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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease

Authors
Mieke Nuytten, Marieke Voets, Eveline Debroux, Katrien Princen, Lentel Pringels, Marc Fivaz, Eline Byl, Steven Ramael, Koen De Witte, Mercé Boada, Xavier Morató, Juan Pablo Tartari, Asunción Lafuente, Emilio Franco Macias, Jordi A Matias-Guiu, Everard Vijverberg, Charlotte E Teunissen, Peter Anderer, Vincent Staggs, Vincent Hayman, Anne Corbett, Clive Ballard, John E Harrison, Manfred Windisch, Ann Brinkmalm Westman, Henrik Zetterberg, Sam Dickson, Craig Mallinckrodt, Suzanne Hendrix, Jeffrey Cummings, Gerard Griffioen
Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Preclinical dementia rating scores are associated with plasma phosphorylated tau-217

Authors
Qi Huang, Erin M Jonaitis, Rachel L Studer, Rachael Wilson, Ramiro Eduardo Rea Reyes, Henrik Zetterberg, Lianlian Du, Bruce P Hermann, Sterling C Johnson, Rebecca E Langhough
Preclinical dementia rating scores are associated with plasma phosphorylated tau-217
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Recent advances in neuroimaging of Alzheimer's disease and related dementias

Authors
Julie Ottoy, Nicole Owsicki, Murat Bilgel, Alexa Pichet Binette, Gemma Salvadó, Min Su Kang, David M Cash, Michael Ewers, Renaud La Joie, Laura E M Wisse, Maged Goubran, Tobey Betthauser
Recent advances in neuroimaging of Alzheimer's disease and related dementias
Clinical nuclear medicine
Published

Prognostic Value of A/T/N Biomarkers: Comparing Plasma and Imaging Modalities in Alzheimer Disease

Authors
Sohyun Yim, Yuna Gu, Heekyung Kang, Daeun Shin, Hyemin Jang, Heejin Yoo, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Michael W Weiner, Theresa A Day, Eun Hye Lee, Duk L Na, Hee Jin Kim, Sung Hoon Kang, Ko Woon Kim, Yeo Jin Kim, Yeshin Kim, Jaeho Kim, Min Young Chun, Na Yeon Jung, Soo Hyun Cho, Jun Pyo Kim, Jihwan Yun, Sang Won Seo, K-ROAD study groups
Prognostic Value of A/T/N Biomarkers: Comparing Plasma and Imaging Modalities in Alzheimer Disease
Molecular psychiatry
Published

Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review

Authors
Luiza S Machado, Pedro Vidor, Lavínia Perquim, Christian Limberger, Leonardo Machado, Andréia Rocha, Carolina Soares, Nesrine Rahmouni, Wagner S Brum, Bruna Bellaver, Pamela C L Ferreira, Wyllians V Borelli, Jaderson C da Costa, Maura Malpetti, Tharick A Pascoal, Diogo O Souza, Paul Edison, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Andrea L Benedet, Alberto Serrano-Pozo, Pedro Rosa-Neto, Eduardo R Zimmer
Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review
Science (New York, N.Y.)
Published

Lewy body dementia promotion by air pollutants

Authors
Xiaodi Zhang, Haiqing Liu, Xiao Wu, Longgang Jia, Kundlik Gadhave, Lena Wang, Kevin Zhang, Hanyu Li, Rong Chen, Ramhari Kumbhar, Ning Wang, Chantelle E Terrillion, Bong Gu Kang, Bin Bai, Minhan Park, Ma Cristine Faye Denna, Shu Zhang, Wenqiang Zheng, Denghui Ye, Xiaoli Rong, Liu Yang, Lili Niu, Han Seok Ko, Weiyi Peng, Lingtao Jin, Mingyao Ying, Liana S Rosenthal, David W Nauen, Alex Pantelyat, Mahima Kaur, Kezia Irene, Liuhua Shi, Rahel Feleke, Sonia García-Ruiz, Mina Ryten, Valina L Dawson, Francesca Dominici, Rodney J Weber, Xuan Zhang, Pengfei Liu, Ted M Dawson, Shizhong Han, Xiaobo Mao
Lewy body dementia promotion by air pollutants
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers

Authors
Timo Kaleck, Rafael Campos-Martin, Amanda Cano, Maria Victoria Fernández, Pamela Martino-Adami, Luca Kleineidam, Victor M Andrade Fuentes, Kumar P Tripathi, Kayenat Parveen, Raquel Puerta, Itziar de Rojas, Kishore A Ravichandran, Oliver Peters, Julian Hellmann-Regen, Josef Priller, Maria Gemenetzi, Anja Schneider, Jens Wiltfang, Emrah Düzel, Katharina Buerger, Robert Perneczky, Stefan Teipel, Christoph Laske, Frederic Brosseron, Marta Marquié, Daniel LA van den Hove, Mercè Boada, Michael T Heneka, Michael Wagner, Natalie Marchant, Jean-Charles Lambert, Ruth Frikke-Schmidt, Frank Jessen, Agustín Ruiz, Alfredo Ramirez
Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers
Science advances
Published

Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification

Authors
Luana Campos Soares, Ning Huang, Hana Bernhardova, Viviana Macarelli, Marva Chan, Lara Nikel, Sara Bandiera, Dongnan Yan, Dhanu Gupta, Elisa M Cruz, Talia Vasaturo-Kolodner, James M Hillis, Matthew Wood, Mootaz Salman, Zoltán Molnár, Eric O'Neill, Francis G Szele
Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification
Nature communications
Published

Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model

Authors
Jack I Wood, Maciej Dulewicz, Alicja Szadziewska, Sophia Weiner, Junyue Ge, Katie Stringer, Sneha Desai, Lydia Fenson, Diana Piotrowska, Gunnar Brinkmalm, Srinivas Koutarapu, Haady B Hajar, Kaj Blennow, Henrik Zetterberg, Damian M Cummings, Jeffrey N Savas, Frances A Edwards, Jörg Hanrieder
Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model