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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Neurology
Published

Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease

Authors
Jorge J Llibre-Guerra, Ruijin Lu, Ma Florencia Clarens, Ian Liu, Alan Renton, Natalie S Ryan, Alison M Goate, David Aguillón, Ricardo Francisco Allegri, Tammie L S Benzinger, Sarah Berman, Jasmeer P Chhatwal, Patricio Chrem Mendez, Gabriela Vigo, Carlos Cruchaga, Gregory S Day, Martin R Farlow, Nick C Fox, Brian Andrew Gordon, Jason Hassenstab, Edward D Huey, Laura Ibanez, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Allan I Levey, Johannes Levin, Yoshiki Niimi, Richard J Perrin, Pedro Rosa-Neto, Raquel Sánchez-Valle, Peter R Schofield, Guoqiao Wang, Yan Li, Chengjie Xiong, John C Morris, Celeste Karch, Alisha J Daniels, Eric McDade, Randall J Bateman
Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease
Nature reviews. Neurology
Published

The potential of low-field MRI for global dementia care

Authors
Tavia E Evans, Joshua Harper, Aram Salehi, Andrew G Webb, James H Cole, Ana Correa, Hieab H H Adams, David M Cash, Derek K Jones
The potential of low-field MRI for global dementia care
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles

Authors
Maria Kreger Karabova, Anna Del Ser-Badia, Anne Hedegaard, Sam J Washer, Zeynep Baykam, Darragh P O'Brien, Iolanda Vendrell, Svenja S Hester, Roman Fischer, Errin Johnson, Charlotte E Melia, Teige R S Matthews-Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A Metrick, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A McEwan, Kenneth S Kosik, Theresa A Day, William S James, Sally A Cowley
Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles
Journal of neurotrauma
Published

Pathophysiology of the Post-Traumatic Confusional State and Post-Traumatic Amnesia: A Scoping Review

Authors
Douglas I Katz, Yelena G Bodien, Afik Faerman, Julie Schwertfeger, Yelena Bogdanova, Sonja Blum, Brigid Dwyer, Natalie Gilmore, Jessica Vaz Goncalves, Keira Hays, Min Jeong P Graf, Michael Marino, Emma-Jane Mallas, Amy Shapiro-Rosenbaum, Mark Sherer, Michael W Williams, Bei Zhang
Pathophysiology of the Post-Traumatic Confusional State and Post-Traumatic Amnesia: A Scoping Review
Journal of neurology
Published

Cerebrospinal fluid alpha-internexin concentrations measured in patients with Guillain-Barré syndrome: a possible prognostic biomarker for disability at 12 months

Authors
Nina Gleisner, Francisco Meda, Magnus Johnsson, Igal Rosenstein, Ellen Alpsten, Lenka Novakova, Jan Lycke, Henrik Zetterberg, Hlin Kvartsberg, Brynhildur Hafsteinsdottir, Markus Axelsson
Cerebrospinal fluid alpha-internexin concentrations measured in patients with Guillain-Barré syndrome: a possible prognostic biomarker for disability at 12 months
Communications medicine
Published

Author Correction: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans

Authors
Bryan J Neth, Kevin Huynh, Corey Giles, Tingting Wang, Natalie A Mellett, Thy Duong, Colette Blach, Leyla Schimmel, Thomas C Register, Kaj Blennow, Henrik Zetterberg, Richa Batra, Annalise Schweickart, Amanda Hazel Dilmore, Cameron Martino, Matthias Arnold, Jan Krumsiek, Xianlin Han, Pieter C Dorrestein, Rob Knight, Peter J Meikle, Suzanne Craft, Rima Kaddurah-Daouk
Author Correction: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans
Alzheimer's research & therapy
Published

Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease

Authors
Valentina Di Caro, Eunah Cho, Jill Thiel, Britney N Lizama, Marleen J A Koel-Simmelink, Kiran Pandey, Duc Duong, Nicholas T Seyfried, Michael Grundman, Charlotte E Teunissen, Henrik Zetterberg, Kaj Blennow, Anthony O Caggiano, Mary E Hamby
Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease
The lancet. Healthy longevity
Published

Risk factors for early-onset and late-onset dementia: a prospective cohort study

Authors
Katherine Giorgio, John J Stephen, Maxwell Mansolf, Elizabeth A Peterson, Alden L Gross, Emily M Briceño, Deborah A Levine, Catherine Helmer, Stéphanie Debette, Aïcha Soumaré, M Arfan Ikram, Frank J Wolters, Sudha Seshadri, Claudia L Satizabal, Jayandra Jung Himali, Lenore J Launer, David Li, Djass Mbangdadji, Donald M Lloyd-Jones, Farzaneh A Sorond, Lihui Zhao, Oscar L Lopez, Suzanne E Judd, Timothy M Hughes, Vilmundur Guðnason, Allison E Aiello, Alison Fohner, Archana Singh-Manoux, Behnam Sabayan, James S Pankow, Paul S de Vries, Kristine Yaffe, Alexa Beiser, Abbas Dehghan, Rachel Zmora, Denise Scholtens, Pamela L Lutsey, Norrina B Allen, Richard MacLehose, Sanaz Sedaghat
Risk factors for early-onset and late-onset dementia: a prospective cohort study
International journal of stroke : official journal of the International Stroke Society
Published

Global burden of cerebral small vessel disease determined from large MRI studies - a systematic review and meta-analysis

Authors
Bonnie Yk Lam, Yuan Cai, Huijing Zheng, Jize Wei, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Lh Chen, Marco Duering, Deborah Gustafson, Saima Hilal, Vincent Hui, Raj Kalaria, SangYun Kim, Maggie Li Man Lam, Frank-Erik de Leeuw, Ami Sm Li, Hugh Stephen Markus, Anna Marseglia, John O'brien, Leonardo Pantoni, Perminder S Sachdev, Eric Edward Smith, Joanna Wardlaw, Adrian Wong, Ho Ko, Vincent Ct Mok
Global burden of cerebral small vessel disease determined from large MRI studies - a systematic review and meta-analysis
JAMA network open
Published

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial

Authors
Noah J Timko, Mary Cooter Wright, Melody R Smith, Piper C Boykin, Jacqueline M Emerson, Marty G Woldorff, Sarada Eleswarpu, J Taylor Herbert, Eugene W Moretti, Michael J Devinney, Chakib M Ayoub, Frank W Rockhold, David Ryu, Ayesha Syed, Keith W VanDusen, Thomas Bunning, Bethany J Hsia, Michael P Bolognesi, William A Jiranek, Henrik Zetterberg, Kaj Blennow, Janet L Huebner, Zhong Li, Tyler H Reekes, Jeffrey N Browndyke, Daniel T Laskowitz, Miles Berger, MARBLE Study Investigators
Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial
EBioMedicine
Published

Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study

Authors
Chenhao Yang, Yongxin Xu, Yichao Du, Xiaonan Shen, Tingting Li, Nan Chen, Yulian Zhu, Lingyan Huang, Jiaojiao Lü, Lu Li, Zhenyu Qian, Zhen Wang, Ulf Ziemann, Nir Grossman, Alvaro Pascual-Leone, Brad Manor, Chencheng Zhang, Junhong Zhou, Yu Liu
Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study
Neurology
Published

Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling

Authors
Jake Mitchell, Stuart J McDonald, Meng Law, Terence J O'Brien, Lars T Westlye, Karen Caeyenberghs, Virginia Newcombe, David J Sharp, Abdalla Z Mohamed, Erin D Bigler, Houshang Amiri, Andrei Irimia, Stefania Mondello, Sophia I Thomopoulos, John Darrell Van Horn, David F Tate, Elisabeth A Wilde, Asta K Håberg, Martin M Monti, Rachel Edelstein, Maheen M Adamson, William C Walker, Kristen Dams-O'Connor, Evelyn M Deutscher, Ekaterina Dobryakova, Torgeir Hellstrøm, Emily L Dennis, Paul M Thompson, Frank G Hillary, Alexander Olsen, Jennie L Ponsford, Sandy R Shultz, Gershon Spitz
Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling
Nature
Published

DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

Authors
Laura Morcom, Wenlong Xia, Zhaoyang Xu, Yashika Awasthi, Celine Geywitz, Matthew O Ellis, Tomas Noli, Amel Zulji, Daniel Yamamoto, Gemma C Girdler, Li Kai, Keying Zhu, Mingming Wei, Xiao-Yan Tang, Kimberly K Hoi, Julio Gonzalez-Maya, Greg J Duncan, Adrien M Vaquie, Diana Gold Diaz, Riki Kawaguchi, Erdong Liu, Yu Sun, Denny Yang, Gregory D Jordan, I-Ling Lu, Staffan Holmqvist, Theresa Bartels, Katherine Ridley, Jennifer Ja-Yoon Choi, Santos J Franco, Eric J Huang, Ben Emery, Daniel Geschwind, Lucas Schirmer, Gabriel Balmus, Brian Popko, Stephen P J Fancy, David H Rowitch
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
Neuron
Published

Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits

Authors
Robert Ellingford, Samuel S Harris, Marten Kehring, Rikesh M Rajani, Francesca Kar Wey Lam, David Graykowski, Dorothea Bӧken, Lindsay A Welikovitch, Anita Khasnavis, Rhiannon Laban, Amanda Heslegrave, Umran Yaman, Anastasie Mate de Gerando, Suraya A Bond, Selina Wray, Dervis A Salih, David Dupret, Raymond J Dolan, David Klenerman, Henrik Zetterberg, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits