​UK DRI at The University of Edinburgh

3713 Edinburgh University Hi Res 008 Lowres

Studies are increasingly highlighting the important role of immune, vascular and metabolic factors in the development of neurodegenerative diseases but the interplay between these components in disease progression is poorly understood. The UK DRI at The University of Edinburgh will broaden out the traditional view of neurodegenerative disease as a disorder of misfolded proteins to encompass the multicellular environment surrounding degenerating neurons.

The research team lead by Professor Giles Hardingham will examine the complex interactions between cells of the brain, immune system and blood vessels that make up the ‘neurogliovascular unit’. They bring together strengths in metabolism, inflammation, blood vessel biology and stem cell medicine to explore how interactions at the neurogliovascular unit control the trajectory of neurodegenerative diseases leading to dementia.

By describing interactions at the neurogliovascular unit that help to maintain cognitive function for several decades in a healthy, ageing brain, the team aim to identify biological regulators that can inform the development of new therapies.

UK DRI at The University of Edinburgh will be located on the BioQuarter, Edinburgh's new multidisciplinary research institute and teaching hospital with access to superb multimodal neuroimaging and clinical research facilities. 

Programmes at this centre:

  • Professorship: Astrocytes as an upstream modulator and downstream effector of neurodegenerative pathology
  • Professorship: Small vessel diseases and vascular contributions to neurodegeneration and dementia 
  • Professorship: Dissecting macroglial-neuronal crosstalk in C9ORF72 Frontotemporal dementia/ amyotrophic lateral sclerosis 
  • Fellowship: Non-cell autonomous mechanisms of synapse pathology 
  • Fellowship: Microglial spatiotemporal diversity and role in susceptibility and resilience to neurodegenerative disease

Founding funders

Latest tweets from @UKDRI

We have several new job opportunities available at UK DRI this month 🥼🔬💻 Take a look at https://t.co/NHSUvCaf6f 🗣️… https://t.co/hO9IK2g4F0
17 Sep 2019 16:36

RT @MathewHHorrocks: We're really grateful once again for Dr. Jim Love's second charitable gift to help fund our work. Dr. Love did a PhD i…
17 Sep 2019 15:07