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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Movement disorders : official journal of the Movement Disorder Society
Published

Systematic Review with Meta-Analysis of Biofluid Markers for Huntington's Disease

Authors
Jane S Paulsen, Natalie A Bovin, Jordan D Clemsen, Alexander Weiss, Abigail M Key, Monica L Janz, Alex Pinto, Deven K Burks, Henrik Zetterberg, Kathleen M Shannon
Systematic Review with Meta-Analysis of Biofluid Markers for Huntington's Disease
Neuron
Published

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis

Authors
Bongsoo Park, Alexandra M Nicaise, Dimitrios Tsitsipatis, Liviu Pirvan, Daniel Zucha, Andi Munteanu, Pranathi Prasad, Miguel Larraz Lopez De Novales, Cristian Bulgaru, Rafael Kollyfas, Julia Whitten, Cory M Willis, Luka Culig, Joseph Llewellyn, Rosana-Bristena Ionescu, Magdy Mekdad, Madalena B C Simões-Abade, Grzegorz Krzak, Jinshui Fan, Supriyo De, Matthew O Ellis, Marta Suarez Cubero, Angeliki Spathopoulou, Luca Peruzzotti-Jametti, Tommaso Leonardi, Gabriel Balmus, Frank Edenhofer, Myriam Gorospe, Lukas Valihrach, Irina Mohorianu, Stefano Pluchino, Isabel Beerman
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
EMBO molecular medicine
Published

Glia inflammation and cell death pathways drive disease progression in preclinical and early AD

Authors
Marcel S Woo, Joseph Therriault, Seyyed Ali Hosseini, Yi-Ting Wang, Arthur C Macedo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Cécile Tissot, Jaime Fernandez-Arias, Lydia Trudel, Brandon Hall, Gleb Bezgin, Kely Quispialaya-Socualaya, Marina Goncalves, Tevy Chan, Jenna Stevenson, Yansheng Zheng, Stuart Mitchell, Robert Hopewell, Ilaria Pola, Kubra Tan, Guglielmo Di Molfetta, Firoza Z Lussier, Gassan Massarweh, Paolo Vitali, Jean-Paul Soucy, Serge Gauthier, Nicholas J Ashton, Kaj Blennow, Tharick A Pascoal, Henrik Zetterberg, Andréa L Benedet, Pedro Rosa-Neto
Glia inflammation and cell death pathways drive disease progression in preclinical and early AD
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations

Authors
Corey J Bolton, Omair A Khan, Dandan Liu, Kimberly R Pechman, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations
European heart journal
Published

Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study

Authors
Devendra Meena, Jingxian Huang, Alexander Smith, James Yarmolinsky, Siwei Wu, Fotios Koskeridis, Yi-Hsuan Ko, Marie-Joe Dib, Charalabos Antonatos, Yiannis Vasilopoulos, Xinzhu Yu, Georg W Otto, Dipender Gill, Manuel Mayr, Paul Elliott, Abbas Dehghan, Ioanna Tzoulaki
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study
Movement disorders : official journal of the Movement Disorder Society
Published

RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications

Authors
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha-Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne-Claire Richard, Olivier Quenez, Camilo Toro, Steven J Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M Riboldi
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Proceedings of the National Academy of Sciences of the United States of America
Published

The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation

Authors
Berta Anuncibay Soto, Ying Ma, Mathieu Nollet, Sara Wong, Giulia Miracca, Daniel Rastinejad, Raquel Yustos, Alexei L Vyssotski, Nicholas P Franks, William Wisden
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
Acta pharmaceutica Sinica. B
Published

Artificial intelligence in drug development for delirium and Alzheimer's disease

Authors
Ruixue Ai, Xianglu Xiao, Shenglong Deng, Nan Yang, Xiaodan Xing, Leiv Otto Watne, Geir Selbæk, Yehani Wedatilake, Chenglong Xie, David C Rubinsztein, Jennifer E Palmer, Bjørn Erik Neerland, Hongming Chen, Zhangming Niu, Guang Yang, Evandro Fei Fang
Artificial intelligence in drug development for delirium and Alzheimer's disease
Journal of neurology, neurosurgery, and psychiatry
Published

Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players

Authors
Neil Graham, Karl Zimmerman, Jessica Hain, Erin Rooney, Ying Lee, Martina Del Giovane, Thomas Parker, Mathew Wilson, Maneesh Patel, Elena Veleva, Owen Swann, Amanda J Heslegrave, Lucia M Li, Henrik Zetterberg, Daniel Friedland, Richard Sylvester, David Sharp
Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players
bioRxiv : the preprint server for biology
Published

Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD

Authors
Rachel Coneys, Alexander J Cammack, Remya R Nair, David Thompson, Jonas Mechtersheimer, Mireia Carcolé, Yashica Gupta, Gabriel E Rech, Michael Flower, Niamh O'Brien, Marc-David Ruepp, Sarah Mizielinska, Fiona Ducotterd, Sarah J Tabrizi, Elizabeth M C Fisher, Thomas J Cunningham, Michael Ward, William C Skarnes, Adrian M Isaacs
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD
Nature biomedical engineering
Published

Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue

Authors
Rebecca Andrews, Bin Fu, Christina E Toomey, Jonathan C Breiter, Joanne Lachica, Joseph S Beckwith, Ru Tian, Emma E Brock, Lisa-Maria Needham, Gregory J Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, Yen Goh, Begüm Kurt, Lenart Senicar, Marisa Edmonds, Tim Bartels, Nora Bengoa-Vergniory, Peter J Magill, Zane Jaunmuktane, Oliver J Freeman, Benjamin J M Taylor, John Hardy, Tammaryn Lashley, Mina Ryten, Michele Vendruscolo, Nicholas W Wood, Lucien E Weiss, Sonia Gandhi, Steven F Lee
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Acta neuropathologica
Published

Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study

Authors
Wagner S Brum, Laia Montoliu-Gaya, Gunnar Brinkmalm, Diana Piotrowska, Elena Camporesi, Carsten Jäger, Helena S Isaksson, Sven Martin, Jonas Kindberg, Juan Lantero-Rodriguez, João Pedro Ferrari-Souza, Alexis Moscoso, Andrea L Benedet, Shorena Janelidze, Johan Gobom, Henrik Zetterberg, Oskar Hansson, Eduardo R Zimmer, Nicholas J Ashton, Thomas Arendt, Tammaryn Lashley, Jens T Stieler, Max Holzer, Ole Fröbert, Kaj Blennow
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study