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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Neurobiology of aging
Published

Plasma p-tau181 and amyloid markers in Alzheimer's disease: A comparison between Lumipulse and SIMOA

Authors
Virginia Quaresima, Andrea Pilotto, Chiara Trasciatti, Chiara Tolassi, Marta Parigi, Diego Bertoli, Cristina Mordenti, Alice Galli, Andrea Rizzardi, Salvatore Caratozzolo, Alberto Benussi, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Silvia Giliani, Duilio Brugnoni, Alessandro Padovani
Plasma p-tau181 and amyloid markers in Alzheimer's disease: A comparison between Lumipulse and SIMOA
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study

Authors
Rebecca G Smith, Ehsan Pishva, Morteza Kouhsar, Jennifer Imm, Valerija Dobricic, Peter Johannsen, Michael Wittig, Andre Franke, Rik Vandenberghe, Jolien Schaeverbeke, Yvonne Freund-Levi, Lutz Frölich, Philip Scheltens, Charlotte E Teunissen, Giovanni Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, Sebastiaan Engelborghs, Ellen de Roeck, Pablo Martinez-Lage, Miren Altuna, Mikel Tainta, Alberto Lleó, Isabel Sala, Julius Popp, Gwendoline Peyratout, Laura Winchester, Alejo Nevado-Holgado, Frans Verhey, Magda Tsolaki, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Stephanie J B Vos, Simon Lovestone, Pieter Jelle Visser, Lars Bertram, Katie Lunnon
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF-AD study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Blood-based multivariate methylation risk score for cognitive impairment and dementia

Authors
Jarno Koetsier, Rachel Cavill, Rick Reijnders, Joshua Harvey, Jan Homann, Morteza Kouhsar, Kay Deckers, Sebastian Köhler, Lars M T Eijssen, Daniel L A van den Hove, Ilja Demuth, Sandra Düzel, Alzheimer's Disease Neuroimaging Initiative, Rebecca G Smith, Adam R Smith, Joe Burrage, Emma M Walker, Gemma Shireby, Eilis Hannon, Emma Dempster, Tim Frayling, Jonathan Mill, Valerija Dobricic, Peter Johannsen, Michael Wittig, Andre Franke, Rik Vandenberghe, Jolien Schaeverbeke, Yvonne Freund-Levi, Lutz Frölich, Philip Scheltens, Charlotte E Teunissen, Giovanni Frisoni, Olivier Blin, Jill C Richardson, Régis Bordet, Sebastiaan Engelborghs, Ellen de Roeck, Pablo Martinez-Lage, Mikel Tainta, Alberto Lleó, Isabel Sala, Julius Popp, Gwendoline Peyratout, Frans Verhey, Magda Tsolaki, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Stephanie J B Vos, Simon Lovestone, Pieter-Jelle Visser, Christina M Lill, Lars Bertram, Katie Lunnon, Ehsan Pishva
Blood-based multivariate methylation risk score for cognitive impairment and dementia
Neurology
Published

Sex-Dependent Effects of Cardiometabolic Health and <em>APOE4</em> on Brain Age: A Longitudinal Cohort Study

Authors
Sivaniya Subramaniapillai, Louise S Schindler, Paul Redmond, Mark E Bastin, Joanna M Wardlaw, Maria Valdés Hernández, Susana Muñoz Maniega, Benjamin Aribisala, Lars T Westlye, William Coath, James Groves, David M Cash, Josephine Barnes, Sarah-Naomi James, Carole H Sudre, Frederik Barkhof, Marcus Richards, Janie Corley, Tom C Russ, Simon R Cox, Jonathan M Schott, James H Cole, Ann-Marie G de Lange
Sex-Dependent Effects of Cardiometabolic Health and <em>APOE4</em> on Brain Age: A Longitudinal Cohort Study
Nature communications
Published

Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

Authors
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A M Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E Wanker, Josef Priller, Jakob J Metzger, Alessandro Prigione
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
Neuropathology and applied neurobiology
Published

Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation

Authors
Owen Dando, Robert McGeachan, Jamie McQueen, Paul Baxter, Nathan Rockley, Hannah McAlister, Adharsh Prasad, Xin He, Declan King, Jamie Rose, Phillip B Jones, Jane Tulloch, Siddharthan Chandran, Colin Smith, Giles Hardingham, Tara L Spires-Jones
Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

CT1812 biomarker signature from a meta-analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease

Authors
Britney N Lizama, Claire Williams, Hilary A North, Kiran Pandey, Duc Duong, Valentina Di Caro, Adam P Mecca, Kaj Blennow, Henrik Zetterberg, Allan I Levey, Michael Grundman, Christopher H van Dyck, Anthony O Caggiano, Nicholas T Seyfried, Mary E Hamby
CT1812 biomarker signature from a meta-analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease
Neurology
Published

Influence of Different Diagnostic Criteria on Alzheimer Disease Clinical Research

Authors
Andrei Bieger, Wagner S Brum, Wyllians V Borelli, Joseph Therriault, Marco A De Bastiani, Amanda G Moreira, Andrea L Benedet, João Pedro Ferrari-Souza, Jaderson C Da Costa, Diogo O Souza, Raphael M Castilhos, Artur Francisco Schumacher Schuh, Marcia L Fagundes Chaves, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Tharick A Pascoal, Serge Gauthier, Pedro Rosa-Neto, Lucas P Schilling, Eduardo R Zimmer, Alzheimer's Disease Neuroimaging Initiative
Influence of Different Diagnostic Criteria on Alzheimer Disease Clinical Research
Neuron
Published

Microglia protect against age-associated brain pathologies.

Authors
David A D Munro, Nadine Bestard-Cuche, Conor McQuaid, Audrey Chagnot, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Upasana Maheshwari, Stefan Szymkowiak, Kim Morris, Mehreen Mohammad, Andrea Corsinotti, Barry Bradford, Neil Mabbott, Ross J Lennen, Maurits A Jansen, Clare Pridans, Barry W McColl, Annika Keller, Mathew Blurton-Jones, Axel Montagne, Anna Williams, Josef Priller
Microglia protect against age-associated brain pathologies.
Neurology
Published

Incident Infarcts in Patients With Stroke and Cerebral Small Vessel Disease: Frequency and Relation to Clinical Outcomes

Authors
Una Clancy, Carmen Arteaga-Reyes, Daniela Jaime Garcia, Will Hewins, Rachel Locherty, Maria Del C Valdés Hernández, Stewart J Wiseman, Michael S Stringer, Michael Thrippleton, Francesca M Chappell, Angela C C Jochems, Xiaodi Liu, Yajun Cheng, Junfang Zhang, Salvatore Rudilosso, Agniete Kampaite, Olivia K L Hamilton, Rosalind Brown, Mark E Bastin, Susana Muñoz Maniega, Iona Hamilton, Dominic Job, Fergus N Doubal, Joanna M Wardlaw
Incident Infarcts in Patients With Stroke and Cerebral Small Vessel Disease: Frequency and Relation to Clinical Outcomes