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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

BMJ public health
Published
Health inequalities in risk of SARS-CoV-2 infection in England's second wave: population-based cross-sectional analysis from the REACT-1 study
Authors
Haowei Wang, Kylie E C Ainslie, Caroline E Walters, Oliver Eales, David Haw, Christina Atchison, Claudio Fronterre, Peter J Diggle, Deborah Ashby, Graham Cooke, Wendy Barclay, Helen Ward, Ara Darzi, Christl A Donnelly, Steven Riley, Paul Elliott
Health inequalities in risk of SARS-CoV-2 infection in England's second wave: population-based cross-sectional analysis from the REACT-1 study
EBioMedicine
Published
CNPY3 variants associated with a recessive developmental and epileptic encephalopathy affect inflammasome and TLR function
Authors
Vera Garloff, Mona Grimmel, Reza Maroofian, Stephanie Efthymiou, Sven Stengel, Dolores Bello, Carolin Tille, Mohamed Ghait, Oliver Ohlenschläger, Andrea Dieckmann, Heike de Vries, Matthias Waginger, Seba Nadeef, Ehsan Barkhordari, Rauan Kaiyrzhanov, Sarah Bühler, Irisa Pjeci, Stefanie Beck-Wödl, Javeria Raza Alvi, Tipu Sultan, Anna Chassevent, Constance Smith-Hicks, Irina Mishina, Agustí Rodríguez-Palmero, Evangeline Wassmer, Julie Vogt, Christopher Manuel Meudt, Rami Abou Jamra, Mohammad Reza Abbaszadegan, Naser Ajami, Reza Azizimalamiri, Hamid Galehdari, Niloofar Chamanrou, Mina Zamani, Gholamreza Shariati, Pardis Nourbakhsh, Farhan Bahadar Ali, Ambrin Fatima, Sohana Nadeem Hashmi, Zafar Iqbal, Sidra Kaleem, Mathias Toft, Erum Afzal, Shazia Maqbool, Fatima Rahman, Vincenzo Salpietro, Margot Grisval, Caroline Racine, Louis Januel, David Cheillan, Cecile Acquaviva-Bourdain, Chadi Al Alam, Majid Alfadhel, Muhammad Umair, Barbara Oehl-Jaschkowitz, Shahzad Haider, Vivek Jain, Bhuvandeep Narang, Fawzia Amer, Nour Elkhateeb, Carolina Alvarez, Eduardo Pérez-Palma, Loreto Ríos-Pohl, Rikke S Møller, Debangana Baruah, Lokesh Lingappa, Ahmad Farooq, Maha S Zaki, Gulnara Svyatova, Alexandra Murtazalieva, Asem Burabayeva, Kamran Salayev, Ulviyya Guliyeva, Kimia Kahrizi, Hossein Najmabadi, Anya Revah-Politi, Maureen S Mulhern, Tristan Timothy Sands, Hafiz Muhammad Mustafa, Hani Akbar Rao, Gabriela Oprea, Aboulfazl Rad, Mohammad Miryounesi, Ali Mardi, Vykuntaraju K Gowda, Varunvenkat M Srinivasan, Rola Mohammed Alanazi, Iman Sabri Abumansour, Bader Alhaddad, Khadijah Bakur, Michael Bauer, Fowzan S Alkuraya, Peter Huppke, Henry Houlden, Tobias B Haack, Ignacio Rubio, Ralf A Husain
CNPY3 variants associated with a recessive developmental and epileptic encephalopathy affect inflammasome and TLR function
Progress in neurobiology
Published
The neuropathy-causing GARS1<sup>∆ETAQ</sup> mutation drives pathology in subsets of motor and sensory neurons in mice
Authors
Rebecca L Simkin, Aurélie Paulo-Ramos, Qiuhan Lang, Elena R Rhymes, Sunaina Surana, David Villarroel-Campos, Louisa Snape, Sijiang Liu, Roberto Bellanti, Elena Veleva, Vlada Drotsevitch, Owen Swann, Amanda Heslegrave, Henrik Zetterberg, Michael P Lunn, Robert W Burgess, James N Sleigh
The neuropathy-causing GARS1<sup>∆ETAQ</sup> mutation drives pathology in subsets of motor and sensory neurons in mice
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Air pollution is associated with sex-specific longitudinal changes in astrocytic and neuroinflammatory processes linked to cognitive decline in Alzheimer's disease at-risk individuals
Authors
Natalia Vilor-Tejedor, Blanca Rodríguez-Fernández, Patricia Genius, Alba Fernández-Bonet, Armand González-Escalante, Anna Brugulat-Serrat, Gonzalo Sanchez-Benavides, Irene Cumplido-Mayoral, Carolina Minguillón, Marta Cirach, Mark Nieuwenhuijsen, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Henrik Zetterberg, Kaj Blennow, Arcadi Navarro, Marc Suárez-Calvet, Juan Domingo Gispert, ALFA study
Air pollution is associated with sex-specific longitudinal changes in astrocytic and neuroinflammatory processes linked to cognitive decline in Alzheimer's disease at-risk individuals
Nature genetics
Published
Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival
Authors
Lotte Brückner, Robin Xu, Jun Tang, Aditi Gnanasekar, Alexander Herrmann, Ivy Tsz-Lo Wong, Shu Zhang, Fengyu Tu, Madison Pilon, Alexander Kukalev, Katharina Pardon, Olga Sidorova, Joshua Atta, Qinghao Yu, Giulia Montuori, Davide Pradella, Mila Ilić, Kentaro Suina, Marco Novais-Cruz, Sarah Kaltenbach, Denise Treue, Mădălina Giurgiu-Kraljič, Sergej Herzog, Ann-Sophie Hollinger, Nadine Wittstruck, Martina Fernandez, Nicole Wolozyn, Finnja Becker, Varvara-Rigina Louma, Xiaowei Yan, Rachel Schmargon, Jan R Dörr, David Gamlin, Annika Lehmann, Dennis Gürgen, Matthias Richter, Frank Dubois, Fabrizio Simeoni, Betheney R Pennycook, Alastair Hamilton, Ralph K Lindemann, Courtney Dawes, Gabriel Balmus, Barbara Hero, Matthias Fischer, Vineet Bafna, Roel Verhaak, Geoffrey Wahl, Yang Liu, Richard P Koche, Stamatis Papathanasiou, René Medema, Bastiaan Spanjaard, Andrea Ventura, Ana Pombo, Weini Huang, Monika Scheer, Benjamin Werner, Howard Y Chang, Paul S Mischel, Anton G Henssen
Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival
Discovery immunology
Published
<em>E. coli</em> O157:H7 evades CD8<sup>+</sup> T cell immunity through T3SS-dependent suppression and limited MHCI presentation of translocated proteins
Authors
Amany Hassan, Annalisa Nicastri, Deepali Vasoya, Joana Alves, Morten Nielsen, David L Gally, Nicola Ternette, Alexander Corbishley, Timothy K Connelley
<em>E. coli</em> O157:H7 evades CD8<sup>+</sup> T cell immunity through T3SS-dependent suppression and limited MHCI presentation of translocated proteins
Brain communications
Published
A cognitive architecture for Long COVID: the interplay of brain fog, fatigue, attention and memory
Authors
Darragh Higgins, Sijia Zhao, Masud Husain, Peter Denno, Peter J Hellyer, William Trender, Christina J Atchison, Bethan Davies, Emily Cooper, Joshua Elliott, Matthew Whitaker, Chiara Di Gravio, Marc Chadeau-Hyam, Paul Elliott, Helen Ward, Adam Hampshire
A cognitive architecture for Long COVID: the interplay of brain fog, fatigue, attention and memory
Nature neuroscience
Published
Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons
Authors
Maria Stavrou, Áine Bríd Heffernan, Roderick N Carter, Owen Dando, Zoeb Jiwaji, Karen Burr, Jyoti Nanda, David Villarroel-Campos, Alya Masoud Abdelhafid, Justyna Cholewa-Waclaw, Daniel Soong, David Story, Giampietro Schiavo, Giles E Hardingham, Siddharthan Chandran, Bhuvaneish T Selvaraj
Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons
Frontiers in aging neuroscience
Published
Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis
Authors
Yaping Zhou, Xingqi Pan, Ziyi Xia, Yuhui Sha, Gan Sun, Fei Han, Ming Yao, Lixin Zhou, Liyun Tu, Feng Feng, Joanna M Wardlaw, Yi-Cheng Zhu, Jun Ni
Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis