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New funding awarded to explore the role of protein interactions in neurodegeneration

We are pleased to announce the recipients of the second round of the UK DRI Collaborative Proteomics Studies Award Programme. This programme is designed to encourage UK DRI researchers to incorporate mass-spectrometry-based proteomics into their work and help them to establish new collaborations.

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Gene expression dampened in synapses to protect against cognitive decline

A new study, led by Prof Tara Spires-Jones and Dr Declan King (UK DRI at Edinburgh), has identified molecular changes in the brain associated with maintaining healthy cognitive abilities in old age. The study, published in the journal Alzheimer’s & Dementia, could provide a new therapeutic approach to improving cognition in people with Alzheimer’s disease.

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Genetics, microglia and complement: fourth round of cross-centre postdocs announced

We are delighted to announce the latest recipients of our cross-centre postdoctoral awards – a scheme designed to stimulate exciting new academic relationships and encourage collaboration between researchers across our seven centres. The five projects awarded in this round will investigate the genetics of different neurodegenerative diseases, the role of microglia in Alzheimer’s, and more.

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UK DRI roundtable: A clinical and scientific perspective on lecanemab

In September, it was announced that anti-amyloid treatment lecanemab had been successful in slowing cognitive decline in people with mild cognitive impairment and early Alzheimer’s. The first of its kind to show clinical benefit, and potentially disease modifying capabilities, the development has been labelled a breakthrough, and even hailed as the ‘beginning of the end’ for life-changing therapies for the condition. Following release of Phase III results, UK DRI hosted a roundtable to dig into the data and what it means for the future of Alzheimer’s treatments and clinical translation.

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2022 in Review: new faces, new discoveries, new hope

As the year draws to a close, we’ve taken a look back at some of the most significant moments for the UK DRI in 2022. From scientific discoveries to new partnerships, it has been another exciting year for the Institute.

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Researchers discover protective role for immune cells in brain health and cognition

Researchers have uncovered a new role for resident brain immune cells in supporting the health of neurons. The study, led by Prof Veronique Miron (UK DRI at Edinburgh), and published in the journal Nature, could pave the way for new treatment opportunities in neurodegeneration.

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Making it Brain founder awarded BNA Public Engagement Prize 2022

We are delighted to announce that Sophie Sanford (UK DRI at Cambridge) has today been awarded the British Neuroscience Association (BNA) Award for Public Engagement of Neuroscience 2022, for her work pioneering Making it Brain: a free, online careers event for students. The award aims to recognise those that make an outstanding contribution to engaging the public in Neuroscience.

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UK DRI comment on new government investment for MND research

The MND community deserves nothing less than a laser focus on research to drive progress towards greater understanding of this devastating disease. Funding for targeted MND research will boost our efforts to beat it, and this investment by the government is a positive step on that journey.

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Researchers develop new diagnostic tool for Huntington’s disease

Researchers have developed an algorithm that could be used to improve diagnosis of Huntington’s and other neurodegenerative diseases. The study, led by Prof Vincent Dion (UK DRI at Cardiff) is published in the journal NAR Genomics and Bioinformatics.

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“I'm not going to give up”: in conversation with 2022 MRC Millennium Medal winner Prof Sarah Tabrizi

For over 25 years, clinical neuroscientist, and UK DRI Group Leader at UCL, Prof Sarah Tabrizi has been at the leading edge of the search for Huntington’s disease treatments. Her breakthroughs have, and continue to, push the field forward at pace and bring real hope to those affected by this heart-breaking neurodegenerative disorder. For her outstanding efforts and achievements, Prof Tabrizi is recognised with this year’s prestigious MRC Millennium Medal. We caught up with Sarah to reflect on her career to date, passion for scientific investigation and tireless drive to deliver a cure for her patients at the National Hospital for Neurology and Neurosurgery (NHNN), part of UCLH.

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MRC announces Millennium Medal winners and Impact Prize finalists

UK DRI neuroscientist and neurologist, Prof Sarah Tabrizi, has today been named one of two winners of the prestigious MRC Millennium Medal for her work on Huntington’s disease.

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UK DRI joins the Campaign for Science and Engineering, CaSE

We’re pleased to announce that the UK DRI has joined CaSE, the Campaign for Science and Engineering.

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Landmark results from trial of new Alzheimer’s drug lecanemab presented at major conference

Results from Eisai and Biogen’s phase 3 trial of new Alzheimer’s drug lecanemab were presented at the Clinical Trials on Alzheimer's Disease conference (CTAD) in San Francisco yesterday and published simultaneously in the New England Journal of Medicine.

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Minister visits UK DRI ahead of reconfirming government’s commitment to the Dementia Mission

We were delighted to welcome Nus Ghani MP, Minister for Industry and Investment Security, to the UK DRI last week, to showcase a range of our research to tackle dementia.

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Making it Brain 2022: inspiring the next generation of dementia researchers

Over two afternoons during World Alzheimer’s Month in September, the UK DRI hosted the second annual Making it Brain, a virtual mini conference for secondary school students interested in neuroscience careers and research.

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In2Research: A student perspective

Aicha Ben Taher is an undergraduate student at Brunel University who undertook a summer placement at the UK DRI at UCL as part of the In2Research scheme. Here, she shares her experience for anyone else thinking about applying for an In2Research placement.

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Connectome 2022: In pictures

Returning in person for the first time since 2019, our annual conference Connectome took place in Brighton earlier this month. More than 600 UK DRI researchers from our seven centres across the UK gathered together for an event packed full of exciting science, with opportunities to make connections and spark new ideas.

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LGBTQ+ STEM Day: the importance of visibility

Today is LGBTQ+ STEM Day, an opportunity to celebrate and highlight the work of LGBTQ+ people in science and recognise the barriers that they face. We spoke to Dr Alexi Nott (UK DRI at Imperial) about his hopes and goals for the LGBTQ+ Allies Network which he recently set up within his department at Imperial.

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Prof Bart De Strooper is to step down as Director of the UK DRI

After six years as Director of the UK DRI, Prof Bart De Strooper is stepping down to focus on his research.

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Nine UK DRI researchers feature on Highly Cited Researcher 2022 list

We are proud to announce that nine UK DRI researchers have featured in this year’s Highly Cited Researcher 2022 list from Clarivate. The annual ranking identifies researchers who have demonstrated significant influence in their chosen field or fields through the publication of multiple highly cited papers during the last decade.

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Latest tweets from @UKDRI

RT @suvankarpal: Congratulations to the formidable @drarpan100 for winning the ECR platform presentation prize at the #CUREND clinical work…
03 Feb 2023 17:11

RT @DrArpan100: Absolutely super, comprehensive talk by @DrNatalieRyan @drcionucl @UKDRI on her research into familial Alzheimer's dementia…
03 Feb 2023 12:09