Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Neurology
Published
Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes
Authors
Eleni Palpatzis, Muge Akinci, Marina Garcia-Prat, Kaj Blennow, Henrik Zetterberg, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Norbert Wild, Juan Domingo Gispert, Marc Suárez-Calvet, Oriol Grau-Rivera, Karine Fauria, Anna Brugulat-Serrat, Gonzalo Sanchez-Benavides, Eider M Arenaza-Urquijo, ALFA study
Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer's disease in clinical and community cohorts
Authors
Jun Wang, Shan Huang, Guoyu Lan, Yu-Jie Lai, Qing-Hua Wang, Yang Chen, Zhong-Song Xiao, Xiao Chen, Xian-Le Bu, Yu-Hui Liu, Fan Zeng, Laihong Zhang, Anqi Li, Yue Cai, Pan Sun, Zhengbo He, Vincent Doré, Jurgen Fripp, Pierrick Bourgeat, Qin Chen, Jin-Tai Yu, Yi Tang, Henrik Zetterberg, Colin L Masters, Tengfei Guo, Yan-Jiang Wang, Translational Biomarker Research of AgIng and Neurodegeneration (TBRAIN)
Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer's disease in clinical and community cohorts
Movement disorders : official journal of the Movement Disorder Society
Published
Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies
Authors
Paul C Donaghy, Jahfer Hasoon, Calum A Hamilton, Joanna Ciafone, Rory Durcan, Nicola Barnett, Kirsty Olsen, Sarah Lawley, Gemma Greenfinch, Michael Firbank, Amanda Heslegrave, Henrik Zetterberg, Louise Allan, John T O'Brien, John-Paul Taylor, Alan J Thomas
Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies
Journal of Alzheimer's disease : JAD
Published
Sex differences on tau, astrocytic, and neurodegenerative plasma biomarkers
Authors
Jacob Labonte, Michael A Sugarman, Erika Pettway, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Thomas K Karikari, Hugo J Aparicio, Brandon Frank, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Lindsay A Farrer, Gyungah R Jun, Katherine W Turk, Andrew E Budson, Maureen K O'Connor, Rhoda Au, Lee E Goldstein, Robert A Stern, Thor D Stein, Ann C McKee, Wei Qiao Qiu, Jesse Mez, Sarah J Banks, Michael L Alosco
Sex differences on tau, astrocytic, and neurodegenerative plasma biomarkers
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Novel blood-based proteomic signatures across multiple neurodegenerative diseases
Authors
Robert Durcan, Amanda Heslegrave, Peter Swann, Julia Goddard, Leonidas Chouliaras, Alexander G Murley, George Savulich, W Richard Bevan-Jones, Owen Swann, Nicholas J Ashton, Kaj Blennow, William McEwan, Henrik Zetterberg, James B Rowe, John T O'Brien, Maura Malpetti
Novel blood-based proteomic signatures across multiple neurodegenerative diseases
Alzheimer's & dementia (Amsterdam, Netherlands)
Published
Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD
Authors
Chinenye C Odo, Joe Strong, Sarah R Lose, Yue Ma, Catherine L Gallagher, Barbara B Bendlin, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nathaniel A Chin, Sanjay Asthana, Sterling C Johnson, Jacqueline Pontes Monteiro, Ozioma C Okonkwo
Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD
Journal of controlled release : official journal of the Controlled Release Society
Published
Biological effects of rapid short pulses of focused ultrasound for drug delivery to the brain
Authors
Sophie V Morse, Sarah Rimer, Grainne Geoghegan, Manaal Shah, Nicholas Chan, Ceren Yalcin, Maria Afonso Mota Cruz Pereira, Lucia Rohfleisch, Neema Nkontchou, Samuel Winiarski, Jamie Ee, Aurna Maitra, Tiffany G Chan, Magdalena Sastre, James J Choi
Biological effects of rapid short pulses of focused ultrasound for drug delivery to the brain
Ticks and tick-borne diseases
Published
Plasma levels of the neuron damage markers brain-derived tau and glial fibrillary acidic protein in Lyme neuroborreliosis: A longitudinal study
Authors
Mathilde Ørbæk, Fernando Gonzalez-Ortiz, Rosa M M Gynthersen, Åse Bengaard Andersen, Kubra Tan, Ulf Andreasson, Kaj Blennow, Helene Mens, Henrik Zetterberg, Anne-Mette Lebech
Plasma levels of the neuron damage markers brain-derived tau and glial fibrillary acidic protein in Lyme neuroborreliosis: A longitudinal study
The Lancet. Neurology
Published
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
Authors
Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford, Alireza Atri, Susan L Mills, Anna M Santacruz, Guoqiao Wang, Charlene Supnet, Tammie L S Benzinger, Brian A Gordon, Laura Ibanez, Gregory Klein, Monika Baudler, Rachelle S Doody, Paul Delmar, Geoffrey A Kerchner, Tobias Bittner, Jakub Wojtowicz, Azad Bonni, Paulo Fontoura, Carsten Hofmann, Luka Kulic, Jason Hassenstab, Andrew J Aschenbrenner, Richard J Perrin, Carlos Cruchaga, Alan E Renton, Chengjie Xiong, Alison A Goate, John C Morris, David M Holtzman, B Joy Snider, Catherine Mummery, William S Brooks, David Wallon, Sarah B Berman, Erik Roberson, Colin L Masters, Douglas R Galasko, Suman Jayadev, Rachel Sanchez-Valle, Jeremie Pariente, Justin Kinsella, Christopher H van Dyck, Serge Gauthier, Ging-Yuek Robin Hsiung, Mario Masellis, Bruno Dubois, Lawrence S Honig, Clifford R Jack, Alisha Daniels, David Aguillón, Ricardo Allegri, Jasmeer Chhatwal, Gregory Day, Nick C Fox, Edward Huey, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Allan I Levey, Johannes Levin, Francisco Lopera, JeeHoon Roh, Pedro Rosa-Neto, Peter R Schofield, Dominantly Inherited Alzheimer's Disease–Trials Unit
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
The journal of prevention of Alzheimer's disease
Published
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Authors
David M Cash, Katy E Morgan, Antoinette O'Connor, Thomas D Veale, Ian B Malone, Teresa Poole, Tammie Ls Benzinger, Brian A Gordon, Laura Ibanez, Yan Li, Jorge J Llibre-Guerra, Eric McDade, Guoqiao Wang, Jasmeer P Chhatwal, Gregory S Day, Edward Huey, Mathias Jucker, Johannes Levin, Yoshiki Niimi, James M Noble, Jee Hoon Roh, Racquel Sánchez-Valle, Peter R Schofield, Randall J Bateman, Chris Frost, Nick C Fox, Dominantly Inherited Alzheimer Network (DIAN)
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Nature communications
Published
Computational memory capacity predicts aging and cognitive decline
Authors
Mite Mijalkov, Ludvig Storm, Blanca Zufiria-Gerbolés, Dániel Veréb, Zhilei Xu, Anna Canal-Garcia, Jiawei Sun, Yu-Wei Chang, Hang Zhao, Emiliano Gómez-Ruiz, Massimiliano Passaretti, Sara Garcia-Ptacek, Miia Kivipelto, Per Svenningsson, Henrik Zetterberg, Heidi Jacobs, Kathy Lüdge, Daniel Brunner, Bernhard Mehlig, Giovanni Volpe, Joana B Pereira
Computational memory capacity predicts aging and cognitive decline
The Clinical neuropsychologist
Published
Associations between the logical memory test story recall metrics and plasma biomarkers for Alzheimer's disease in individuals free of dementia
Authors
Ainara Jauregi-Zinkunegi, Rachael E Wilson, Rebecca E Langhough, Nicholas J Ashton, Kaj Blennow, Sterling C Johnson, Henrik Zetterberg, Davide Bruno, Kimberly D Mueller
Associations between the logical memory test story recall metrics and plasma biomarkers for Alzheimer's disease in individuals free of dementia
Brain, behavior, and immunity
Published
The schizophrenia-associated gene CSMD1 encodes a complement classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mice and humans
Authors
Robert A J Byrne, Jacqui Nimmo, Megan Torvell, Sarah M Carpanini, Nikoleta Daskoulidou, Timothy R Hughes, Lucy V Noble, Aurora Veteleanu, Lewis M Watkins, Wioleta M Zelek, Michael C O'Donovan, B Paul Morgan
The schizophrenia-associated gene CSMD1 encodes a complement classical pathway inhibitor predominantly expressed by astrocytes and at synapses in mice and humans
The lancet. Psychiatry
Published
The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia
Authors
Nobuyuki Nomura, Spyridon Siafis, Johannes Schneider-Thoma, Lasse Brandt, Jinyoung Park, Orestis Efthimiou, Josef Priller, John M Davis, Hiroyoshi Takeuchi, Stefan Leucht
The trajectory of sedative adverse events caused by antipsychotics: a meta-analysis of individual participant data from randomised, placebo-controlled, clinical trials in acute phase schizophrenia