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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Molecular psychiatry
Published

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

Authors
David Mengel, Ester Soter, Julia Maren Ott, Madeleine Wacker, Alejandra Leyva, Oliver Peters, Julian Hellmann-Regen, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emra Düzel, Wenzel Glanz, Enise I Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Sebastian Sodenkamp, Annika Spottke, Johanna Brustkern, Frederic Brosseron, Michael Wagner, Melina Stark, Luca Kleineidam, Kai Shao, Falk Lüsebrink, Renat Yakupov, Matthias Schmid, Stefan Hetzer, Peter Dechent, Klaus Scheffler, David Berron, Frank Jessen, Matthis Synofzik, DELCODE study group
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease
EBioMedicine
Published

Dissection of blood-brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders

Authors
Agathe Vrillon, Nicholas J Ashton, Elodie Bouaziz-Amar, François Mouton-Liger, Emmanuel Cognat, Julien Dumurgier, Matthieu Lilamand, Thomas K Karikari, Vincent Prevot, Henrik Zetterberg, Kaj Blennow, Claire Paquet
Dissection of blood-brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The CentiMarker project: Standardizing quantitative Alzheimer's disease fluid biomarkers for biologic interpretation

Authors
Guoqiao Wang, Yan Li, Chengjie Xiong, Yuchen Cao, Suzanne E Schindler, Eric McDade, Kaj Blennow, Oskar Hansson, Jeffrey L Dage, Clifford R Jack, Charlotte E Teunissen, Leslie M Shaw, Henrik Zetterberg, Laura Ibanez, Jigyasha Timsina, Cruchaga Carlos, Alzheimer's Disease Neuroimaging Initiative, Randall J Bateman
The CentiMarker project: Standardizing quantitative Alzheimer's disease fluid biomarkers for biologic interpretation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Authors
Emre Fertan, Jeff Y L Lam, Giulia Albertini, Maarten Dewilde, Yunzhao Wu, Oluwatomi E S Akingbade, Dorothea Böken, Elizabeth A English, Bart De Strooper, David Klenerman
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
Brain : a journal of neurology
Published

Intronic FGF14 GAA repeat expansions impact progression and survival in multiple system atrophy

Authors
Viorica Chelban, David Pellerin, Nirosen Vijiaratnam, Hamin Lee, Yen Yee Goh, Lauren Brown, Sara Sambin, Danielle Seilhean, Stephane Lehericy, Pablo Iruzubieta, Rahema Mohammad, Eleanor Self, Annarita Scardamaglia, Cameron Lee, Miriama Ostrozovicova, Marie-Josée Dicaire, Christine Girges, Emil K Gustavsson, David Murphy, Toby Curless, Joshua Laβ, Joanne Trinh, Timothy Rittman, James B Rowe, Marios Hadjivassiliou, Neil Archibald, Matt C Danzi, Catherine Ashton, Virginie Roth, Marion Wandzel, Warren A Cheung, Djordje O Gveric, Bart De Vil, Jordan Follett, P Nigel Leigh, Lukas Beichert, Tomi Pastinen, Céline Bonnet, Mathilde Renaud, Wassilios G Meissner, Anne Sieben, David Crosiers, Patrick Cras, Stephan Zuchner, Jean-Christophe Corvol, Matthew J Farrer, Matthis Synofzik, Bernard Brais, Tom Warner, Huw R Morris, Zane Jaunmuktane, Tom Foltynie, Henry Houlden
Intronic FGF14 GAA repeat expansions impact progression and survival in multiple system atrophy
Cell reports methods
Published

Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community

Authors
Takahiro Morito, Mohan Qi, Naoko Kamano, Hiroki Sasaguri, Sumi Bez, Martha Foiani, Karen Duff, Seico Benner, Toshihiro Endo, Hiroshi Hama, Hiroshi Kurokawa, Atushi Miyawaki, Hiroshi Mizuma, Naruhiko Sahara, Masafumi Shimojo, Makoto Higuchi, Takaomi C Saido, Naoto Watamura
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community
Science advances
Published

Astrocytic RNA editing regulates the host immune response to alpha-synuclein

Authors
Karishma D'Sa, Minee L Choi, Aaron Z Wagen, Núria Setó-Salvia, Olga Kopach, James R Evans, Margarida Rodrigues, Patricia Lopez-Garcia, Joanne Lachica, Benjamin E Clarke, Jaijeet Singh, Ali Ghareeb, James Bayne, Melissa Grant-Peters, Sonia Garcia-Ruiz, Zhongbo Chen, Samuel Rodriques, Dilan Athauda, Emil K Gustavsson, Sarah A Gagliano Taliun, Christina Toomey, Regina H Reynolds, George Young, Stephanie Strohbuecker, Thomas Warner, Dmitri A Rusakov, Rickie Patani, Clare Bryant, David A Klenerman, Sonia Gandhi, Mina Ryten
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Neuroimaging clinics of North America
Published

Avenues in the Analysis of Enlarged Perivascular Spaces Quantified from Brain Magnetic Resonance Images Acquired at 1.5T and 3T Magnetic Field Strengths

Authors
Maria C Valdés Hernández, Roberto Duarte Coello, Alexandra Morozova, John McFadden, Charlotte Jardine, Gayle Barclay, Donna McIntyre, Francesca M Chappell, Michael Stringer, Michael J Thrippleton, Joanna M Wardlaw
Avenues in the Analysis of Enlarged Perivascular Spaces Quantified from Brain Magnetic Resonance Images Acquired at 1.5T and 3T Magnetic Field Strengths
Cell reports
Published

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation

Authors
Dunxin Shen, Alec Vincent, Evan Udine, Yazead Buhidma, Sharifah Anoar, Elli Tsintzas, Marie Maeland, Dongwei Xu, Mireia Carcolé, David Osumi-Sutherland, Benjamin Aleyakpo, Alexander Hull, Guillermo Martínez Corrales, Nathan Woodling, Rosa Rademakers, Adrian M Isaacs, Carlo Frigerio, Marka van Blitterswijk, Tammaryn Lashley, Teresa Niccoli
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation
Nature communications
Published

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

Authors
Diana Acosta Ingram, Emir Turkes, Tae Yeon Kim, Sheeny Vo, Nicholas Sweeney, Marie-Amandine Bonte, Ryan Rutherford, Dominic L Julian, Meixia Pan, Jacob Marsh, Andrea R Argouarch, Min Wu, Douglas W Scharre, Erica H Bell, Lawrence S Honig, Jean Paul Vonsattel, Geidy E Serrano, Thomas G Beach, Celeste M Karch, Aimee W Kao, Mark E Hester, Xianlin Han, Hongjun Fu
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau