Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Basic Science and Pathogenesis
Authors
Sarah Marzi
Basic Science and Pathogenesis
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Basic Science and Pathogenesis
Authors
Jonathan Vöglein, Natalie S Ryan, Carlos Cruchaga, Priyanka Gorijala, Randall J Bateman, Eric McDade, Katrina L Paumier, Nigel J Cairns, Erin E Franklin, Chengjie Xiong, Mathias Jucker, Tammaryn Lashley, Thomas Arzberger, Jochen Herms, Richard J Perrin, Adrian Danek, Günter Höglinger, John C Morris, Nick C Fox, Johannes Levin
Basic Science and Pathogenesis
Nature communications
Published
On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies
Authors
Kambiz Nanbakhsh, Ahmad Shah Idil, Callum Lamont, Csaba Dücső, Ömer Can Akgun, Domonkos Horváth, Kinga Tóth, Domokos Meszéna, István Ulbert, Federico Mazza, Timothy G Constandinou, Wouter Serdijn, Anne Vanhoestenberghe, Nick Donaldson, Vasiliki Giagka
On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies
Brain communications
Published
Increased cell-free DNA in CSF and serum of hip fracture patients with delirium
Authors
Vibeke Bratseth, Leiv Otto Watne, Bjørn Erik Neerland, Nathalie Bodd Halaas, Christian Thomas Pollmann, Adi Karabeg, Olav Tobias Odegaard, Kristian Sydnes, Henrik Zetterberg, Ingebjørg Seljeflot, Ragnhild Helseth
Increased cell-free DNA in CSF and serum of hip fracture patients with delirium
BMJ neurology open
Published
Climate change and neurological diseases: report from the Hot Brain 2: Climate Change and Brain Health meeting, 2024
Authors
James D Mills, Medine I Gulcebi, Jo Allatt, Action Amos, Jack Atkinson, Jason Berwick, Susan Clayton, Derk-Jan Dijk, Kimberly C Doell, Kristie Ebi, Candace C Fleischer, Shakoor Hajat, Candice Howarth, Oliver Jones, Mark Maslin, Lisa Page, Marina Romanello, Lisa Vanhala, Sanjay M Sisodiya
Climate change and neurological diseases: report from the Hot Brain 2: Climate Change and Brain Health meeting, 2024
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Non-APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities
Authors
Hannah Louise Chandler, Joshua Wheeler, Valentina Escott-Price, Kevin Murphy, Thomas Matthew Lancaster
Non-APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities
Neurobiology of aging
Published
Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers
Authors
Elettra Capogna, Øystein Sørensen, Leiv Otto Watne, James Roe, Marie Strømstad, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study of ageing, Anders Martin Fjell, Didac Vidal-Piñeiro
Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group
Authors
Ted K S Ng, Chinedu Udeh-Momoh, Mei-Ann Lim, Helena Sophia Gleerup, Wayne Leifert, Catherine Ajalo, Nicholas Ashton, Henrik Zetterberg, Robert A Rissman, Charisse N Winston, Sid O' Bryant, Robert Jenkins, Eva Carro, Gorka Orive, Stefano Tamburin, Marcos Olvera-Rojas, Patricio Solis-Urra, Irene Esteban-Cornejo, Gustavo Alves Andrade Dos Santos, Kumar B Rajan, David Koh, Anja Hviid Simonsen, Paul D Slowey, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)
Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group
Molecular neurodegeneration
Published
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
Authors
Amir T Marvian, Tabea Strauss, Qilin Tang, Benjamin J Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S Sutherland, William A McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies
Authors
Lucy L Gibson, Maria C Gonzalez, Nicholas J Ashton, Diego Tovar-Rios, Frédéric Blanc, Andrea Pilotto, Afina Lemstra, Claire Paquet, Clive Ballard, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E‐DLB) Consortium
Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies
Brain communications
Published
The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer's disease
Authors
Raffaele Cacciaglia, Mahnaz Shekari, Gemma Salvadó, Marta Milà-Alomà, Carles Falcon, Gonzalo Sánchez-Benavides, Carolina Minguillón, Karine Fauria, Oriol Grau-Rivera, José Luis Molinuevo, Kaj Blennow, Henrik Zetterberg, Frances-Catherine Quevenco, Marc Suárez-Calvet, Juan Domingo Gispert, ALFA Study
The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer's disease
Alzheimer's research & therapy
Published
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease
Authors
Georgette Argiris, Muge Akinci, Cleofé Peña-Gómez, Eleni Palpatzis, Marina Garcia-Prat, Mahnaz Shekari, Kaj Blennow, Henrik Zetterberg, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nicholas J Ashton, Thomas K Karikari, Ann Brinkmalm-Westman, Juan Lantero-Rodriguez, Karine Fauria, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Eider M Arenaza-Urquijo, For The Alfa Study
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease
Nature neuroscience
Published
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
Authors
Naoto Watamura, Martha S Foiani, Sumi Bez, Mathieu Bourdenx, Alessia Santambrogio, Claire Frodsham, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Saisha Patel, Naoko Kamano, Mika Takahashi, Javier Rueda-Carrasco, Loukia Katsouri, Stephanie Fowler, Emir Turkes, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Afm Saiful Islam, Seico Benner, Toshihiro Endo, Katsuji Kobayashi, Chiho Ishida, Michele Vendruscolo, Masahito Yamada, Karen E Duff, Takaomi C Saido
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds