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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Diagnostics (Basel, Switzerland)
Published

Analytical Performance and Evaluation in Clinical Cohorts of a Fully Automated Immunoassay for Plasma Glial Fibrillary Acidic Protein

Authors
Ben Schlichtmann, Burak Arslan, Kara Johnson, Jason Patzlaff, Dusten Unruh, Miklos Szabo, Mark Holland, Jeff Todtleben, Mike Salvati, Kubra Tan, Ulf Andreasson, Jeremiah Hinson, Scott Levin, Henrik Zetterberg, Andrea Lessa Benedet, Holly Ann Hill
Analytical Performance and Evaluation in Clinical Cohorts of a Fully Automated Immunoassay for Plasma Glial Fibrillary Acidic Protein
Stroke
Published

Quantitative Relationship Between White Matter Hyperintensity Volume and Fazekas Score on Brain MRI

Authors
Yu-Yuan Xu, Francesca M Chappell, Maria Valdes Hernandez, Carmen Arteaga Reyes, Una Clancy, Daniela Jaime Garcia, Stephen Makin, Michael Stringer, Michael Thrippleton, Stewart Wiseman, Yajun Cheng, Dillys Xiaodi Liu, Rosalind Brown, Fergus Doubal, Ian J Deary, Simon Cox, Danielle Kerkhofs, Julie Staals, Walter Backes, Robert van Oostenbrugge, Anna Kopczak, Marco Duering, Joanna Wardlaw
Quantitative Relationship Between White Matter Hyperintensity Volume and Fazekas Score on Brain MRI
International journal of stroke : official journal of the International Stroke Society
Published

The Vascular Contribution to Dementia. World Stroke Organisation Scientific Statement

Authors
Geert Jan Biessels, Stephanie Debette, Fanny M Elahi, Fatemeh Geranmayeh, Gurpreet Hansra, Timothy M Hughes, Masafumi Ihara, Jeremy Isaacs, Hanna Jokinen, Alexi Nott, Sarah Pendlebury, Ruth Peters, Julie Schneider, Colin Smith, Eric Edward Smith, Prashanthi Vemuri, Joanna Wardlaw, Alastair Webb, Donna M Wilcock, Atticus H Hainsworth
The Vascular Contribution to Dementia. World Stroke Organisation Scientific Statement
Nature aging
Published

Spatiotemporal dynamics of tau extent and load increase in Alzheimer's disease across four longitudinal cohorts

Authors
Arthur C Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Étienne Aumont, Gleb Bezgin, Seyyed Ali Hosseini, Cécile Tissot, Tevy Chan, Stijn Servaes, Brandon Hall, Yi-Ting Wang, Kely Quispialaya-Socualaya, Marcel S Woo, Jaime Fernandez-Arias, Jenna Stevenson, Yansheng Zheng, Marina Pereira Gonçalves, Firoza Z Lussier, João Pedro Ferrari-Souza, Pamela C L Ferreira, Bruna Bellaver, Guilherme Povala, Livia Silva do Amaral, Gassan Massarweh, Jean-Paul Soucy, Karin L Meeker, Meredith N Braskie, Tobey J Betthauser, Bradley T Christian, Ramiro Eduardo Rea Reyes, Jessica K Caldwell, Nicholas J Ashton, Thomas K Karikari, Henrik Zetterberg, Kaj Blennow, Eduardo R Zimmer, Andréa L Benedet, Sterling C Johnson, Tharick A Pascoal, Pedro Rosa-Neto, Alzheimer’s Disease Neuroimaging Initiative
Spatiotemporal dynamics of tau extent and load increase in Alzheimer's disease across four longitudinal cohorts
Epilepsia
Published

New onset refractory status epilepticus (NORSE) versus refractory status epilepticus not meeting NORSE criteria: A comparative clinical and electroencephalography-based study

Authors
Seren Hawksworth, Nina Moutonnet, Gregory Scott, Sanjeev Rajakulendran, Mahinda Yogarajah, Matthew C Walker, Umesh Vivekananda
New onset refractory status epilepticus (NORSE) versus refractory status epilepticus not meeting NORSE criteria: A comparative clinical and electroencephalography-based study
European journal of neurology
Published

Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia

Authors
Joel Simrén, Andrea L Benedet, Guglielmo Di Molfetta, Ilaria Pola, Kübra Tan, Valentina Cantoni, Ilenia Libri, Jasmine Rivolta, Roberta Ghidoni, Henrik Zetterberg, Barbara Borroni, Nicholas J Ashton
Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia
JAMA network open
Published

Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy

Authors
Annalise E Miner, Henrik Zetterberg, Kaj Blennow, Jenna R Groh, Alpana Singh, Kari Dieckhoff, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Elaine Peskind, Breton M Asken, Jeremy A Tanner, Gil D Rabinovici, Sarah J Banks, William B Barr, Jennifer V Wethe, Robert C Cantu, David W Dodick, Jesse Mez, Joseph N Palmisano, Brett Martin, Thor D Stein, Ann C McKee, Jeffrey L Cummings, Martha E Shenton, Eric M Reiman, Robert A Stern, Nicholas J Ashton, Michael L Alosco, DIAGNOSE CTE Research Project
Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy
JAMA
Published

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis

Authors
Ganna Blazhenets, David N Soleimani-Meigooni, Konstantinos Chiotis, Isabel E Allen, Gil D Rabinovici, Renaud La Joie, Meta-Centiloid Study Group, Liana G Apostolova, Breton M Asken, Alexandre Bejanin, Tammie L S Benzinger, Tobey J Betthauser, Marina Bluma, Stephanie Bombois, Pierrick Bourgeat, Vincent Bouteloup, Meredith N Braskie, Matthias Brendel, Adam M Brickman, Natalie Bryant, Santiago Bullich, Maria C Carrillo, Kaitlin Casaletto, David M Cash, Chiung-Chih Chang, Hsin-I Chang, Yishu Chao, Genevieve Chêne, Gaël Chételat, William Coath, Lyduine E Collij, Lise Colmant, Maria M Corrada, Suzanne Craft, Bradford C Dickerson, Bruno Dubois, Carole Dufouil, Alfonso Fajardo, Gill Farrar, Juan Fortea, Lars Frings, Giovanni B Frisoni, Raquel C Gardner, Valentina Garibotto, Johannes S Gnörich, Brian A Gordon, Yuna Gu, Yihui Guan, Tengfei Guo, Bernard J Hanseeuw, Oskar Hansson, Theresa M Harrison, Qi Huang, Shu-Hua Huang, Leonardo Iaccarino, Kazunari Ishii, Kenji Ishi, William J Jagust, Sterling C Johnson, Takashi Kato, Yuta Katsumi, Jeffrey Kaye, Robert A Koeppe, Guilherme D Kolinger, Joel H Kramer, Susan M Landau, Brigitte Landeau, Patrick J Lao, Sangwon Lee, Alberto Lleó, Brian J Lopresti, Val J Lowe, Jose A Luchsinger, Maura Malpetti, Xiaoxie Mao, Andrew March, Colin L Masters, Philipp T Meyer, Florence Mezenge, Elizabeth C Mormino, Maria Franquesa-Mullerat, Akinori Nakamura, Agneta Nordberg, John T O'Brien, Sid E O'Bryant, Ioannis Pappas, Debora E Peretti, Lisa Quenon, Christopher C Rowe, James B Rowe, Marc D Rudolph, Gemma Salvadó, Jonathan M Schott, Daniel L Schwartz, Christopher G Schwarz, Sang Won Seo, Mahnaz Shekari, Lisa C Silbert, Ruben Smith, Heather M Snyder, Andrzej Sokolowski, Reisa A Sperling, Pan Sun, Jacinda Z Taggett, Arthur W Toga, Alexandra Touroutoglou, David E Vaillancourt, Elsmarieke van de Giessen, Jort Vijverberg, Prashanthi Vemuri, Nicolas Villain, Victor L Villemagne, Sylvia Villeneuve, Wei-En Wang, Michael Weiner, Davis Woodworth, Cally Xiao, Fang Xie, Yeojun Yoon, Christina B Young, Mijin Yun, A4, ABIDE, ADNI*, ADNI-DoD, AgeWell, AIBL, AMYPAD, BACS, BATON, BIOCARD, BLSA, BioFINDER-2, BrANCH, CPAS, DETECT-AD, GEMS, GHABS, HABS, HABS-HD, IDEAS, IMAP, INSIGHT-preAD, Insight46, K-ROAD, LEADS, MCSA, MULNIAD, MEMENTO, SCAN, PREVENT-AD, SPIN, Severanc
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis
EBioMedicine
Published

CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum

Authors
Javier Arranz, Juan Lantero-Rodríguez, Luisa Sophie Braun-Wohlfahrt, Lídia Vaqué-Alcázar, Íñigo Rodríguez-Baz, Przemysław R Kac, Burak Arslan, Lucía Maure-Blesa, Lucía Pertierra, Laura Videla, María Carmona-Iragui, Bessy Benejam, Laura Del Hoyo Soriano, Isabel Barroeta, Susana Fernández, Alexandre Bejanin, Alberto Lleó, Nicholas J Ashton, Henrik Zetterberg, Juan Fortea, Daniel Alcolea, Laia Montoliu-Gaya
CSF and plasma tau biomarkers in the Down syndrome-Alzheimer's disease continuum
medRxiv : the preprint server for health sciences
Published

<em>LRRK2</em> in Focus: A Global Browser Linking Genetic Diversity to Functional Effects

Authors
Spencer M Grant, Vesna van Midden, Elias Fernandez-Toledo, Momodou Cham, Esther Sammler, Dario R Alessi, Global Parkinson’s Genetics Program, Huw R Morris, Cornelis Blauwendraat, Andrew B Singleton, Lara M Lange
<em>LRRK2</em> in Focus: A Global Browser Linking Genetic Diversity to Functional Effects
Science (New York, N.Y.)
Published

C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain

Authors
Gerard Crowley, Minjung Kim, Nathanael O'Neill, Emir Turkes, Fateme Ghasemi, Luca Giudice, Sebastiaan De Schepper, Benjy J Y Tan, Benito Maffei, Laís S S Ferreira, Julie Rebejac, Javier Rueda-Carrasco, Margarita Toneva, John Christian Fajardo, Judy Z Ge, Zhengyue Grace Yang, Paula Korhonen, Phillip Muckett, Damaris Bennett, Camille Paoletti, Tammie T M Sow, David A Posner, Annerieke Sierksma, Dimitra Sokolova, Viktoras Konstantellos, Leen Ali, Kiavash Movahedi, Andrew F MacAskill, Victor L J Tybulewicz, Tarja Malm, Gabriele Lignani, Menna R Clatworthy, Soyon Hong
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease

Authors
Abhay R Moghekar, James A Rock, Richard C Mohs, Oskar Hansson, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Sterling C Johnson, Henrik Zetterberg, Rachel R Radwan, Jessica Junfola, M Craig Miller, Luna Buitrago, Francesca I De Simone, Katie Martin, Diana Dickson, Natalya Benina, Douglas M Hawkins
Multicenter validation of plasma p-tau217/ amyloid beta 1-42 ratio in symptomatic Alzheimer's disease