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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's research & therapy
Published

Prognostic value of plasma biomarkers in early Alzheimer's disease: a longitudinal clinical and neuroimaging study

Authors
Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Fernando Gonzalez-Ortiz, Andréa Lessa Benedet, Kübra Tan, Wiebke Traichel, Ulrich Lindberg, Otto Mølby Henriksen, Henrik Zetterberg, Kaj Blennow, Ian Law, Anja Hviid Simonsen, Kristian Steen Frederiksen, Steen Gregers Hasselbalch
Prognostic value of plasma biomarkers in early Alzheimer's disease: a longitudinal clinical and neuroimaging study
Alzheimer's research & therapy
Published

Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration

Authors
Thomas D Parker, Richard A I Bethlehem, Jakob Seidlitz, Simon R White, Michael C B David, Magdalena A Kolanko, Joshua D Bernstock, Lena Dorfschmidt, Niall Bourke, Anastasia Gailly de Taurines, Jessica A Hain, Martina Del Giovane, Neil S N Graham, Karl A Zimmerman, Ethan J F Losty, Michael Schöll, Meera Srikrishna, Paresh A Malhotra, Maneesh C Patel, Gregory Scott, Aaron F Alexander-Bloch, Edward T Bullmore, David J Sharp, Alzheimer’s Disease Neuroimaging Initiative, Frontotemporal Lobar Degeneration Neuroimaging Initiative, Lifespan Brain Chart Consortium
Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration
Scientific reports
Published

An unsupervised XAI framework for dementia detection with context enrichment

Authors
Devesh Singh, Yusuf Brima, Fedor Levin, Martin Becker, Bjarne Hiller, Andreas Hermann, Irene Villar-Munoz, Lukas Beichert, Alexander Bernhardt, Katharina Buerger, Michaela Butryn, Peter Dechent, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Silka D Freiesleben, Wenzel Glanz, Stefan Hetzer, Daniel Janowitz, Doreen Görß, Ingo Kilimann, Okka Kimmich, Christoph Laske, Johannes Levin, Andrea Lohse, Falk Luesebrink, Matthias Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Johannes Prudlo, Diana Prychynenko, Boris S Rauchmann, Ayda Rostamzadeh, Nina Roy-Kluth, Klaus Scheffler, Anja Schneider, Louise Droste Zu Senden, Björn H Schott, Annika Spottke, Matthis Synofzik, Jens Wiltfang, Frank Jessen, Marc-André Weber, Stefan J Teipel, Martin Dyrba
An unsupervised XAI framework for dementia detection with context enrichment
The Journal of neuroscience : the official journal of the Society for Neuroscience
Published

Astrocytes as Therapeutic Targets in Neurodegenerative Disorders

Authors
Isabel H Salas, Maria Alfonso-Triguero, Blanca Díaz Castro, Nimrod Elazar, Carole Escartin, Camilo Faust Akl, Steven A Hill, Francisco J Quintana, Amaia M Arranz
Astrocytes as Therapeutic Targets in Neurodegenerative Disorders
European journal of neurology
Published

Miglustat in Alzheimer's Disease Associated With Heterozygous NPC1 Mutation: Exploratory Case Series and Preliminary Findings

Authors
Diego Lopergolo, Daniele Gasparini, Silvia Bianchi, Barbara Pucci, Domenico Tripodi, Valerio Leoni, Andrea Chincarini, Stelvio Sestini, Henrik Zetterberg, Nicola De Stefano, Andrea Mignarri
Miglustat in Alzheimer's Disease Associated With Heterozygous NPC1 Mutation: Exploratory Case Series and Preliminary Findings
Journal of neurotrauma
Published

Diffusion Alterations at the Gray Matter/White Matter Boundary in Traumatic Encephalopathy Syndrome

Authors
Tim L T Wiegand, Lara Pankatz, Hector Arciniega, Leonard B Jung, Fatima Tuz-Zahra, Sylvain Bouix, Haley Lubeck, Philine Rojczyk, Luisa S Schuhmacher, Janna Buring, Douglas I Katz, Yorghos Tripodis, Ofer Pasternak, Suheyla Cetin-Karayumak, Yogesh Rathi, Charles H Adler, Ann C McKee, Laura J Balcer, Charles Bernick, Michael J Coleman, Elizabeth A Colasurdo, Alexander P Lin, Elaine R Peskind, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Michael L Alosco, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Inga K Koerte, DIAGNOSE CTE Research Project
Diffusion Alterations at the Gray Matter/White Matter Boundary in Traumatic Encephalopathy Syndrome
Alzheimer's research & therapy
Published

Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes

Authors
Mario Tranfa, Leonard Pieperhoff, Giuseppe Pontillo, Emma S Luckett, Lyduine E Collij, Tiago Gil Oliveira, Niccoló Tesi, Natalia Vilor-Tejedor, André Altmann, Luca Roccatagliata, Matteo Pardini, Henne Holstege, Marcel Reinders, Pierre Payoux, Pablo Martinez-Lage, Craig W Ritchie, Adam Waldman, Joanna M Wardlaw, Juan Domingo Gispert, Gemma Salvadó, Arturo Brunetti, Henk J M M Mutsaerts, Alle Meije Wink, Frederik Barkhof, Luigi Lorenzini
Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes
BMJ open
Published

Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study

Authors
Mathias N P Hella, Nathalie B Halaas, Hogne Soennesyn, Anne K Bergland, Hanne B Hetland, Kaj Blennow, Henrik Zetterberg, Audun O Vik-Mo, Ane-Victoria Idland, Christian T Pollmann, Marius Myrstad, Bjørn E Neerland, Dag Aarsland, Leiv O Watne
Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study
Nature communications
Published

Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome

Authors
Hanna Huber, Javier Arranz, Burak Arslan, Antoine Leuzy, Oscar Kittel, Guglielmo di Molfetta, Bessy Benejam, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Lucía Maure-Blesa, Íñigo Rodríguez-Baz, José Enrique Arriola Infante, Ignacio Illán-Gala, Alexandre Bejanin, Laia Montoliu-Gaya, Alberto Lleó, María Carmona-Iragui, Daniel Alcolea, Kaj Blennow, Henrik Zetterberg, Juan Fortea, Nicholas J Ashton
Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome
Nature communications
Published

Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human

Authors
Steven A Hill, Isabel Bravo-Ferrer, Austėja Čiulkinytė, Noelia Pérez Ramos, Ilaria Rossetti, Chiara Colvin, Paula Beltran-Lobo, Carlos Parra-Pérez, Katie Emelianova, Owen Dando, Beth Geary, Raja S Nirujogi, Dario R Alessi, Do-Young Lee, Youn-Bok Lee, Blanca Díaz Castro
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
Nature neuroscience
Published

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease

Authors
João Pedro Ferrari-Souza, Guilherme Povala, Nesrine Rahmouni, Bruna Bellaver, Pamela C L Ferreira, Marco Antônio De Bastiani, Douglas T Leffa, Firoza Z Lussier, Cristiano S Aguzzoli, Wagner S Brum, Giovanna Carello-Collar, Wyllians V Borelli, Joseph Therriault, Arthur C Macedo, Stijn Servaes, Jenna Stevenson, Ilaria Pola, Serge Gauthier, Diogo O Souza, Lucas Porcello Schilling, Mychael V Lourenco, Gallen Triana-Baltzer, Hartmuth C Kolb, Andréa L Benedet, Nicholas J Ashton, Dana L Tudorascu, Henrik Zetterberg, Kaj Blennow, Sterling C Johnson, Tharick A Pascoal, Pedro Rosa-Neto, Eduardo R Zimmer
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease