This work will be enhanced by clinical resource to link lab work to the clinic.

  UK DRI at UCL will examine changes in gene expression and biological pathways in single cells to get a detailed picture of the changes happening during the initiation and development of Alzheimer’s disease. The UCL team will also develop new biomarkers to monitor disease progression. Programmes of work will look specifically at deficits in axonal transport as a very early step in neurodegeneration and at the role of the Wnt signaling pathway in the maintenance and function of synapses to see whether it is a promising target for future dementia therapies.

  Location: UK DRI at UCL will initially be located in a refurbished space within the Cruciform building, within UCL’s Bloomsbury campus. This location is near to Alzheimer's Research UK's UCL Drug Discovery Institute, the MRC Laboratory for Molecular Cellular Biology, the MRC Prion Unit, the Sainsbury Wellcome Centre for Neural Circuits and Behaviour, and genetic facilities. 

Apply for latest jobs at UCL

• Centre Senior Administrator, UK DRI at UCL

  Applications are open for a Centre Senior Adminstrator to support the UK DRI at UCL, one of seven centres of the UK Dementia Research Institute. The successful candidate will provide administrative and day-to-day operational support to the Centre Manager and research groups. Duties will include assisting with planning and organising Centre events, seminars and lab tours, servicing various Centre meetings and committees, financial administration of Centre research grants, assisting with recruitment and appraisal processes and acting as a first point of contact for staff, students and visitors, updating and maintaining the Centre's webpages, distributing Centre communications, and maintaining and managing the Centre's various mailing lists. Ref: 1818872, Closing date: 2 September

  Apply to centre
• Science Review Manager - UK Dementia Research Institute Headquarters

  Applications are invited for a Science Review Manager, based at the UK Dementia Research Institute Headquarters at UCL. This is a new role, created to deliver the UK DRI’s portfolio of research initiatives and programmes. The successful candidate will establish transparent and fair assessment mechanisms for our competitive internal financial award opportunities and manage the application, review and reporting processes for our various funded programmes. Responsibilities will include coordinating peer review activities, providing constructive advice and guidance to applicants & designing metrics to assess the success of the different strategic initiatives. We're looking for someone with a PhD in Neuroscience (or a cognate area), coupled with project management skills and an understanding of how to utilise communication channels to target audiences. Ref: 1819553, Closing date: 25 August

  Apply to centre
• UK DRI Group Leader (Senior/Principal Fellow) in dementia and neurodegeneration at UCL

  The UK DRI at UCL are looking to appoint a new Group Leader (Senior/Principal Fellow), who will lead an internationally competitive research programme, relevant to the area of neurodegeneration, with the ultimate aim of improving human health. You will receive extensive support from the UK DRI, including up to £1.5 million start-up funding over a five-year period, appointment based on the MRC tenure-track route, access to shared equipment and technology across a national institute and membership of a community of world-leading scientists. You are also entitled to the full range of UCL staff benefits and development opportunities. You will have substantial postdoctoral experience, a proven track record of internationally competitive scientific research relevant to the UK DRI and a commitment to, appreciation and understanding of the mission of the UK DRI. You’ll be experienced in planning and developing projects or programmes of research and have a wide knowledge of techniques and methodologies related to research in neurodegeneration. You’ll propose an exciting and innovative programme of research that demonstrably interfaces and compliments the UK DRI’s current portfolio and science strategy, and evidence that you have the potential to lead, inspire and develop a research group into an excellent team. Rolling deadline.

  Apply to centre