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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Neurology
Published

Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling

Authors
Jake Mitchell, Stuart J McDonald, Meng Law, Terence J O'Brien, Lars T Westlye, Karen Caeyenberghs, Virginia Newcombe, David J Sharp, Abdalla Z Mohamed, Erin D Bigler, Houshang Amiri, Andrei Irimia, Stefania Mondello, Sophia I Thomopoulos, John Darrell Van Horn, David F Tate, Elisabeth A Wilde, Asta K Håberg, Martin M Monti, Rachel Edelstein, Maheen M Adamson, William C Walker, Kristen Dams-O'Connor, Evelyn M Deutscher, Ekaterina Dobryakova, Torgeir Hellstrøm, Emily L Dennis, Paul M Thompson, Frank G Hillary, Alexander Olsen, Jennie L Ponsford, Sandy R Shultz, Gershon Spitz
Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling
Nature
Published

DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

Authors
Laura Morcom, Wenlong Xia, Zhaoyang Xu, Yashika Awasthi, Celine Geywitz, Matthew O Ellis, Tomas Noli, Amel Zulji, Daniel Yamamoto, Gemma C Girdler, Li Kai, Keying Zhu, Mingming Wei, Xiao-Yan Tang, Kimberly K Hoi, Julio Gonzalez-Maya, Greg J Duncan, Adrien M Vaquie, Diana Gold Diaz, Riki Kawaguchi, Erdong Liu, Yu Sun, Denny Yang, Gregory D Jordan, I-Ling Lu, Staffan Holmqvist, Theresa Bartels, Katherine Ridley, Jennifer Ja-Yoon Choi, Santos J Franco, Eric J Huang, Ben Emery, Daniel Geschwind, Lucas Schirmer, Gabriel Balmus, Brian Popko, Stephen P J Fancy, David H Rowitch
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
Neuron
Published

Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits

Authors
Robert Ellingford, Samuel S Harris, Marten Kehring, Rikesh M Rajani, Francesca Kar Wey Lam, David Graykowski, Dorothea Bӧken, Lindsay A Welikovitch, Anita Khasnavis, Rhiannon Laban, Amanda Heslegrave, Umran Yaman, Anastasie Mate de Gerando, Suraya A Bond, Selina Wray, Dervis A Salih, David Dupret, Raymond J Dolan, David Klenerman, Henrik Zetterberg, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
BMC biology
Published

Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Authors
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M Chakrabarti, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Authors
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J Devine, Edgar R Gomes, Joseph Chambers, Elena Koslover, Edward Avezov
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
Alzheimer's research & therapy
Published

Independent and interactive contributions of white matter hyperintensities and Alzheimer's disease imaging and plasma biomarkers to cognitive decline in older adults without dementia

Authors
Dario Bachmann, Christoph Gericke, Maha Wybitul, Antje Saake, Sandro Studer, Katrin Rauen, Esmeralda Gruber, Andreas Buchmann, Martin Hüllner, Kaj Blennow, Henrik Zetterberg, Roger M Nitsch, Christoph Hock, Valerie Treyer, Anton Gietl
Independent and interactive contributions of white matter hyperintensities and Alzheimer's disease imaging and plasma biomarkers to cognitive decline in older adults without dementia
The European journal of neuroscience
Published

Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease

Authors
Francesco Gobbo, Declan King, Jane Tulloch, Davide Gobbo, Calum Bonthron, Soraya Meftah, Caleb Stoddart-Campbelton, Arisa Tamura, Jamie Rose, Colin Smith, Claire Durrant, Tara L Spires-Jones
Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease
Brain : a journal of neurology
Published

Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease

Authors
Hemanth R Nelvagal, Nancy Chiraki, Toby Curless, Patrick W Cullinane, Alice Rockliffe, Samarth Pimparkar, Haruka Kawamura, Sophie Ollerenshaw, Isha Elahi, Sebastian Brandner, Lesley Wu, Raquel Real, Mina Ryten, John Hardy, Eduardo De Pablo Fernandez, Thomas T Warner, Huw R Morris, Yau Mun Lim, Zane Jaunmuktane
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease
Journal of Alzheimer's disease : JAD
Published

Generalizability of blood-based biomarkers of Alzheimer's disease and related dementias in a multicultural cohort of older adults: The effect of adjustment for kidney function

Authors
Ángel García de la Garza, Cuiling Wang, Carol A Derby, Qi Gao, Kenny Q Ye, Henrik Zetterberg, Christopher G Engeland, Richard B Lipton, Mindy J Katz
Generalizability of blood-based biomarkers of Alzheimer's disease and related dementias in a multicultural cohort of older adults: The effect of adjustment for kidney function
Brain communications
Published

Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease

Authors
Michalis Kassinopoulos, Paula Montesinos, Carles Falcon, Jordi Huguet, Carolina Minguillon, Karine Fauria, Gwendlyn Kollmorgen, Clara Quijano-Rubio, José Luis Molinuevo, Oriol Grau-Rivera, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Javier Sanchez-Gonzalez, Juan Domingo Gispert, ALFA study
Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease
Brain communications
Published

<em>C9orf72</em> poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia

Authors
Carmelo Milioto, Mireia Carcolé, Matteo Zanovello, Mhoriam Ahmed, Raja S Nirujogi, Daniel Biggs, Martha J Roberts, Kyra Schweers, Alexander J Cammack, Paolo M Marchi, Eszter Katona, Idoia Glaria, Almudena Santos, Anny Devoy, Pietro Fratta, Dario R Alessi, Ben Davies, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
<em>C9orf72</em> poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia