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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Analytical chemistry
Published

Profiling Protein Aggregate Size Using Single-Molecule Array Technology

Authors
Dorothea Böken, Yunzhao Wu, Jianli Zhang, Zengjie Xia, Paula Beltran-Lobo, Cara L Croft, Savinu Weerasekera, Amanda Heslegrave, Henrik Zetterberg, Ashvini Keshavan, Jonathan M Schott, Maria Jimenez-Sanchez, David C Duffy, David Klenerman
Profiling Protein Aggregate Size Using Single-Molecule Array Technology
Stem cell reports
Published

A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells

Authors
Galbha Duggal, Xinyu Li, Philippa Pettingill, Tatjana Lalic, Shailesh Kumar Gupta, Christine Flodgaard Høgsbro, Viola Volpato, Caleb Webber, Rory Bowden, Despoina Charou, Kanisa Arunasalam, Marcello Maresca, Ryan Hicks, Satyan Chintawar, M Zameel Cader
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Nature communications
Published

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress

Authors
Rebecca Casterton, Aitana Martinez-Cotrina, Jodi Barnard, Eleanor Wycherley, Yanling Hu, Rhys Anderson, Sebastien Janel, Jiin Byun, Olivia Houghton, Daniel A Solomon, Juan Alcalde, Frank Lafont, Marc-David Ruepp, Frank Hirth, Bart Tummers, Yong-Yeon Cho, Gian De Nicola, Sarah Mizielinska, Manolis Fanto
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
Acta neuropathologica
Published

Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP

Authors
Przemysław R Kac, Katheryn A Q Cousins, Alicja Szadziewska, Leslie M Shaw, Michael Turton, Vivianna M Van Deerlin, Peter Harrison, Henrik Zetterberg, David A Wolk, Corey T McMillan, Douglas Galasko, Jörg Hanrieder, Edward B Lee, Hlin Kvartsberg, David J Irwin, Kaj Blennow
Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP
Alzheimer's & dementia (New York, N. Y.)
Published

Aβ- and tau-associated neuroinflammatory signatures in Alzheimer's disease

Authors
Bruna Bellaver, Guilherme Povala, Marco Antônio De Bastiani, Ilaria Pola, Pamela C L Ferreira, Guilherme Bauer-Negrini, João Pedro Ferrari-Souza, Douglas T Leffa, Firoza Z Lussier, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Riddhi Patira, Serge Gauthier, Dana L Tudorascu, Thomas K Karikari, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Eduardo R Zimmer, Andrea L Benedet, Pedro Rosa-Neto, Tharick A Pascoal
Aβ- and tau-associated neuroinflammatory signatures in Alzheimer's disease
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases

Authors
Bárbara Fernandes Gomes, Mathias Sauer, Laia Montoliu-Gaya, Maria Franquesa-Mullerat, Alexandre Bejanin, Daniel Alcolea, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Kaj Blennow, Henrik Zetterberg, Johanna Nilsson, Olivia Belbin, Nicholas J Ashton
Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Emerging directions in tauopathy research

Authors
Luc Buée, Kristin R Wildsmith, Suvarna Alladi, Taylor Bertucci, Delphine Boche, Kathryn R Bowles, Adam Boxer, Jennifer Brummet, Sarah L DeVos, Kristophe Diaz, Anna Jane Dreyer, Karen Duff, Claudia Duran-Aniotz, Claire S Durrant, Kurt Farrell, Igor C Fontana, Nicolai Franzmeier, Bess Frost, Kanta Horie, Petr Kaňovský, Aimee W Kao, Simin Mahinrad, Maura Malpetti, Huw R Morris, Carla Palleis, Leonard Petrucelli, Jessica Rexach, Larisa Reyderman, Amy Rommel, James B Rowe, Sandra M Sanabria Bohórquez, Chihiro Sato, Michael Schöll, Anja Schneider, Rohan de Silva, Heather M Snyder, Lawren VandeVrede, Andrew W Varga, Jacob W Vogel, Felix L Yeh, Andrew S Yoo, Maria C Carrillo
Emerging directions in tauopathy research
BMC neurology
Published

Neurofilament light chain and glial fibrillary acidic protein as biomarkers of peripheral nervous system involvement in multiple sclerosis: diagnostic and prognostic evaluation

Authors
Alina Flintere-Flinte, Vladimirs Krutovs, Elizabete Pantelejeva, Kaj Blennow, Henrik Zetterberg, Maksims Zolovs, Viktorija Kenina
Neurofilament light chain and glial fibrillary acidic protein as biomarkers of peripheral nervous system involvement in multiple sclerosis: diagnostic and prognostic evaluation