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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Mammalian genome : official journal of the International Mammalian Genome Society
Published
Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory
Authors
Mehwish Anwer, Tetiana Poliakova, Ricardo D'Oliveira Albanus, Mohammad Iqbal H Bhuiyan, Adam M Brickman, Soumilee Chaudhuri, Leah Cuddy, Maxwell Eisenbaum, Kate Foley, Douglas B Gould, Catherine Hall, Costantino Iadecola, Olivia Marola, Christopher M Norris, Alaina Reagan, Julie Schneider, Donna Wilcock, Isabella Xu, Andrew Yang, Gareth Howell, Cheryl L Wellington
Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe
Authors
Francesco Bax, Jan Oltmer, Corinne A Auger, Anna Bonkhoff, Gillian T Coughlan, Alexandra Melloni, Methasit Jaisa-Aad, Jean Augustinack, Alberto Serrano-Pozo, Matthew P Frosch, Steven M Greenberg, Teresa Gomez-Isla, Bradley T Hyman, Susanne J van Veluw, Valentina Perosa
APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe
Journal of neurology, neurosurgery, and psychiatry
Published
Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 367 988 people using natural language processing
Authors
Matthew Henry Iveson, Mome Mukherjee, Emma M Davidson, Huayu Zhang, Laura Sherlock, Emily L Ball, Grant Mair, Alice Hosking, Heather Whalley, Michael T C Poon, Joanna M Wardlaw, David Kent, Richard Tobin, Claire Grover, Beatrice Alex, William Whiteley
Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 367 988 people using natural language processing
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies
Authors
Jun Pyo Kim, Minku Song, Minyoung Cho, Hyunwoo Lee, Sang-Hyuk Jung, Soohyun Lim, Chanhee Kim, Beomjin Jang, Daeun Shin, Heekyoung Kang, Sohyun Yim, Hyemin Jang, Bo-Hyun Kim, Hee Jin Kim, Duk L Na, Joon-Yong An, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Theresa A Day, Sang Won Seo, Hong-Hee Won
Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's disease via genome-wide association studies
Sleep
Published
Sleep and circadian health in the UK Biobank: Report on the 2023 sleep questionnaire enhancement
Authors
Katrina Y K Tse, Hang Yuan, Charilaos Zisou, Jo Holliday, Colin A Espie, Derk-Jan Dijk, Angus Burns, Aiden Doherty, Jacqueline Lane, Hanna M Ollila, Allan Pack, David Ray, Susan Redline, Rebecca Richmond, Richa Saxena, Eva S Schernhammer, Barbara Schormair, Kai Spiegelhalder, Heming Wang, Julianne Winkelmann, Andrew R Wood, Martin K Rutter, Emmanuel Mignot, Simon D Kyle
Sleep and circadian health in the UK Biobank: Report on the 2023 sleep questionnaire enhancement
Nature communications
Published
Selective weakening of population-coupled synaptic activity in vivo in a mouse model of amyloid-beta pathology
Authors
Leire Melgosa-Ecenarro, Carola I Radulescu, Nazanin Doostdar, Joe Airey, Francesca A Chaloner, Nawal Zabouri, Giada Pedretti, Francesca Osso, Leire Garrido Perez, Kjara S Pilch, Xingjian Wang, Anna Mallach, Sadra Sadeh, Johanna Jackson, Paul M Matthews, Samuel J Barnes
Selective weakening of population-coupled synaptic activity in vivo in a mouse model of amyloid-beta pathology
Journal of Alzheimer's disease : JAD
Published
Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in <em>KLOTHO</em> KL-VS heterozygotes
Authors
Ira Driscoll, Rachael E Wilson, Sterling C Johnson, Sanjay Asthana, Catherine L Gallagher, Bruce P Hermann, Mark A Sager, Cynthia M Carlsson, Kaj Blennow, Henrik Zetterberg, Dena B Dubal, Ozioma C Okonkwo
Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in <em>KLOTHO</em> KL-VS heterozygotes
Nature communications
Published
USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
Authors
Giulio Collotta, Marco Gatti, Irina-Maria Ungureanu, Vanessa van Ackeren, Emilie Rannou, Francesca Vivalda, Diego Gomez Vieito, Keri M Fishwick, Christine von Aesch, Antonio Porro, Kyra Ungerleider, Ailin Heidari, Raphaël Guérois, Rachel J Harding, Sylvain Bischof, Gabriel Balmus, Alessandro A Sartori
USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
Nature communications
Published
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases
Authors
Kanta Chechi, Rima Chakaroun, Antonis Myridakis, Sofia K Forslund-Startceva, Sebastien Fromentin, Trine Nielsen, Judith Aron-Wisneswky, Eugeni Belda, Edi Prifti, Pierre Bel Lassen, Gwen Falony, Sara Vieira-Silva, Julien Chilloux, Kazuhiro Sonomura, Lesley Hoyles, Laura Martinez-Gili, Francesco Pallotti, Petros Andrikopoulos, Francesc Puig-Castellví, Romina Pacheco Tapia, Inés Castro-Dionicio, Hugo Roume, Nicolas Pons, Emmanuelle Le Chatelier, Benoit Quinquis, Nathalie Galleron, Magali Berland, Michael T Olanipekun, Manyi Jia, Angelos Manolias, Bridget Holmes, Solia Adriouch, Matthias Blüher, Luis Pedro Coelho, Kévin Da Silva, Pilar Galan, Boyang Ji, Ana Luisa Neves, Christine Rouault, Joe-Elie Salem, Valentina Tremaroli, Tue H Hansen, Nadja B Søndertoft, Christian Lewinter, Helle K Pedersen, MetaCardis Consortium, Peter D Mark, Jens P Goetze, Lars Køber, Henrik Vestergaard, Torben Hansen, Jean-Daniel Zucker, Taka-Aki Sato, Serge Hercberg, Fredrik Bäckhed, Ivica Letunic, Jean-Michel Oppert, Jens Nielsen, Jeroen Raes, Ioanna Tzoulaki, Abbas Dehghan, Verena Zuber, Emmanuelle Bouzigon, Mark Lathrop, Parminder Raina, Philippe Froguel, Fumihiko Matsuda, Florence Demenais, Dominique Gauguier, Michael Stumvoll, Peer Bork, Oluf Pedersen, S Dusko Ehrlich, Karine Clément, Marc-Emmanuel Dumas
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases