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Academy Of Medical Sciences Website

UK DRI researcher elected to prestigious Academy of Medical Sciences fellowship

We are thrilled to announce that Prof Tara Spires-Jones (UK DRI at Edinburgh) is one of 58 exceptional scientists today elected to the Academy of Medical Sciences Fellowship.

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UK DRI appoints Chief Scientific Officer

We are delighted to announce that Jo Latimer will join the UK DRI as Chief Scientific Officer, commencing mid-August 2024.

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Three UK DRI researchers elected to prestigious Royal Society Fellowship

We are delighted to announce that Prof Sarah Tabrizi (UK DRI at UCL), Prof Bill Wisden and Prof Paul Elliott (both UK DRI at Imperial) have been elected as Fellows of the Royal Society for their outstanding research.

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Scientists find sleep may not clear brain toxins as previously thought

The brain’s ability to rid itself of toxins may be reduced during sleep, surprising new UK DRI research reveals. The study, led by Prof Bill Wisden (UK DRI at Imperial) and Prof Nick Franks (Imperial College London), is published in the journal Nature Neuroscience.

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Reduced clearance of damaged microglia contributes to Alzheimer’s progression

A study led by Prof Paul Matthews and Dr Nurun Fancy (both UK DRI at Imperial) provides important new insights into the mechanisms by which a process known as age-related cell senescence contributes to the progression of Alzheimer’s disease.

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New UK DRI scheme launched to fund bold and boundary pushing research

We are delighted to announce the first recipients of the new ‘Key Questions’ intramural funding programme, leveraging the unique strengths and capabilities of our Institute to catalyse bold and ambitious research projects, which adopt multidisciplinary and innovative approaches.

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Dr Kiran K G Ravindran, UK DRI Care Research & Technology: My Week in Westminster at the Royal Society Pairing Scheme 2024

Dr Kiran K G Ravindran is a Postdoctoral Research Fellow working with Prof Derk-Jan Dijk at the UK DRI Centre for Care Research & Technology and the Surrey Sleep Research Centre at the University of Surrey. Dr Ravindran was one of 30 scientists who participated in this year’s Royal Society Pairing Scheme, an initiative facilitating collaboration between scientists and policymakers. Here, he shares his experience with the scheme and its impact on his perspective.

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Dr Georgina Starling, UK DRI at UCL: My Week in Westminster at the Royal Society Pairing Scheme 2024

Dr Georgina (George) Starling is a Postdoctoral Research Fellow joint between Prof Adrian Isaacs lab (UK DRI at UCL) and Dr Jeremy Carlton's lab at King's College London and the Francis Crick Institute. Here she tells us about her experience on the Royal Society pairing scheme which saw her travel to Westminster to experience first-hand how science and policy intersect and are used in government.

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A critical time for AI, dementia and better brain health

Ahead of BioBeat24, Iraida Soria-Espinosa, Senior Innovation & Business Manager at UK DRI, and Miranda Weston-Smith, Founder of BioBeat, caught up with keynote speaker Zoe Kourtzi, Professor of Computational Cognitive Neuroscience at the University of Cambridge.

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Introducing Philip Hasel, UK DRI at Edinburgh: Unlocking the role of astrocytes in brain health and disease

During his postdoc Dr Philip Hasel (UK DRI at Edinburgh) discovered a distinct type of astrocyte that is only found in a single cell layer on the surface of the brain. In this Q&A, Dr Hasel explains what is so significant about these cells in disease, and why he has made them his research focus as he starts his lab at the UK DRI.

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How temperature and circadian rhythms intersect to regulate a protein shown to protect against neurodegeneration

A new study led by Dr Marco Brancaccio (UK DRI at Imperial) and Dr Marieke Hoekstra (former UK DRI at Imperial, now VIB-KU Leuven Center for Brain & Disease Research) offers a deeper insight into how a neuroprotective pathway is regulated both by temperature and the body clock.

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World Parkinson’s Day: What do we know about Parkinson’s?

Parkinson’s is a progressive neurological condition, affecting over 150,000 people in the UK. It is considered to be the fastest growing neurological condition in the world, with the number of people affected expected to double by 2050. In this blog for World Parkinson's Day, we take stock of what we know about the condition, and what UK DRI scientists are doing to help advance research in this area.

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Major project launched to deliver blood tests for dementia

A world-class research team at UCL led by UK DRI Co-Investigator Prof Jonathan Schott, and Dr Ashvini Keshavan, will carry out a countrywide trial to identify accurate and quick blood tests that can diagnose dementia. The team will work closely with the UK DRI Biomarker Factory, led by Prof Henrik Zetterberg and Dr Amanda Heslegrave, to validate the tests.

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Professor David Attwell appointed to spearhead the BHF-UK DRI Centre for Vascular Dementia Research

We are thrilled to announce the appointment of Prof David Attwell as the Centre Director for the groundbreaking new BHF-UK DRI Centre for Vascular Dementia Research. With a distinguished career spanning decades and a wealth of expertise in neuroscience and physiology, Prof Attwell brings unparalleled leadership and vision to this pivotal role.

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Understanding the role of microglia in Alzheimer’s using a novel humanised model of disease

Microglia, the brain’s resident immune cells, are implicated in Alzheimer’s and other neurodegenerative diseases, but the exact mechanisms behind this are not yet understood. A team led by Prof Bart De Strooper (UK DRI at UCL and VIB-KU Leuven) and Prof Renzo Mancuso (VIB-UAntwerp) has transplanted human microglia into mouse brains to better observe how the microglia respond to the disease environment.

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World Down Syndrome Day: Down syndrome and dementia-associated seizures

There are approximately 6 million people worldwide who have Down syndrome. About two in three people with Down syndrome will have been diagnosed with dementia by the time they are 65. Dr Frances Wiseman (UK DRI at UCL) aims to understand dementia in people with Down syndrome, including why individuals who have Down syndrome and develop dementia also experience seizures.

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UK DRI Grand Challenge: uncovering the earliest signs of Alzheimer’s disease

A major new UK DRI Grand Challenge project, led by Prof Karen Duff, Centre Director of the UK DRI at UCL, seeks to understand the earliest stages of Alzheimer’s, by simultaneously examining molecular and cellular changes in mice and studying the very first behavioural changes in humans at risk of the disease. Through greater understanding of the underlying mechanisms of Alzheimer's, the project could lead to the development of new biomarkers to aid in early disease detection, and therapeutics to treat the condition.

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UK DRI at Cambridge researcher awarded 2024 Novo Nordisk Prize for development of revolutionary DNA sequencing techniques

Prof Sir David Klenerman (UK DRI and Yusuf Hamied Department of Chemistry at the University of Cambridge) and Prof Sir Shankar Balasubramanian (University of Cambridge) are being honoured with the 2024 Novo Nordisk Prize for their pioneering work, which enables the human genome to be sequenced in just an hour.

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UK DRI at King's scientists develop novel pipeline to create custom cell culture devices

The SOL3D pipeline is cheaper, versatile, highly reproducible and “democratises” the microfabrication of cell culture devices by allowing potentially any wet lab, regardless of equipment, expertise or field, to produce their own customised systems.

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Reducing brain vascular inflammation could slow Alzheimer’s progression

A new study led by Prof Paul Matthews (UK DRI at Imperial) reveals insight into the molecular mechanisms underlying vascular changes associated with early Alzheimer’s disease. The work, published in Nature Communications, could lead to new therapeutic targets for the disease.

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