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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature biomedical engineering
Published

Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue

Authors
Rebecca Andrews, Bin Fu, Christina E Toomey, Jonathan C Breiter, Joanne Lachica, Joseph S Beckwith, Ru Tian, Emma E Brock, Lisa-Maria Needham, Gregory J Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, Yen Goh, Begüm Kurt, Lenart Senicar, Marisa Edmonds, Tim Bartels, Nora Bengoa-Vergniory, Peter J Magill, Zane Jaunmuktane, Oliver J Freeman, Benjamin J M Taylor, John Hardy, Tammaryn Lashley, Mina Ryten, Michele Vendruscolo, Nicholas W Wood, Lucien E Weiss, Sonia Gandhi, Steven F Lee
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Acta neuropathologica
Published

Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study

Authors
Wagner S Brum, Laia Montoliu-Gaya, Gunnar Brinkmalm, Diana Piotrowska, Elena Camporesi, Carsten Jäger, Helena S Isaksson, Sven Martin, Jonas Kindberg, Juan Lantero-Rodriguez, João Pedro Ferrari-Souza, Alexis Moscoso, Andrea L Benedet, Shorena Janelidze, Johan Gobom, Henrik Zetterberg, Oskar Hansson, Eduardo R Zimmer, Nicholas J Ashton, Thomas Arendt, Tammaryn Lashley, Jens T Stieler, Max Holzer, Ole Fröbert, Kaj Blennow
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression

Authors
Michael C B David, Magdalena A Kolanko, Thomas D Parker, Ramin Nilforooshan, Karl A Zimmerman, Cristina Bonet Olivares, Karen Hoang, Johanna Brandt, Charikleia Triantafyllou, Peter J Lally, Gregory Scott, CR&T Group of UKDRI, David J Sharp, Paresh A Malhotra
Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium

Authors
Inge M W Verberk, Mariam Gouda, Daniel Antwi-Berko, Mardou van Leeuwenstijn, Bram Bongers, Isabel M Houtkamp, Wiesje M van der Flier, Shorena Janelidze, Oskar Hansson, Nathalie Le Bastard, Manu Vandijck, Jacob Hunter, Lee Honigberg, Kristopher M Kirmess, Philip B Verghese, Kaj Blennow, Henrik Zetterberg, Emily A Meyers, Rebecca M Edelmayer, Charlotte Teunissen
Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic

Authors
Dhamidhu Eratne, Matthew Kang, Charles B Malpas, Christa Dang, Courtney Lewis, Oneil G Bhalala, Qiao-Xin Li, Steven Collins, Colin L Masters, Samantha M Loi, Alexander F Santillo, Kaj Blennow, Henrik Zetterberg, Dennis Velakoulis, And The MiND Study Group
Plasma p-tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond

Authors
Sylvia Villeneuve, Judes Poirier, John C S Breitner, Jennifer Tremblay-Mercier, Jordana Remz, Jean-Michel Raoult, Yara Yakoub, Jonathan Gallego-Rudolf, Ting Qiu, Alfonso Fajardo Valdez, Bery Mohammediyan, Mohammadali Javanray, Amelie Metz, Safa Sanami, Valentin Ourry, Alfie Wearn, Alexandre Pastor-Bernier, Manon Edde, Julie Gonneaud, Cherie Strikwerda-Brown, Christine L Tardif, Claudine J Gauthier, Maxime Descoteaux, Mahsa Dadar, Étienne Vachon-Presseau, Andrée-Ann Baril, Simon Ducharme, Maxime Montembeault, Maiya R Geddes, Jean-Paul Soucy, Natasha Rajah, Robert Laforce, Christian Bocti, Christos Davatzikos, Lune Bellec, Pedro Rosa-Neto, Sylvain Baillet, Alan C Evans, D Louis Collins, M Mallar Chakravarty, Kaj Blennow, Henrik Zetterberg, R Nathan Spreng, Alexa Pichet Binette, PREVENT‐AD Research Group
The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond
Neurology
Published

Continuous Positive Airway Pressure and Progression of Enlarged Perivascular Spaces in Adults With Obstructive Sleep Apnea

Authors
Rosa Sommer, Elizabeth A Hill, Joel Ramirez, Roberto Duarte Coello, Lucia Ballerini, Erin Gibson, Stephanie Berberian, Maria Del C Valdés Hernández, Andrew Centen, Francesca M Chappell, Nasim Montazeri, Michael S Stringer, Michael Thrippleton, Daniela Jaime Garcia, Stewart Wiseman, Marc Narayansingh, Anu Tandon, Mark I Boulos, Brian James Murray, Fergus Doubal, Renata L Riha, Maged Goubran, Bradley J Macintosh, Joanna M Wardlaw, Sandra E Black, Andrew S P Lim
Continuous Positive Airway Pressure and Progression of Enlarged Perivascular Spaces in Adults With Obstructive Sleep Apnea
Lancet (London, England)
Published

New landscape of the diagnosis of Alzheimer's disease

Authors
Giovanni B Frisoni, Oskar Hansson, Emma Nichols, Valentina Garibotto, Suzanne E Schindler, Wiesje M van der Flier, Frank Jessen, Nicolas Villain, Eider M Arenaza-Urquijo, Lucia Crivelli, Juan Fortea, Lea T Grinberg, Zahinoor Ismail, Satoshi Minoshima, Rik Ossenkoppele, Henrik Zetterberg, Ronald C Petersen, Bruno Dubois
New landscape of the diagnosis of Alzheimer's disease
Lancet (London, England)
Published

Treatment for Alzheimer's disease

Authors
Nick C Fox, Christopher Belder, Clive Ballard, Helen C Kales, Catherine Mummery, Paulo Caramelli, Olga Ciccarelli, Kristian S Frederiksen, Teresa Gomez-Isla, Zahinoor Ismail, Claire Paquet, Ronald C Petersen, Robert Perneczky, Louise Robinson, Ozge Sayin, Giovanni B Frisoni
Treatment for Alzheimer's disease
Lancet (London, England)
Published

Alzheimer's disease outlook: controversies and future directions

Authors
Giovanni B Frisoni, Emil Aho, Carol Brayne, Olga Ciccarelli, Bruno Dubois, Nick C Fox, Kristian S Frederiksen, Cem Gabay, Valentina Garibotto, Thomas Hofmarcher, Clifford R Jack, Miia Kivipelto, Ronald C Petersen, Federica Ribaldi, Christopher C Rowe, Sebastian Walsh, Henrik Zetterberg, Oskar Hansson
Alzheimer's disease outlook: controversies and future directions
Nature
Published

Collective homeostasis of condensation-prone proteins via their mRNAs

Authors
Rupert Faraway, Neve Costello Heaven, Holly Digby, Klara Kuret Hodnik, Jure Rebselj, Oscar G Wilkins, Anob M Chakrabarti, Ira A Iosub, Neža Vadnjal, Rhys Dore, Lea Knez, Stefan L Ameres, Clemens Plaschka, Jernej Ule
Collective homeostasis of condensation-prone proteins via their mRNAs
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology

Authors
Eric M McDade, Nicolas R Barthélemy, Guoqiao Wang, Yan Li, Yuchen Cao, Brian Gordon, Tammie L S Benzinger, David Clifford, Alison M Goate, Alan E Renton, Jason Hassenstab, Jorge J Llibre-Guerra, Richard J Perrin, Chengjie Xiong, Carlos Cruchaga, Catherine J Mummery, Sarah B Berman, James Lah, Erik D Roberson, Christopher Van Dyck, Serge Gauthier, Colin L Masters, Mario Masellis, Tobias Bittner, Roy Yaari, Jasmeer Chhatwal, Patricio Chrem, William Brooks, Kazushi Suzuki, Johannes J Levin, Mathias Jucker, John Ringman, David Wallon, Takeshi Ikeuchi, Jae-Hong Lee, Jee Hoon Roh, Peter Schofield, Nick C Fox, Natalie S Ryan, Jonathan Vöglein, Celeste Karch, Laura Ibáñez, Gregory S Day, Raquel Sánchez-Valle, Alisha Daniels, John C Morris, Charlene Supnet-Bell, Allan I Levey, Randall J Bateman, DIAN‐TU Study Team and DIAN Obs Team
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology