Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Journal of Alzheimer's disease : JAD
Published
Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in <em>KLOTHO</em> KL-VS heterozygotes
Authors
Ira Driscoll, Rachael E Wilson, Sterling C Johnson, Sanjay Asthana, Catherine L Gallagher, Bruce P Hermann, Mark A Sager, Cynthia M Carlsson, Kaj Blennow, Henrik Zetterberg, Dena B Dubal, Ozioma C Okonkwo
Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in <em>KLOTHO</em> KL-VS heterozygotes
Nature communications
Published
USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
Authors
Giulio Collotta, Marco Gatti, Irina-Maria Ungureanu, Vanessa van Ackeren, Emilie Rannou, Francesca Vivalda, Diego Gomez Vieito, Keri M Fishwick, Christine von Aesch, Antonio Porro, Kyra Ungerleider, Ailin Heidari, Raphaël Guérois, Rachel J Harding, Sylvain Bischof, Gabriel Balmus, Alessandro A Sartori
USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion
Nature communications
Published
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases
Authors
Kanta Chechi, Rima Chakaroun, Antonis Myridakis, Sofia K Forslund-Startceva, Sebastien Fromentin, Trine Nielsen, Judith Aron-Wisneswky, Eugeni Belda, Edi Prifti, Pierre Bel Lassen, Gwen Falony, Sara Vieira-Silva, Julien Chilloux, Kazuhiro Sonomura, Lesley Hoyles, Laura Martinez-Gili, Francesco Pallotti, Petros Andrikopoulos, Francesc Puig-Castellví, Romina Pacheco Tapia, Inés Castro-Dionicio, Hugo Roume, Nicolas Pons, Emmanuelle Le Chatelier, Benoit Quinquis, Nathalie Galleron, Magali Berland, Michael T Olanipekun, Manyi Jia, Angelos Manolias, Bridget Holmes, Solia Adriouch, Matthias Blüher, Luis Pedro Coelho, Kévin Da Silva, Pilar Galan, Boyang Ji, Ana Luisa Neves, Christine Rouault, Joe-Elie Salem, Valentina Tremaroli, Tue H Hansen, Nadja B Søndertoft, Christian Lewinter, Helle K Pedersen, MetaCardis Consortium, Peter D Mark, Jens P Goetze, Lars Køber, Henrik Vestergaard, Torben Hansen, Jean-Daniel Zucker, Taka-Aki Sato, Serge Hercberg, Fredrik Bäckhed, Ivica Letunic, Jean-Michel Oppert, Jens Nielsen, Jeroen Raes, Ioanna Tzoulaki, Abbas Dehghan, Verena Zuber, Emmanuelle Bouzigon, Mark Lathrop, Parminder Raina, Philippe Froguel, Fumihiko Matsuda, Florence Demenais, Dominique Gauguier, Michael Stumvoll, Peer Bork, Oluf Pedersen, S Dusko Ehrlich, Karine Clément, Marc-Emmanuel Dumas
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases
Brain communications
Published
Peripheral and CSF protein quantification in Parkinson's disease and multiple system atrophy-the nucleic acid-linked immuno-sandwich assay
Authors
Nirosen Vijiaratnam, Christine Girges, Arthur Mitchell, Dilan Athauda, Riona Fumi, Jennifer Hay, Nicola O'Reilly, Huw Morris, Camille Carroll, Michele T M Hu, Monty A Silverdale, Gordon Duncan, Amanda Heslegrave, Eliza Chai, Sonia Gandhi, Thomas Foltynie
Peripheral and CSF protein quantification in Parkinson's disease and multiple system atrophy-the nucleic acid-linked immuno-sandwich assay
Journal of the American Heart Association
Published
Different Characteristics of Incidental Diffusion-Weighted Imaging-Positive Lesions and Recent Small Subcortical Infarct in Patients With Cerebral Small Vessel Disease
Authors
Zi-Ang Pan, Ming Yao, Zi-Yue Liu, Xing-Qi Pan, Yan-Yan Wang, Cheng-Qian Li, Mei-Jun Shu, Tain-Qi Bao, Si-Han Tang, Ding-Ding Zhang, Li-Xin Zhou, Jun Ni, Joanna M Wardlaw, Fei Han, Yi-Cheng Zhu, CSVD Disability and Outcome Cohort Study Investigators †
Different Characteristics of Incidental Diffusion-Weighted Imaging-Positive Lesions and Recent Small Subcortical Infarct in Patients With Cerebral Small Vessel Disease
Scientific reports
Published
Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation-a controlled study
Authors
Roald Omdal, Ole Bernt Lenning, Grete Jonsson, Jan Terje Kvaløy, Guglielmo Di Molfetta, Kubra Tan, Andrea L Benedet, Nicholas J Ashton, Geir Sverre Braut, Henrik Zetterberg, Tore Grimstad
Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation-a controlled study
Proceedings of the National Academy of Sciences of the United States of America
Published
Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification
Authors
Yuanbing Jiang, Wenyue Zheng, Zengjie Xia, Wan Wa Wong, Lily K W Cheng, Fanny C Ip, Siu Man Choi, Andrew L T Chan, Ching Yu Lam, Ka Shing Ho, Chun Keung Shum, Jacqueline K Y Yuen, Yat Fung Shea, Hok Man Wai, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, Hiu Yi Wong, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip
Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Patient and public involvement and engagement in clinical trials at scale: Analysis of the first 3250 responses on the POrtal for Patient and Public Engagement in Dementia (POPPED)
Authors
Hongyi Qin, Linda Pointon, James Carpenter, Vanessa Raymont, Ross Dunne, Suzanne Reeves, Shabinah Ali, Sabahat Iqbal, Cristina Bonet-Olivares, Joanne Whittle, Laura Rizzo, Paresh Malhotra, Benjamin R Underwood, AD‐SMART team
Patient and public involvement and engagement in clinical trials at scale: Analysis of the first 3250 responses on the POrtal for Patient and Public Engagement in Dementia (POPPED)
Brain communications
Published
Increased cerebrospinal fluid YKL-40 concentration in hip fracture patients with delirium
Authors
Thea Berntsen, Kaj Blennow, Henrik Zetterberg, Ingrid Fæhn Brekke, Mathias Nikolai Petersen Hella, Tom Tarjei Lian, Lene B Solberg, Christian Thomas Pollmann, Adi Karabeg, Olav Tobias Ødegaard, Marius Myrstad, Kristian Sydnes, Roy Bjørkholt Olsen, Torgeir Bruun Wyller, Leiv Otto Watne, Bjørn Erik Neerland
Increased cerebrospinal fluid YKL-40 concentration in hip fracture patients with delirium
Brain communications
Published
Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers
Authors
Oriol Perera-Cruz, Cristina Solé-Padullés, Lídia Mulet-Pons, María Cabello-Toscano, Rachel M Morse, Kilian Abellaneda-Pérez, Rubén Perellón-Alfonso, Gabriele Cattaneo, Javier Solana-Sánchez, Vanessa Alviarez-Schulze, Nuria Bargalló, Juan Fortea, Josep M Tormos, Alvaro Pascual-Leone, Henrik Zetterberg, Lídia Vaqué-Alcázar, David Bartrés-Faz
Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers