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Making it Brain 2022: inspiring the next generation of dementia researchers

Over two afternoons during World Alzheimer’s Month in September, the UK DRI hosted the second annual Making it Brain, a virtual mini conference for secondary school students interested in neuroscience careers and research.

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In2Research: A student perspective

Aicha Ben Taher is an undergraduate student at Brunel University who undertook a summer placement at the UK DRI at UCL as part of the In2Research scheme. Here, she shares her experience for anyone else thinking about applying for an In2Research placement.

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Connectome 2022: In pictures

Returning in person for the first time since 2019, our annual conference Connectome took place in Brighton earlier this month. More than 600 UK DRI researchers from our seven centres across the UK gathered together for an event packed full of exciting science, with opportunities to make connections and spark new ideas.

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LGBTQ+ STEM Day: the importance of visibility

Today is LGBTQ+ STEM Day, an opportunity to celebrate and highlight the work of LGBTQ+ people in science and recognise the barriers that they face. We spoke to Dr Alexi Nott (UK DRI at Imperial) about his hopes and goals for the LGBTQ+ Allies Network which he recently set up within his department at Imperial.

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Prof Bart De Strooper is to step down as Director of the UK DRI

After six years as Director of the UK DRI, Prof Bart De Strooper is stepping down to focus on his research.

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Nine UK DRI researchers feature on Highly Cited Researcher 2022 list

We are proud to announce that nine UK DRI researchers have featured in this year’s Highly Cited Researcher 2022 list from Clarivate. The annual ranking identifies researchers who have demonstrated significant influence in their chosen field or fields through the publication of multiple highly cited papers during the last decade.

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Disappointment as phase 3 trials for Alzheimer's drug ganteneurumab show no clinical benefit

In a press release today, pharmaceutical company Roche announced results from its phase 3 trials of immunotherapy drug ganteneurumab. The results show that the drug failed to slow cognitive decline in people with early-stage Alzheimer's disease.

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Three UK DRI researchers awarded major Chan Zuckerberg Initiative funding for collaborative projects

Dr Soyon Hong, Dr Tim Bartels, and Prof Adrian Isaacs, all from UK DRI at UCL, have each been awarded further funding from the Chan Zuckerberg Initiative (CZI), for phase 2 of the organisation’s Collaborative Pairs Programme.

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UK DRI joins call to place medical and health research at the heart of economic plans

Ahead of the government’s Autumn Statement, the UK DRI has joined a call led by the Academy of Medical Sciences, for the Chancellor to place medical and health research at the heart of plans for growth.

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First recipients of UK DRI Recognition Prizes announced at Connectome 2022

For the 5th anniversary of the UK DRI, we introduced a series of special prizes to recognise the efforts and achievements of staff across the Institute over the past year. The Directors awarded certificates and personal awards during the conclusion to Connectome 2022, highlighting those individuals excelling in the categories of computational reproducibility, 3R’s, publications, posters and engagement.

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Macroglia: introducing the UK DRI’s newest research theme

When thinking about the cells that are involved in neurodegenerative diseases, it is easy to zero in on neurons – the fundamental units of the brain that receive and transmit sensory information. But there is strong evidence to indicate that other cells are also involved in the development and progression of dementia. Among them are macroglia cells; the focus of the UK DRI’s newest research theme.

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Scientists reveal new insight into how Alzheimer’s risk gene may cause disease

Researchers have uncovered a new biological pathway that could be linked to Alzheimer’s disease, in a study led by Prof Paul Elliott (UK DRI at Imperial). The findings, published in the journal Proceedings of the National Academy of Sciences (PNAS), provide new insight into the underlying mechanisms of the disease, and could offer targets for future drug discovery.

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Discussing diversity in dementia research

How health inequalities are impacting people with dementia, and how research can help to address this was the subject of a lively webinar hosted by the UK DRI on Thursday 20 October.

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‘Cell-penetrating’ proteins implicated in Parkinson’s and dementia with Lewy bodies

Small, aggregated proteins capable of entering cells have been shown to cause distinctive toxic effects in Parkinson’s disease and dementia with Lewy bodies, according to a new study led by Dr Yu Ye (UK DRI at Imperial). The findings, published in the journal Proceedings of the National Academy of Sciences (PNAS), offer useful insight into the underlying mechanisms of these diseases, and highlight potential future targets for disease detection and therapeutic intervention.

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UK DRI Director elected to the U.S. National Academy of Medicine

Prof Bart De Strooper, UK DRI Director, has today been elected to the U.S. National Academy of Medicine (NAM), for his work in understanding the mechanisms of Alzheimer’s disease, ‘in an unrelenting search for therapeutic targets that can help patients’.

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Major donation to accelerate Alzheimer's disease research at the UK DRI at Imperial

We are delighted to announce a generous £7.5 million gift from the Michael Uren Foundation that will drive forward four experimental research projects at the UK DRI, aiming to improve diagnosis of Alzheimer’s disease and develop effective new avenues for treatment.

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Translation award: catching up with past recipients of the UK DRI’s innovation scheme

Launched in March 2021, the UK DRI Translation Award programme was established to kick start the early development of projects with high translational potential, bringing us closer to new technologies and treatments for dementia. We caught up with a selection of the successful past recipients to discover the impact these awards have had on their research.

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Milestone in search for Alzheimer’s treatment as lecanemab slows cognitive decline in phase 3 trial

Today the pharmaceutical company Eisai, in collaboration with Biogen, has announced positive results from its phase 3 trial of lecanemab for the treatment of Alzheimer’s disease. Eisai reports, using a numeric scale to quantify severity of symptoms, that the drug slowed rate of cognitive decline by 27% compared with a placebo.

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Prof Nick Fox awarded Grand Prix Européen 2022

We are delighted to announce that Prof Nick Fox (UK DRI at UCL) has been awarded the European Grand Prix 2022 by the French Alzheimer Research Foundation.

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How will dementia diagnosis and treatment change in the next 10 years?

Every year, the number of people with dementia increases, with estimates suggesting more than 1 million people in the UK will be living with the condition by 2030. As this figure increases, there is an even greater need for breakthroughs in developing treatments and improving lives. So how close are we to new therapeutics? And what innovations will help us get there? This World Alzheimer's Day, we asked UK DRI researchers for their predictions on what we can expect over the next decade, and where they see the most promising advances.

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Latest tweets from @UKDRI

RT @UCLBrainScience: The Dementia Research Charity #Chatathon is a 12+ hour non-stop livestream discussion, hosted by Adam Smith @BetterRes
25 Nov 2022 14:33

In #WorldAlzheimersMonth we hosted the 2nd annual 'Making it Brain', a virtual free STEM conference for students ag… https://t.co/6gLWpMyG6U
25 Nov 2022 09:00