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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

bioRxiv : the preprint server for biology
Published
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease
Authors
Clíona Farrell, Yazead Buhidma, Paige Mumford, Wendy E Heywood, Jenny Hällqvist, Lisi Flores-Aguilar, Elizabeth Andrews, Negin Rahimzadah, Orjona Stella Taso, Eric Doran, Vivek Swarup, Elizabeth Head, Tammaryn Lashley, Kevin Mills, Christina E Toomey, Frances K Wiseman
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease
Annals of clinical and translational neurology
Published
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Authors
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M Brody, Ann Brinkmalm, Simon Sjödin, Adama J Berndt, Marc Carceles-Cordon, EunRan Suh, Vivianna M Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B Lee, Henrik Zetterberg, Alice S Chen-Plotkin
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Nature neuroscience
Published
Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Authors
Ashling Giblin, Alexander J Cammack, Niek Blomberg, Sharifah Anoar, Alla Mikheenko, Mireia Carcolé, Magda L Atilano, Alex Hull, Dunxin Shen, Xiaoya Wei, Rachel Coneys, Lele Zhou, Yassene Mohammed, Damien Olivier-Jimenez, Lian Y Wang, Kerri J Kinghorn, Teresa Niccoli, Alyssa N Coyne, Rik van der Kant, Tammaryn Lashley, Martin Giera, Linda Partridge, Adrian M Isaacs
Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Cell systems
Published
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders
Authors
Yuan Mei, Maya L Gosztyla, Xinzhu Tan, Lara E Dozier, Brent Wilkinson, Justin McKetney, John Lee, Michael Chen, Dorothy Tsai, Hema Kopalle, Marina A Gritsenko, Nicolas Hartel, Nicholas A Graham, Ilse Flores, Stephen K Gilmore-Hall, Shuhao Xu, Charlotte A Marquez, Sophie N Liu, Dylan Fong, Jing Chen, Kate Licon, Derek Hong, Sarah N Wright, Jason F Kreisberg, Alexi Nott, Richard D Smith, Wei-Jun Qian, Danielle L Swaney, Lilia M Iakoucheva, Nevan J Krogan, Gentry N Patrick, Yang Zhou, Guoping Feng, Marcelo P Coba, Gene W Yeo, Trey Ideker
Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders
The Journal of pharmacology and experimental therapeutics
Published
γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice
Authors
Gunnar Nordvall, Ping Yan, Lotta Agholme, Johan Lundkvist, Johan Sandin, Henrik Biverstål, Bengt Winblad, Henrik Zetterberg, Rebecka Klintenberg, Mats Ferm, John R Cirrito, Jin-Moo Lee
γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice
Journal of neurology
Published
Tau levels in platelets isolated from Huntington's disease patients serve as a biomarker of disease severity
Authors
Melanie Alpaugh, Juan Lantero-Rodriguez, Andrea L Benedet, Uriel Manseau, Martine Boutin, Massimo Maiuri, Helena L Denis, Maria Masnata, Shaline V Fazal, Sylvain Chouinard, Pedro Rosa-Neto, Roger A Barker, Kaj Blennow, Henrik Zetterberg, Richard Labib, Francesca Cicchetti
Tau levels in platelets isolated from Huntington's disease patients serve as a biomarker of disease severity
JAMA network open
Published
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
Authors
Seung Ae Kim, Daeun Shin, Hongki Ham, Yeshin Kim, Yuna Gu, Hee Jin Kim, Duk L Na, Henrik Zetterberg, Kaj Blennow, Sang Won Seo, Hyemin Jang, Precision Medicine Platform for Mild Cognitive Impairment Based on Multi-omics, Imaging, Evidence-Based R&BD (PREMIER) Consortium
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease
Authors
Antoine Leuzy, Ariane Bollack, Daniela Pellegrino, Charlotte E Teunissen, Renaud La Joie, Gil D Rabinovici, Nicolai Franzmeier, Keith Johnson, Frederik Barkhof, Leslie M Shaw, Alexander Arkhipenko, Suzanne E Schindler, Lawrence S Honig, Alexis Moscoso Rial, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Oskar Hansson, Gill Farrar
Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease
Neurobiology of disease
Published
2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
Authors
A Peck, A Dadi, Z Yavarow, L N Alfano, D Anderson, M R Arkin, T F Chou, E S D'Ambrosio, J Diaz-Manera, J P Dudley, A G Elder, N Ghoshal, C E Hart, None Hart, None Huryn, A E Johnson, K B Jones, V Kimonis, E Kiskinis, E B Lee, T E Lloyd, M Mapstone, A Martin, H Meyer, T Mozaffar, C U Onyike, G Pfeffer, A Pindon, M Raman, I Richard, D C Rubinsztein, M Schiava, A K Schütz, P S Shen, D R Southworth, A M Staffaroni, M Taralio-Gravovac, C C Weihl, Q Yao, Y Ye, N Peck
2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
The Journal of infectious diseases
Published
Increased cerebrospinal fluid ACE2 fragments as a read-out of brain infection in COVID-19 encephalopathy patients
Authors
Matthew P Lennol, María-Salud García-Ayllón, Carlos Avilés-Granados, Chiara Trasciatti, Chiara Tolassi, Virginia Quaresima, Davide Arici, Viviana Cristillo, Irene Volonghi, Francesca Caprioli, Valeria De Giuli, Sara Mariotto, Sergio Ferrari, Gianluigi Zanusso, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Alessandro Padovani, Andrea Pilotto, Javier Sáez-Valero
Increased cerebrospinal fluid ACE2 fragments as a read-out of brain infection in COVID-19 encephalopathy patients
Brain : a journal of neurology
Published
Post-mortem validation of in vivo TSPO PET as a microglial biomarker
Authors
Sasvi S Wijesinghe, James B Rowe, Hannah D Mason, Kieren S J Allinson, Reuben Thomas, Davi S Vontobel, Tim D Fryer, Young T Hong, Mehtap Bacioglu, Maria Grazia Spillantini, Jelle van den Ameele, John T O'Brien, Sanne Kaalund, Maura Malpetti, Annelies Quaegebeur
Post-mortem validation of in vivo TSPO PET as a microglial biomarker
Neuropathology and applied neurobiology
Published
Enhancing Lateral Resolution Using Two-Colour Direct Stochastic Optical Reconstruction Microscopy to Unravel Synaptic Tau Pathology in Alzheimer's Disease
Authors
Érika Sánchez-Aced, Borja Moya-Llamas, Joaquim Aumatell Escabias, Soraya Torres, Martí Colom-Cadena, Jordi Pegueroles, Cristian de Quintana-Schmidt, Àlex Bayés, Laura Molina-Porcel, Iban Aldecoa, Olivia Belbin, Juan Fortea, Tara Spires-Jones, Sílvia Pujals, Sònia Sirisi, Alberto Lleó
Enhancing Lateral Resolution Using Two-Colour Direct Stochastic Optical Reconstruction Microscopy to Unravel Synaptic Tau Pathology in Alzheimer's Disease