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Milestone in search for Alzheimer’s treatment as lecanemab slows cognitive decline in phase 3 trial

Today the pharmaceutical company Eisai, in collaboration with Biogen, has announced positive results from its phase 3 trial of lecanemab for the treatment of Alzheimer’s disease. Eisai reports, using a numeric scale to quantify severity of symptoms, that the drug slowed rate of cognitive decline by 27% compared with a placebo.

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Prof Nick Fox awarded Grand Prix Européen 2022

We are delighted to announce that Prof Nick Fox (UK DRI at UCL) has been awarded the European Grand Prix 2022 by the French Alzheimer Research Foundation.

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How will dementia diagnosis and treatment change in the next 10 years?

Every year, the number of people with dementia increases, with estimates suggesting more than 1 million people in the UK will be living with the condition by 2030. As this figure increases, there is an even greater need for breakthroughs in developing treatments and improving lives. So how close are we to new therapeutics? And what innovations will help us get there? This World Alzheimer's Day, we asked UK DRI researchers for their predictions on what we can expect over the next decade, and where they see the most promising advances.

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Research reveals new insights into disease mechanisms underlying ALS

A new study led by Prof. Giampietro Schiavo (UK DRI at UCL) has uncovered why certain types of motor neurons are differentially affected in amyotrophic lateral sclerosis (ALS). The findings, published in the journal Acta Neuropathologica Communications, could open up new avenues for drug discovery and treatments for this disease.

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UK DRI report urges action to reduce health inequalities in dementia

Today, the UK DRI published a new report, detailing the impact of scientific research on health inequalities for people affected by dementia. As the report launches at the start of World Alzheimer’s Month, the UK DRI is urging the Government to prioritise funding for scientific innovation, to facilitate larger dementia trials, remove barriers that stop people taking part in research and close the gap on health inequalities.

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CURE-ND: European partners unite in scientific and political spheres

The first half of the 2022 saw the European alliance for neurodegenerative research, CURE-ND, come together for a London meeting of early career researchers (ECRs), a networking and showcase event at Europe’s biggest neuroscience conference and a collective request for urgent clarity and action surrounding the UK’s association with Horizon Europe.

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New study reveals genetic link between heart health and vascular dementia

A new study led by Prof Paul Matthews (UK DRI at Imperial) has identified a genetic link between damage to the main blood vessels of the heart, and brain small vessel disease, a common cause of vascular dementia.

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Researchers identify way to enhance breakdown of misfolded proteins in neurodegenerative disease

A new study led by Prof David Rubinsztein (UK DRI at Cambridge) has identified a way to enhance the cell’s ability to clear away misfolded proteins, such as those implicated in neurodegenerative diseases like Alzheimer’s.

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OVID Health: the UK has a genuinely rich dementia research ecosystem

In a new blog post this week, Roudie Shafie, a partner at OVID Health, argues that while beating dementia is a “Herculean task”, the UK has all the necessary components in its research ecosystem to achieve real results.

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Comment: Government policy paper on Horizon Europe alternative

Amid ongoing negotiations about the UK’s association to Horizon Europe, the UK Government's Department for Business, Energy & Industrial Strategy (BEIS)​ has published a policy paper outlining how the UK will transition to a new R&D programme. UK DRI Director Prof Bart De Strooper comments on the release.

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The quality of your night’s sleep can affect dementia symptoms the next day

Prof Derk-Jan Dijk (UK DRI Care Research & Technology) published an article in The Conversation discussing his latest study into sleep and dementia - read it here.

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Researchers develop new model for studying key protein implicated in neurodegenerative disease

Researchers led by Prof Karen Duff (UK DRI Centre Director at UCL) and Prof Andrew Yoo (Washington University School of Medicine) have created a new model system for studying the pathology of tau, a protein implicated in Alzheimer’s disease (AD), frontotemporal lobe dementias (FTD) and other neurodegenerative conditions, as reported in a new study published in Cell Stem Cell.

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Study into Down syndrome reveals genes that may protect against Alzheimer’s

A new study led by Dr Frances Wiseman (UK DRI at UCL) has identified a subset of genes that may protect against the accumulation of amyloid beta, a protein implicated in Alzheimer’s disease, in people who have Down syndrome. The study is published in The Journal of Neuroscience.

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Leading European neuroscientists call on Commission to end Horizon Europe uncertainty

The directors of four of Europe’s leading neuroscience research institutes – which together form the CURE-ND alliance (Catalysing a United Response in Europe to Neurodegeneration) – have today called upon the President of the European Commission, Ursula von der Leyen, to confirm the UK’s full association to Horizon Europe without delay.

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Brain injury and modelling microglia: third round of cross-centre postdocs announced

We are pleased to announce the latest recipients of our cross-centre postdoctoral awards – a scheme designed to stimulate exciting new academic relationships, and encourage collaboration between researchers across our seven centres.

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Cardiff researchers host public showcase for World Parkinson’s Day 2022

This World Parkinson’s Day (11 April), researchers from the UK DRI Centre at Cardiff welcomed people affected by the condition to hear about the latest cutting-edge research in the field, and discuss future therapeutic prospects for the disease. A portion of the event was broadcast virtually and can now be accessed online.

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UK DRI researcher designs "chemical antibody" to provide insight into neurodegenerative disease

Researchers led by Prof David Klenerman (UK DRI at Cambridge) have designed a new ‘chemical antibody’ that will help them understand the origins of neurological disorders such as Parkinson’s and Alzheimer’s disease.

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Boosting REM sleep could relieve emotional distress in people living with dementia

A new mouse study led by Prof Bill Wisden (UK DRI at Imperial) has found that stress can boost sleep and subsequently relieve anxiety. With emotional distress being a common symptom for those living with dementia, the findings could lead to new treatments targeting the underlying mechanism identified.

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A tribute to Baroness Sally Greengross

Baroness Sally Greengross sadly passed away on 23 June this year – a loss that will be felt by the whole dementia research community.

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Dementia Demystified: breaking barriers to public understanding of dementia

Members of the public gathered at the Francis Crick Institute to learn about cutting edge dementia research from scientists at ‘Dementia Demystified’, an open event run in collaboration with UK DRI to enhance public understanding of the condition.

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What role will AI have in the future of healthcare? Prof Caleb Webber, UK DRI Director of Informatics, believes we… https://t.co/osuj336b1Y
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RT @Cara_Croft: If you are at @autophagyuk annual conference then be sure to stop by @DaviVontobel's poster showcasing some of the work he'…
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