Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma biomarker progression across the Alzheimer's disease amyloid beta and tau positron emission tomography trajectories

Authors
Rodrigo Cánovas, Christopher J Fowler, Azadeh Feizpour, Vincent Dóre, Pierrick Bourgeat, Ziad S Saad, Gallen Triana-Baltzer, Hartmuth C Kolb, Manu Vandijck, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Jurgen Fripp, Simon Laws, Anthony W Bannon, Kaj Blennow, Henrik Zetterberg, Stephanie Rainey-Smith, Sulantha Mathotaarachchi, Christopher C Rowe, Colin L Masters, James D Doecke, AIBL Research Group
Plasma biomarker progression across the Alzheimer's disease amyloid beta and tau positron emission tomography trajectories
Journal of neurochemistry
Published

N-Truncated Superoxide Dismutase-1 in Cerebrospinal Fluid Is Folded and Active

Authors
Laura Leykam, Karin M E Forsberg, Peter M Andersen, Thomas Brännström, Sophia Weiner, John Rönnholm, Kaj Blennow, Henrik Zetterberg, Stefan L Marklund, Johan Gobom, Per Zetterström
N-Truncated Superoxide Dismutase-1 in Cerebrospinal Fluid Is Folded and Active
JAMA network open
Published

Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries

Authors
Rebecca Halbgebauer, Fernando Gonzalez-Ortiz, Benjamin Mayer, Claudius Berger, Christian Bergmann, Helen Rinderknecht, Eberhard Barth, Lisa Wohlgemuth, Marco Mannes, Markus Otto, Hayrettin Tumani, Borna Relja, Florian Gebhard, Markus Huber-Lang, Henrik Zetterberg, Steffen Halbgebauer, Kaj Blennow
Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Quantitative susceptibility mapping of the brain is associated with inflammatory changes in Alzheimer's disease related areas

Authors
Seyyed Ali Hosseini, Stijn Servaes, Arthur C Macedo, Etienne Aumont, Nesrine Rahmouni, Tevy Chan, Joseph Therriault, Lydia Trudel, Brandon Hall, Yi-Ting Wang, Jaime Fernandez Arias, Gleb Bezgin, Yansheng Zheng, Marina P Gonçalves, Kely Quispialaya Socualaya, Marcel S Woo, Cécile Tissot, Delphine Oliva-Lopez, Jieying Li, Stuart Mitchell, Aurélie Lebrun, Robert Hopewell, Sanjeev Chawla, Vladimir Fonov, Gassan Massarweh, Yasser Iturria Medina, Jean-Paul Soucy, Maxime Montembeault, Paolo Vitali, Kaj Blennow, Thomas K Karikari, Andréa L Benedet, Nicholas J Ashton, Henrik Zetterberg, Tharick A Pascoal, Serge Gauthier, Jesse Klostranec, Hangwei Zhuang, Junghun Cho, D Louis Collins, Yi Wang, David A Rudko, Pedro Rosa-Neto
Quantitative susceptibility mapping of the brain is associated with inflammatory changes in Alzheimer's disease related areas
Molecular neurodegeneration
Published

Targeting tau in Alzheimer's Disease: rationale, approach and challenges

Authors
Aram Aslanyan, Martha S Foiani, Tatiana A Giovannucci, Eric McDade, Karen E Duff, Catherine J Mummery, Michael Schöll, Kristin R Wildsmith, Ross W Paterson
Targeting tau in Alzheimer's Disease: rationale, approach and challenges
Human brain mapping
Published

segcsvd<sub>PVS</sub>: A Convolutional Neural Network-Based Tool for Quantification of Enlarged Perivascular Spaces (PVS) on T<sub>1</sub>-Weighted Images

Authors
Erin Gibson, Joel Ramirez, Lauren Abby Woods, Stephanie Berberian, Julie Ottoy, Christopher J M Scott, Vanessa Yhap, Fuqiang Gao, Roberto Duarte Coello, Maria Valdes Hernandez, Anthony E Lang, Carmela M Tartaglia, Sanjeev Kumar, Malcolm A Binns, Robert Bartha, Sean Symons, Richard H Swartz, Mario Masellis, Navneet Singh, Bradley J MacIntosh, Joanna M Wardlaw, Sandra E Black, ONDRI Investigators, ADNI, CAHHM Investigators, CAIN Investigators, colleagues from the Foundation Leducq Transatlantic Network of Excellence, Andrew S P Lim, Maged Goubran
segcsvd<sub>PVS</sub>: A Convolutional Neural Network-Based Tool for Quantification of Enlarged Perivascular Spaces (PVS) on T<sub>1</sub>-Weighted Images
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF-21), and insulin-like growth factor binding protein 2 (IGFBP-2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum

Authors
Caroline Dallaire-Théroux, Helena L Denis, Rosalie Cottez, Cyntia Tremblay, Amélie Provencher, Josue Valentin-Escalera, Manon Leclerc, Andreanne Loiselle, Marine Tournissac, Olivier Potvin, Sylvie Belleville, Anne Gangloff, Frederic Picard, Henrik Zetterberg, Consortium for the Early Identification of Alzheimer's Disease – Quebec (CIMA‐Q), Frédéric Calon
Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF-21), and insulin-like growth factor binding protein 2 (IGFBP-2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum
Neurology. Genetics
Published

Pilot Study of Fingolimod Treatment in Neuronal Ceroid Lipofuscinosis Type 1

Authors
Martina Messina, Rebecca Whiteley, Chin Gan, Wendy E Heywood, Amanda J Heslegrave, Megan Keating, Sophie Taylor, Emma Footitt, Philippa Mills, Cheryl Hemingway, Paul Gissen, Katy Vecchiato
Pilot Study of Fingolimod Treatment in Neuronal Ceroid Lipofuscinosis Type 1
Cerebral circulation - cognition and behavior
Published

Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease

Authors
Michael S Stringer, Xingfeng Shao, Hedok Lee, Antoine Vallatos, Carmen Arteaga-Reyes, Una Clancy, Francesca Chappell, Cameron Manning, Maria Valdes-Hernandez, Daniela Jaime Garcia, Rosalind Brown, Fergus N Doubal, Helene Benveniste, Michael J Thrippleton, Danny Jj Wang, Joanna M Wardlaw, Mild Stroke Study 3 study group
Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease
Mammalian genome : official journal of the International Mammalian Genome Society
Published

Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities

Authors
Nikoleta Daskoulidou, Jacqui Nimmo, Matthew Bright, Zhizhong Yang, Laura Elisabeth Nicholls, Bryan Paul Morgan, Nikoleta Daskoulidou, Wioleta Milena Zelek
Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities