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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature medicine
Published

Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks

Authors
Kellen K Petersen, Marta Milà-Alomà, Yan Li, Lianlian Du, Chengjie Xiong, Duygu Tosun, Benjamin Saef, Ziad S Saad, Lei Du-Cuny, Janaky Coomaraswamy, Yulia Mordashova, Carrie E Rubel, Emily A Meyers, Leslie M Shaw, Jeffrey L Dage, Nicholas J Ashton, Henrik Zetterberg, Kyle Ferber, Gallen Triana-Baltzer, Michael Baratta, Erin G Rosenbaugh, Carlos Cruchaga, Eric McDade, David M Holtzman, John C Morris, J Martin Sabandal, Randall J Bateman, Anthony W Bannon, William Z Potter, Suzanne E Schindler, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer’s Disease Project Team
Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks
NPJ dementia
Published

15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN

Authors
Alisha J Daniels, Eric McDade, Jorge J Llibre-Guerra, Chengjie Xiong, Richard J Perrin, Laura Ibanez, Charlene Supnet-Bell, Carlos Cruchaga, Alison Goate, Alan E Renton, Tammie L S Benzinger, Brian A Gordon, Jason Hassenstab, Celeste Karch, Allan Levey, John C Morris, Virginia Buckles, Ricardo F Allegri, Patricio Chrem, Sarah B Berman, Jasmeer P Chhatwal, Martin R Farlow, Nick C Fox, Gregory S Day, Takeshi Ikeuchi, Mathias Jucker, Johannes Levin, Jae-Hong Lee, David Aguillon, Leonel Takada, Ana Luisa Sosa, Ralph Martins, Hiroshi Mori, James M Noble, Stephen Salloway, Edward Huey, Raquel Sánchez-Valle, Peter R Schofield, Jee Hoon Roh, Randall J Bateman, Dominantly Inherited Alzheimer Network
15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The Alzheimer's Disease Diagnosis and Plasma Phospho-Tau217 (ADAPT) study stage 1: Validating clinical cut-points against CSF and amyloid PET

Authors
Ashvini Keshavan, Katharine Wiltshire, Ryan Wee, Irene Gorostiaga Belio, Katie Tucker, Melanie Hart, Michael P Lunn, Michael C B David, Laura Rizzo, Omid Sadeghi-Alavijeh, Patricia Wilson, Daniel P Gale, Amanda J Heslegrave, Henrik Zetterberg, Nick C Fox, Paresh Malhotra, Jonathan M Schott
The Alzheimer's Disease Diagnosis and Plasma Phospho-Tau217 (ADAPT) study stage 1: Validating clinical cut-points against CSF and amyloid PET
Nature communications
Published

Structural defects in amyloid-β fibrils drive secondary nucleation

Authors
Jing Hu, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska, Stefan Wennmalm, Georg Meisl, Samo Curk, Maria Andreasen, Michele Vendruscolo, Paolo Arosio, Anđela Šarić, Jeremy D Schmit, Tuomas P J Knowles, Emma Sparr, Sara Linse, Thomas C T Michaels, Alexander J Dear
Structural defects in amyloid-β fibrils drive secondary nucleation
Scientific reports
Published

GluN2A-mediated currents and calcium signal in human iPSC-derived neurons

Authors
Sergio Escamilla, Carlos Avilés-Granados, Francisco Andrés Peralta, Ana V Paternain, María-Ángeles Cortés-Gómez, Henrik Zetterberg, Elvira de la Peña, Federico Salas-Lucia, Javier Sáez-Valero, Inmaculada Cuchillo-Ibáñez
GluN2A-mediated currents and calcium signal in human iPSC-derived neurons
Frontiers in neuroscience
Published

Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations

Authors
Claudio Villegas-Llerena, Solange R Paredes-Moscosso, María Luisa Guevara-Fujita, Daisy Obispo, Nilton Custodio, Rosa Montesinos, José F Parodi, Oscar Flores-Flores, John Hardy, Ricardo Fujita
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations
Nature communications
Published

Characterising processing conditions that artifactually bias human brain tissue transcriptomes

Authors
Moein Yaqubi, Michael Thomas, Jonathan Talbot-Martin, Abdulshakour Mohammadnia, Alexis Allot, Adam M R Groh, Nurun Fancy, Marianna Papageorgopoulou, Xiaowen Zhang, Aisling McGarry, Paul M Matthews, Kevin Petrecca, Johanna S Jackson, Jo Anne Stratton
Characterising processing conditions that artifactually bias human brain tissue transcriptomes
Nature neuroscience
Published

Author Correction: Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

Authors
Sebastiaan De Schepper, Judy Z Ge, Annerieke Sierksma, Gerard Crowley, Laís S S Ferreira, Dylan Garceau, Christina E Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong
Author Correction: Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population

Authors
Han Cao, Ziyu Zheng, Xiaopu Zhou, Masataka Kikuchi, Hiu Yi Wong, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Maryam Shoai, Joyce R Chong, Andrew L T Chan, Christopher Chen, Linda C W Lam, Vincent C T Mok, Timothy C Y Kwok, Japanese Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Neuroimaging Initiative, Yu Chen, Fanny C F Ip, Kin Y Mok, Akinori Miyashita, Takeshi Ikeuchi, John Hardy, Amy K Y Fu, Nancy Y Ip
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population
Frontiers in aging neuroscience
Published

The temporal and stimuli-specific effects of LPS and IFNγ on microglial activation

Authors
Christina N Heiss, Andrew S Naylor, Ida Pesämaa, Arketa Meshi, Benjamin Céspedes-Cortés, Chiméne Lounès, Ayat Taki, Katarina Türner Stenström, Dzeneta Vizlin-Hodzic, Henrik Zetterberg, Verónica Palma, Gunnar Brinkmalm, Ann Brinkmalm, Stefanie Fruhwürth
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activation
Alzheimer's research & therapy
Published

Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort

Authors
Paulina Orellana, Fernando Henríquez, Felipe Cabral-Miranda, Hernán Hernandez, Pamela C L Ferreira, Bruna Bellaver, Ariel Caviedes, Matias Pizarro, Carolina Gonzalez-Silva, Nickole Marin-Diaz, Patricio Riquelme, Natalia Pozo, Francisca Damm, Felipe A Court, Christian Gonzalez-Billault, Patricia Lillo, Daniela Thumala-Dockendorff, Mauricio Cerda, Roque Villagra, Rolando de la Cruz, Thomas K Karikari, Agustín Ibañez, Henrik Zetterberg, Tharick A Pascoal, Claudia Duran-Aniotz, Andrea Slachevsky
Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort