Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Nature neuroscience
Published

Falling asleep follows a predictable bifurcation dynamic

Authors
Junheng Li, Anastasia Ilina, Robert Peach, Tianyu Wei, Edward Rhodes, Valeria Jaramillo, Ines R Violante, Mauricio Barahona, Derk-Jan Dijk, Nir Grossman
Falling asleep follows a predictable bifurcation dynamic
Journal of Alzheimer's disease : JAD
Published

Plasma p-tau<sub>217</sub> correlates strongly with cerebrospinal fluid Aβ<sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men

Authors
Elisabeth Hellquist, Shorena Janelidze, Bodil Weidung, Kristin Franzon, Vilmantas Giedraitis, Martin Ingelsson, Divya Bali, Vilma Velickaite, Henrik Zetterberg, Oskar Hansson, Lena Kilander
Plasma p-tau<sub>217</sub> correlates strongly with cerebrospinal fluid Aβ<sub>42</sub> and increases over a ten-year period in amyloid-positive, non-demented very old men
Alzheimer's research & therapy
Published

CT-derived brain volumes and plasma p-Tau217 for risk stratification of amyloid positivity in early-stage Alzheimer's disease

Authors
Sohyun Yim, Seongbeom Park, Kyoung Yoon Lim, Heekyoung Kang, Daeun Shin, Hyemin Jang, Michael Weiner, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Sung Hoon Kang, Jihwan Yun, Minyoung Chun, Eunjoo Kim, Heejin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo, Kichang Kwak, K-ROAD study
CT-derived brain volumes and plasma p-Tau217 for risk stratification of amyloid positivity in early-stage Alzheimer's disease
ACS central science
Published

Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson's Disease

Authors
Vinod Udayar, Pierre-André Gilormini, Julien Bryois, Alexandra Gehrlein, Xi Chen, Stephanie Sonea, Sha Zhu, Matthew C Deen, Nadia Anastasi, Alan E Murphy, Nathan Skene, Manuela M X Tan, Jon-Anders Tunold, Filip Roudnicky, Wilma D J van de Berg, Lasse Pihlstrøm, David J Vocadlo, Ravi Jagasia
Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson's Disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Contactless longitudinal monitoring in the home characterizes aging and Alzheimer's disease-related night-time behavior and physiology

Authors
Eyal Soreq, Magdalena A Kolanko, CRT group, Kiran K G Ravindran, Ciro Della Monica, Victoria Revell, Sarah Daniels, Anna Joffe, Helen Lai, Mara Golemme, Martina Del Giovane, Chloe Walsh, David Wingfield, Ramin Nilforooshan, Marie-Ange Stefanos, Benjamin Vittrant, Paul de Villèle, Derk-Jan Dijk, David J Sharp
Contactless longitudinal monitoring in the home characterizes aging and Alzheimer's disease-related night-time behavior and physiology
Nature communications
Published

Distinct spatiotemporal patterns of white matter hyperintensity progression

Authors
Jinyong Chung, Gilsoon Park, Wi-Sun Ryu, Dawid Schellingerhout, Hang-Rai Kim, Dong-Seok Gwak, Elizabeth Haddad, Neda Jahanshad, Beom Joon Kim, Keun-Sik Hong, Hyerin Oh, Sang-Wuk Jeong, Joon-Tae Kim, Man Seok Park, Kang-Ho Choi, Kyungbok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Yong-Jin Cho, Byung-Chul Lee, Philip M Bath, Joanna M Wardlaw, Hee-Joon Bae, Hosung Kim, Dong-Eog Kim
Distinct spatiotemporal patterns of white matter hyperintensity progression
International journal of stroke : official journal of the International Stroke Society
Published

Intravenous thrombolysis in patients with acute ischemic stroke and cerebral microbleeds: results from the ENCHANTED trial

Authors
Zien Zhou, Yilun Ge, Sohei Yoshimura, Takako Torii-Yoshimura, Yuki Sakamoto, Xiaoqiu Liu, Cheryl Carcel, Xiaoying Chen, Leibo Liu, Mark Parsons, Grant Mair, Richard Lindley, Joanna Wardlaw, Anderson Craig, Candice Delcourt
Intravenous thrombolysis in patients with acute ischemic stroke and cerebral microbleeds: results from the ENCHANTED trial
Scientific data
Published

The RESILIENT Dataset: Multimodal Monitoring of Ageing-Related Comorbidities and Cognitive Decline

Authors
Nathalia Céspedes Gómez, Yu Chen, Samaneh Kouchaki, Mahan Heydari, Alexandra Cairns, Sergio David Sierra Marín, Alexander Capstick, Jaye Somers, Kirsty Harris, Wilson Wen Bin Goh, Chloe Walsh, Jessica True, Olga Balazikova, Ramin Nilforooshan, Payam Barnaghi
The RESILIENT Dataset: Multimodal Monitoring of Ageing-Related Comorbidities and Cognitive Decline
Intensive care medicine experimental
Published

Hypothermia after Cardiac Arrest in Large Animals (HACA-LA): a randomized controlled experimental study

Authors
Olof Persson, Anna Valerianova, Leos Tejkl, Jan Bělohlávek, Tobias Cronberg, Niklas Nielsen, Attila Frigyesi, Susann Ullén, Wolfgang Weihs, Alexandra-Maria Stommel, Kaj Blennow, Henrik Zetterberg, Sandra Högler, Elisabet Englund, Mikuláš Mlček, Hans Friberg
Hypothermia after Cardiac Arrest in Large Animals (HACA-LA): a randomized controlled experimental study