Skip to main content
Search
Main content

Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Multiple sclerosis (Houndmills, Basingstoke, England)
Published

Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity

Authors
Sofia Sandgren, Aleksandra Maleska Maceski, Pascal Benkert, Maximilian Einsiedler, Sabine Schaedelin, Johanna Oechtering, Lutz Achtnichts, Patrice H Lalive, Stefanie Müller, Caroline Pot, Amanda Heslegrave, David Hunt, Jan Lycke, Robert Hoepner, Patrick Roth, Claudio Gobbi, Manuel Comabella, Tobias Derfuss, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline Aj Willemse, Henrik Zetterberg, Jens Kuhle
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Neurology
Published

In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy: An Exploratory Study

Authors
Hilde van den Brink, Mariel G Kozberg, Nazanin Makkinejad, John E Kirsch, Michael J Thrippleton, Thijs W van Harten, Sabine Voigt, Whitney M Freeze, Matthias J P Van Osch, Anand Viswanathan, Susanne J van Veluw
In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy: An Exploratory Study
Brain : a journal of neurology
Published

Estimating the time course of biomarker changes in Alzheimer's disease

Authors
Lars Lau Raket, Alexa Pichet Binette, Niklas Mattsson-Carlgren, Shorena Janelidze, Henrik Zetterberg, Nicholas J Ashton, Kaj Blennow, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson
Estimating the time course of biomarker changes in Alzheimer's disease
Translational psychiatry
Published

Interplay between age, APOE Ɛ4 and the metabolome in plasma and brain in Alzheimer's disease

Authors
Najaf Amin, Jun Liu, William Sproviero, Matthias Arnold, Richa Batra, Bruno Bonnechere, Yu-Jie Chiou, Marco Fernandes, Jan Krumsiek, Danielle Newby, Kwangsik Nho, Jun Pyo Kim, Andrew J Saykin, Liu Shi, Laura M Winchester, Yang Yang, Alejo J Nevado-Holgado, Gabi Kastenmüller, Rima Kaddurah-Daouk, Cornelia M van Duijn
Interplay between age, APOE Ɛ4 and the metabolome in plasma and brain in Alzheimer's disease
Translational psychiatry
Published

Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures

Authors
Joanna E Moodie, Colin R Buchanan, Anna E Fürtjes, Eleanor L S Conole, Aleks Stolicyn, Janie Corley, Karen Ferguson, Maria Valdés Hernández, Susana Muñoz Maniega, Tom C Russ, Michelle Luciano, Heather Whalley, Mark E Bastin, Joanna Wardlaw, Ian J Deary, Simon R Cox
Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures
Neuron
Published

The brain neurovascular epigenome and its association with dementia

Authors
Kevin Chris Ziegler, Aydan Askarova, Charbel Gergian, Reuben M Yaa, Janna D van Dalen, Janis Lisa Transfeld, Filippo Zoppi, Jia Du, Daniel Clode, Fatemeh Rahbar, Rebecca E Graham, Muralidharan Sargurupremraj, Stéphanie Debette, David D Gonda, Michael L Levy, Siddharthan Chandran, Sven Falk, Marisa Karow, Paul M Matthews, Nicole G Coufal, Alexi Nott
The brain neurovascular epigenome and its association with dementia
Nature communications
Published

A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate dynamics

Authors
Yuki Kamijo, Philipp Mächler, Natalie Ness, Cong Quang Vu, Tsukasa Kusakizako, Jamsad Mannuthodikayil, Zaneta Ku, Marc Boisvert, Ekaterina Grebenik, Ikumi Miyazaki, Rina Hashizume, Haruaki Sato, Rui Liu, Yukiko Hori, Taisuke Tomita, Tetsuro Katayama, Akihiro Furube, Gabriela Caraveo, Marie-Eve Paquet, Mikhail Drobizhev, Osamu Nureki, Satoshi Arai, Marco Brancaccio, Robert E Campbell, David Kleinfeld, Yusuke Nasu
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate dynamics
Imaging neuroscience (Cambridge, Mass.)
Published

Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age

Authors
Mathijs B J Dijsselhof, Candace Moore, Saba Amiri, Mervin Tee, Saima Hilal, Christopher Chen, Bert-Jan H van den Born, Wibeke Nordhøy, Ole A Andreassen, Lars T Westlye, Nishi Chaturvedi, Alun D Hughes, David M Cash, Jonathan M Schott, Carole H Sudre, Frederik Barkhof, Joost P A Kuijer, Francesca Biondo, James H Cole, Henk J M M Mutsaerts, Jan Petr
Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

International recommendations for sleep and circadian research in aging and Alzheimer's disease: A Delphi consensus study

Authors
Claire André, Laura Stankeviciute, Johannes C Michaelian, Inga M Antonsdottir, Ruth M Benca, Elizabeth J Coulthard, Angela L D'Rozario, Derk-Jan Dijk, Sandra Gimenez, Maurizio Gorgoni, Yue Leng, Brendan P Lucey, Matthew P Pase, Stephanie R Rainey-Smith, Ivana Rosenzweig, Adam P Spira, Joseph R Winer, Géraldine Rauchs, Sharon L Naismith, Sleep and Circadian Rhythms Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment (ISTAART)
International recommendations for sleep and circadian research in aging and Alzheimer's disease: A Delphi consensus study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts

Authors
Veerle van Gils, Willemijn J Jansen, Wiesje M van der Flier, Pablo Martinez-Lage, Jakub Hort, Inez H G B Ramakers, Olivier Rouaud, Markku Laakso, Sebastiaan Engelborghs, Julius Popp, Alberto Lleó, Anders Wallin, Magda Tsolaki, Charlotte E Teunissen, Rik Vandenberghe, Yvonne Freund-Levi, Lutz Frölich, Henrik Zetterberg, Johannes Streffer, Simon Lovestone, Justine Moonen, Argonde van Harten, Katerina Veverová, Nienke Legdeur, Anouk den Braber, Daniel Damian, Anette Hall, Janita Bralten, Giuseppe Fanelli, Barbara Franke, Geert Poelmans, Monica Bulló, Susana Jimenez-Murcia, Fernando Fernandez-Arande, Jordi Salas Salvadó, Søren Dalsgaard, Pieter Jelle Visser, Stephanie J B Vos
The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts
Nature neuroscience
Published

Falling asleep follows a predictable bifurcation dynamic

Authors
Junheng Li, Anastasia Ilina, Robert Peach, Tianyu Wei, Edward Rhodes, Valeria Jaramillo, Ines R Violante, Mauricio Barahona, Derk-Jan Dijk, Nir Grossman
Falling asleep follows a predictable bifurcation dynamic
Journal of neuroinflammation
Published

TSPO contributes to neuropathology and cognitive deficits in Alzheimer's disease

Authors
Kelly Ceyzériat, Aurélien M Badina, Laurene Abjean, Léa Meyer, Farha Bouteldja, Marta Balkota, Quentin Amossé, Oriane Prudhomme, Ryan J Middleton, Guo-Jun Liu, Richard B Banati, Thomas Zilli, Aurelien Lathuiliere, David Owen, Pierre Maechler, Valentina Garibotto, Stergios Tsartsalis, Philippe Millet, Benjamin B Tournier
TSPO contributes to neuropathology and cognitive deficits in Alzheimer's disease
Alzheimer's research & therapy
Published

CT-derived brain volumes and plasma p-Tau217 for risk stratification of amyloid positivity in early-stage Alzheimer's disease

Authors
Sohyun Yim, Seongbeom Park, Kyoung Yoon Lim, Heekyoung Kang, Daeun Shin, Hyemin Jang, Michael Weiner, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Sung Hoon Kang, Jihwan Yun, Minyoung Chun, Eunjoo Kim, Heejin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo, Kichang Kwak, K-ROAD study
CT-derived brain volumes and plasma p-Tau217 for risk stratification of amyloid positivity in early-stage Alzheimer's disease
Journal of Alzheimer's disease : JAD
Published

Plasma p-tau<sub>217</sub> correlates strongly with cerebrospinal fluid Aβ<sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men

Authors
Elisabeth Hellquist, Shorena Janelidze, Bodil Weidung, Kristin Franzon, Vilmantas Giedraitis, Martin Ingelsson, Divya Bali, Vilma Velickaite, Henrik Zetterberg, Oskar Hansson, Lena Kilander
Plasma p-tau<sub>217</sub> correlates strongly with cerebrospinal fluid Aβ<sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men