Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Brain communications
Published

Blood-based biomarker discovery in motor neuron disease using nucleic acid-linked immuno-sandwich assay

Authors
Hatice Bozkurt, Katy R Reid, Judith Newton, Jessica Gill, Isaac Chau, Chloe Parker, Hatice Kurucu King, Johnny Tam, Dominic Ng, Maria Stavrou, Paul Baxter, Orla Marland, Karen Burr, Amanda Heslegrave, Elena Veleva, Owen J Swann, Henrik Zetterberg, David P J Hunt, Bhuvaneish Thangaraj Selvaraj, Siddharthan Chandran, Suvankar Pal
Blood-based biomarker discovery in motor neuron disease using nucleic acid-linked immuno-sandwich assay
Alzheimer's & dementia. Behavior & socioeconomics of aging
Published

Bridging Research, Policy, and Practice: Advancing Evidence-Informed Approaches for Dementia Care and Prevention: an expert review by the Health Policy Professional Interest Area from ISTAART

Authors
Juliana Souza-Talarico, Maria M Pinzon, Jayalakshmi Viswanathan, Tuan Anh Nguye, Walter D Dawson, Jay Lusk, Crystal Glover, Perlina Desai, Anna Shelander, Lesley E Williamson, Dallas Seitz, Joseph M Costello, Magdalena Pereyra, Yixuan Cheng, Sharon Naismith, Andrea Slachevsky, Lycia Tramujas Vasconcellos Neumann, Preeti Pushpalata Zanwar
Bridging Research, Policy, and Practice: Advancing Evidence-Informed Approaches for Dementia Care and Prevention: an expert review by the Health Policy Professional Interest Area from ISTAART
Nature aging
Published

Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts

Authors
Oliver Robinson, Han Xiao, Jan Homann, Vivian Viallon, Pietro Ferrari, Philipp Frank, José M Huerta, Ana Jiménez Zabala, Rudolf Kaaks, Verena A Katzke, Mika Kivimaki, Claudia Langenberg, Chung-Ho E Lau, Lefkos Middleton, N Charlotte Onland-Moret, Salvatore Panico, Anna Prizment, Fulvio Ricceri, María-José Sánchez, Karl Smith-Byrne, W M Monique Verschuren, Roel Vermeulen, Paolo Vineis, Shuo Wang, Nick Wareham, Christina M Lill, Elio Riboli, Marc J Gunter
Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts
Neurobiology of aging
Published

Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals

Authors
David López-Martos, Marc Suárez-Calvet, Gemma Salvadó, Raffaele Cacciaglia, Mahnaz Shekari, Armand González-Escalante, Andrea Horta-Barba, Helena Palma-Gudiel, Marta Milà-Alomà, Anna Brugulat-Serrat, Carolina Minguillon, Matteo Tonietto, Edilio Borroni, Gregory Klein, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, ALFA study
Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals
Nature communications
Published

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Authors
Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Eric R McGregor, James R Hilser, Ruben Aquino-Martinez, Sandra Harding, Joseph Lawrence Harpt, Katharina R Beck, Hailey Bussan, Jessamine F Kuehn, Yuetiva Deming, Rachel Studer, Sterling C Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Corinne D Engelman, Hooman Allayee, Rozalyn M Anderson, Tyler K Ulland, Fredrik Bäckhed, Barbara B Bendlin, Federico E Rey
Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Analytical chemistry
Published

Profiling Protein Aggregate Size Using Single-Molecule Array Technology

Authors
Dorothea Böken, Yunzhao Wu, Jianli Zhang, Zengjie Xia, Paula Beltran-Lobo, Cara L Croft, Savinu Weerasekera, Amanda Heslegrave, Henrik Zetterberg, Ashvini Keshavan, Jonathan M Schott, Maria Jimenez-Sanchez, David C Duffy, David Klenerman
Profiling Protein Aggregate Size Using Single-Molecule Array Technology
Stem cell reports
Published

A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells

Authors
Galbha Duggal, Xinyu Li, Philippa Pettingill, Tatjana Lalic, Shailesh Kumar Gupta, Christine Flodgaard Høgsbro, Viola Volpato, Caleb Webber, Rory Bowden, Despoina Charou, Kanisa Arunasalam, Marcello Maresca, Ryan Hicks, Satyan Chintawar, M Zameel Cader
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Nature communications
Published

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress

Authors
Rebecca Casterton, Aitana Martinez-Cotrina, Jodi Barnard, Eleanor Wycherley, Yanling Hu, Rhys Anderson, Sebastien Janel, Jiin Byun, Olivia Houghton, Daniel A Solomon, Juan Alcalde, Frank Lafont, Marc-David Ruepp, Frank Hirth, Bart Tummers, Yong-Yeon Cho, Gian De Nicola, Sarah Mizielinska, Manolis Fanto
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
Acta neuropathologica
Published

Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP

Authors
Przemysław R Kac, Katheryn A Q Cousins, Alicja Szadziewska, Leslie M Shaw, Michael Turton, Vivianna M Van Deerlin, Peter Harrison, Henrik Zetterberg, David A Wolk, Corey T McMillan, Douglas Galasko, Jörg Hanrieder, Edward B Lee, Hlin Kvartsberg, David J Irwin, Kaj Blennow
Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP