Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Brain communications
Published

A novel multiplexed biomarker panel reveals key molecular pathways in progressive multiple sclerosis

Authors
Christina N Heiss, Lenka Novakova, Markus Axelsson, Kübra Tan, Ilaria Pola, Wiebke Traichel, Ida Pesämaa, Magnus Johnsson, Sofia Sandgren, Clas Malmeström, Andrea L Benedet, Henrik Zetterberg, Jan N Lycke, Stefanie Fruhwürth, Igal Rosenstein
A novel multiplexed biomarker panel reveals key molecular pathways in progressive multiple sclerosis
Cardiovascular research
Published

Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural prediction

Authors
Jingxian Huang, Devendra Meena, Margaux Achtari, Alexander Smith, Renae Judy, Nour Mimouni, Joshua C Bis, Nora Franceschini, Kenneth Fung, Patricia B Munroe, Scott M Damrauer, Ioanna Tzoulaki, Abbas Dehghan
Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural prediction
The Lancet. Neurology
Published

Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study

Authors
Maulikkumar Patel, Wei Feng, Nicole S Mckay, Peter R Millar, Menghan Liu, Chengran Yang, Arda Cetin, Matthew Johnson, John Budde, Daniel Western, Thomas W Marsh, Ibrahim O Saliu, Brian A Gordon, Jorge J Llibre Guerra, John C Morris, Randall J Bateman, Eric McDade, David M Holtzman, Natalie S Ryan, Tammie L S Benzinger, Alan E Renton, Alison M Goate, Laura Ibanez, Yun Ju Sung, Guoyan Zhao, Carlos Cruchaga, Cyril Pottier, Dominantly Inherited Alzheimer Network
Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study
Nature communications
Published

Clinically-applicable prediction of hospital stay and patient similarity retrieval in paediatric cardiology using machine learning

Authors
Louise Rigny, Iona Biggart, Kimberley Zakka, Jingteng Li, Alexander Capstick, Sebin Sabu, Pavithra Rajendran, Shankar Sridharan, Sumera Farooq, Andrew Taylor, John Booth, Shiren Patel, Padmanabhan Ramnarayan, Neil Sebire, Cho Ng, Payam Barnaghi
Clinically-applicable prediction of hospital stay and patient similarity retrieval in paediatric cardiology using machine learning
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit

Authors
Charles Bernick, Brooke Conway Kleven, Michael L Alosco, Hector Arciniega, Nicholas Ashton, Andrew Bender, Kevin F Bieniek, Dietmar Cordes, Laura Cordes, Douglas I Katz, Dirk Keene, Jefferson Kinney, LeeAnn Mandarino, Dawn Matthews, Anne McKee, Jesse Mez, Edwin C Oh, Elaine Peskind, Gil D Rabinovici, Eric M Reiman, Robert A Stern, Neil Vasdev, Henrik Zetterberg, Xiaowei Zhuang, Jeffrey L Cummings
Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit
Brain & spine
Published

Blood biomarker outliers and clinical events during intensive care in patients with traumatic brain injury

Authors
Pia Koivikko, Jussi P Posti, Iftakher Hossain, Mehrbod Mohammadian, Olli Tenovuo, Peter Hutchinson, Ari J Katila, Henna-Riikka Maanpää, David K Menon, Virginia F Newcombe, Jean-Charles Sanchez, Jussi Tallus, Mark van Gils, Henrik Zetterberg, Riikka Sk Takala
Blood biomarker outliers and clinical events during intensive care in patients with traumatic brain injury
Journal of Alzheimer's disease : JAD
Published

Non-economic social deprivation and cognitive functioning later in life: Results from the DELCODE study

Authors
Francisca S Rodriguez, Luca Kleineidam, Wolfgang Hoffmann, Oliver Peters, Daria Gref, Louise Droste Zu Senden, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy-Kluth, Michael Wagner, Steffen Wolfsgruber, Melina Stark, Sophia Stoecklein, Frank Jessen, DELCODE study group
Non-economic social deprivation and cognitive functioning later in life: Results from the DELCODE study
Journal of neurology, neurosurgery, and psychiatry
Published

The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts

Authors
Xuelin Tang, Vishaal Sumra, Christine Sato, Danielle Moreno, Mozhgan Khodadadi, Nusrat Sadia, Carmen Wong, Brenda Colella, Robin E A Green, Janet Ta, Kaj Blennow, Henrik Zetterberg, Richard Wennberg, Charles H Tator, Ming Zhang, Ekaterina Rogaeva, Maria Carmela Tartaglia
The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts
Journal of neurochemistry
Published

Circulating Sphingomyelins Correlate With Plasma T-Tau in Cognitively Unimpaired Older Adults at Risk of Developing Alzheimer's Disease

Authors
Tahmida Sharmin, James D Doecke, Pratishtha Chatterjee, Steve Pedrini, Hamid R Sohrabi, Nicholas J Ashton, Henrik Zetterberg, Manohar L Garg, Kaj Blennow, Ralph N Martins
Circulating Sphingomyelins Correlate With Plasma T-Tau in Cognitively Unimpaired Older Adults at Risk of Developing Alzheimer's Disease
NPJ Parkinson's disease
Published

Identifying maximal beta power from directional subthalamic local field potentials in Parkinson's disease

Authors
Jennifer K Behnke, Robert L Peach, Moritz Gerster, Richard M Köhler, Jeroen G V Habets, Johannes L Busch, Varvara Mathiopoulou, Jonathan Kaplan, Lucia K Feldmann, Juliette Vivien, Chi Wang Ip, Gerd-Helge Schneider, Katharina Faust, Patricia Krause, Andrea A Kühn
Identifying maximal beta power from directional subthalamic local field potentials in Parkinson's disease
Science (New York, N.Y.)
Published

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Authors
Katie E Copley, Jocelyn C Mauna, Helen L Danielson, Qizan Chen, Busra Ozguney, Marilyn Ngo, Longxin Xie, Ashleigh Smirnov, Matt Davis, Leland Mayne, Miriam Linsenmeier, Jack D Rubien, Cristian A Bergmann, Bede Portz, Bo Lim Lee, Hana M Odeh, Longsheng Lai, Yi-Wei Chang, Martina Hallegger, Jernej Ule, Piera Pasinelli, Yan Poon, Jeetain Mittal, Nicolas L Fawzi, Ben E Black, Christopher J Donnelly, Brigid K Jensen, James Shorter
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration