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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

European journal of nuclear medicine and molecular imaging
Published

Comparing and combining TSPO-PET tracers in tauopathies

Authors
Harry Crook, Nicolai Franzmeier, Nesrine Rahmouni, Johannes S Gnörich, Tim D Fryer, Young T Hong, Sebastian N Roemer-Cassiano, Carla Palleis, Alexandra Strauss, P Simon Jones, Franklin I Aigbirhio, Robert Hopewell, Boris-Stephan Rauchmann, Gassan Massarweh, Robert Perneczky, Johannes Levin, Günter U Höglinger, James B Rowe, John T O'Brien, Pedro Rosa-Neto, Matthias Brendel, Maura Malpetti
Comparing and combining TSPO-PET tracers in tauopathies
Neurology
Published

Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease

Authors
David López-Martos, Marc Suárez-Calvet, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Anna Brugulat-Serrat, Mahnaz Shekari, Carolina Minguillon, Henrik Zetterberg, Kaj Blennow, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, ALFA study
Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease
Molecular neurodegeneration
Published

Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study

Authors
Mariana I Muñoz-García, Yuetiva Deming, Ferran Lugo-Hernández, Sterling Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Cynthia Carlsson, Ozioma C Okonkwo, David Pérez-Martinez, Alberto Villarejo-Galende, Kaj Blennow, Marc Suárez-Calvet, Henrik Zetterberg, Barbara B Bendlin, Estrella Morenas-Rodríguez
Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study
Schizophrenia research
Published

The infraslow fluctuation of sigma power during sleep in young individuals with schizophrenia

Authors
Maria E Dimitriades, Eve Schumacher, Janani Arudchelvam, Sara Fattinger, Salome Kurth, Fiona Pugin, Flavia Wehrle, Valeria Jaramillo, Carina Volk, Sven Leach, Ashura Buckley, David I Driver, Andjela Markovic, Judith L Rapoport, Leila Tarokh, Reto Huber, Miriam Gerstenberg
The infraslow fluctuation of sigma power during sleep in young individuals with schizophrenia
Nature cell biology
Published

Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome

Authors
Rabia R Khawaja, Ernesto Griego, Kristen Lindenau, Asma Salek, Jessica Gambardella, Aurora Scrivo, Hannah R Monday, Mathieu Bourdenx, Jesús Madero-Pérez, Zohaib N Khan, Bhakti Chavda, Ronald Cutler, Sarah Graff, Simone Sidoli, Gaetano Santulli, Laura Santambrogio, Inmaculada Tasset, Susmita Kaushik, Li Gan, Pablo E Castillo, Ana Maria Cuervo
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome
Molecular neurodegeneration
Published

Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer's disease genetic pathways

Authors
Bjørn-Eivind Kirsebom, Johanna Nilsson, Ellen Vromen, Peter Mikael Arnesen, Atle Bjørnerud, Ann Brinkmalm, Geir Bråthen, Gøril Rolfseng Grøntvedt, Jonas Jarholm, Kaja Nordengen, Lene Pålhaugen, Per Selnes, Nikias Siafarikas, Ragnhild Eide Skogseth, Sandra Tecelão, Knut Waterloo, Panpan You, Henrik Zetterberg, Dag Aarsland, Betty Tijms, Pieter Jelle Visser, Kaj Blennow, Tormod Fladby
Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer's disease genetic pathways
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease

Authors
Eleonora M Vromen, Senne B Lageman, Johan Gobom, Rik van der Kant, Valerija Dobricic, Lars Bertram, Johannes Streffer, Simon Lovestone, Stephanie J B Vos, Mikel Tainta, Yvonne Freund-Levi, Lutz Frölich, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Frans Verhey, Rik Vandenberghe, Jolien Schaeverbeke, Kaj Blennow, Sven J van der Lee, Philip Scheltens, Yolande A L Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Henrik Zetterberg, Pieter Jelle Visser, Betty Tijms
Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease
Movement disorders : official journal of the Movement Disorder Society
Published

Systematic Review with Meta-Analysis of Biofluid Markers for Huntington's Disease

Authors
Jane S Paulsen, Natalie A Bovin, Jordan D Clemsen, Alexander Weiss, Abigail M Key, Monica L Janz, Alex Pinto, Deven K Burks, Henrik Zetterberg, Kathleen M Shannon
Systematic Review with Meta-Analysis of Biofluid Markers for Huntington's Disease
Neuron
Published

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis

Authors
Bongsoo Park, Alexandra M Nicaise, Dimitrios Tsitsipatis, Liviu Pirvan, Daniel Zucha, Andi Munteanu, Pranathi Prasad, Miguel Larraz Lopez De Novales, Cristian Bulgaru, Rafael Kollyfas, Julia Whitten, Cory M Willis, Luka Culig, Joseph Llewellyn, Rosana-Bristena Ionescu, Magdy Mekdad, Madalena B C Simões-Abade, Grzegorz Krzak, Jinshui Fan, Supriyo De, Matthew O Ellis, Marta Suarez Cubero, Angeliki Spathopoulou, Luca Peruzzotti-Jametti, Tommaso Leonardi, Gabriel Balmus, Frank Edenhofer, Myriam Gorospe, Lukas Valihrach, Irina Mohorianu, Stefano Pluchino, Isabel Beerman
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
EMBO molecular medicine
Published

Glia inflammation and cell death pathways drive disease progression in preclinical and early AD

Authors
Marcel S Woo, Joseph Therriault, Seyyed Ali Hosseini, Yi-Ting Wang, Arthur C Macedo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Cécile Tissot, Jaime Fernandez-Arias, Lydia Trudel, Brandon Hall, Gleb Bezgin, Kely Quispialaya-Socualaya, Marina Goncalves, Tevy Chan, Jenna Stevenson, Yansheng Zheng, Stuart Mitchell, Robert Hopewell, Ilaria Pola, Kubra Tan, Guglielmo Di Molfetta, Firoza Z Lussier, Gassan Massarweh, Paolo Vitali, Jean-Paul Soucy, Serge Gauthier, Nicholas J Ashton, Kaj Blennow, Tharick A Pascoal, Henrik Zetterberg, Andréa L Benedet, Pedro Rosa-Neto
Glia inflammation and cell death pathways drive disease progression in preclinical and early AD
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations

Authors
Corey J Bolton, Omair A Khan, Dandan Liu, Kimberly R Pechman, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations