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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Current biology : CB
Published

Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep

Authors
Wei Ba, Edward C Harding, Mathieu Nollet, Kyoko Tossell, Li-Li Li, Sara Wong, Berta Anuncibay Soto, Raquel Yustos, Li Li, Jagoda Ostaszewska, Hanns Ulrich Zeilhofer, Alexei L Vyssotski, Michael J Courtney, William Wisden, Nicholas P Franks
Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep
BMC geriatrics
Published

CSF neurofilament light chain concentration in patients with delirium following hip fracture: a multicenter prospective study

Authors
Irit Titlestad, Leiv Otto Watne, Kaj Blennow, Henrik Zetterberg, Marius Myrstad, Emilija Dunjic, Christian Thomas Pollmann, Adi Karabeg, Lene B Solberg, Ane-Victoria Idland, Allan Gulestøl, Aasmund Godø, Bjørn Erik Neerland, Lasse M Giil, Nathalie Bodd Halaas
CSF neurofilament light chain concentration in patients with delirium following hip fracture: a multicenter prospective study
Pathologica
Published

Technical feasibility of a long read, fourth generation sequencing platform in diagnostic profiling of clinical routine samples: a proof-of-concept study

Authors
Domenico Vitale, Lorenzo Colarossi, Gianluca Russo, Claudia Scimone, Domenico Cozzolino, Caterina De Luca, Andrey D Prjibelski, Alla Mikheenko, Cristina Colarossi, Francesco Delli Muti, Francesco Pepe, Lorenzo Memeo, Giancarlo Troncone, Lucia Anna Muscarella, Umberto Malapelle
Technical feasibility of a long read, fourth generation sequencing platform in diagnostic profiling of clinical routine samples: a proof-of-concept study
The journal of prevention of Alzheimer's disease
Published

Class-level aggregation obscures clinically relevant heterogeneity in anti-amyloid antibody trials: comments on a Cochrane review by individual members of the EADC

Authors
Kristian Steen Frederiksen, Mercè Boada, Lutz Frölich, Milica Kramberger, Nikolaos Scarmeas, Everard Vijverberg, Pieter Jelle Visser, Gunhild Waldemar, Eric Westman, Henrik Zetterberg, Sebastiaan Engelborghs, Frank Jessen
Class-level aggregation obscures clinically relevant heterogeneity in anti-amyloid antibody trials: comments on a Cochrane review by individual members of the EADC
Journal of neurology
Published

Diagnostic and prognostic value of blood neurofilament light chain in ischemic stroke: an individual patient data meta-analysis

Authors
Lorenzo Barba, Michele Romoli, Pascal Benkert, Lisa Hofer, Luis F Maia, Alexandre Dias, Rui Magalhães, Catarina Guedes Vaz, Jan Emmerich, Kristian Barlinn, Christoph Vollmuth, Hermann Neugebauer, Marta Truffi, Carlo Morasso, Federica Ferrari, Grant O'Connell, Steffen Tiedt, Dilara Moumin, Thomas Gattringer, Markus Kneihsl, Michael Khalil, Annie Pedersen, Tara M Stanne, Sofia Furutjäll, Christina Jern, Helle H Nielsen, Kate L Lambertsen, Mi-Yeon Eun, June Woo Ahn, Poosanu Thanapornsangsuth, Wanakorn Rattanawong, Fani Pujol-Calderón, Henrik Zetterberg, Kaj Blennow, Marianne Hahn, Timo Uphaus, Klaus Gröschel, Valentina Tudisco, Julian Klingbeil, Arthur Guthknecht, Samir Abu-Rumeileh, Simona Sacco, Matteo Foschi, Lucio D'Anna, Jens Kuhle, Markus Otto, Valeria Caso
Diagnostic and prognostic value of blood neurofilament light chain in ischemic stroke: an individual patient data meta-analysis
Movement disorders : official journal of the Movement Disorder Society
Published

Wearable Movement-Tracking for Prodromal Parkinson's Disease Detection: A Cross-Country Validation Study

Authors
Fabian Kahl, Ann-Kathrin Schalkamp, Katarina Mary Gunter, Anja Ophey, Sinah Röttgen, Jamil Razzaque, Konstantin Kufer, Cynthia Sandor, Gereon R Fink, Elke Kalbe, Walter Maetzler, Clint Hansen, Stephan M Jonas, Michele T Hu, Lara Marie Reimer, Michael Sommerauer
Wearable Movement-Tracking for Prodromal Parkinson's Disease Detection: A Cross-Country Validation Study
Nature aging
Published

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology

Authors
Jun-Ping Pan, Ping-Jie Wang, Jianying Zhang, Anne-Brita Knapskog, Leiv Otto Watne, He-Ling Wang, Maria Jose Lagartos-Donate, Sofie Lautrup, Li-Peng Mao, Qian Wang, Zhi-Peng Ling, Shi-Qi Zhang, Tomás Schmauck-Medina, Ruixue Ai, Trine Holt Edwin, Tianjiao Zhang, Ingvild Saltvedt, Rannveig Sakshaug Eldholm, Annabel Smith, Kateřina Veverová, Domenica Caponio, Asgeir Kobro-Flatmoen, Huanhuan Pang, Zijian Wang, Haoyun Wang, Li-Juan Gao, Nathalie Bodd Halaas, Garry Wong, Martin Vyhnalek, Oscar Junhong Luo, William A McEwan, Jon Storm-Mathisen, Li Gan, Zeping Hu, Henrik Zetterberg, Menno P Witter, Dag Aarsland, Geir Selbæk, Guobing Chen, Evandro Fei Fang
Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology
Brain communications
Published

A novel multiplexed biomarker panel reveals key molecular pathways in progressive multiple sclerosis

Authors
Christina N Heiss, Lenka Novakova, Markus Axelsson, Kübra Tan, Ilaria Pola, Wiebke Traichel, Ida Pesämaa, Magnus Johnsson, Sofia Sandgren, Clas Malmeström, Andrea L Benedet, Henrik Zetterberg, Jan N Lycke, Stefanie Fruhwürth, Igal Rosenstein
A novel multiplexed biomarker panel reveals key molecular pathways in progressive multiple sclerosis
Cardiovascular research
Published

Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural prediction

Authors
Jingxian Huang, Devendra Meena, Margaux Achtari, Alexander Smith, Renae Judy, Nour Mimouni, Joshua C Bis, Nora Franceschini, Kenneth Fung, Patricia B Munroe, Scott M Damrauer, Ioanna Tzoulaki, Abbas Dehghan
Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural prediction
The Lancet. Neurology
Published

Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study

Authors
Maulikkumar Patel, Wei Feng, Nicole S Mckay, Peter R Millar, Menghan Liu, Chengran Yang, Arda Cetin, Matthew Johnson, John Budde, Daniel Western, Thomas W Marsh, Ibrahim O Saliu, Brian A Gordon, Jorge J Llibre Guerra, John C Morris, Randall J Bateman, Eric McDade, David M Holtzman, Natalie S Ryan, Tammie L S Benzinger, Alan E Renton, Alison M Goate, Laura Ibanez, Yun Ju Sung, Guoyan Zhao, Carlos Cruchaga, Cyril Pottier, Dominantly Inherited Alzheimer Network
Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study
Nature communications
Published

Clinically-applicable prediction of hospital stay and patient similarity retrieval in paediatric cardiology using machine learning

Authors
Louise Rigny, Iona Biggart, Kimberley Zakka, Jingteng Li, Alexander Capstick, Sebin Sabu, Pavithra Rajendran, Shankar Sridharan, Sumera Farooq, Andrew Taylor, John Booth, Shiren Patel, Padmanabhan Ramnarayan, Neil Sebire, Cho Ng, Payam Barnaghi
Clinically-applicable prediction of hospital stay and patient similarity retrieval in paediatric cardiology using machine learning