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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Journal of Alzheimer's disease : JAD
Published

Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease

Authors
Prita R Asih, Cameron W Morris, Hong Wang, Steve Pedrini, Kathryn Goozee, Simon M Laws, Pratishtha Chatterjee, Kevin Taddei, Hamid R Sohrabi, Stephanie R Rainey-Smith, Chai K Lim, Gilles J Guillemin, Thomas K Karikari, Colin L Masters, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Ralph N Martins
Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease
BMJ open
Published

Digital App for Speech and Health Monitoring Study (DASH): protocol for a prospective longitudinal case-control observational study for developing speech datasets in neurodegenerative disorders and dementia

Authors
Johnny Tam, Christine Weaver, Amarachi Ihenacho, Judith Newton, Bruce Virgo, Steven Barrett, Jonathan Neale, David Perry, Alice Smith, Siddharthan Chandran, Oliver Watts, Suvankar Pal, DASH Consortium
Digital App for Speech and Health Monitoring Study (DASH): protocol for a prospective longitudinal case-control observational study for developing speech datasets in neurodegenerative disorders and dementia
Scientific reports
Published

Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study

Authors
Felix Klawitter, Johanna Hackenberg, Lena Danckert, Astrid Bertsche, Axel Petzold, Heidi A B Smith, Eugene Wesley Ely, Christian Spang, Rika Bajorat, Dagmar-Christiane Fischer, Gerd Klinkmann, Anne Körmann-Günther, Robert Fleischmann, Amanda Heslegrave, Henrik Zetterberg, Hessel Peters-Sengers, Johannes Ehler, Critical Care Consultant
Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study

Authors
Gaia Brezzo, Kristy A Zera, Dana E Straus, Jennifer E Goertz, Sanna H Loppi, Rachel R Crumpacker, Jennifer B Frye, Danielle A Becktel, Maria Isabel Cuartero, Alicia García Culebras, Claudia Dames, Daniel Berchtold, Jill H Fowler, Andreas Meisel, Josef Anrather, Maria Angeles Moro, Stuart M Allan, Kristian P Doyle, Marion S Buckwalter, Barry W McColl
Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study
Pituitary
Published

Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas

Authors
Martin Thorsson, P Trimpou, M Asztély, T Hallén, V Hantelius, K Blennow, H Zetterberg, G Johannsson, J Oras, T Skoglund
Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas
EJNMMI physics
Published

Performance evaluation of the nanoScan<sup>®</sup> P123S total-body PET

Authors
Dániel Réti, Carlos-Alcaide Corral, Islay Cranston, Victoria J M Reid, Kerry M O'Rourke, Timaeus E F Morgan, Axel Montagne, Maurits A Jansen, Valeria K Burianova, Andrew Sutherland, Péter Major, Kálmán Nagy, Gergő Bagaméry, Adriana A S Tavares
Performance evaluation of the nanoScan<sup>®</sup> P123S total-body PET
Alzheimer's research & therapy
Published

Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology

Authors
Larissa Fischer, Dana Parker, Samira Maboudian, Corrina Fonseca, Claudia Tato-Fernández, Lucie Annen, Prithvi Arunachalam, Julia R Bacci, Michelle Barboure, Serena Capelli, Stamatia Karagianni, Lyduine E Collij, Paul Edison, Nick C Fox, Nicolai Franzmeier, Michel J Grothe, William J Jagust, Anne Maass, Maura Malpetti, Ross W Paterson, Aitana Sogorb-Esteve, Michael Schöll
Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology
Brain : a journal of neurology
Published

Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration

Authors
Julie F H De Houwer, Elise G Dopper, Renee van Buuren, Marijke Stokkel, Liset de Boer, Tine Swartenbroekx, Pam A Boesjes, Ana Rajicic, Aitana Sogorb-Esteve, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Simon Ducharme, Chris R Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Henrik Zetterberg, Jonathan D Rohrer, Betty M Tijms, Yolande A L Pijnenburg, Charlotte Teunissen, Harro Seelaar
Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration
Brain and neuroscience advances
Published

The UK National Mouse Genetics Network: Translating genetic findings using preclinical mouse models to better understand neurodevelopmental, neuropsychiatric and neurodegenerative disorders

Authors
Sevda T Boyanova, Nicholas E Clifton, Karolina Dec, Michal M Milczarek, MURIDAE Cluster, Anthony R Isles
The UK National Mouse Genetics Network: Translating genetic findings using preclinical mouse models to better understand neurodevelopmental, neuropsychiatric and neurodegenerative disorders
Molecular neurodegeneration
Published

Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease

Authors
Olav M Andersen, Matthijs W J de Waal, Giulia Monti, Niccolo Tesi, Anne Mette G Jensen, Christa de Geus, Rosalina van Spaendonk, Maartje Vogel, Shahzad Ahmad, Najaf Amin, Philippe Amouyel, Gary W Beecham, Céline Bellenguez, Claudine Berr, Joshua C Bis, Anne Boland, Paola Bossù, Femke Bouwman, Jose Bras, Camille Charbonnier, Jordi Clarimon, Carlos Cruchaga, Antonio Daniele, Jean-François Dartigues, Stéphanie Debette, Jean-François Deleuze, Nicola Denning, Anita L DeStefano, Oriol Dols-Icardo, Cornelia M van Duijn, Lindsay A Farrer, Maria Victoria Fernández, Wiesje M van der Flier, Nick C Fox, Daniela Galimberti, Emmanuelle Genin, Johan J P Gille, Benjamin Grenier-Boley, Detelina Grozeva, Yann Le Guen, Rita Guerreiro, Jonathan L Haines, Clive Holmes, Holger Hummerich, M Arfan Ikram, M Kamran Ikram, Amit Kawalia, Robert Kraaij, Jean-Charles Lambert, Marc Lathrop, Afina W Lemstra, Alberto Lleó, Richard M Myers, Marcel M A M Mannens, Rachel Marshall, Eden R Martin, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Alun Meggy, Merel O Mol, Benedetta Nacmias, Adam C Naj, Valerio Napolioni, J Nicholas Cochran, Gaël Nicolas, Florence Pasquier, Pau Pastor, Margaret A Pericak-Vance, Yolande A L Pijnenburg, Fabrizio Piras, Olivier Quenez, Alfredo Ramirez, Rachel Raybould, Richard Redon, Marcel J T Reinders, Anne-Claire Richard, Steffi G Riedel-Heller, Fernando Rivadeneira, Jeroen G J van Rooij, Stéphane Rousseau, Natalie S Ryan, Pascual Sanchez-Juan, Gerard D Schellenberg, Philip Scheltens, Jonathan M Schott, Sudha Seshadri, Daoud Sie, Rebecca Sims, Erik A Sistermans, Sandro Sorbi, John C van Swieten, Betty Tijms, André G Uitterlinden, Pieter Jelle Visser, Michael Wagner, David Wallon, Li-San Wang, Julie Williams, Jennifer S Yokoyama, Aline Zarea, Sven J van der Lee, Johan G Olsen, Marc Hulsman, Henne Holstege
Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer's disease
EMBO molecular medicine
Published

Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid

Authors
Niklas Mattsson-Carlgren, Linda Karlsson, Weizhong Tang, Kaj Blennow, Henrik Zetterberg, Randall J Bateman, Suzanne E Schindler, Nicolas Barthelemy, Sebastian Palmqvist, Erik Stomrud, Shorena Janelidze, Oskar Hansson
Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid
Journal of neurochemistry
Published

Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain-Derived Tau Across the Biochemical Spectrum of Alzheimer's Disease

Authors
Maciej Dulewicz, Przemysław Radosław Kac, Fernando Gonzalez Ortiz, Thomas K Karikari, Agnieszka Kulczyńska-Przybik, Barbara Mroczko, Michael Turton, Peter Harrison, Manuel Maler, Timo Oberstein, Johannes Kornhuber, Jörg Hanrieder, Henrik Zetterberg, Kaj Blennow, Piotr Lewczuk
Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain-Derived Tau Across the Biochemical Spectrum of Alzheimer's Disease