Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
iScience
Published
Deletion of Snap25 disrupts glial remodeling in aging mouse brain
Authors
Auguste Vadisiute, Florina Szabo, Sofia Luchanskaya, Vanessa Drevenakova, Fernando Messore, Albert Ugwudike, Gretchen Greene, Marissa Mueller, Sophie V Morse, Anna Hoerder-Suabedissen, Zoltán Molnár
Deletion of Snap25 disrupts glial remodeling in aging mouse brain
Pituitary
Published
Postoperative changes in circulating brain injury biomarkers in relation to long-term fatigue and cognitive outcomes after surgery for nonfunctioning pituitary adenomas
Authors
Kristin Eyglóardóttir, Thomas Skoglund, Victor Hantelius, Oskar Ragnarsson, David Krabbe, Katharina S Sunnerhagen, Sofie Jakobsson, Henrik Zetterberg, Gudmundur Johannsson, Tobias Hallén
Postoperative changes in circulating brain injury biomarkers in relation to long-term fatigue and cognitive outcomes after surgery for nonfunctioning pituitary adenomas
Brain communications
Published
Blood-based biomarker discovery in motor neuron disease using nucleic acid-linked immuno-sandwich assay
Authors
Hatice Bozkurt, Katy R Reid, Judith Newton, Jessica Gill, Isaac Chau, Chloe Parker, Hatice Kurucu King, Johnny Tam, Dominic Ng, Maria Stavrou, Paul Baxter, Orla Marland, Karen Burr, Amanda Heslegrave, Elena Veleva, Owen J Swann, Henrik Zetterberg, David P J Hunt, Bhuvaneish Thangaraj Selvaraj, Siddharthan Chandran, Suvankar Pal
Blood-based biomarker discovery in motor neuron disease using nucleic acid-linked immuno-sandwich assay
Alzheimer's & dementia. Behavior & socioeconomics of aging
Published
Bridging Research, Policy, and Practice: Advancing Evidence-Informed Approaches for Dementia Care and Prevention: an expert review by the Health Policy Professional Interest Area from ISTAART
Authors
Juliana Souza-Talarico, Maria M Pinzon, Jayalakshmi Viswanathan, Tuan Anh Nguye, Walter D Dawson, Jay Lusk, Crystal Glover, Perlina Desai, Anna Shelander, Lesley E Williamson, Dallas Seitz, Joseph M Costello, Magdalena Pereyra, Yixuan Cheng, Sharon Naismith, Andrea Slachevsky, Lycia Tramujas Vasconcellos Neumann, Preeti Pushpalata Zanwar
Bridging Research, Policy, and Practice: Advancing Evidence-Informed Approaches for Dementia Care and Prevention: an expert review by the Health Policy Professional Interest Area from ISTAART
Cerebrovascular diseases extra
Published
Rates, Risks, and Routes to Reduce Vascular Dementia: A UK-Wide Multicentre Prospective Observational Cohort Study of Cognition after Stroke - Baseline Data and Statistical Analysis Plan (ISRCTN18274006)
Authors
Philip M Bath, Ellen V Backhouse, Rosalind Brown, Lisa J Woodhouse, Lee J Haywood, Fergus N Doubal, Terence J Quinn, Hugh S Markus, Richard J McManus, John T O Apos Brien, Thompson G Robinson, David J Werring, Nikola Sprigg, Adrian R Parry-Jones, Rhian M Touyz, Steven Williams, Yee-Haur Mah, Hedley C Emsley, Joanna M Wardlaw
Rates, Risks, and Routes to Reduce Vascular Dementia: A UK-Wide Multicentre Prospective Observational Cohort Study of Cognition after Stroke - Baseline Data and Statistical Analysis Plan (ISRCTN18274006)
Nature aging
Published
Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts
Authors
Oliver Robinson, Han Xiao, Jan Homann, Vivian Viallon, Pietro Ferrari, Philipp Frank, José M Huerta, Ana Jiménez Zabala, Rudolf Kaaks, Verena A Katzke, Mika Kivimaki, Claudia Langenberg, Chung-Ho E Lau, Lefkos Middleton, N Charlotte Onland-Moret, Salvatore Panico, Anna Prizment, Fulvio Ricceri, María-José Sánchez, Karl Smith-Byrne, W M Monique Verschuren, Roel Vermeulen, Paolo Vineis, Shuo Wang, Nick Wareham, Christina M Lill, Elio Riboli, Marc J Gunter
Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts
Neurobiology of aging
Published
Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals
Authors
David López-Martos, Marc Suárez-Calvet, Gemma Salvadó, Raffaele Cacciaglia, Mahnaz Shekari, Armand González-Escalante, Andrea Horta-Barba, Helena Palma-Gudiel, Marta Milà-Alomà, Anna Brugulat-Serrat, Carolina Minguillon, Matteo Tonietto, Edilio Borroni, Gregory Klein, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, ALFA study
Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals
Nature communications
Published
Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Authors
Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Eric R McGregor, James R Hilser, Ruben Aquino-Martinez, Sandra Harding, Joseph Lawrence Harpt, Katharina R Beck, Hailey Bussan, Jessamine F Kuehn, Yuetiva Deming, Rachel Studer, Sterling C Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Corinne D Engelman, Hooman Allayee, Rozalyn M Anderson, Tyler K Ulland, Fredrik Bäckhed, Barbara B Bendlin, Federico E Rey
Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Analytical chemistry
Published
Profiling Protein Aggregate Size Using Single-Molecule Array Technology
Authors
Dorothea Böken, Yunzhao Wu, Jianli Zhang, Zengjie Xia, Paula Beltran-Lobo, Cara L Croft, Savinu Weerasekera, Amanda Heslegrave, Henrik Zetterberg, Ashvini Keshavan, Jonathan M Schott, Maria Jimenez-Sanchez, David C Duffy, David Klenerman
Profiling Protein Aggregate Size Using Single-Molecule Array Technology
Stem cell reports
Published
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Authors
Galbha Duggal, Xinyu Li, Philippa Pettingill, Tatjana Lalic, Shailesh Kumar Gupta, Christine Flodgaard Høgsbro, Viola Volpato, Caleb Webber, Rory Bowden, Despoina Charou, Kanisa Arunasalam, Marcello Maresca, Ryan Hicks, Satyan Chintawar, M Zameel Cader
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Nature communications
Published
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
Authors
Rebecca Casterton, Aitana Martinez-Cotrina, Jodi Barnard, Eleanor Wycherley, Yanling Hu, Rhys Anderson, Sebastien Janel, Jiin Byun, Olivia Houghton, Daniel A Solomon, Juan Alcalde, Frank Lafont, Marc-David Ruepp, Frank Hirth, Bart Tummers, Yong-Yeon Cho, Gian De Nicola, Sarah Mizielinska, Manolis Fanto
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress