The UK DRI at The University of Cambridge will focus on the mechanistic processes involved in the earliest stages of neurodegenerative disease to identify therapeutic targets with the greatest potential to prevent dementia. These processes include the spreading of misfolded tau protein, the cold shock protein response in the repair of synapses and autophagy as a protective cellular response, all of which are relevant to several different types of dementia.
Led by Professor Giovanna Mallucci, the team will use cellular and molecular approaches to better characterise these important processes with a strong emphasis on identifying molecular targets that can be rapidly translated into new dementia treatments for those in the early stages.
UK DRI at The University of Cambridge, embraces biological and physical sciences in the newly refurbished Island Research Building on the Cambridge Biomedical Campus.
Foundation programmes at this centre:
- Professorship: Driving synaptic repair in early neurodegeneration
- Lead: Professor Giovanna Mallucci
- Professorship: Identification of novel pathways that induce autophagy to enable neuroprotection
- Lead: Professor David C Rubinsztein
- Professorship: Understanding the molecular basis of tau aggregation and spreading
- Lead: Professor David Klenerman