Mechanistic insights into the pathophysiology of ALS

A virtual meeting bringing together the ALS research community.

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Mechanistic insights into the pathophysiology of ALS

Amyotrophic Lateral Sclerosis is a disease without cure and the underlying mechanisms that lead to selective motor neuron death are not elucidated. With this virtual meeting we want to bring the ALS community together to share recently gained pathomechanistic insights. We hope to provide a platform for the fostering of new collaborations across the ALS research community that will accelerate the development of therapeutic approaches.

The event will take place over three days, 26-28 May 2021. Each day will run for approx. 4.5 hours, 11:00 - 15:30 BST (12:00 - 16:30 CEST), daily. You will be able to use the same registration link for all three days.

Abstract Submission

Abstract submissions are welcome for short & rapid fire talks. Speakers will be chosen to give either a short talk (15 min live) or rapid fire presentation (2 min pre-recorded video) during the three day event. 

Deadline for abstract submission: Friday 16 April 2021

Abstract submission is now closed 

Speakers will be notified on/before Tuesday 4 May 2021.

Schedule of Events
  • Day 1 - Wednesday 26 May
    • Please note all times are in BST

    11:00 Welcome address

    11:05 Ludo Van Den Bosch (VIB-KU Leuven, Belgium)
    The role of HDAC6 in axonal degeneration and regeneration

    11:45 Emanuele Buratti (International Centre for Genetic Engineering and Biotechnology, Italy)
    Cross-comparison of hnRNP controlled transcripts identifies NOS1AP as a new target in ALS pathology

    12:15 – Eva Hedlund (Stockholm University, Sweden)
    Decoding motor neuron vulnerability and resilience in ALS

    12:45 – Break (15 minutes)

    13:00 – Rapid fire talks (to be selected from submitted abstracts)

    13:15 - Sebastian Lewandowski (Karolinska Institute, Sweden)
    Early perivascular fibroblast activity precedes the onset of ALS neurodegeneration

    13:30 – Laura Ranum (University of Florida, USA)
    Targeting RAN proteins rescues ALS/FTD in C9orf72 BAC mice

    14:00 – Alyssa Coyne (John Hopkins University, School of Medicine, USA)
    Nuclear accumulation of CHMP7 initiates NPC injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

    14:15 – Kurt De Vos (University of Sheffield, UK)
    Loss of TMEM106B increases C9ALS/FTD DPR proteins by disrupting lysosome positioning and autophagy

    14:30 – Break (15 minutes)

    14:45 – Adrian Isaacs (UK Dementia Research Institute at University College London, UK)
    C9orf72 FTD/ALS disease mechanisms

    15:15 – Conclusion of the day

  • Day 2 - Thursday 27 May
    • Please note all times are in BST

    11:00 – Welcome address

    11:05 – Dorothee Dormann (Johannes Gutenberg University and Institute of Molecular Biology Mainz, Germany)
    Regulation of ALS/FTD-linked proteins by nuclear import receptors and post-translational modifications

    11:45 – Hideyuki Okano (Keio University, Japan)
    iPSCs-based drug development for ALS and clinical trial

    12:15 – Laura Ferraiuolo (University of Sheffield, UK)
    Patient stratification approaches based on drug response using patient-derived cells

    12:45 – Break (15 minutes)

    13:00 – Rapid fire talks (to be selected from submitted abstracts)

    13:15 – Alessandro Rosa (Sapienza University of Rome, Italy)
    RNA-binding protein network alteration causes axonal phenotypes in FUS ALS mutant motoneurons

    13:30 – Aaron Gitler (Stanford University, USA)
    New TDP-43 targets

    14:00 – Clotilde Lagier-Tourenne (Massachusetts General Hospital & Harvard Medical School, USA)
    Disruption of RNA metabolism in ALS/FTD and emerging therapeutic strategies

    14:30 – Break (15 minutes)

    14:45 – Rapid fire talks (to be selected from submitted abstracts)

    15:00 – Daniel Jutzi (UK Dementia Research Institute at King’s College London)
    UK Aberrant FUS-U1 snRNA interactions in FUS-linked ALS

    15:15 - Nicol Birsa (UCL Queen Square Institute of Neurology, UK)  Protein translation and LLPS impairments in ALS-FUS motor neurons

    15:30 – Conclusion of the day

  • Day 3 - Friday 28 May
    • Please note all times are in BST

    11:00 – Welcome address

    11:05 – Séverine Boillée (Paris Brain Institute, France)
    Microglia/macrophage contribution to ALS

    11:45 – Luc Dupuis (University of Strasbourg, France)
    Role of FUS in synaptic gene expression: from the neuromuscular junction to the central nervous system

    12:15 – Rickie Patani (University College London & Francis Crick Institute, UK)
    Decoding cell type-specific molecular aberrations in ALS using human stem cell models

    12:45 – Break (15 minutes)

    13:00 – Rapid fire talks (to be selected from submitted abstracts)

    13:15 – Karthik Krishnamurthy (Thomas Jefferson University, USA) Aberrant expression of the axon guidance cue netrin-1 by SOD1-ALS astrocytes contributes to motor neuron dysfunction in models of SOD1-ALS

    13:30 – Chris Shaw (UK Dementia Research Institute at King’s College London)
    Genetic therapies for ALS: Are we there yet?

    14:00 – Magdalini Polymenidou (University of Zürich, Switzerland)
    Synaptic accumulation of FUS triggers early misregulation of synaptic RNAs in ALS-FUS mice

    14:30 – Break (15 minutes)

    14:45 – Ilary Allodi (University of Copenhagen, DK)
    Locomotor deficits in a mouse model of ALS are paralleled by loss of Engrailed-1 interneurons

    15:00 – Alain Prochiantz (College de France, France)
    EN1 homeoprotein transcription factor is a direct non-cell autonomous survival factor for spinal cord a-Motoneurons

    15:30 – Conclusion of the meeting

Meet the organisers

Marc-David Ruepp
(UK DRI at King's)

Eva Hedlund
(Stockholm University)

Alain Prochiantz
(Collège de France)

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If you have any questions or queries about the event, please get in touch with us at