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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

The lancet. Healthy longevity
Published

Risk factors for early-onset and late-onset dementia: a prospective cohort study

Authors
Katherine Giorgio, John J Stephen, Maxwell Mansolf, Elizabeth A Peterson, Alden L Gross, Emily M Briceño, Deborah A Levine, Catherine Helmer, Stéphanie Debette, Aïcha Soumaré, M Arfan Ikram, Frank J Wolters, Sudha Seshadri, Claudia L Satizabal, Jayandra Jung Himali, Lenore J Launer, David Li, Djass Mbangdadji, Donald M Lloyd-Jones, Farzaneh A Sorond, Lihui Zhao, Oscar L Lopez, Suzanne E Judd, Timothy M Hughes, Vilmundur Guðnason, Allison E Aiello, Alison Fohner, Archana Singh-Manoux, Behnam Sabayan, James S Pankow, Paul S de Vries, Kristine Yaffe, Alexa Beiser, Abbas Dehghan, Rachel Zmora, Denise Scholtens, Pamela L Lutsey, Norrina B Allen, Richard MacLehose, Sanaz Sedaghat
Risk factors for early-onset and late-onset dementia: a prospective cohort study
International journal of stroke : official journal of the International Stroke Society
Published

Global burden of cerebral small vessel disease determined from large MRI studies - a systematic review and meta-analysis

Authors
Bonnie Yk Lam, Yuan Cai, Huijing Zheng, Jize Wei, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Lh Chen, Marco Duering, Deborah Gustafson, Saima Hilal, Vincent Hui, Raj Kalaria, SangYun Kim, Maggie Li Man Lam, Frank-Erik de Leeuw, Ami Sm Li, Hugh Stephen Markus, Anna Marseglia, John O'brien, Leonardo Pantoni, Perminder S Sachdev, Eric Edward Smith, Joanna Wardlaw, Adrian Wong, Ho Ko, Vincent Ct Mok
Global burden of cerebral small vessel disease determined from large MRI studies - a systematic review and meta-analysis
JAMA network open
Published

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial

Authors
Noah J Timko, Mary Cooter Wright, Melody R Smith, Piper C Boykin, Jacqueline M Emerson, Marty G Woldorff, Sarada Eleswarpu, J Taylor Herbert, Eugene W Moretti, Michael J Devinney, Chakib M Ayoub, Frank W Rockhold, David Ryu, Ayesha Syed, Keith W VanDusen, Thomas Bunning, Bethany J Hsia, Michael P Bolognesi, William A Jiranek, Henrik Zetterberg, Kaj Blennow, Janet L Huebner, Zhong Li, Tyler H Reekes, Jeffrey N Browndyke, Daniel T Laskowitz, Miles Berger, MARBLE Study Investigators
Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial
EBioMedicine
Published

Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study

Authors
Chenhao Yang, Yongxin Xu, Yichao Du, Xiaonan Shen, Tingting Li, Nan Chen, Yulian Zhu, Lingyan Huang, Jiaojiao Lü, Lu Li, Zhenyu Qian, Zhen Wang, Ulf Ziemann, Nir Grossman, Alvaro Pascual-Leone, Brad Manor, Chencheng Zhang, Junhong Zhou, Yu Liu
Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study
Neurology
Published

Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling

Authors
Jake Mitchell, Stuart J McDonald, Meng Law, Terence J O'Brien, Lars T Westlye, Karen Caeyenberghs, Virginia Newcombe, David J Sharp, Abdalla Z Mohamed, Erin D Bigler, Houshang Amiri, Andrei Irimia, Stefania Mondello, Sophia I Thomopoulos, John Darrell Van Horn, David F Tate, Elisabeth A Wilde, Asta K Håberg, Martin M Monti, Rachel Edelstein, Maheen M Adamson, William C Walker, Kristen Dams-O'Connor, Evelyn M Deutscher, Ekaterina Dobryakova, Torgeir Hellstrøm, Emily L Dennis, Paul M Thompson, Frank G Hillary, Alexander Olsen, Jennie L Ponsford, Sandy R Shultz, Gershon Spitz
Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling
Nature
Published

DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

Authors
Laura Morcom, Wenlong Xia, Zhaoyang Xu, Yashika Awasthi, Celine Geywitz, Matthew O Ellis, Tomas Noli, Amel Zulji, Daniel Yamamoto, Gemma C Girdler, Li Kai, Keying Zhu, Mingming Wei, Xiao-Yan Tang, Kimberly K Hoi, Julio Gonzalez-Maya, Greg J Duncan, Adrien M Vaquie, Diana Gold Diaz, Riki Kawaguchi, Erdong Liu, Yu Sun, Denny Yang, Gregory D Jordan, I-Ling Lu, Staffan Holmqvist, Theresa Bartels, Katherine Ridley, Jennifer Ja-Yoon Choi, Santos J Franco, Eric J Huang, Ben Emery, Daniel Geschwind, Lucas Schirmer, Gabriel Balmus, Brian Popko, Stephen P J Fancy, David H Rowitch
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
Neuron
Published

Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits

Authors
Robert Ellingford, Samuel S Harris, Marten Kehring, Rikesh M Rajani, Francesca Kar Wey Lam, David Graykowski, Dorothea Bӧken, Lindsay A Welikovitch, Anita Khasnavis, Rhiannon Laban, Amanda Heslegrave, Umran Yaman, Anastasie Mate de Gerando, Suraya A Bond, Selina Wray, Dervis A Salih, David Dupret, Raymond J Dolan, David Klenerman, Henrik Zetterberg, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
BMC biology
Published

Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Authors
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M Chakrabarti, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Authors
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J Devine, Edgar R Gomes, Joseph Chambers, Elena Koslover, Edward Avezov
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
medRxiv : the preprint server for health sciences
Published

Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated with All-Cause Mortality

Authors
Maira Pyrgioti, Ines Mesa Eguiagaray, Paul Redmond, Janie Corley, Mark E Bastin, Maria Valdés Hernández, Tom C Russ, Joanna M Wardlaw, Eilis Hannon, Ian J Deary, Keenan A Walker, Elliot M Tucker-Drob, Simon R Cox, Riccardo E Marioni, Sarah E Harris
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated with All-Cause Mortality
Alzheimer's research & therapy
Published

Independent and interactive contributions of white matter hyperintensities and Alzheimer's disease imaging and plasma biomarkers to cognitive decline in older adults without dementia

Authors
Dario Bachmann, Christoph Gericke, Maha Wybitul, Antje Saake, Sandro Studer, Katrin Rauen, Esmeralda Gruber, Andreas Buchmann, Martin Hüllner, Kaj Blennow, Henrik Zetterberg, Roger M Nitsch, Christoph Hock, Valerie Treyer, Anton Gietl
Independent and interactive contributions of white matter hyperintensities and Alzheimer's disease imaging and plasma biomarkers to cognitive decline in older adults without dementia
The European journal of neuroscience
Published

Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease

Authors
Francesco Gobbo, Declan King, Jane Tulloch, Davide Gobbo, Calum Bonthron, Soraya Meftah, Caleb Stoddart-Campbelton, Arisa Tamura, Jamie Rose, Colin Smith, Claire Durrant, Tara L Spires-Jones
Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease