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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain communications
Published

Cerebrospinal fluid proteomic profiling of cognitively unimpaired individuals with suspected non-Alzheimer's disease pathophysiology

Authors
Aurore Delvenne, Johan Gobom, Lianne M Reus, Valerija Dobricic, Mara Ten Kate, Suzanne E Schindler, Inez Ramakers, Betty M Tijms, Rik Vandenberghe, Jolien Schaeverbeke, Pablo Martinez-Lage, Mikel Tainta, Charlotte E Teunissen, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J B Vos
Cerebrospinal fluid proteomic profiling of cognitively unimpaired individuals with suspected non-Alzheimer's disease pathophysiology
Journal of neurology
Published

Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases

Authors
Annabelle Coleman, Alexiane Touzé, Mena Farag, Marta Pengo, Michael J Murphy, Yara Hassan, Olivia Thackeray, Kate Fayer, Sophie Field, Mitsuko Nakajima, Elizabeth L Broom, Nicola Z Hobbs, Brook Huxford, Natalie Donkor, Ellen Camboe, Kamalesh C Dey, Alexandra Zirra, Aisha Ahmed, Ana Rita Gameiro Costa, Harriet Sorrell, Luca Zampedri, Vittoria Lombardi, Charles Wade, Sean Mangion, Batoul Fneich, Amanda Heslegrave, Henrik Zetterberg, Rachael Scahill, Alastair Noyce, Andrea Malaspina, Jeremy Chataway, Sarah J Tabrizi, Lauren M Byrne
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases
The journal of prevention of Alzheimer's disease..
Published

Comment by European Alzheimer's Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer' s disease

Authors
Frank Jessen, Javier Arbizu, Mercé Boada, Mircea Balasa, Karim Bennys, Marina Boban, Katharina Bürger, Andrea Chincarini, Annachiara Cagnin, Peter Paul De Deyn, Emrah Düzel, Sebastiaan Engelborghs, Michael Ewers, Lieza G Exalto, Wiesje M van der Flier, Juan Fortea, Kristian Steen Frederiksen, Giovanni B Frisoni, Lutz Frölich, Alejandro J Garza-Martinez, Timo Grimmer, Bernard Hanseeuw, Jakub Hort, Adrian Ivanoiu, Patrick G Kehoe, Sean P Kennelly, Silke Kern, Stefan Klöppel, Lenka Krajčovičová, Milica G Kramberger, Bernadette McGuinness, Patrizia Mecocci, Timo Jan Oberstein, Pierre-Jean Ousset, Claire Paquet, Robert Perneczky, Fabrizio Piazza, Domenico Plantone, Innocenzo Rainero, Guillaume Sacco, Eric Salmon, Isabel Santana, Nikolaos Scarmeas, Anja Schneider, Jonathan M Schott, Eino Solje, Elka Stefanova, Elisabeth Stögmann, Mélanie Strauss, Stanislav Sutovsky, Gunhild Waldemar, Bengt Winblad
Comment by European Alzheimer's Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer' s disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease

Authors
Alexandra Gogola, Xuemei Zeng, Lilcelia A Williams, Theresa Chapple-McGruder, Anum Saeed, Brian J Lopresti, Beth Snitz, Dana Tudorascu, Davneet Minhas, Milos D Ikonomovic, Julia Kofler, Cristy Matan, Tharick A Pascoal, Howard Aizenstein, Henrik Zetterberg, Kaj Blennow, Oscar Lopez, Victor L Villemagne, Thomas K Karikari, Ann D Cohen
Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease
Science advances
Published

Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors

Authors
Yue Li, Sarah Jacques, Hanmant Gaikwad, Morgan Nebbia, Nirmal K Banda, V Michael Holers, Stephen A Tomlinson, Robert I Scheinman, Andrew Monte, Laura Saba, Erika Lasda, Jay Hasselberth, Nicolas Busquet, Wioleta M Zelek, S Moein Moghimi, Dmitri Simberg
Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors
Stem cell reports
Published

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource

Authors
Emily Maguire, Jincy Winston, Sarah H Ellwood, Rachel O'Donoghue, Bethany Shaw, Atahualpa Castillo Morales, Samuel Keat, Alexandra Evans, Rachel Marshall, Lauren Luckcuck, Laura Brown, Elisa Salis, Ganna Leonenko, Nicola Denning, EADB consortium, Nicholas D Allen, Valentina Escott-Price, Caleb Webber, Philip R Taylor, Rebecca Sims, Sally A Cowley, Julie Williams, Sarah M Carpanini, Hazel Hall-Roberts
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource
Communications biology
Published

3BTRON: A Blood-Brain Barrier Recognition Network

Authors
Nan Fletcher-Lloyd, Isabel Bravo-Ferrer, Katrine Gaasdal-Bech, Blanca Díaz Castro, Payam Barnaghi
3BTRON: A Blood-Brain Barrier Recognition Network
Nature genetics
Published

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types

Authors
Pui Ying Chan, Diana Alexander, Ishan Mehta, Larissa Satiko Alcantara Sekimoto Matsuyama, Victoria Harle, Rebeca Olvera-León, Jun Sung Park, Fernanda G Arriaga-González, Louise van der Weyden, Saamin Cheema, Vivek Iyer, Victoria Offord, David Barneda, Phillip T Hawkins, Len Stephens, Zuza Kozik, Michael Woods, Kim Wong, Gabriel Balmus, Alessandro Vinceti, Nicola A Thompson, Martin Del Castillo Velasco-Herrera, Lodewyk Wessels, Joris van de Haar, Emanuel Gonçalves, Sanju Sinha, Martha Estefania Vázquez-Cruz, Luisa Bisceglia, Francesco Raimondi, Jyoti Choudhary, Sumeet Patiyal, Anjan Venkatesh, Francesco Iorio, Colm J Ryan, David J Adams
The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis

Authors
Haşim Gezegen, Merve Alaylıoğlu, Erdi Şahin, Owen Swann, Elena Veleva, Gamze Güven, Umran Yaman, Derviş A Salih, Başar Bilgiç, Haşmet Hanağası, Hakan Gürvit, Murat Emre, Duygu Gezen-Ak, Erdinç Dursun, Henrik Zetterberg, John Hardy, Amanda Heslegrave, Maryam Shoai, Bedia Samanci
Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Gut microbiome compositional and functional features associate with Alzheimer's disease pathology

Authors
Jea Woo Kang, Lora A Khatib, Margo B Heston, Amanda H Dilmore, Jennifer S Labus, Yuetiva Deming, Leyla Schimmel, Colette Blach, Daniel McDonald, Antonio Gonzalez, MacKenzie Bryant, Tyler K Ulland, Sterling C Johnson, Sanjay Asthana, Cynthia M Carlsson, Nathaniel A Chin, Kaj Blennow, Henrik Zetterberg, Federico E Rey, Alzheimer Gut Microbiome Project Consortium, Rima Kaddurah-Daouk, Rob Knight, Barbara B Bendlin
Gut microbiome compositional and functional features associate with Alzheimer's disease pathology
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference

Authors
Neus Falgàs, Lucia Maure-Blesa, Beau Ances, Lisi Flores-Aguilar, Sigan Hartley, Jason Hassenstab, M Florencia Iulita, Matthew Janicki, Katherine Koenig, Patrick Lao, Johannes Levin, Eric McDade, Laurent Meijer, Michael S Rafii, Heather M Snyder, Raquel Sánchez-Valle, Juan Fortea, DSAD‐ADAD conference group, Jose Arriola Infante, Mirea Balasa, Isabel Barroeta, Nicolas Barthelemy R, Alexandre Bejanin, Bessy Benejam, Beatriz Bosch, Angela Bradshaw, Maria Carmona-Iragui, Ann Cohen, Aina Comas Albertí, Lajos Csincsik, A Claudio Cuello, Laura Del Hoyo Soriano, Janna Dijkstra, Natalie Edwards, Sandra Giménez, Fernando Gonzalez-Ortiz, Brian Gordon, Sara Gutiérrez Fernández, Benjamin Handen, Charlotte Jacob, Erik Johnson, Charlotte Johansson, Albert Lladó, Alberto Lleó, Samuel Morabito, Alejandra O Morcillo-Nieto, Laia Montoliu-Gaya, Michael Okafor, Agnes Pérez-Millan, Marie Claude Potier, John Ringman, Íñigo Rodríguez-Baz, Eric Rubenstein, Natalie S Ryan, André Strydom, Lidia Vaqué-Alcázar, Lisa Vermunt, Laura Videla Toro, Shahid Zaman
Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference
Journal of Alzheimer's disease : JAD
Published

Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders

Authors
Ella Liu, Sherri Lee Jones, Victoria Light, Charlotte Teunissen, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Chris R Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Henrik Zetterberg, Jonathan D Rohrer, Simon Ducharme, Genetic Frontotemporal Dementia Initiative (GENFI) and Banque Signature (BbS)
Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders