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New clue in understanding increased Alzheimer’s risk

Research from the University of Sheffield’s Institute of Translational Neuroscience (SITraN), together with scientists from the UK DRI at Cambridge, reveals how a protein known as apolipoprotein E (APOE) interacts with amyloid-beta, and how this interaction affects the likelihood of developing Alzheimer's disease.

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UK DRI and sector leaders launch Dementia Manifesto calling on next UK government to take action on dementia

The UK DRI has joined forces with other leading organisations across the sector to launch the Dementia Manifesto, urging the next UK government to take action on dementia. In the manifesto, the UK DRI together with Dementia UK, Alzheimer’s Research UK, Alzheimer’s Society and Alzheimer Scotland, have set out five key areas for change.

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UK DRI appoints Chief Innovation and Business Officer

We are delighted to announce that Róisín NicAmhlaoibh will join the UK DRI as Chief Innovation and Business Officer, commencing September 2024.

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Insight into cause of rare childhood brain disease reveals treatment targets

A study co-led by Professor David Hunt (UK DRI at Edinburgh) and Associate Professor Markus Hofer (The University of Sydney) reveals fresh insight into the mechanisms underlying a rare disease that can cause childhood dementia.

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Why digital matters for neurodegeneration treatments

Neurodegenerative disorders are a global challenge - and in the UK are the leading cause of death, with the cost of dementia in the UK in 2024 estimated to be £42 billion. It’s no surprise that digital solutions within the field of neurodegeneration are currently exploding as a consequence. The BioBeat24 half-day event, co-organised by the UK DRI, was all about exploring emerging opportunities both from research and clinical perspectives as well as understanding the fundraising environment for entrepreneurs.

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How immune cells in the brain respond to stroke

A new study led by Dr Barry McColl and Dr Jack Barrington (UK DRI at Edinburgh) reveals insight into cellular changes in the brain that occur after a stroke. The research, published in the journal Cell Reports, could open up new therapeutic avenues for the condition.

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Brain cell communication linked to Alzheimer's disease

Researchers led by Dr Lorena Arancibia Cárcamo ​and Dr Anna Mallach ​at the UK DRI at UCL, the Francis Crick Institute and the VIB-KU Leuven Center for Brain & Disease Research have revealed how communication between support cells in the brain disrupts signals between neurons in mice modelling Alzheimer’s disease.

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Accelerating Parkinson’s research: Insights from ECRs at the UK DRI x ASAP meeting

Researchers across the UK DRI are tackling Parkinson's from multiple angles, aiming to develop new diagnostic tools and treatments. We recently co-organised an event with Aligning Science Across Parkinson’s (ASAP), bringing together nearly 100 early career researchers (ECRs) from the UK DRI and ASAP, to discuss their work, share ideas and form new collaborations.

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UK DRI researcher elected to prestigious Academy of Medical Sciences fellowship

We are thrilled to announce that Prof Tara Spires-Jones (UK DRI at Edinburgh) is one of 58 exceptional scientists today elected to the Academy of Medical Sciences Fellowship.

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UK DRI appoints Chief Scientific Officer

We are delighted to announce that Jo Latimer will join the UK DRI as Chief Scientific Officer, commencing mid-August 2024.

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Three UK DRI researchers elected to prestigious Royal Society Fellowship

We are delighted to announce that Prof Sarah Tabrizi (UK DRI at UCL), Prof Bill Wisden and Prof Paul Elliott (both UK DRI at Imperial) have been elected as Fellows of the Royal Society for their outstanding research.

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Scientists find sleep may not clear brain toxins as previously thought

The brain’s ability to rid itself of toxins may be reduced during sleep, surprising new UK DRI research reveals. The study, led by Prof Bill Wisden (UK DRI at Imperial) and Prof Nick Franks (Imperial College London), is published in the journal Nature Neuroscience.

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Reduced clearance of damaged microglia contributes to Alzheimer’s progression

A study led by Prof Paul Matthews and Dr Nurun Fancy (both UK DRI at Imperial) provides important new insights into the mechanisms by which a process known as age-related cell senescence contributes to the progression of Alzheimer’s disease.

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New UK DRI scheme launched to fund bold and boundary pushing research

We are delighted to announce the first recipients of the new ‘Key Questions’ intramural funding programme, leveraging the unique strengths and capabilities of our Institute to catalyse bold and ambitious research projects, which adopt multidisciplinary and innovative approaches.

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Dr Kiran K G Ravindran, UK DRI Care Research & Technology: My Week in Westminster at the Royal Society Pairing Scheme 2024

Dr Kiran K G Ravindran is a Postdoctoral Research Fellow working with Prof Derk-Jan Dijk at the UK DRI Centre for Care Research & Technology and the Surrey Sleep Research Centre at the University of Surrey. Dr Ravindran was one of 30 scientists who participated in this year’s Royal Society Pairing Scheme, an initiative facilitating collaboration between scientists and policymakers. Here, he shares his experience with the scheme and its impact on his perspective.

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Dr Georgina Starling, UK DRI at UCL: My Week in Westminster at the Royal Society Pairing Scheme 2024

Dr Georgina (George) Starling is a Postdoctoral Research Fellow joint between Prof Adrian Isaacs lab (UK DRI at UCL) and Dr Jeremy Carlton's lab at King's College London and the Francis Crick Institute. Here she tells us about her experience on the Royal Society pairing scheme which saw her travel to Westminster to experience first-hand how science and policy intersect and are used in government.

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A critical time for AI, dementia and better brain health

Ahead of BioBeat24, Iraida Soria-Espinosa, Senior Innovation & Business Manager at UK DRI, and Miranda Weston-Smith, Founder of BioBeat, caught up with keynote speaker Zoe Kourtzi, Professor of Computational Cognitive Neuroscience at the University of Cambridge.

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Introducing Philip Hasel, UK DRI at Edinburgh: Unlocking the role of astrocytes in brain health and disease

During his postdoc Dr Philip Hasel (UK DRI at Edinburgh) discovered a distinct type of astrocyte that is only found in a single cell layer on the surface of the brain. In this Q&A, Dr Hasel explains what is so significant about these cells in disease, and why he has made them his research focus as he starts his lab at the UK DRI.

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How temperature and circadian rhythms intersect to regulate a protein shown to protect against neurodegeneration

A new study led by Dr Marco Brancaccio (UK DRI at Imperial) and Dr Marieke Hoekstra (former UK DRI at Imperial, now VIB-KU Leuven Center for Brain & Disease Research) offers a deeper insight into how a neuroprotective pathway is regulated both by temperature and the body clock.

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World Parkinson’s Day: What do we know about Parkinson’s?

Parkinson’s is a progressive neurological condition, affecting over 150,000 people in the UK. It is considered to be the fastest growing neurological condition in the world, with the number of people affected expected to double by 2050. In this blog for World Parkinson's Day, we take stock of what we know about the condition, and what UK DRI scientists are doing to help advance research in this area.

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