Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Acta neuropathologica
Published
TSPO-PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia
Authors
Davi S Vontobel, Kei Onn Lai, Mehtap Bacioglu, George Nolan, Daniel C Maddison, Amelie Adamski, Julia Goddard, Noah L Shapiro, Harry Crook, Tim Fryer, Young Hong, Sasvi Wijesinghe, Franklin Aigbirhio, Edward Avezov, Kieren S J Allinson, Annelies Quaegebeur, John T O'Brien, James B Rowe, Maria Grazia Spillantini, Maura Malpetti
TSPO-PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia
Practical neurology
Published
Blood biomarkers for Alzheimer's disease: guidance on appropriate testing from the Association of British Neurologists and Royal College of Psychiatrists
Authors
Haniah Habash-Bailey, Robert Barber, Nicholas Bass, Matthew J Harris, Jemma Hazan, Ashvini Keshavan, Michael Pt Lunn, Simon Mead, Catherine Pennington, Duncan Street, Ben R Underwood, Jonathan M Schott, Charles R Marshall
Blood biomarkers for Alzheimer's disease: guidance on appropriate testing from the Association of British Neurologists and Royal College of Psychiatrists
Nature communications
Published
Navigational strategy dictates hippocampal representation of space in an everyday memory task
Authors
Francesco Gobbo, Rufus Mitchell-Heggs, Adrian J Duszkiewicz, Elena Faillace, Dorothy Tse, Nuria Garcia-Font, Omer Hazon, Kathrine Clarke, Patrick A Spooner, Adana Keshishian, Mark Schnitzer, Simon R Schultz, Richard G M Morris
Navigational strategy dictates hippocampal representation of space in an everyday memory task
Science translational medicine
Published
Cas9 nickase-mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington's disease mouse model
Authors
Alvaro Murillo, Melanie Alpaugh, Ruban Rex Peter Durairaj, Emma L Randall, Meghan Larin, Laura Heraty, Alys N Aston, Alysha S Taylor, Alex Mas Monteys, Nina Stöberl, Aeverie E R Heuchan, Pascale Aeschlimann, Kyle Fears, Christian Landles, Georgina F Osborne, Antoine Mangin, Soumyasree Bhattacharyya, Emmanouil Metzakopian, Nicholas D Allen, Jack Puymirat, Gillian P Bates, Beverly L Davidson, Francesca Cicchetti, Mariah J Lelos, Vincent Dion
Cas9 nickase-mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington's disease mouse model
Molecular cell
Published
Protein arginine methylation promotes global 3'UTR shortening in proliferating cells
Authors
Llywelyn Griffith, Charlotte Capitanchik, Shaun Moore, Anca Farcas, Mags Gwynne, Martina Pedna, Ivana Vukšinić, Veronika Bračič, Karen Davey, D Marc Jones, Anob M Chakrabarti, Dimitris Lagos, Jelena Urosevic, James T Lynch, Jernej Ule
Protein arginine methylation promotes global 3'UTR shortening in proliferating cells
Nature communications
Published
Imaging nanoscopic co-assemblies of α-synuclein and Tau in human samples
Authors
Yu P Zhang, Amber Wallis, Clara Obensa Bertroli, Cherida Zhang, Melanie Burke, Florence Layburn, Evgeniia Lobanova, Martin Furlepa, Shekhar Kedia, Yuhao Cui, Prasanna Suresh, Woo Suk Yang, Annelies Quaegebeur, Tim Bartels, Caroline H Williams-Gray, David Klenerman
Imaging nanoscopic co-assemblies of α-synuclein and Tau in human samples
International journal of computer assisted radiology and surgery
Published
Improving the fairness and robustness of deep learning classification models through bias mitigation and post hoc calibration
Authors
Majid Ramedani, Jaya C Terli, Ole H Martensen, Tobias Strauß, Katharina Buerger, Peter Dechent, Emrah Düzel, Klaus Fliessbach, Maria Gemenetzi, Wenzel Glanz, Julian Hellmann-Regen, Stefan Hetzer, Enise I Incesoy, Daniel Janowitz, Marie T Kronmüller, Christoph Laske, Falk Lüsebrink, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Ayda Rostamzadeh, Anja Schneider, Björn H Schott, Sebastian Sodenkamp, Annika Spottke, Eike J Spruth, Sophia Stöcklein, Jens Wiltfang, Frank Jessen, Stefan J Teipel, Martin Dyrba
Improving the fairness and robustness of deep learning classification models through bias mitigation and post hoc calibration
Brain communications
Published
Correlation of blood biomarkers with microstructural brain injury in survivors of out-of-hospital cardiac arrest
Authors
Mikael V Laaksonen, Jussi P Posti, Carita C Hollmén, Kaj Blennow, Henrik Zetterberg, Jaakko K Rinne, Sami M Virtanen, Jani P Saunavaara, Riitta K Parkkola, Ruut M Laitio, Olli J Arola, Marja S Hynninen, Emmi K Ylikoski, Juha A Martola, Marjaana S Tiainen, Risto O Roine, Harry Scheinin, Mervyn Maze, Timo Roine, Tero Vahlberg, Timo T Laitio, Xe-HYPOTHECA Working Group, Xe-HYPOTHECA Working Group
Correlation of blood biomarkers with microstructural brain injury in survivors of out-of-hospital cardiac arrest
Frontiers in pharmacology
Published
Self-reported prescription medication use and polypharmacy following physical combat injury in the UK: the ADVANCE cohort study
Authors
Daniel Dyball, Laura E Grover, Susie Schofield, Sarah Dixon Smith, Alex Kumar, Alexander N Bennett, Christopher J Boos, Anthony M J Bull, Neil S N Graham, Cheryl R Z See, Lydia Orton, Grace Blissitt, David J Sharp, Nicola T Fear, Harriet I Kemp
Self-reported prescription medication use and polypharmacy following physical combat injury in the UK: the ADVANCE cohort study
Brain communications
Published
Comparison of brain-derived versus conventional pTau biomarkers in CSF and plasma for detecting Alzheimer's disease
Authors
Lydia Trudel, Joseph Therriault, Valentina Ghisays, Arthur C Macedo, Serge Gauthier, Paolo Vitali, Andrea L Benedet, Henrik Zetterberg, Yi Su, Alpana Singh, Tainá Marques, Marisa N Denkinger, Nicholas T Seyfried, Allan I Levey, Michael W Weiner, Kendall Van Keuren-Jensen, Eric M Reiman, Nicholas J Ashton, Pedro Rosa-Neto
Comparison of brain-derived versus conventional pTau biomarkers in CSF and plasma for detecting Alzheimer's disease
Journal of Alzheimer's disease : JAD
Published
Lower cardiac output is associated with longitudinal decreases in cerebrospinal fluid amyloid-β42, a core Alzheimer's disease biomarker, in women but not men
Authors
Amalia J Peterson, Yunyi Sun, Dandan Liu, Kimberly R Pechman, Francis E Cambronero, Elizabeth E Moore, Deepak K Gupta, Timothy J Hohman, Henrik Zetterberg, Angela L Jefferson
Lower cardiac output is associated with longitudinal decreases in cerebrospinal fluid amyloid-β42, a core Alzheimer's disease biomarker, in women but not men
BMJ public health
Published
Health inequalities in risk of SARS-CoV-2 infection in England's second wave: population-based cross-sectional analysis from the REACT-1 study
Authors
Haowei Wang, Kylie E C Ainslie, Caroline E Walters, Oliver Eales, David Haw, Christina Atchison, Claudio Fronterre, Peter J Diggle, Deborah Ashby, Graham Cooke, Wendy Barclay, Helen Ward, Ara Darzi, Christl A Donnelly, Steven Riley, Paul Elliott
Health inequalities in risk of SARS-CoV-2 infection in England's second wave: population-based cross-sectional analysis from the REACT-1 study