Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Science (New York, N.Y.)
Published

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

Authors
Donia Arafa, Julia van de Korput, Philipp N Braaker, Kieran P Higgins, Niels R C Meijns, Katy L H Marshall-Phelps, Julia Meng, Daniel Soong, Eleonora Scalia, Kyle Lathem, Marcus Keatinge, Claire Richmond, Anna Klingseisen, Marja Main, Sarah A Neely, David W Hampton, Greg J Duncan, Geert J Schenk, Marie Louise Groot, Siddharthan Chandran, Ben Emery, Antonio Luchicchi, Maarten H P Kole, Anna C Williams, David A Lyons
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Nature communications
Published

FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing

Authors
Pierre Parutto, Yutong Yuan, Valentina Davì, Roger Pons-Lanau, Svenja Ebeling, Karnika Gupta, Francesca Bottanelli, Maria F Garcia-Parajo, Felix Campelo, Clemens F Kaminski, Joseph E Chambers, Jonathon Nixon-Abell, Edward Avezov
FidlTrack: high-fidelity structure-aware single particle tracking resolves intracellular molecular motion in organelles sensing APP processing
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma biomarker progression across the Alzheimer's disease amyloid beta and tau positron emission tomography trajectories

Authors
Rodrigo Cánovas, Christopher J Fowler, Azadeh Feizpour, Vincent Dóre, Pierrick Bourgeat, Ziad S Saad, Gallen Triana-Baltzer, Hartmuth C Kolb, Manu Vandijck, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Jurgen Fripp, Simon Laws, Anthony W Bannon, Kaj Blennow, Henrik Zetterberg, Stephanie Rainey-Smith, Sulantha Mathotaarachchi, Christopher C Rowe, Colin L Masters, James D Doecke, AIBL Research Group
Plasma biomarker progression across the Alzheimer's disease amyloid beta and tau positron emission tomography trajectories
Journal of neurochemistry
Published

N-Truncated Superoxide Dismutase-1 in Cerebrospinal Fluid Is Folded and Active

Authors
Laura Leykam, Karin M E Forsberg, Peter M Andersen, Thomas Brännström, Sophia Weiner, John Rönnholm, Kaj Blennow, Henrik Zetterberg, Stefan L Marklund, Johan Gobom, Per Zetterström
N-Truncated Superoxide Dismutase-1 in Cerebrospinal Fluid Is Folded and Active
JAMA network open
Published

Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries

Authors
Rebecca Halbgebauer, Fernando Gonzalez-Ortiz, Benjamin Mayer, Claudius Berger, Christian Bergmann, Helen Rinderknecht, Eberhard Barth, Lisa Wohlgemuth, Marco Mannes, Markus Otto, Hayrettin Tumani, Borna Relja, Florian Gebhard, Markus Huber-Lang, Henrik Zetterberg, Steffen Halbgebauer, Kaj Blennow
Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Quantitative susceptibility mapping of the brain is associated with inflammatory changes in Alzheimer's disease related areas

Authors
Seyyed Ali Hosseini, Stijn Servaes, Arthur C Macedo, Etienne Aumont, Nesrine Rahmouni, Tevy Chan, Joseph Therriault, Lydia Trudel, Brandon Hall, Yi-Ting Wang, Jaime Fernandez Arias, Gleb Bezgin, Yansheng Zheng, Marina P Gonçalves, Kely Quispialaya Socualaya, Marcel S Woo, Cécile Tissot, Delphine Oliva-Lopez, Jieying Li, Stuart Mitchell, Aurélie Lebrun, Robert Hopewell, Sanjeev Chawla, Vladimir Fonov, Gassan Massarweh, Yasser Iturria Medina, Jean-Paul Soucy, Maxime Montembeault, Paolo Vitali, Kaj Blennow, Thomas K Karikari, Andréa L Benedet, Nicholas J Ashton, Henrik Zetterberg, Tharick A Pascoal, Serge Gauthier, Jesse Klostranec, Hangwei Zhuang, Junghun Cho, D Louis Collins, Yi Wang, David A Rudko, Pedro Rosa-Neto
Quantitative susceptibility mapping of the brain is associated with inflammatory changes in Alzheimer's disease related areas
Molecular neurodegeneration
Published

Targeting tau in Alzheimer's Disease: rationale, approach and challenges

Authors
Aram Aslanyan, Martha S Foiani, Tatiana A Giovannucci, Eric McDade, Karen E Duff, Catherine J Mummery, Michael Schöll, Kristin R Wildsmith, Ross W Paterson
Targeting tau in Alzheimer's Disease: rationale, approach and challenges
Human brain mapping
Published

segcsvd<sub>PVS</sub>: A Convolutional Neural Network-Based Tool for Quantification of Enlarged Perivascular Spaces (PVS) on T<sub>1</sub>-Weighted Images

Authors
Erin Gibson, Joel Ramirez, Lauren Abby Woods, Stephanie Berberian, Julie Ottoy, Christopher J M Scott, Vanessa Yhap, Fuqiang Gao, Roberto Duarte Coello, Maria Valdes Hernandez, Anthony E Lang, Carmela M Tartaglia, Sanjeev Kumar, Malcolm A Binns, Robert Bartha, Sean Symons, Richard H Swartz, Mario Masellis, Navneet Singh, Bradley J MacIntosh, Joanna M Wardlaw, Sandra E Black, ONDRI Investigators, ADNI, CAHHM Investigators, CAIN Investigators, colleagues from the Foundation Leducq Transatlantic Network of Excellence, Andrew S P Lim, Maged Goubran
segcsvd<sub>PVS</sub>: A Convolutional Neural Network-Based Tool for Quantification of Enlarged Perivascular Spaces (PVS) on T<sub>1</sub>-Weighted Images