Five years of innovation
in discovery science

The UK’s leading biomedical research institute
dedicated to neurodegenerative diseases

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Our research

See how our science is tackling dementia

Lab profiles

Our teams are growing

Come join us in transforming dementia research

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How UK DRI research is being shaped by people affected by dementia

The UK DRI exists to improve the lives of those at risk of or living with dementia, and their carers. By involving people with lived experience of neurodegenerative diseases, we believe our research is strengthened, leading to better treatments and technologies for dementia. We recently saw the impact of this approach when running a series of workshops and activities to understand how best to develop an innovative new brain stimulation technology.

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UK DRI Grand Challenge: developing a functional circuit biomarker for Alzheimer’s disease

With emerging treatments for Alzheimer's on the horizon, it is critical that people can be diagnosed early in the disease for intervention to be most effective. In this new UK DRI Grand Challenge, Dr Marc Aurel Busche and a team of collaborators will carry out animal and human studies in parallel, to develop a new functional biomarker for Alzheimer's that measures subtle changes to the brain’s circuitry in the earliest stages of disease.

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Developing 3D stem cell models of motor neuron disease

In an exciting new project, Dr Bhuvaneish T Selvaraj, Emerging Leader at the UK DRI at Edinburgh, will investigate the mechanisms underlying motor neuron disease (MND) using cutting-edge human stem cell technology.

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“I'm not going to give up”: in conversation with 2022 MRC Millennium Medal winner Prof Sarah Tabrizi

For her outstanding efforts and achievements, Prof Tabrizi is recognised with this year’s prestigious MRC Millennium Medal. We caught up with Sarah to reflect on her career to date, passion for scientific investigation and tireless drive to deliver a cure for her patients at the National Hospital for Neurology and Neurosurgery (NHNN), part of UCLH.

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Research partners

Building connections across the dementia ecosystem

The Dementia UK Ecosystem (DUKE) brings together leaders from the UK DRI, Dementias Platform UK, the National Institute for Health Research, the pharmaceutical industry, and funders to create a cohesive community, coordinating efforts to accelerate progress in tackling dementia.

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Trial recruitment

Get involved in dementia research

Group Leader Dr Nir Grossman (UK DRI at Imperial) is leading a new trial using deep electrical currents applied to the brain of people living with Alzheimer's disease. The team are recruiting participants over the next year.

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Discovering hope
for dementia

Find out how we are leading the
journey of discovery in dementia

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Translation and innovation

Turning breakthroughs into treatments

We have a clearly defined vision at the UK DRI to develop effective therapeutics, diagnostics and technologies for people living with dementia. Alongside building our disease knowledge over the coming years, we will also make progress in translating these discoveries into the clinic.

Translation and innovation
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Science Vision

Our priorities as a research institute

We accelerate, innovate, deepen and broaden discovery science in dementia, with the goal of filling the huge knowledge gap in this field. We exist to bring forward the day when research benefits people living with and those at risk of dementia.

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Equity, Diversity and Inclusion

Collaboration and connection

Our efforts to increase the diversity of our team, ensure inclusion and promote equality of opportunity, align with our vision for the UK DRI’s Institute culture and identity as a world-leader in dementia research.

Equity, Diversity and Inclusion
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Research themes

Bringing together researchers to address major scientific questions

We study a range of neurodegenerative disorders that cause dementia. Many of them share fundamental disease mechanisms and characteristics, and greater understanding gained in one can often benefit others. To ensure we capitalise on diverse expertise, approaches and perspectives, we have established cross-centre themes.

Research themes

Founding funders

Latest tweets from @UKDRI

RT @BritishNeuro: From academia to industry to clinical applications and beyond, coming to #BNA2023 will help you build bridges, make conne…
24 Mar 2023 13:19

"We discovered the surprising role of perivascular macrophages in synapse pathology" @soyonhonglab &…
24 Mar 2023 12:03