UK DRI at Imperial College London has innovation as its theme. This draws on the university’s unique strengths and focus on science, engineering, medicine and business. Led by Professor Paul Matthews, the research team will bring novel, cutting edge approaches and research tools to the study of dementia to discover new disease mechanisms and therapeutic targets. They will initially focus on the earliest pre-symptomatic stages of Alzheimer’s disease, addressing what determines the transition to neurodegeneration, but will investigate mechanisms that are likely shared across many of the dementias.
With access to large, well characterized longitudinal cohorts the team will explore causes of individual variation in dementia within populations, looking at changes that occur across the lifespan and specifically addressing metabolic factors, the relationship with microorganisms in gut (the microbiome) and the role of sleep. The team will use a range of resources including Dementias Platform UK and the MRC-NIHR National Phenome Centre.
UK DRI at Imperial College London will be located at the White City campus Hammersmith, London, in the Sir Michael Uren Biomedical Engineering Research Hub due to be completed in 2019, alongside Imperial’s translation and innovation ‘I-HUB’.
Programmes at this centre:
- Professorship: Linking genetic, epidemiology and metabolic phenotyping in dementia in the context of aging, environment and lifestyle
- Lead: Professor Paul Elliott
- Professorship: The microbiome and its influence on cognition, brain health and neurodegeneration
- Lead: Professor Elaine Holmes
- Professorship: Exploring glial-neuronal interactions at the transition from brain vulnerability to pathology
- Professorship: The role of sleep in protecting against amyloid and glial pathology in dementia.
- Lead: Professor William Wisden
- Fellowship: Developing novel bioelectronics technologies to modulate neurons and glia in the study of sleep, neuroprotection and cognition
- Lead: Dr Nir Grossman
- Fellowship: Exploring the role of neural circuit plasticity in the susceptibility of the aged brain to neurodegeneration
- Lead: Dr Samuel Barnes
- Fellowship: Exploring the role of circadian dysfunction in the early stages of dementia
- Lead: Dr Marco Brancaccio