Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Discovery immunology
Published
<em>E. coli</em> O157:H7 evades CD8<sup>+</sup> T cell immunity through T3SS-dependent suppression and limited MHCI presentation of translocated proteins
Authors
Amany Hassan, Annalisa Nicastri, Deepali Vasoya, Joana Alves, Morten Nielsen, David L Gally, Nicola Ternette, Alexander Corbishley, Timothy K Connelley
<em>E. coli</em> O157:H7 evades CD8<sup>+</sup> T cell immunity through T3SS-dependent suppression and limited MHCI presentation of translocated proteins
Brain communications
Published
A cognitive architecture for Long COVID: the interplay of brain fog, fatigue, attention and memory
Authors
Darragh Higgins, Sijia Zhao, Masud Husain, Peter Denno, Peter J Hellyer, William Trender, Christina J Atchison, Bethan Davies, Emily Cooper, Joshua Elliott, Matthew Whitaker, Chiara Di Gravio, Marc Chadeau-Hyam, Paul Elliott, Helen Ward, Adam Hampshire
A cognitive architecture for Long COVID: the interplay of brain fog, fatigue, attention and memory
Nature neuroscience
Published
Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons
Authors
Maria Stavrou, Áine Bríd Heffernan, Roderick N Carter, Owen Dando, Zoeb Jiwaji, Karen Burr, Jyoti Nanda, David Villarroel-Campos, Alya Masoud Abdelhafid, Justyna Cholewa-Waclaw, Daniel Soong, David Story, Giampietro Schiavo, Giles E Hardingham, Siddharthan Chandran, Bhuvaneish T Selvaraj
Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons
Frontiers in aging neuroscience
Published
Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis
Authors
Yaping Zhou, Xingqi Pan, Ziyi Xia, Yuhui Sha, Gan Sun, Fei Han, Ming Yao, Lixin Zhou, Liyun Tu, Feng Feng, Joanna M Wardlaw, Yi-Cheng Zhu, Jun Ni
Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis
Developmental cell
Published
Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo
Authors
Anna Martinez-Muriana, Nicola Fattorelli, Leen Wolfs, Lena Jutz, Emanuela Pasciuto, Heidi Denton, Maxim van Hoek, Jessie Premereur, Gaia Zen, Baukje Bijnens, Alma Mohebiany, Tim Meese, Arthi Shanmugavadivu, V Hugh Perry, Bart De Strooper, Renzo Mancuso
Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Clusterin is enriched in plaque-associated astrocytes and localizes to synapses in Alzheimer's disease
Authors
Robert A J Byrne, Aurora Veteleanu, Hannah L Cramp, Olivia G Bacon, Kirsten L Baillie, Matthew Bright, Rebekah S Cooke, Gareth D Fenn, Mariana Flores Castelán, Kok Yung Lee, Wioleta M Zelek, B Paul Morgan, Nikoleta Daskoulidou
Clusterin is enriched in plaque-associated astrocytes and localizes to synapses in Alzheimer's disease
PloS one
Published
Optimised fluorescence-activated nuclei sorting for epigenomic analysis of cortical cell types
Authors
Barry Chioza, Stefania Policicchio, Joe Burrage, Georgina E T Blake, Rosemary A Bamford, Alice Franklin, Darren Soanes, Philippa M Wells, Ann Babtie, Marina Flores Payan, Jonathan P Davies, Anthony Klokkaris, Emma M Walker, Joy N Ismail, Paulina Urbanaviciute, Sarah J Marzi, Eilis Hannon, Jonathan Mill, Emma L Dempster
Optimised fluorescence-activated nuclei sorting for epigenomic analysis of cortical cell types
Aging cell
Published
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality
Authors
Maira Pyrgioti, Ines Mesa Eguiagaray, Paul Redmond, Janie Corley, Mark E Bastin, Maria Valdés Hernández, Tom C Russ, Joanna M Wardlaw, Eilis Hannon, Ian J Deary, Keenan A Walker, Elliot M Tucker-Drob, Simon R Cox, Riccardo E Marioni, Sarah E Harris
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality
Alzheimer's & dementia (Amsterdam, Netherlands)
Published
Screening GGC repeat expansion in the <em>NOTCH2NLC</em> in early-onset dementia: The Longitudinal Study of Early Onset Dementia and Family Members (LEAF) Study
Authors
Seung-Yeon Lee, Takeshi Mizuguchi, Hee Jin Kim, Young-Eun Kim, Cho Hanna, Won-Joo Kim, Gha-Hyun Lee, Ahro Kim, Ji-Yun Park, Eun Joo Chung, Hyemin Jang, Na-Yeon Jung, Sun Min Lee, Sang Won Seo, Seong-Ho Koh, Henrik Zetterberg, Liana G Apostolova, Naomichi Matsumoto, So Young Moon, Eun-Joo Kim, LEAF investigators
Screening GGC repeat expansion in the <em>NOTCH2NLC</em> in early-onset dementia: The Longitudinal Study of Early Onset Dementia and Family Members (LEAF) Study
Nature reviews. Drug discovery
Published
From N-of-1 therapy to health-system implementation
Authors
Haiyan Zhou, Alice E Davidson, Mina Ryten, Ella F Whittle, Catherine Ryan, Nick Lench, Daniel J O'Connor, Carlo Rinaldi, Francesco Muntoni
From N-of-1 therapy to health-system implementation