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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature genetics
Published
APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease
Authors
Jesper Qvist Thomassen, Hampton Leonard, Brittany Ulms, Benjamin Grenier-Boley, Sami Heikkinen, Pablo Garcia-González, Atahualapa Castillo-Morales, Masataka Kikuchi, Jungsoo Gim, Han Cao, Fahri Küçükali, Najaf Amin, Dabin Yoon, Itziar de Rojas, Pilar Alvarez Jerez, Victoria Alvarez, Beatrice Arosio, Céline Bellenguez, Sverre Bergh, Kimberley Billingsley, Cornelis Blauwendraat, Merce Boada, Barbara Borroni, Paola Bossù, María J Bullido, Antonio Daniele, Ángel Carracedo, Alexandre de Mendonça, Mark Cookson, Jürgen Deckert, Martin Dichgans, Srdjan Djurovic, Oriol Dols-Icardo, Carole Dufouil, Emrah Düzel, Valentina Escott-Price, Tormod Fladby, Laura Fratiglioni, Amy K Y Fu, Daniela Galimberti, Jose Maria García-Alberca, Vilmantas Giedraitis, Guillermo Garcia-Ribas, Caroline Graff, Timo Grimmer, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Jakub Hort, Frank Jessen, Kendall Jensen, Caroline Jonson, Yoontae Kim, Nicole Kuznetsov, Ville Leinonen, Anssi Lipponen, Jiao Luo, Mary Makarious, Henna Martiskainen, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Pablo Mir, Akinori Miyashita, Susanne Moebus, Kin Y Mok, Laura Molina Porcel, Fermin Moreno, Benedetta Nacmias, Lucilla Parnetti, Pau Pastor, Jordi Pérez-Tur, Oliver Peters, Yolande A L Pijnenburg, Gerard Piñol-Ripoll, Julius Popp, Innocenzo Rainero, Luis M Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Arvid Rongve, Giacomina Rossi, Jose Luis Royo, Dan Rujescu, Ingvild Saltvedt, María Eugenia Sáez, Raquel Sánchez-Valle, Florentino Sanchez-Garcia, Nicolai Sandau, Nikolaos Scarmeas, Katja Scheffler, Norbert Scherbaum, Anja Schneider, Geir Selbæk, Davide Seripa, Vincenzo Solfrizzi, Marco Spallazzi, Alessio Squassina, Eystein Stordal, Niccoló Tesi, Lucio Tremolizzo, Kumar P Tripathi, Wiesje M van der Flier, Julie Williams, Jens Wiltfang, Dag Aarsland, Andrew B Singleton, Philippe Amouyel, Stéphanie Debette, Magda Tsolaki, Gael Nicolas, Sven van der Lee, Henne Holstege, Maria Victoria Fernandez, Patrick Gavin Kehoe, Kristel Sleegers, Martin Ingelsson, Roberta Ghidoni, Ole A Andreassen, Peter A Holmans, Pascual Sánchez-Juan, Rebecca Sims, Nancy Y Ip, Kun Ho Lee, Takeshi Ikeuchi, Alfredo Ramirez, Agustin Ruiz, Mikko Hiltunen, Jean-Charles Lambert, Cornelia van Duijn, Mike Nalls, Ruth Frikke-Schmidt
APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease
Brain : a journal of neurology
Published
Modelling the effect of ventricular expansion on white matter in normal pressure hydrocephalus
Authors
Martina Del Giovane, Vahid Darvishi, Michael C B David, Magdalena A Kolanko, Gregory Scott, Karl A Zimmerman, Valentina Giunchiglia, Anastasia Gontsarova, Adam Hampshire, Paresh A Malhotra, Mazdak Ghajari, Christopher Carswell, David J Sharp
Modelling the effect of ventricular expansion on white matter in normal pressure hydrocephalus
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts
Authors
Margaret Gatz, Wendy J Mack, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Jesus Bani Cuata, Helena C Chui, Ellen E Walters, Daniel K Cummings, Paul L Hooper, Henrik Zetterberg, Caleb E Finch, Benjamin C Trumble, Jonathan Stieglitz, Michael D Gurven, Randall C Thompson, Gregory S Thomas, HORUS Team, Tsimane Health and Life History Project, Hillard S Kaplan
Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts
Neurology
Published
Retinal Optical Coherence Tomography-Angiography and Longitudinal Changes in Cognition and Cerebral Small Vessel Disease
Authors
Samuel Gibbon, Ylenia Giarratano, Charlene Hamid, Carmen Arteaga-Reyes, Una Clancy, Stewart Wiseman, Daniela Jaime Garcia, Ellen V Backhouse, Maria Del C Valdés Hernández, Michael S Stringer, Michael J Thrippleton, Francesca M Chappell, Fergus Doubal, Ian Maccormick, Charlotte Jardine, Iona Hamilton, Gayle Barclay, Donna McIntyre, Borja Marin, Oskar Panek, Baljean Dhillon, Thomas J MacGillivray, Miguel O Bernabeu, Joanna M Wardlaw
Retinal Optical Coherence Tomography-Angiography and Longitudinal Changes in Cognition and Cerebral Small Vessel Disease
Neurobiology of disease
Published
Matrix metalloproteinase-9 is associated with CX3CL1 on tau and amyloid biomarker pathways in APOE4 carriers
Authors
Aimee K Johnson, Carol A Van Hulle, Hannah Zylstra, Kate Cronin, Kevin Johnson, Leonardo Rivera-Rivera, Richard Chappell, Rachael Wilson, Przemysław R Kac, Carey E Gleason, Henrik Zetterberg, Sterling C Johnson, Anthony P Auger, Cynthia M Carlsson
Matrix metalloproteinase-9 is associated with CX3CL1 on tau and amyloid biomarker pathways in APOE4 carriers
Molecular neurobiology
Published
Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults
Authors
Tahmida Sharmin, James D Doecke, Pratishtha Chatterjee, Hamid R Sohrabi, Henrik Zetterberg, Nicholas J Ashton, Manohar L Garg, Kaj Blennow, Ralph N Martins
Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults
Journal of sleep research
Published
Comparison of Actigraphy and Polysomnography in a Sleep Centre Cohort
Authors
Panagis Drakatos, Iain Duncan, Laura Pérez-Carbonell, Abidemi I Otaiku, Fotis Kapsimalis, Sean Higgins, Meir H Kryger, Adrian J Williams, Guy D Leschziner
Comparison of Actigraphy and Polysomnography in a Sleep Centre Cohort
Journal of neuroinflammation
Published
Neuroinflammation-associated thalamocortical functional connectivity and cognition in older adults
Authors
Jeffrey Browndyke, Tyler Reekes, Mary C Wright, Melody R Smith, Michael Devinney, Piper Boykin, Vinith R Upadhya, Daphne Zhu, Katherine T Martucci, Leslie M Shaw, Teresa Waligorska, Charlotte Herber, Connie Tian Yu, Henrik Zetterberg, Kaj Blennow, Janet L Huebner, Harvey J Cohen, Heather Whitson, Joseph P Mathew, Miles Berger, INTUIT & MADCO-PC Trial Investigators
Neuroinflammation-associated thalamocortical functional connectivity and cognition in older adults
Resuscitation plus
Published
Neurofilament light chain for assessment of brain injury in four porcine cardiac arrest models
Authors
Olof Persson, Attila Frigyesi, Anna Valerianova, Mikuláš Mlček, Renaud Tissier, Fanny Lidouren, Matthias Kohlhauer, Giuseppe Ristagno, Aurora Magliocca, Francesca Fumagalli, Kaj Blennow, Henrik Zetterberg, Mohamad Hakam Tiba, Cindy H Hsu, Thomas H Sanderson, Robert Neumar, Hans Friberg
Neurofilament light chain for assessment of brain injury in four porcine cardiac arrest models
GeroScience
Published
Parental longevity and polygenic longevity scores in relation to ageing-related factors in a population of 70-year-olds followed over six years: The Gothenburg H70 Birth Cohort Study
Authors
Nazib M Seidu, Lina Rydén, Johan Skoog, Jessica Samuelsson, Silke Kern, Margda Waern, Henrik Zetterberg, Henne Holstege, Hanna Falk Erhag, Eric Westman, Ingmar Skoog
Parental longevity and polygenic longevity scores in relation to ageing-related factors in a population of 70-year-olds followed over six years: The Gothenburg H70 Birth Cohort Study
Acta neuropathologica
Published
Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vulnerability
Authors
Bernard Mulvey, Heena R Divecha, Madhavi Tippani, Svitlana V Bach, Rahul Bharadwaj, Ishbel Del Rosario, Sarah E Maguire, Ryan A Miller, Aaron J Salisbury, Atharv Chandra, Beau A Oster, Kelsey D Montgomery, Sang Ho Kwon, Haya A Algrain, Alexis R Papariello, Louise A Huuki-Myers, Joel E Kleinman, Leonardo Collado-Torres, Thomas M Hyde, Shizhong Han, Stephanie C Hicks, Daniel R Weinberger, Stephanie C Page, Kristen R Maynard, Keri Martinowich
Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vulnerability
Alzheimer's & dementia (New York, N. Y.)
Published
Remote digital cognitive assessment in a trial-ready Alzheimer's disease cohort: A scalable approach for early intervention studies
Authors
Andrew J Aschenbrenner, Hannah Wilks, Matthew Welhaf, Samhita Katteri, Sarah H Stout, Martin J Sliwinski, Tammie L S Benzinger, Brian Gordon, Yan Li, Richard J Perrin, Alan Renton, Guoqiao Wang, Chengjie Xiong, Christopher H van Dyck, Ricardo Allegri, William S Brooks, Jacob A Bechara, Suman Jayadev, Johannes Levin, Catherine J Mummery, Raquel Sanchez-Valle, David Aguillon, Eric M McDade, Randall J Bateman, Dominantly Inherited Alzheimer Network Trials Unit (DIAN‐TU), Jason Hassenstab
Remote digital cognitive assessment in a trial-ready Alzheimer's disease cohort: A scalable approach for early intervention studies
Brain : a journal of neurology
Published
Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis-frontotemporal spectrum disorders
Authors
Michael J Strong, Neil Donison, Ammar Al-Chalabi, Bradley Boeve, Elizabeth C Finger, Henne Holstege, Edward D Huey, Edward B Lee, Sarah J Marzi, Caroline McHutchison, Corey T McMillan, Markus Otto, Leonard Petrucelli, Mercedes Prudencio, Tanya Simuni, Maria Carmela Tartaglia, Martin R Turner, Philip Van Damme, David A Wolk
Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis-frontotemporal spectrum disorders