Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Brain : a journal of neurology
Published
Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis-frontotemporal spectrum disorders
Authors
Michael J Strong, Neil Donison, Ammar Al-Chalabi, Bradley Boeve, Elizabeth C Finger, Henne Holstege, Edward D Huey, Edward B Lee, Sarah J Marzi, Caroline McHutchison, Corey T McMillan, Markus Otto, Leonard Petrucelli, Mercedes Prudencio, Tanya Simuni, Maria Carmela Tartaglia, Martin R Turner, Philip Van Damme, David A Wolk
Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis-frontotemporal spectrum disorders
NPJ dementia
Published
Blood-based biomarkers of Alzheimer's disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms
Authors
Tolulope Akinyemi, Ilaria Pola, Kubra Tan, Oladotun Olalusi, Joseph Yaria, Gabriel Ogunde, Wiebke Traichel, Nesrine Rahmouni, Olabode Oguntiloye, Ayotomiwa Fagbemi, Eniola Cadmus, Femi Popoola, Joseph Therriault, Mayowa Ogunronbi, Dorcas Olujobi, Olaoluwa Famuyiwa, Joshua Akinyemi, Tharick Pascoal, Mayowa Owolabi, Pedro Rosa-Neto, Chinedu T Udeh-Momoh, Olusola Ladokun, Roman Romero-Ortuno, Adesola Ogunniyi, Brian Lawlor, Rajesh Kalaria, Henrik Zetterberg, Andrea L Benedet, Rufus Akinyemi
Blood-based biomarkers of Alzheimer's disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms
Research square
Published
Integrated B and T Cell Repertoire Analysis Reveals Organized but Heterogeneous Adaptive Immunity in Chronic Experimental Stroke
Authors
Sangeetha Senthil Kumar, Danielle A Becktel, Erin D Chapman, Susan A Whitman, Rachel Crumpacker, Jacob C Zbesko, Daniel Berchtold, Claudia Dames, María I Cuartero, Alicia Garcia-Culebras, Lizi M Hegarty, Gaia Brezzo, Jennifer E Goertz, Kristy A Zera, Craig J Smith, Stuart M Allan, Christian Meisel, Andreas Meisel, María Ángeles Moro, Barry W McColl, Josef Anrather, Marion S Buckwalter, Helena W Morrison, Rick G Schnellmann, Kristian P Doyle
Integrated B and T Cell Repertoire Analysis Reveals Organized but Heterogeneous Adaptive Immunity in Chronic Experimental Stroke
Science advances
Published
Activation of transposable elements is linked to a region- and cell type-specific interferon response in Parkinson's disease
Authors
Raquel Garza, Anita Adami, Arun Thiruvalluvan, Sasvi Wijesinghe, Annabel Curle, Oliver Tam, Talitha Forcier, Danai A Lagka, Nina L Kazakou, Diahann A M Atacho, Yogita Sharma, Vivien Horvath, Sara Bermudez, Jenny Johansson, Daniel B Rainbow, Laura Castilla-Vallmanya, Joanne L Jones, Annelies Quaegebeur, Molly Gale Hammell, Agnete Kirkeby, Roger A Barker, Johan Jakobsson
Activation of transposable elements is linked to a region- and cell type-specific interferon response in Parkinson's disease
Nature communications
Published
Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7
Authors
Camilla Maffezzini, Raffaele Iennaco, Andrea Scolz, Simone Maestri, Christian Landles, Georgina F Osborne, Marta M Bronzini, Camilla Trovesi, Thomas Carzaniga, Luca Casiraghi, Jimena Quiros Ramirez, Thomas F Vogt, Dan P Felsenfeld, Tommaso Bellini, Chiara Zuccato, Gillian P Bates, Elena Cattaneo
Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7
Journal of the American Geriatrics Society
Published
Preoperative Moderate-Severe Excessive Daytime Sleepiness Is Associated With Postoperative Cognitive Dysfunction in Older Surgical Patients
Authors
Michael J Devinney, Jeffry Takla, Keith VanDusen, Mary C Wright, Andrew R Spector, Jake Thomas, Pallavi Avasarala, Ashley Hall, Ayesha Syed, Melissa Adams, Eugene Moretti, Jennifer E Dominguez, Patrick J Smith, Megan K Wong, Victor Cai, Sarada Eleswarpu, Jeffrey N Browndyke, Harvey J Cohen, Heather E Whitson, Sigrid C Veasey, Miriam Treggiari, Kaj Blennow, Henrik Zetterberg, Joseph P Mathew, Miles Berger, INTUIT Study Investigators
Preoperative Moderate-Severe Excessive Daytime Sleepiness Is Associated With Postoperative Cognitive Dysfunction in Older Surgical Patients
Artificial intelligence in medicine
Published
Comparative evaluation of training strategies using partially labelled datasets for segmentation of white matter hyperintensities and stroke lesions in FLAIR MRI
Authors
Jesse Phitidis, Alison Q Smithard, William N Whiteley, Joanna M Wardlaw, Miguel O Bernabeu, Maria Valdés Hernández
Comparative evaluation of training strategies using partially labelled datasets for segmentation of white matter hyperintensities and stroke lesions in FLAIR MRI
Nature reviews. Molecular cell biology
Published
Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease
Authors
Carsten Janke, Anna Akhmanova, Francesca Bartolini, Satish Bodakuntla, Filippo Del Bene, Virginie Hamel, Timothy J Mitchison, Thomas Müller-Reichert, François Nédélec, Eva Nogales, Gaia Pigino, Antonina Roll-Mecak, Giampietro Schiavo, Thomas Surrey, Zdenek Lansky
Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease
Molecular psychiatry
Published
CSF p-tau205: a biomarker of Alzheimer's disease progression and biological staging
Authors
Juan Lantero-Rodriguez, Shorena Janelidze, Sebastian Palmqvist, Luisa Sophie Braun-Wohlfahrt, Jakub Vavra, Divya Bali, Anna Orduña Dolado, Niklas Mattsson-Carlgren, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Oskar Hansson, Laia Montoliu-Gaya, Gemma Salvadó
CSF p-tau205: a biomarker of Alzheimer's disease progression and biological staging
International journal of molecular sciences
Published
Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease
Authors
Eliza-Mihaela Arbănași, Emil-Marian Arbănași, Tudor-Gabriel Boghițoiu, Stephanie Ada Cărare, Bogdan Andrei Cordoș, Kawthar Braysh, Nicoleta Suciu, Laura Chinezu, Doina Ramona Manu, Axel Montagne, Jennifer Dewing, Eliza Russu, Claudia-Violeta Bănescu, Septimiu-Toader Voidăzan, Roxana-Octavia Cărare
Cerebral Intramural Cells: A Missing Cellular Link Between Vascular Aging and Alzheimer's Disease