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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain : a journal of neurology
Published
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum
Authors
Jaime Fernández Arias, Wagner S Brum, Gemma Salvadó, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Etienne Aumont, Nesrine Rahmouni, Arthur Macedo, Kely Quispialaya, Seyyed Ali Hosseini, Peter Kunach, Wan Lu Jia, Tevy Chan, Lydia Trudel, Brandon Hall, Yanseng Zheng, Sejal Mohapatra, Sulantha S Mathotaarachchi, Paolo Vitali, Cécile Tissot, Gleb Bezgin, Yasser Iturria-Medina, Nicholas J Ashton, Andréa Lessa Benedet, Thomas K Karikari, Gallen Triana-Baltzer, Jesse Klostranec, Hartmuth C Kolb, Eduardo R Zimmer, Shorena Janelidze, Niklas Mattson-Carlgren, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Tharick Pascoal, Maxime Montembeault, Oskar Hansson, Pedro Rosa-Neto
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum
Journal of neuroinflammation
Published
Characteristics of TSPO expression in marmoset EAE
Authors
Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J Luciano, Joseph Guy, Seung-Kwon Ha, David R Owen, Franklin Aigbirhio, Paul M Matthews, Daniel S Reich, Steven Jacobson
Characteristics of TSPO expression in marmoset EAE
Nature communications
Published
Splicing accuracy varies across human introns, tissues, age and disease
Authors
S García-Ruiz, D Zhang, E K Gustavsson, G Rocamora-Perez, M Grant-Peters, A Fairbrother-Browne, R H Reynolds, J W Brenton, A L Gil-Martínez, Z Chen, D C Rio, J A Botia, S Guelfi, L Collado-Torres, M Ryten
Splicing accuracy varies across human introns, tissues, age and disease
bioRxiv : the preprint server for biology
Published
Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk
Authors
Nagham Khouri-Farah, Emma Wentworth Winchester, Brian M Schilder, Kelsey Robinson, Sarah W Curtis, Nathan G Skene, Elizabeth J Leslie-Clarkson, Justin Cotney
Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk
European psychiatry : the journal of the Association of European Psychiatrists
Published
Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts
Authors
A J Edmondson-Stait, E Davyson, X Shen, M J Adams, G M Khandaker, V E Miron, A M McIntosh, S M Lawrie, A S F Kwong, H C Whalley
Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts
Medicina (Kaunas, Lithuania)
Published
Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels
Authors
Elina Polunosika, Joel Simren, Arta Akmene, Nikita Klimovskis, Kaj Blennow, Daina Pastare, Henrik Zetterberg, Renars Erts, Guntis Karelis
Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels
Cell chemical biology
Published
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
Authors
Shekhar Kedia, Emre Fertan, Yunzhao Wu, Yu P Zhang, Georg Meisl, Jeff Y L Lam, Frances K Wiseman, William A McEwan, Annelies Quaegebeur, Maria Grazia Spillantini, John S H Danial, David Klenerman
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
Clinical epigenetics
Published
Blood-based epigenome-wide association study and prediction of alcohol consumption
Authors
Elena Bernabeu, Aleksandra D Chybowska, Jacob K Kresovich, Matthew Suderman, Daniel L McCartney, Robert F Hillary, Janie Corley, Maria Del C Valdés-Hernández, Susana Muñoz Maniega, Mark E Bastin, Joanna M Wardlaw, Zongli Xu, Dale P Sandler, Archie Campbell, Sarah E Harris, Andrew M McIntosh, Jack A Taylor, Paul Yousefi, Simon R Cox, Kathryn L Evans, Matthew R Robinson, Catalina A Vallejos, Riccardo E Marioni
Blood-based epigenome-wide association study and prediction of alcohol consumption
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Polygenic risk discriminates Lewy body dementia from Alzheimer's disease
Authors
Anna McKeever, Peter Swann, Maura Malpetti, Paul C Donaghy, Alan Thomas, Elijah Mak, Stephen F Carter, Jerry H K Tan, Young T Hong, Tim D Fryer, Amanda Heslegrave, Henrik Zetterberg, Li Su, Leonidas Chouliaras, James B Rowe, John T O'Brien
Polygenic risk discriminates Lewy body dementia from Alzheimer's disease
Scientific reports
Published
Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms
Authors
Marc Dörner, Malte Pfister, Anthony Tyndall, Roland von Känel, Katja Neumann, Frank Schreiber, Philipp Arndt, Erelle Fuchs, Cornelia Garz, Wenzel Glanz, Michaela Butryn, Anna-Charlotte John, Annkatrin Hildebrand, Sebastian Euler, Andreas B Hofmann, Lena Machetanz, Johannes Kirchebner, Pawel Tacik, Alexander Grimm, Robin Jansen, Marc Pawlitzki, Solveig Henneicke, Valentina Perosa, Bendix Labeit, Emrah Düzel, Sven G Meuth, Stefan Vielhaber, Hendrik Mattern, Jose Bernal, Stefanie Schreiber
Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms
Brain communications
Published
Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay
Authors
Yi-Ting Wang, Nicholas J Ashton, Joseph Therriault, Andréa L Benedet, Arthur C Macedo, Ilaria Pola, Etienne Aumont, Guglielmo Di Molfetta, Jaime Fernandez-Arias, Kubra Tan, Nesrine Rahmouni, Stijn Johannes G Servaes, Richard Isaacson, Tevy Chan, Seyyed Ali Hosseini, Cécile Tissot, Sulantha Mathotaarachchi, Jenna Stevenson, Firoza Z Lussier, Tharick A Pascoal, Serge Gauthier, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto
Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay
JAMA network open
Published
Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study
Authors
Julie E Oomens, Veerle van Gils, Stephanie J B Vos, Whitney M Freeze, Nancy N Maserejian, Gioacchino Curiale, Cai Gillis, Mercè Boada, Wiesje M van der Flier, Jakub Hort, Sterling C Johnson, Alberto Lleó, Inez H Ramakers, Karen M Rodrigue, Pascual Sánchez-Juan, Marie Sarazin, Nikolaos Scarmeas, Henrik Zetterberg, Daniel Alcolea, Frederik Barkhof, Kaj Blennow, Michel Bottlaender, Anouk den Braber, Jirí Cerman, Marta Drake-Perez, Juan Fortea, Ron Handels, Silvia Ingala, Julio F Jiménez-Bonilla, Stratos Karavasilis, Julien Lagarde, Nienke Legdeur, Luigi Lorenzini, Marta Marquié, Justine E F Moonen, Pauline Olivieri, Adelina Orellana, Rik Ossenkoppele, Leonardo A Rivera-Rivera, Eloy Rodríguez-Rodriguez, Agustín Ruiz Laza, Charlotte E Teunissen, Betty M Tijms, Giorgos Velonakis, Frans R J Verhey, Pieter Jelle Visser, Willemijn J Jansen, European Prevention of Alzheimer’s Dementia (EPAD) Consortium, Fundació ACE Healthy Brain Initiative (FACEHBI) Study Group, BIOFACE Study Group
Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study