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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain communications
Published

Increased cerebrospinal fluid YKL-40 concentration in hip fracture patients with delirium

Authors
Thea Berntsen, Kaj Blennow, Henrik Zetterberg, Ingrid Fæhn Brekke, Mathias Nikolai Petersen Hella, Tom Tarjei Lian, Lene B Solberg, Christian Thomas Pollmann, Adi Karabeg, Olav Tobias Ødegaard, Marius Myrstad, Kristian Sydnes, Roy Bjørkholt Olsen, Torgeir Bruun Wyller, Leiv Otto Watne, Bjørn Erik Neerland
Increased cerebrospinal fluid YKL-40 concentration in hip fracture patients with delirium
Brain communications
Published

Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers

Authors
Oriol Perera-Cruz, Cristina Solé-Padullés, Lídia Mulet-Pons, María Cabello-Toscano, Rachel M Morse, Kilian Abellaneda-Pérez, Rubén Perellón-Alfonso, Gabriele Cattaneo, Javier Solana-Sánchez, Vanessa Alviarez-Schulze, Nuria Bargalló, Juan Fortea, Josep M Tormos, Alvaro Pascual-Leone, Henrik Zetterberg, Lídia Vaqué-Alcázar, David Bartrés-Faz
Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Authors
Elisa M Cruz, Luana C Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo-Kolodner, Mona Barkat, Roslyn M Bill, Edward Mann, Linna Zhou, Mootaz M Salman, Hagan Bayley, Zoltán Molnár, Francis G Szele
Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair
Brain communications
Published

CSF protein clearance impairment revealed using stable isotope kinetics in normal pressure hydrocephalus

Authors
Claire A Leckey, Tatiana A Giovannucci, Eimear C Murphy, Eleanor M Moncur, Kanza Tariq, Aram Aslanyan, Michael Schöll, Meera Srikrishna, William Coath, Suzanne Barker, Dylan Esguerra, Ahmed K Toma, Laurence D Watkins, Lewis Thorne, Sylvain Lehmann, Jerome Vialaret, Selina Wray, Randall J Bateman, Kevin Mills, Donald L Elbert, Laura Pellegrini, Ross W Paterson
CSF protein clearance impairment revealed using stable isotope kinetics in normal pressure hydrocephalus
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease

Authors
Seyyed Ali Hosseini, Etienne Aumont, Nesrine Rahmouni, Marcel S Woo, Arthur C Macedo, Brandon Hall, Tevy Chan, Joseph Therriault, Lydia Trudel, Yansheng Zheng, Gleb Bezgin, Aurélie Lebrun, Jaime Fernandez Arias, Kely Quispialaya Socualaya, Cécile Tissot, Stijn Servaes, Yi-Ting Wang, Delphine Oliva-Lopez, Stuart Mitchell, Robert Hopewell, Chris Hung-Hsin Hsiao, Catherine Saleh, Jenna Stevenson, Firoza Lussier, Liyong Wu, Min Chu, Sanjeev Chawla, Vladimir Fonov, Gassan Massarweh, Yasser Iturria Medina, Jean-Paul Soucy, Karine Provost, David A Rudko, Thomas Karikari, Andréa Lessa Benedet, Nicholas J Ashton, Henrik Zetterberg, Maxime Montembeault, Paolo Vitali, Kaj Blennow, Serge Gauthier, D Louis Collins, Jesse Klostranec, Tharick A Pascoal, Pedro Rosa-Neto
Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease
Neurology
Published

Inflammation, Limbic White Matter Microstructure, and Clinical Symptoms in Retired American Football Players With Repetitive Head Impacts

Authors
Olivia M Emanuel, Annalise E Miner, Shannon Y Lee, Emily F Matusz, Jared J Tanner, Michael Marsiske, Allison Holgerson, Monica T Ly, Fatima Tuz-Zahra, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Elaine R Peskind, Sarah J Banks, William B Barr, Jennifer Voreis Wethe, Robert C Cantu, Michael J Coleman, David W Dodick, Michael D McClean, Jesse Mez, Joseph Palmisano, Brett Martin, Alexander P Lin, Ofer Pasternak, Inga K Koerte, Jeffrey L Cummings, Eric M Reiman, Martha E Shenton, Robert A Stern, Sylvain Bouix, Michael L Alosco, Breton M Asken
Inflammation, Limbic White Matter Microstructure, and Clinical Symptoms in Retired American Football Players With Repetitive Head Impacts
The Lancet. Neurology
Published

A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA

Authors
Eric M Reiman, Robert C Alexander, Jessica B Langbaum, Paul S Aisen, Nicholas Ashton, Alireza Atri, Paola Barbarino, Goldie S Byrd, Howard H Feldman, Nicole R Fowler, Valentina Ghisays, Joshua D Grill, Jason Hassenstab, George R Heaton, William L Herring, Clifford R Jack, Sterling C Johnson, Jason Karlawish, Nancy L Keach, Miia Kivipelto, Harlan M Krumholz, Emily A Largent, Tamiko MaGee-Rodgers, Eric McDade, Michelle M Mielke, Doris Molina-Henry, Ronald C Petersen, Gil D Rabinovici, Craig Ritchie, Suzanne E Schindler, Reisa A Sperling, Marc Suárez-Calvet, George Vradenburg, Michael W Weiner, Kathleen A Welsh-Bohmer, Henrik Zetterberg, Michael T Zuendel, Soeren Mattke, Jeffrey L Cummings
A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA
npj aging
Published

Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential

Authors
Nazia Saiyed, Vaibhav Pandya, Xiaobei Pan, Miroslava Cuperlovic-Culf, Nadia Ashrafi, Shiva Kant, Marie Migaud, Jyothi Dhuguru, Henrik Zetterberg, Bernadette McGuinness, Anthony P Passmore, Leiv Otto Watne, Brian D Green, Emma L Cunningham, Stewart F Graham
Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential
Nature medicine
Published

Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks

Authors
Kellen K Petersen, Marta Milà-Alomà, Yan Li, Lianlian Du, Chengjie Xiong, Duygu Tosun, Benjamin Saef, Ziad S Saad, Lei Du-Cuny, Janaky Coomaraswamy, Yulia Mordashova, Carrie E Rubel, Emily A Meyers, Leslie M Shaw, Jeffrey L Dage, Nicholas J Ashton, Henrik Zetterberg, Kyle Ferber, Gallen Triana-Baltzer, Michael Baratta, Erin G Rosenbaugh, Carlos Cruchaga, Eric McDade, David M Holtzman, John C Morris, J Martin Sabandal, Randall J Bateman, Anthony W Bannon, William Z Potter, Suzanne E Schindler, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer’s Disease Project Team
Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks
NPJ dementia
Published

15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN

Authors
Alisha J Daniels, Eric McDade, Jorge J Llibre-Guerra, Chengjie Xiong, Richard J Perrin, Laura Ibanez, Charlene Supnet-Bell, Carlos Cruchaga, Alison Goate, Alan E Renton, Tammie L S Benzinger, Brian A Gordon, Jason Hassenstab, Celeste Karch, Allan Levey, John C Morris, Virginia Buckles, Ricardo F Allegri, Patricio Chrem, Sarah B Berman, Jasmeer P Chhatwal, Martin R Farlow, Nick C Fox, Gregory S Day, Takeshi Ikeuchi, Mathias Jucker, Johannes Levin, Jae-Hong Lee, David Aguillon, Leonel Takada, Ana Luisa Sosa, Ralph Martins, Hiroshi Mori, James M Noble, Stephen Salloway, Edward Huey, Raquel Sánchez-Valle, Peter R Schofield, Jee Hoon Roh, Randall J Bateman, Dominantly Inherited Alzheimer Network
15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The Alzheimer's Disease Diagnosis and Plasma Phospho-Tau217 (ADAPT) study stage 1: Validating clinical cut-points against CSF and amyloid PET

Authors
Ashvini Keshavan, Katharine Wiltshire, Ryan Wee, Irene Gorostiaga Belio, Katie Tucker, Melanie Hart, Michael P Lunn, Michael C B David, Laura Rizzo, Omid Sadeghi-Alavijeh, Patricia Wilson, Daniel P Gale, Amanda J Heslegrave, Henrik Zetterberg, Nick C Fox, Paresh Malhotra, Jonathan M Schott
The Alzheimer's Disease Diagnosis and Plasma Phospho-Tau217 (ADAPT) study stage 1: Validating clinical cut-points against CSF and amyloid PET
Nature communications
Published

Structural defects in amyloid-β fibrils drive secondary nucleation

Authors
Jing Hu, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska, Stefan Wennmalm, Georg Meisl, Samo Curk, Maria Andreasen, Michele Vendruscolo, Paolo Arosio, Anđela Šarić, Jeremy D Schmit, Tuomas P J Knowles, Emma Sparr, Sara Linse, Thomas C T Michaels, Alexander J Dear
Structural defects in amyloid-β fibrils drive secondary nucleation
Scientific reports
Published

GluN2A-mediated currents and calcium signal in human iPSC-derived neurons

Authors
Sergio Escamilla, Carlos Avilés-Granados, Francisco Andrés Peralta, Ana V Paternain, María-Ángeles Cortés-Gómez, Henrik Zetterberg, Elvira de la Peña, Federico Salas-Lucia, Javier Sáez-Valero, Inmaculada Cuchillo-Ibáñez
GluN2A-mediated currents and calcium signal in human iPSC-derived neurons
Frontiers in neuroscience
Published

Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations

Authors
Claudio Villegas-Llerena, Solange R Paredes-Moscosso, María Luisa Guevara-Fujita, Daisy Obispo, Nilton Custodio, Rosa Montesinos, José F Parodi, Oscar Flores-Flores, John Hardy, Ricardo Fujita
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations