Current Vacancies
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Key details
- Location UK DRI at UCL
- Salary: £43,374 £51,860
- Lab: Dr Lorena Arancibia
About the role
We are looking for a motivated postdoctoral researcher to join our team investigating how Alzheimer’s disease (AD) risk genes influence microglial function in disease. The project focuses on the antigen-presenting role of microglia in amyloid pathology and the immunological impact of MHC-II–mediated responses in the brain.
You will use a wide range of techniques, including our unique human microglia xenograft model (PMID: 31659342, 38539015), and work closely with both computational and experimental teams at the Francis Crick Institute and VIB, Leuven.
This is a unique opportunity to contribute to high-impact research in a world-class, collaborative environment.
About you
You’ll have a PhD in Immunology, Neuroscience, or a related field, with experience with macrophage and/or microglia biology and knowledge of molecular biology, cell biology, immunology, or related disciplines, as well as proficiency in cell culture and cell biology techniques, with a strong understanding of immunology and/or antigen presentation.
Experience with animal experiments, particularly in handling and working with mice is also essential for this role.
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Key details
- Location: UK DRI at Edinburgh, Edinburgh
- Salary: £40,497 - £48,149 per annum
- Lab: Dr Rikesh Rajan
We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.
The Opportunity:
The Rajani Lab investigates the mechanisms of white matter damage in vascular and other dementias. We use a range of innovative methodologies and models to understand oligodendrocyte changes in vascular disease, and the interaction of these with neuronal activity. In this project the Research Fellow will use advanced techniques to investigate and manipulate neuronal activity in rodent models of vascular dementia, with the aim of understanding how this affects white matter.
Your skills and attributes for success:
- A PhD (or close to completion) in neuroscience or other relevant discipline.
- Extensive experience with in vivo two-photon calcium imaging.
- Ability to work independently.
- Proactive and creative independent thinker.
- Ability to problem-solve and troubleshoot technical difficulties.