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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature reviews. Neurology
Published

UK Biobank at 20 - a growing, global resource for dementia research

Authors
Paul M Matthews, Naomi E Allen, Stephanie Debette, Aiden Doherty, Gwenaëlle Douaud, Eugene P Duff, Paul Elliott, Evelynne S Fulda, Anastasia Illina, Quentin Le Grand, Adam J Lewandowski, Rebecca Mahoney, Karla Miller, Cecilia Rodriguez, Martin K Rutter, Cynthia Sandor, Rebecca Sims, Stephen M Smith, Chaoyue Wang
UK Biobank at 20 - a growing, global resource for dementia research
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation

Authors
Burak Arslan, Johan Gobom, Ulf Andreasson, Laia Montoliu-Gaya, Andrea L Benedet, Anna Dittrich, Silke Kern, Ingmar Skoog, Nicholas J Ashton, Tevy Chan, Nesrine Rahmouni, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg
Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Traumatic brain injury and risk of early-onset dementia: A population-based cohort study

Authors
Aishwarya Saravanan, Katherine Giorgio, Natalia Lakomski, Andrea L C Schneider, Barbara A Olson-Bullis, Behnam Sabayan, James S Pankow, Paul S de Vries, Kristine Yaffe, Alexa Beiser, Abbas Dehghan, Elizabeth A Peterson, Rachel Zmora, John J Stephen, Denise Scholtens, Maxwell Mansolf, Lenore J Launer, Richard F MacLehose, Pamela L Lutsey, Norrina B Allen, Sanaz Sedaghat
Traumatic brain injury and risk of early-onset dementia: A population-based cohort study
Science signaling
Published

Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

Authors
Jose Norberto S Vargas, Anna-Leigh Brown, Kai Sun, Cathleen Hagemann, Bethany Geary, David Villarroel-Campos, Sam Bryce-Smith, Matteo Zanovello, Madeline Lombardo, Stan Majewski, Andrew Tosolini, Maria Secrier, Matthew J Keuss, Andrea Serio, James N Sleigh, Pietro Fratta, Giampietro Schiavo
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons
EBioMedicine
Published

Biomarkers of Alzheimer's disease pathophysiology and delirium

Authors
Kristi Henjum, Bjørn Erik Neerland, Kaj Blennow, Henrik Zetterberg, Christian Thomas Pollmann, Roy Bjørkholt Olsen, Lene Solberg, Marius Myrstad, Olav Tobias Ødegaard, Adi Karabeg, Alan Gulestøl, Ane Victoria Idland, Leiv Otto Watne
Biomarkers of Alzheimer's disease pathophysiology and delirium
European journal of clinical investigation
Published

Prognostic Added Value of GFAP in Patients With Minor Ischemic Stroke

Authors
Andrea Morotti, Mathias Sauer, Francesco Berinato, Marcello Catania, Andrea L Benedet, Chiara Tolassi, Guglielmo Di Molfetta, Ilaria Pola, Henrik Zetterberg, Nicholas J Ashton, Andrea Pilotto, Alessandro Padovani
Prognostic Added Value of GFAP in Patients With Minor Ischemic Stroke
NPJ Parkinson's disease
Published

Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease

Authors
Alena M Smith, Sara A Lorkiewicz, Burak Arslan, Laia Montoliu-Gaya, Nicholas J Ashton, Edward N Wilson, Daniel Alcolea, Íñigo Rodríguez-Baz, Juan Fortea, Christina B Young, Joseph R Winer, Marian Shahid-Besanti, Hillary Vossler, Melanie J Plastini, Tianyu Pan, Elena Vera-Campuzano, Isabel Sala, Justin H Mendiola, Veronica Ramirez, Geoffrey A Kerchner, Katrin I Andreasson, Victor W Henderson, Thomas J Montine, Lu Tian, Elizabeth C Mormino, Henrik Zetterberg, Kathleen L Poston, Carla Abdelnour
Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease
Acta neuropathologica communications
Published

Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease

Authors
Carlos Avilés-Granados, Adriana Gea-González, Jorge Sáez-Leyva, Sylvia E Perez, Elliott J Mufson, Ann-Charlotte Granholm, María Carmona-Iragui, Henrik Zetterberg, Kaj Blennow, Juan Fortea, María-Salud García-Ayllón, Javier Sáez-Valero
Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease
Neurology
Published

Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease

Authors
Jorge J Llibre-Guerra, Ruijin Lu, Ma Florencia Clarens, Ian Liu, Alan Renton, Natalie S Ryan, Alison M Goate, David Aguillón, Ricardo Francisco Allegri, Tammie L S Benzinger, Sarah Berman, Jasmeer P Chhatwal, Patricio Chrem Mendez, Gabriela Vigo, Carlos Cruchaga, Gregory S Day, Martin R Farlow, Nick C Fox, Brian Andrew Gordon, Jason Hassenstab, Edward D Huey, Laura Ibanez, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Allan I Levey, Johannes Levin, Yoshiki Niimi, Richard J Perrin, Pedro Rosa-Neto, Raquel Sánchez-Valle, Peter R Schofield, Guoqiao Wang, Yan Li, Chengjie Xiong, John C Morris, Celeste Karch, Alisha J Daniels, Eric McDade, Randall J Bateman
Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease
Nature reviews. Neurology
Published

The potential of low-field MRI for global dementia care

Authors
Tavia E Evans, Joshua Harper, Aram Salehi, Andrew G Webb, James H Cole, Ana Correa, Hieab H H Adams, David M Cash, Derek K Jones
The potential of low-field MRI for global dementia care
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles

Authors
Maria Kreger Karabova, Anna Del Ser-Badia, Anne Hedegaard, Sam J Washer, Zeynep Baykam, Darragh P O'Brien, Iolanda Vendrell, Svenja S Hester, Roman Fischer, Errin Johnson, Charlotte E Melia, Teige R S Matthews-Palmer, Rishi Matadeen, Alessia Santambrogio, Michael A Metrick, Michele Vendruscolo, Sophie Keeling, Kimberly Ai Xian Cheam, William A McEwan, Kenneth S Kosik, Theresa A Day, William S James, Sally A Cowley
Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles
Journal of neurotrauma
Published

Pathophysiology of the Post-Traumatic Confusional State and Post-Traumatic Amnesia: A Scoping Review

Authors
Douglas I Katz, Yelena G Bodien, Afik Faerman, Julie Schwertfeger, Yelena Bogdanova, Sonja Blum, Brigid Dwyer, Natalie Gilmore, Jessica Vaz Goncalves, Keira Hays, Min Jeong P Graf, Michael Marino, Emma-Jane Mallas, Amy Shapiro-Rosenbaum, Mark Sherer, Michael W Williams, Bei Zhang
Pathophysiology of the Post-Traumatic Confusional State and Post-Traumatic Amnesia: A Scoping Review