Skip to main content
Search
Main content

Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Practical neurology
Published

Genetic testing in dementia

Authors
Antoinette O'Connor, Natalie S Ryan, Christopher R S Belder, David S Lynch, Nayana Lahiri, Henry Houlden, Jonathan D Rohrer, Nick C Fox, Sean O'Dowd
Genetic testing in dementia
Neurology
Published

Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia

Authors
Luigi Lorenzini, Alessio Maranzano, Silvia Ingala, Lyduine E Collij, Mario Tranfa, Kaj Blennow, Carol Di Perri, Christopher Foley, Nick C Fox, Giovanni B Frisoni, Sven Haller, Pablo Martinez-Lage, Daisy Mollison, John O'Brien, Pierre Payoux, Craig Ritchie, Philip Scheltens, Adam J Schwarz, Carole H Sudre, Betty M Tijms, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Pieter Jelle Visser, Adam Waldman, Robin Wolz, Gael Chételat, Michael Ewers, Alle Meije Wink, Henk Mutsaerts, Juan Domingo Gispert, Joanna M Wardlaw, Frederik Barkhof
Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia
Acta neuropathologica communications
Published

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids

Authors
Astrid T van der Geest, Channa E Jakobs, Tijana Ljubikj, Christiaan F M Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H Rutten, Marthe Kaal, Maria M Zwartkruis, Mireia Carcolé, Ewout J N Groen, Elly M Hol, Onur Basak, Adrian M Isaacs, Henk-Jan Westeneng, Leonard H van den Berg, Jan H Veldink, Domino K Schlegel, R Jeroen Pasterkamp
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids
Wellcome open research
Published

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization

Authors
Sara M Willems, Natasha H J Ng, Juan Fernandez, Rebecca S Fine, Eleanor Wheeler, Jennifer Wessel, Hidetoshi Kitajima, Gaelle Marenne, Xueling Sim, Hanieh Yaghootkar, Shuai Wang, Sai Chen, Yuning Chen, Yii-Der Ida Chen, Niels Grarup, Ruifang Li-Gao, Tibor V Varga, Jennifer L Asimit, Shuang Feng, Rona J Strawbridge, Erica L Kleinbrink, Tarunveer S Ahluwalia, Ping An, Emil V Appel, Dan E Arking, Juha Auvinen, Lawrence F Bielak, Nathan A Bihlmeyer, Jette Bork-Jensen, Jennifer A Brody, Archie Campbell, Audrey Y Chu, Gail Davies, Ayse Demirkan, James S Floyd, Franco Giulianini, Xiuqing Guo, Stefan Gustafsson, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Järvelin, Richard A Jensen, Stavroula Kanoni, Sirkka Keinanen-Kiukaanniemi, Man Li, Yingchang Lu, Jian'an Luan, Alisa K Manning, Jonathan Marten, Karina Meidtner, Dennis O Mook-Kanamori, Taulant Muka, Giorgio Pistis, Bram Prins, Kenneth M Rice, Serena Sanna, Albert Vernon Smith, Jennifer A Smith, Lorraine Southam, Heather M Stringham, Vinicius Tragante, Sander W van der Laan, Helen R Warren, Jie Yao, Andrianos M Yiorkas, Weihua Zhang, Wei Zhao, Mariaelisa Graff, Heather M Highland, Anne E Justice, Eirini Marouli, Carolina Medina-Gomez, Saima Afaq, Wesam A Alhejily, Najaf Amin, Folkert W Asselbergs, Lori L Bonnycastle, Michiel L Bots, Ivan Brandslund, Ji Chen, John Danesh, Renée de Mutsert, Abbas Dehghan, Tapani Ebeling, Paul Elliott, EPIC-Interact Consortium, Aliki-Eleni Farmaki, Jessica D Faul, Paul W Franks, Steve Franks, Andreas Fritsche, Anette P Gjesing, Mark O Goodarzi, Vilmundur Gudnason, Göran Hallmans, Tamara B Harris, Karl-Heinz Herzig, Marie-France Hivert, Torben Jørgensen, Marit E Jørgensen, Pekka Jousilahti, Eero Kajantie, Maria Karaleftheri, Sharon L R Kardia, Leena Kinnunen, Heikki A Koistinen, Pirjo Komulainen, Peter Kovacs, Johanna Kuusisto, Markku Laakso, Leslie A Lange, Lenore J Launer, Aaron Leong, Jaana Lindström, Jocelyn E Manning Fox, Satu Männistö, Nisa M Maruthur, Leena Moilanen, Antonella Mulas, Mike A Nalls, Matthew Neville, James S Pankow, Alison Pattie, Eva R B Petersen, Hannu Puolijoki, Asif Rasheed, Paul Redmond, Frida Renström, Michael Roden, Danish Saleheen, Juha Saltevo, Kai Savonen, Sylvain Sebert, Tea Skaaby, Kerrin S Small, Alena Stančáková, Jakob Stokholm, Konstantin Strauch, E-Shyong Tai, Kent D Taylor, Betina H Thuesen, Anke Tönjes, Emmanouil Tsafantakis, Tiinamaija Tuomi, Jaakko Tuomilehto, Understanding Society Scientific Group, Matti Uusitupa, Marja Vääräsmäki, Ilonca Vaartjes, Magdalena Zoledziewska, Goncalo Abecasis, Beverley Balkau, Hans Bisgaard, Alexandra I Blakemore, Matthias Blüher, Heiner Boeing, Eric Boerwinkle, Klaus Bønnelykke, Erwin P Bottinger, Mark J Caulfield, John C Chambers, Daniel I Chasman, Ching-Yu Cheng, Francis S Collins, Josef Coresh, Francesco Cucca, Gert J de Borst, Ian J Deary, George Dedoussis, Panos Deloukas, Hester M den Ruijter, Josée Dupuis, Michele K Evans, Ele Ferrannini, Oscar H Franco, Harald Grallert, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Joel N Hirschhorn, Arfan Ikram, Erik Ingelsson, Fredrik Karpe, Kay-Tee Kaw, Wieland Kiess, Jaspal S Kooner, Antje Körner, Timo Lakka, Claudia Langenberg, Lars Lind, Cecilia M Lindgren, Allan Linneberg, Leonard Lipovich, Ching-Ti Liu, Jun Liu, Yongmei Liu, Ruth J F Loos, Patrick E MacDonald, Karen L Mohlke, Andrew D Morris, Patricia B Munroe, Alison Murray, Sandosh Padmanabhan, Colin N A Palmer, Gerard Pasterkamp, Oluf Pedersen, Patricia A Peyser, Ozren Polasek, David Porteous, Michael A Province, Bruce M Psaty, Rainer Rauramaa, Paul M Ridker, Olov Rolandsson, Patrik Rorsman, Frits R Rosendaal, Igor Rudan, Veikko Salomaa, Matthias B Schulze, Robert Sladek, Blair H Smith, Timothy D Spector, John M Starr, Michael Stumvoll, Cornelia M van Duijn, Mark Walker, Nick J Wareham, David R Weir, James G Wilson, Tien Yin Wong, Eleftheria Zeggini, Alan B Zonderman, Jerome I Rotter, Andrew P Morris, Michael Boehnke, Jose C Florez, Mark I McCarthy, James B Meigs, Anubha Mahajan, Robert A Scott, Anna L Gloyn, Inês Barroso
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization
medRxiv : the preprint server for health sciences
Published

Gut Microbiome Compositional and Functional Features Associate with Alzheimer's Disease Pathology

Authors
Jea Woo Kang, Lora A Khatib, Margo B Heston, Amanda H Dilmore, Jennifer S Labus, Yuetiva Deming, Leyla Schimmel, Colette Blach, Daniel McDonald, Antonio Gonzalez, MacKenzie Bryant, Karenina Sanders, Ara Schwartz, Tyler K Ulland, Sterling C Johnson, Sanjay Asthana, Cynthia M Carlsson, Nathaniel A Chin, Kaj Blennow, Henrik Zetterberg, Federico E Rey, Alzheimer Gut Microbiome Project Consortium, Rima Kaddurah-Daouk, Rob Knight, Barbara B Bendlin
Gut Microbiome Compositional and Functional Features Associate with Alzheimer's Disease Pathology
Cold Spring Harbor perspectives in biology
Published

Glia in Neurodegenerative Disease

Authors
Gerard Crowley, David Attwell, Hemali Phatnani, Harald Sontheimer, Soyon Hong
Glia in Neurodegenerative Disease
Cell
Published

Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function

Authors
Lauren V C Miller, Guido Papa, Marina Vaysburd, Shi Cheng, Paul W Sweeney, Annabel Smith, Catarina Franco, Taxiarchis Katsinelos, Melissa Huang, Sophie A I Sanford, Jonathan Benn, Jasmine Farnsworth, Katie Higginson, Holly Joyner, William A McEwan, Leo C James
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function
Neurology
Published

Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease

Authors
Hye Joo Son, Jae Seung Kim, Randall J Bateman, Seonok Kim, Jorge J Llibre-Guerra, Gregory S Day, Jasmeer P Chhatwal, Sarah B Berman, Peter R Schofield, Mathias Jucker, Johannes Levin, Jae-Hong Lee, Richard J Perrin, John C Morris, Carlos Cruchaga, Jason Hassenstab, Stephen P Salloway, Jai-Hyuen Lee, Alisha Daniels, Dominantly Inherited Alzheimer Network (DIAN)
Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease
The Journal of biological chemistry
Published

Three classes of propofol binding sites on GABA<sub>A</sub> receptors

Authors
Zi-Wei Chen, Satyanarayana M Chintala, John Bracamontes, Yusuke Sugasawa, Spencer R Pierce, Balazs R Varga, Edward H Smith, Christopher J Edge, Nicholas P Franks, Wayland Wl Cheng, Gustav Akk, Alex S Evers
Three classes of propofol binding sites on GABA<sub>A</sub> receptors
Translational psychiatry
Published

P-tau217 and other blood biomarkers of dementia: variation with time of day

Authors
Ciro Della Monica, Victoria Revell, Giuseppe Atzori, Rhiannon Laban, Simon S Skene, Amanda Heslegrave, Hana Hassanin, Ramin Nilforooshan, Henrik Zetterberg, Derk-Jan Dijk
P-tau217 and other blood biomarkers of dementia: variation with time of day
bioRxiv : the preprint server for biology
Published

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
The Journal of neuroscience : the official journal of the Society for Neuroscience
Published

<em>Atp13a5</em> Marker Reveals Pericyte Specification in The Mouse Central Nervous System

Authors
Xinying Guo, Shangzhou Xia, Tenghuan Ge, Yangtao Lin, Shirley Hu, Haijian Wu, Xiaochun Xie, Bangyan Zhang, Sonia Zhang, Jianxiong Zeng, Jian-Fu Chen, Axel Montagne, Fan Gao, Qingyi Ma, Zhen Zhao
<em>Atp13a5</em> Marker Reveals Pericyte Specification in The Mouse Central Nervous System
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Overview of ADNI MRI

Authors
Clifford R Jack, Arvin Arani, Bret J Borowski, Dave M Cash, Karen Crawford, Sandhitsu R Das, Charles DeCarli, Evan Fletcher, Nick C Fox, Jeffrey L Gunter, Ranjit Ittyerah, Danielle J Harvey, Neda Jahanshad, Pauline Maillard, Ian B Malone, Talia M Nir, Robert I Reid, Denise A Reyes, Christopher G Schwarz, Matthew L Senjem, David L Thomas, Paul M Thompson, Duygu Tosun, Paul A Yushkevich, Chadwick P Ward, Michael W Weiner, Alzheimer's Disease Neuroimaging Initiative
Overview of ADNI MRI