Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Lancet (London, England)
Published

Alzheimer's disease

Authors
Alberto Serrano-Pozo, Valentina Escott-Price, Lea T Grinberg, Tharick Pascoal, Marc Suárez-Calvet, Bruno Dubois, Reisa A Sperling
Alzheimer's disease
Nature communications
Published

GWAS of extended prescription analgesic use identifies genetic loci in chronic pain

Authors
Charli E Harlow, Emeka Uzochukwu, Hazel A Fernando, Charles E Mordaunt, Jordan M Hughey, John D Eicher, Lara Robinson, Nicholas Bowker, Laurence Howe, Jimmy Liu, Adrian Cortes, Paul Wilson, Usha Gungabissoon, Victoria S Benson, Anthony Nash, Gareth Young, Laura Addis, Chun-Fang Xu, Caleb Webber, Jonathan Davitte, M Zameel Cader
GWAS of extended prescription analgesic use identifies genetic loci in chronic pain
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Repurposed drug prioritization pipeline for a multi-arm platform trial in clinical Alzheimer's disease

Authors
Sabahat Iqbal, Cristina Bonet Olivares, Laura Rizzo, Thomas D Parker, Charis Wong, Benjamin R Underwood, James Carpenter, Ross Dunne, Vanessa Raymont, Alastair Reith, Catherine J Mummery, Eric H Karran, Fiona Ducotterd, Gordon Wilcock, Jeffrey L Cummings, John T O'Brien, Leah Mursaleen, Lon S Schneider, Rik Vandenberghe, Malcolm Macleod, Zunera Khan, Paresh Malhotra, Suzanne Reeves
Repurposed drug prioritization pipeline for a multi-arm platform trial in clinical Alzheimer's disease
Small (Weinheim an der Bergstrasse, Germany)
Published

Ultrasensitive Detection of Neurofilament Light in Plasma Using F(Ab')<sub>2</sub>-Modified Graphene Field-Effect Biosensor

Authors
Selvinaz Burcu Kizilates, Rica Asrosa, Lenart Senicar, Anuja Sharma, Seda Gungordu Er, Nisha Naeem, Ahmad Nizamuddin Bin Muhammad Mustafa, Yang Wu, Neil Graham, Amanda Heslegrave, Mohan Edirisinghe, Antonio Lombardo, Elias Torres, Henrik Zetterberg, Sami Ramadan, David J Sharp, Bing Li
Ultrasensitive Detection of Neurofilament Light in Plasma Using F(Ab')<sub>2</sub>-Modified Graphene Field-Effect Biosensor
The journal of prevention of Alzheimer's disease
Published

Hypertension acts together with Aβ pathology in late-life to promote memory loss

Authors
Lucas U Da Ros, João Pedro Ferrari-Souza, Marco Antônio de Bastiani, Lucas A Hauschild, Bruna Bellaver, Pamela C L Ferreira, Douglas Teixeira Leffa, Guilherme Povala, Firoza Z Lussier, Mira Chamoun, Gleb Bezgin, Andrea L Benedet, Nesrine Rahmouni, Arthur C Macedo, Kaj Blennow, Nicholas Ashton, Henrik Zetterberg, Wyllians Vendramini Borelli, Diogo O Souza, Tharick A Pascoal, Pedro Rosa-Neto, Eduardo R Zimmer, Alzheimer’s Disease Neuroimaging Initiative
Hypertension acts together with Aβ pathology in late-life to promote memory loss
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Age-related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome

Authors
Monika Rataj Baniowska, Paige Mumford, Francesca Prestia, Pauline Stephan, Millie Beament, Marie-Christine Birling, Chiara Lanzillotta, Letizia Ciafardini, Eugenio Barone, Gloria Lau, Claire Chevalier, Chadia Nahy, Nadia Messaddeq, Thais Lestra, Yixing Wu, Valérie Nalesso, Fabio Di Domenico, Frances Wiseman, Yann Herault
Age-related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome
Current biology : CB
Published

Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep

Authors
Wei Ba, Edward C Harding, Mathieu Nollet, Kyoko Tossell, Li-Li Li, Sara Wong, Berta Anuncibay Soto, Raquel Yustos, Li Li, Jagoda Ostaszewska, Hanns Ulrich Zeilhofer, Alexei L Vyssotski, Michael J Courtney, William Wisden, Nicholas P Franks
Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep