Impaired clearance of waste proteins from the brain implicated in the progression of amyotrophic lateral sclerosis and frontotemporal dementia
A team of researchers led by Prof Siddharthan Chandran, UK DRI at Edinburgh, has published a perspective review evaluating whether poor clearance of toxic proteins from the brain contributes to the progression of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Focusing on the glymphatic system, the model proposed in the review could offer additional avenues to further explore features of the diseases, with the ultimate aim of uncovering novel therapeutics.
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