The UK DRI at The University of Cambridge will focus on the mechanistic processes involved in the earliest stages of neurodegenerative disease to identify therapeutic targets with the greatest potential to prevent dementia. These processes include the spreading of misfolded tau protein, the cold shock protein response in the repair of synapses and autophagy as a protective cellular response, all of which are relevant to several different types of dementia.
Led by Professor Giovanna Mallucci, the team will use cellular and molecular approaches to better characterise these important processes with a strong emphasis on identifying molecular targets that can be rapidly translated into new dementia treatments for those in the early stages.
UK DRI at The University of Cambridge, embraces biological and physical sciences in the newly refurbished Island Research Building on the Cambridge Biomedical Campus.
Programmes at this centre:
- Professorship: Driving synaptic repair in early neurodegeneration
- Professorship: Identification of novel pathways that induce autophagy to enable neuroprotection
- Professorship: Understanding the molecular basis of tau aggregation and spreading
- Fellowship: CRISPR-Cas9 genetic screens for novel synaptic maintenance genes and therapeutic targets
- Lead: Dr Emmanouil Metzakopian
- Fellowship: Role of ER dynamics and morphological regulation in neuronal health and disease
- Lead: Dr Edward Avezov
- Fellowship: Understanding the role of DNA damage response in neurodegeneration
- Lead: Dr Gabriel Balmus