Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Alzheimer's & dementia (Amsterdam, Netherlands)
Published
Perceptions of the use of biomarkers for Alzheimer's disease diagnosis: A systematic review and synthesis of the qualitative literature
Authors
Jemma Hazan, Mitchell Mealing, Emma Mittelman, Sarah Godsell, Sophie Roche, Fabiana Lorencatto, Penny Rapaport, Ashvini Keshavan, Jonathan M Schott, Robert Howard
Perceptions of the use of biomarkers for Alzheimer's disease diagnosis: A systematic review and synthesis of the qualitative literature
Brain pathology (Zurich, Switzerland)
Published
Dysregulated TIE-2 expression is associated with blood-brain barrier leakiness and Alzheimer's disease-related neuropathology
Authors
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Carey Gleason, Barbara B Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C Johnson, Seth Love, J Scott Miners
Dysregulated TIE-2 expression is associated with blood-brain barrier leakiness and Alzheimer's disease-related neuropathology
Neuromolecular medicine
Published
Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research Society
Authors
Fabio Di Domenico, Marzia Perluigi, Antonella Tramutola, Maria Giulia Bacalini, Daniella Balduino Victorino, Isabel Barroeta, Renata Bartesaghi, Angelo Carfi, Maria Carmona-Iragui, Ann D Cohen, Alberto C S Costa, Floriana Costanzo, Mara Dierssen, Lauren Dunn, Marco Emili, Edward J Evans, Clíona Farrell, Lisi Flores-Aguilar, Abi Fukami-Gartner, Sandra Gimenez, Ann-Charlotte Granholm, Thessa Hilgenkamp, Antonella Izzo, Sharon J Krinsky-McHale, Laura Del Hoyo Soriano, Laurent Meijer, Bill Mobley, Ivan P Moskowitz, Dean Nizetic, Jonathan Pierce, Lauren T Ptomey, Angela L Rachubinski, Anne-Sophie Rebillat, Randall Roper, Jonathan D Santoro, Brian G Skotko, Fiorenza Stagni, Andre Strydom, Louis Valay, Shahid Zaman, Bruna Lancia Zampieri, Trisomy 21 Research Society Executive Board, Marie-Claude Potier, Eugenio Barone
Promoting Research Excellence in Down Syndrome: Proceedings of the 5th International Conference of the Trisomy 21 Research Society
Molecular neurodegeneration
Published
Tau extent outperforms tau load as a predictor of neurodegeneration in Alzheimer's disease
Authors
Arthur C Macedo, Lydia Trudel, Seyyed Ali Hosseini, Joseph Therriault, Étienne Aumont, Gleb Bezgin, Nesrine Rahmouni, Jenna Stevenson, Cécile Tissot, Marcel S Woo, Stijn Servaes, Stuart Mitchell, Jaime Fernandez-Arias, Brandon Hall, Tevy Chan, Marina Pereira Gonçalves, Pamela C L Ferreira, João Pedro Ferrari-Souza, Bruna Bellaver, Firoza Z Lussier, Andréa L Benedet, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Dana L Tudorascu, Eduardo R Zimmer, Maxime Montembeault, Jean-Paul Soucy, Jesse Klostranec, Tharick A Pascoal, Paolo Vitali, Pedro Rosa-Neto
Tau extent outperforms tau load as a predictor of neurodegeneration in Alzheimer's disease
Nature neuroscience
Published
Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition
Authors
Edoardo Moretto, Anna Masato, Chiara Panzi, André T Lopes, Skye Stuart, Samantha De La-Rocque, Maria Giuseppa Caso, Ian J White, Samuel S Harris, Marc Aurel Busche, Giampietro Schiavo
Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition
Nature medicine
Published
Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience
Authors
Ashley Lu, Wei-Ting Chen, Maria Dalby, Diego Sainz Garcia, Marisa Vanheusden, Luuk E de Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick Swaab, Dietmar Rudolf Thal, Inge Huitinga, Annemieke Rozemuller, Susan Karijn Rohde, Marc Hulsman, Henne Holstege, Rita Balice-Gordon, Niels Plath, Mark Fiers, Bart De Strooper
Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience
Molecular cell
Published
TRIM21 induces selective autophagy of viruses and bacteria
Authors
Tyler Rhinesmith, Anna Albecka, Marina Vaysburd, Claudia Puri, Jakub Luptak, Jerome Boulanger, Quynh-Mai Nguyen Le, Matthew J Gratian, Kevin O'Connell, Lara Few, Mark Donaldson-Wing, Patrycja Kozik, David C Rubinsztein, Leo C James
TRIM21 induces selective autophagy of viruses and bacteria
European psychiatry : the journal of the Association of European Psychiatrists
Published
Definition of treatment-resistant late-life depression: Conclusions from a European task force Delphi process
Authors
B Pozuelo Moyano, A von Gunten, C Mueller, R Yaman-Deveci, R Howard, R Stewart, A Young, H Costello, S Bulteau, B Calvet, S Bonin-Guillaume, N Hoertel, G H Robert, J Roche, A Lepetit, S Louchart de la Chapelle, L Agüera-Ortiz, J Pla-Vidal, F Bouckaert, O Voshaar, L Fernandes, O Vasiliu, M Dominiak, J Priller, M Preisig, F Triolo, M Belvederi Murri, E Aakhus, S Ranjbar, K Swierkosz-Lenart, V Orgeta, P Vandel
Definition of treatment-resistant late-life depression: Conclusions from a European task force Delphi process
JAMA neurology
Published
Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio
Authors
Alicia Algeciras-Schimnich, Joshua A Bornhorst, Daniel J Figdore, Ramiro Eduardo Rea Reyes, Susan Ashrafzadeh-Kian, Rachel Wilson, Brian J Burkett, Derek R Johnson, Hugo Botha, Stuart J McCarter, Gregory S Day, Jonathan Graff-Radford, Vijay K Ramanan, Clifford R Jack, Sterling C Johnson, Henrik Zetterberg, Ronald C Petersen
Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio