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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Neurotrauma reports
Published

Natural History and Clinical Associations of Plasma Interleukin-6 Levels in Traumatic Brain Injury

Authors
Leo Layzell, Eleftheria Kodosaki, Xiaoying Sun, Sonia Jain, Amanda Heslegrave, Eyal Soreq, Giovanni Nattino, Elena Garbero, Karl A Zimmerman, Neil S N Graham, Federico Moro, Deborah Novelli, Primož Gradišek, Sandra Magnoni, Henrik Zetterberg, Kevin W Wang, Firas H Kobeissy, John K Yue, Ava M Puccio, Guido Bertolini, Ramon Diaz-Arrastia, Geoffrey T Manley, David J Sharp, Lucia M Li
Natural History and Clinical Associations of Plasma Interleukin-6 Levels in Traumatic Brain Injury
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

Authors
Christos Panagiotis Lisgaras, Tovia Jacobs, Luisa Figueredo, Elizabeth Pirraglia, Caleb H Radtke, Jonah N Keller, Nikolaos Karvelas, Jennifer Bernal, Joaquin Ruiz, Henrik Zetterberg, Lidia Glodzik, Mony J de Leon, Laura Beth McIntire, Allal Boutajangout, Thomas Wisniewski, Jaime Ramos-Cejudo, Daniel Alcolea, Sandra Giménez, Juan Fortea, Katerina Akassoglou, Fanny M Elahi, Ricardo S Osorio
CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults
JAMA neurology
Published

Plasma Biomarkers for Neocortical Tau Burden

Authors
Guglielmo Di Molfetta, Wagner S Brum, Ilaria Pola, Kübra Tan, Andrea L Benedet, Mathias Sauer, Laia Montoliu-Gaya, Shorena Janelidze, Niklas Mattsson-Carlgren, Nesrine Rahmouni, Tevy Chan, Marisa N Denkinger, Petroula Proitsi, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Nicholas J Ashton
Plasma Biomarkers for Neocortical Tau Burden
Cell reports
Published

APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice

Authors
Joan Cruz-Sese, Marta Mirón-Alcala, María Alfonso-Triguero, Jon Olalde, Leire Ruiz, Nuria Galbis-Gramage, Lorea Cortes, Laura Escobar, Pranav Preman, An Snellinx, Takashi Saito, Takaomi C Saido, Laura Saiz-Aúz, Alberto Rábano-Gutiérrez, Ana M Aransay, Ibai Diez, Julia Tcw, Alison Goate, Bart De Strooper, Elena Alberdi, Amaia M Arranz
APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice
Blood neoplasia
Published

Expression of RUNX1::RUNX1T1 deregulates the proteome, induces C/EBPβ suppression, and blocks myeloid differentiation

Authors
Aleksandra Azevedo, Adam Leckenby, Rachael Nicholson, Ana Catarina Menezes, Sara Davies, Amanda F Gilkes, Sarah Baker, Raymond Toghill, Ellie McCracken, Andrew Pierce, Bethany Geary, Anthony D Whetton, Richard L Darley, Alex Tonks
Expression of RUNX1::RUNX1T1 deregulates the proteome, induces C/EBPβ suppression, and blocks myeloid differentiation
Environment international
Published

Exploring molecular signatures of exposure to water disinfection by-products: A multi-omic analysis across multiple exposure routes

Authors
Sibo Lucas Cheng, Pekka Keski-Rahkonen, Anastasia Chrysovalantou Chatziioannou, Dragana Vuckovic, Leon P Barron, Abbas Dehghan, Jelle Vlaanderen, Lützen Portengen, Ana Jiménez Zabala, Marcela Guevara, Ines Gomez Acebo, Antonio José Molina de la Torre, Augustin Scalbert, Paolo Vineis, Paul Elliott, Roel Vermeulen, Manolis Kogevinas, Cristina M Villanueva, Sonia Dagnino, Marc Chadeau-Hyam
Exploring molecular signatures of exposure to water disinfection by-products: A multi-omic analysis across multiple exposure routes
Brain : a journal of neurology
Published

Defining the underlying pathology of corticobasal syndrome using clinical features and biomarkers

Authors
David P Vaughan, Marte Theilmann Jensen, Raquel Real, Riona G Fumi, Lesley Wu, Danielle Lux, Megan Hodgson, P Simon Jones, Negin Holland, William J Scotton, Oiher Serrano-Assensio, Andrea Quattrone, Amanda J Heslegrave, Elena Veleva, Owen Swann, Henrik Zetterberg, Tim Lynch, Pablo Mir, Maria Stamelou, Klaus Seppi, Rik Vandenberghe, Thomas T Warner, Andrew Lees, Kailash P Bhatia, Alistair Church, Christopher Kobylecki, P Nigel Leigh, Michele T Hu, Pille Taba, Terje Matsalu, Nicola Pavese, Boyd C P Ghosh, Marina Picillo, Johan Wallin, Per Svenningson, Almudena Sánchez-Gómez, Manel Fernández, Ana Cámara, Lluís Planellas, Yaroslau Compta, PROSPECT consortium, MD-GAP, Annelies Quaegebeur, Zane Jaunmuktane, Tamas Revesz, Edwin Jabbari, Jonathan D Rohrer, James B Rowe, Huw R Morris
Defining the underlying pathology of corticobasal syndrome using clinical features and biomarkers
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Predicting continuous amyloid PET levels with CSF and plasma brain-derived p-tau217

Authors
Lydia Trudel, Joseph Therriault, Arthur C Macedo, Etienne Aumont, Seyyed Ali Hosseini, Andrea L Benedet, Lili-Naz Hazrati, Serge Gauthier, Henrik Zetterberg, Paolo Vitali, Nicholas J Ashton, Pedro Rosa-Neto, Alzheimer's Disease Neuroimaging Initiative
Predicting continuous amyloid PET levels with CSF and plasma brain-derived p-tau217
eLife
Published

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

Authors
Giulia Tombesi, Shiva Kompella, Giulia Favetta, Chuyu Chen, Marta Ornaghi, Yibo Zhao, Ester Morosin, Martina Sevegnani, Adriano Lama, Antonella Marte, Ilaria Battisti, Lucia Iannotta, Nicoletta Plotegher, Laura Civiero, Franco Onofri, Britta J Eickholt, Giovanni Piccoli, Giorgio Arrigoni, Dayne Beccano-Kelly, Claudia Manzoni, Loukia Parisiadou, Elisa Greggio
LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics
Nature
Published

Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours

Authors
Sara G Pelaz, Katsukuni Mitsui, Natalia Kolosowska, Haley Fritch, Chiranjivi Neupane, Vanessa H Casha, Marta Alonso-Gardón, Vijaya Pandey, Lizheng Wang, Riki Kawaguchi, James A Wohlschlegel, Jiami Guo, Steven A McCarroll, Sabina Berretta, Baljit S Khakh
Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours
Brain communications
Published

Evaluating MAPT p.A152T as a risk factor for the 3R tauopathy Pick's disease

Authors
Nicole Tamvaka, William Scotton, Meredith T Lilley, Maryam Shoai, Marios Gavrielatos, Michael G Heckman, Alexandra I Soto-Beasley, Shanu F Roemer, Matthew C Baker, Rosa Rademakers, Melissa E Murray, Dennis W Dickson, John A Hardy, Casey N Cook, Jonathan D Rohrer, Owen A Ross, Pick’s disease international consortium, Pick’s disease international consortium
Evaluating MAPT p.A152T as a risk factor for the 3R tauopathy Pick's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Temporal order of clinical, imaging, and biomarker changes in frontotemporal lobar degeneration-associated syndromes

Authors
Alberto Benussi, Valeria Bracca, Enrico Premi, Valentina Cantoni, Federica Palacino, Aurora Saccavini, Maria Sofia Cotelli, Giuliano Binetti, Rosa Manenti, Antonella Alberici, Roberto Gasparotti, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Roberta Ghidoni, Barbara Borroni
Temporal order of clinical, imaging, and biomarker changes in frontotemporal lobar degeneration-associated syndromes
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine-related dysfunction on tau and its impact on cognition

Authors
Prokopis C Prokopiou, Maxime Van Egroo, Joost M Riphagen, Marion Baillet, Nicholas J Ashton, Shorena Janelidze, Reisa A Sperling, Keith A Johnson, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Heidi I L Jacobs
Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine-related dysfunction on tau and its impact on cognition