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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

European journal of neurology
Published

Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia

Authors
Joel Simrén, Andrea L Benedet, Guglielmo Di Molfetta, Ilaria Pola, Kübra Tan, Valentina Cantoni, Ilenia Libri, Jasmine Rivolta, Roberta Ghidoni, Henrik Zetterberg, Barbara Borroni, Nicholas J Ashton
Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia
JAMA network open
Published

Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy

Authors
Annalise E Miner, Henrik Zetterberg, Kaj Blennow, Jenna R Groh, Alpana Singh, Kari Dieckhoff, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Elaine Peskind, Breton M Asken, Jeremy A Tanner, Gil D Rabinovici, Sarah J Banks, William B Barr, Jennifer V Wethe, Robert C Cantu, David W Dodick, Jesse Mez, Joseph N Palmisano, Brett Martin, Thor D Stein, Ann C McKee, Jeffrey L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern, Nicholas J Ashton, Michael L Alosco, DIAGNOSE CTE Research Project
Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy
JAMA
Published

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis

Authors
Ganna Blazhenets, David N Soleimani-Meigooni, Konstantinos Chiotis, Isabel E Allen, Gil D Rabinovici, Renaud La Joie, Meta-Centiloid Study Group, Liana G Apostolova, Breton M Asken, Alexandre Bejanin, Tammie L S Benzinger, Tobey J Betthauser, Marina Bluma, Stephanie Bombois, Pierrick Bourgeat, Vincent Bouteloup, Meredith N Braskie, Matthias Brendel, Adam M Brickman, Natalie Bryant, Santiago Bullich, Maria C Carrillo, Kaitlin Casaletto, David M Cash, Chiung-Chih Chang, Hsin-I Chang, Yishu Chao, Genevieve Chêne, Gaël Chételat, William Coath, Lyduine E Collij, Lise Colmant, Maria M Corrada, Suzanne Craft, Bradford C Dickerson, Bruno Dubois, Carole Dufouil, Alfonso Fajardo, Gill Farrar, Juan Fortea, Lars Frings, Giovanni B Frisoni, Raquel C Gardner, Valentina Garibotto, Johannes S Gnörich, Brian A Gordon, Yuna Gu, Yihui Guan, Tengfei Guo, Bernard J Hanseeuw, Oskar Hansson, Theresa M Harrison, Qi Huang, Shu-Hua Huang, Leonardo Iaccarino, Kazunari Ishii, Kenji Ishi, William J Jagust, Sterling C Johnson, Takashi Kato, Yuta Katsumi, Jeffrey Kaye, Robert A Koeppe, Guilherme D Kolinger, Joel H Kramer, Susan M Landau, Brigitte Landeau, Patrick J Lao, Sangwon Lee, Alberto Lleó, Brian J Lopresti, Val J Lowe, Jose A Luchsinger, Maura Malpetti, Xiaoxie Mao, Andrew March, Colin L Masters, Philipp T Meyer, Florence Mezenge, Elizabeth C Mormino, Maria Franquesa-Mullerat, Akinori Nakamura, Agneta Nordberg, John T O'Brien, Sid E O'Bryant, Ioannis Pappas, Debora E Peretti, Lisa Quenon, Christopher C Rowe, James B Rowe, Marc D Rudolph, Gemma Salvadó, Jonathan M Schott, Daniel L Schwartz, Christopher G Schwarz, Sang Won Seo, Mahnaz Shekari, Lisa C Silbert, Ruben Smith, Heather M Snyder, Andrzej Sokolowski, Reisa A Sperling, Pan Sun, Jacinda Z Taggett, Arthur W Toga, Alexandra Touroutoglou, David E Vaillancourt, Elsmarieke van de Giessen, Jort Vijverberg, Prashanthi Vemuri, Nicolas Villain, Victor L Villemagne, Sylvia Villeneuve, Wei-En Wang, Michael Weiner, Davis Woodworth, Cally Xiao, Fang Xie, Yeojun Yoon, Christina B Young, Mijin Yun, A4, ABIDE, ADNI*, ADNI-DoD, AgeWell, AIBL, AMYPAD, BACS, BATON, BIOCARD, BLSA, BioFINDER-2, BrANCH, CPAS, DETECT-AD, GEMS, GHABS, HABS, HABS-HD, IDEAS, IMAP, INSIGHT-preAD, Insight46, K-ROAD, LEADS, MCSA, MULNIAD, MEMENTO, SCAN, PREVENT-AD, SPIN, Severanc
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis
EBioMedicine
Published

CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum

Authors
Javier Arranz, Juan Lantero-Rodríguez, Luisa Sophie Braun-Wohlfahrt, Lídia Vaqué-Alcázar, Íñigo Rodríguez-Baz, Przemysław R Kac, Burak Arslan, Lucía Maure-Blesa, Lucía Pertierra, Laura Videla, María Carmona-Iragui, Bessy Benejam, Laura Del Hoyo Soriano, Isabel Barroeta, Susana Fernández, Alexandre Bejanin, Alberto Lleó, Nicholas J Ashton, Henrik Zetterberg, Juan Fortea, Daniel Alcolea, Laia Montoliu-Gaya
CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum
medRxiv : the preprint server for health sciences
Published

<em>LRRK2</em> in Focus: A Global Browser Linking Genetic Diversity to Functional Effects

Authors
Spencer M Grant, Vesna van Midden, Elias Fernandez-Toledo, Momodou Cham, Esther Sammler, Dario R Alessi, Global Parkinson’s Genetics Program, Huw R Morris, Cornelis Blauwendraat, Andrew B Singleton, Lara M Lange
<em>LRRK2</em> in Focus: A Global Browser Linking Genetic Diversity to Functional Effects
Science (New York, N.Y.)
Published

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

Authors
Gerard Crowley, Minjung Kim, Nathanael O'Neill, Emir Turkes, Fateme Ghasemi, Luca Giudice, Sebastiaan De Schepper, Benjy J Y Tan, Benito Maffei, Laís S S Ferreira, Julie Rebejac, Javier Rueda-Carrasco, Margarita Toneva, John Christian Fajardo, Judy Z Ge, Zhengyue Grace Yang, Paula Korhonen, Phillip Muckett, Damaris Bennett, Camille Paoletti, Tammie T M Sow, David A Posner, Annerieke Sierksma, Dimitra Sokolova, Viktoras Konstantellos, Leen Ali, Kiavash Movahedi, Andrew F MacAskill, Victor L J Tybulewicz, Tarja Malm, Gabriele Lignani, Menna R Clatworthy, Soyon Hong
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease

Authors
Abhay R Moghekar, James A Rock, Richard C Mohs, Oskar Hansson, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Sterling C Johnson, Henrik Zetterberg, Rachel R Radwan, Jessica Junfola, M Craig Miller, Luna Buitrago, Francesca I De Simone, Katie Martin, Diana Dickson, Natalya Benina, Douglas M Hawkins
Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease
NPJ dementia
Published

Common and rare variant analyses implicate <em>JARID2</em> in cerebral tau deposition

Authors
Tamil Iniyan Gunasekaran, Devendra Meena, Annie J Lee, Siwei Wu, Logan Dumitrescu, Reisa Sperling, Timothy J Hohman, Jingxian Huang, A4 Study, Alzheimer’s Disease Sequencing Project (ADSP), Abbas Dehghan, Ioanna Tzoulaki, Richard Mayeux, Badri Vardarajan
Common and rare variant analyses implicate <em>JARID2</em> in cerebral tau deposition
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme

Authors
Ruth M McKernan, James B Rowe, Sally John, Eric Karran, Helene A Fachim, Sara Imarisio, Raj Long, Charlotte Teunissen, Sarah P Slight, Catherine Mummery, John Hardy
Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme
EMBO reports
Published

Lipid droplets promote aberrant liquid-liquid phase separation of alpha-synuclein impairing energy homeostasis

Authors
Jose Cevallos, Elena Eubanks, Sunghoo Jung, Yiming Huang, Elyse Guadagno, Nora Jaber, Yuzhou Xia, Jinying Wang, Huan Wang, Neeharika Rao Suvvari, Aryan Doshi, Nitya Ravinutala, Alejandro Mosera, Timothy Hsu, Jiya Mody, Benjamin Sacks, Anvi Narayan, Breanna Smith, Maia Wang, Meghana Gottapu, Heba Alnakhala, Nagendran Ramalingam, Arati Tripathi, Tim Bartels, Ulf Dettmer, Zheng Shi, Wei Dai, Eleanna Kara
Lipid droplets promote aberrant liquid-liquid phase separation of alpha-synuclein impairing energy homeostasis
Intensive care medicine
Published

Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy

Authors
Manu Shankar-Hari, Sarah Benghanem, Lena Bourhy, Colm Cunningham, Johannes Ehler, Timothy D Girard, Teneille E Gofton, Bertrand Hermann, Zoeb Jiwaji, Aurelien Mazeraud, Ed Needham, Regis G Rosa, Mervyn Singer, Arjen J C Slooter, Romain Sonneville, Robert D Stevens, Fabio Silvio Taccone, Tarek Sharshar
Publisher Correction: Current knowledge and challenges of sepsis-associated encephalopathy