The UK DRI at King’s College London, will map out the earliest changes in the brain associated with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) in cellular and animal models and in people to gain a much deeper understanding of the causes of these conditions. Led by Professor Chris Shaw, the team will focus on the misfolding and aggregation of the protein TDP-43. They aim to uncover fundamental mechanism common to several protein misfolding disorders that can inform the development of therapies for multiple forms of dementia.
They will examine the causes and consequences of TDP-43 accumulation at the molecular level, specifically looking at its RNA binding activity, the transport of proteins in and out of the cell nucleus through the nuclear pore and the clearing away of aggregated proteins.
UK DRI at King’s College London will be located in the newly built Maurice Wohl Clinical Neuroscience Institute on the Denmark Hill Campus which houses the Nikon Centre of Excellence for Neuroscience Imaging.
Foundation programmes at this centre:
- Professorship: Proteostatic mechanisms in FTD and ALS
- Lead: Professor Chris Shaw
- Professorship: Understanding the role of RNA in the molecular mechanisms of FTD/ALS
- Lead: Professor Annalisa Pastore
- Fellowship: Single molecule nucleocytoplasmic transport dynamics in FTD/ALS
- Lead: Dr Sarah Mizielinska