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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain : a journal of neurology
Published

Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration

Authors
Maura Malpetti, Peter Swann, Kamen A Tsvetanov, Leonidas Chouliaras, Alexandra Strauss, Tanatswa Chikaura, Alexander G Murley, Nicholas J Ashton, Peter Barker, P Simon Jones, Tim D Fryer, Young T Hong, Thomas E Cope, George Savulich, Duncan Street, W Richard Bevan-Jones, Timothy Rittman, Kaj Blennow, Henrik Zetterberg, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration
Multiple sclerosis and related disorders
Published

Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis

Authors
Andreja Emeršič, Thomas K Karikari, Przemysław R Kac, Fernando Gonzalez-Ortiz, Maciej Dulewicz, Nicholas J Ashton, Gregor Brecl Jakob, Alenka Horvat Ledinek, Jörg Hanrieder, Henrik Zetterberg, Uroš Rot, Saša Čučnik, Kaj Blennow
Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis
medRxiv : the preprint server for health sciences
Published

15 Years of Longitudinal Genetic, Clinical, Cognitive, Imaging, and Biochemical Measures in DIAN

Authors
Alisha J Daniels, Eric McDade, Jorge J Llibre-Guerra, Chengjie Xiong, Richard J Perrin, Laura Ibanez, Charlene Supnet-Bell, Carlos Cruchaga, Alison Goate, Alan E Renton, Tammie L S Benzinger, Brian A Gordon, Jason Hassenstab, Celeste Karch, Brent Popp, Allan Levey, John Morris, Virginia Buckles, Ricardo F Allegri, Patricio Chrem, Sarah B Berman, Jasmeer P Chhatwal, Martin R Farlow, Nick C Fox, Gregory S Day, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Leonel Takada, Ana Luisa Sosa, Ralph Martins, Hiroshi Mori, James M Noble, Stephen Salloway, Edward Huey, Pedro Rosa-Neto, Raquel Sánchez-Valle, Peter R Schofield, Jee Hoon Roh, Randall J Bateman, Dominantly Inherited Alzheimer Network
15 Years of Longitudinal Genetic, Clinical, Cognitive, Imaging, and Biochemical Measures in DIAN
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults

Authors
Maria Misiura, Chinkuli Munkombwe, Kay Igwe, Danielle D Verble, Kelly D S Likos, Lex Minto, Alexandria Bartlett, Henrik Zetterberg, Jessica A Turner, Vonetta M Dotson, Adam M Brickman, William T Hu, Whitney Wharton
Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults
The Journal of cell biology
Published

The endolysosomal system in conventional and unconventional protein secretion

Authors
Eloïse Néel, Marioara Chiritoiu-Butnaru, William Fargues, Morgane Denus, Maëlle Colladant, Aurore Filaquier, Sarah E Stewart, Sylvain Lehmann, Chiara Zurzolo, David C Rubinsztein, Philippe Marin, Marie-Laure Parmentier, Julien Villeneuve
The endolysosomal system in conventional and unconventional protein secretion
Brain communications
Published

<em>Drosophila</em> appear resistant to trans-synaptic tau propagation

Authors
James H Catterson, Edmond N Mouofo, Inés López De Toledo Soler, Gillian Lean, Stella Dlamini, Phoebe Liddell, Graham Voong, Taxiarchis Katsinelos, Yu-Chun Wang, Nils Schoovaerts, Patrik Verstreken, Tara L Spires-Jones, Claire S Durrant
<em>Drosophila</em> appear resistant to trans-synaptic tau propagation
Science (New York, N.Y.)
Published

PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress

Authors
Karinder K Brar, Daniel T Hughes, Jordan L Morris, Kelly Subramanian, Shivaani Krishna, Fei Gao, Lara-Sophie Rieder, Sebastian Uhrig, Joshua Freeman, Heather L Smith, Rebekkah Jukes-Jones, Edward Avezov, Jodi Nunnari, Julien Prudent, Adrian J Butcher, Giovanna R Mallucci
PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress
medRxiv : the preprint server for health sciences
Published

The CentiMarker Project: Standardizing Quantitative Alzheimer's disease Fluid Biomarkers for Biologic Interpretation

Authors
Guoqiao Wang, Yan Li, Chengjie Xiong, Yuchen Cao, Suzanne E Schindler, Eric McDade, Kaj Blennow, Oskar Hansson, Jeffrey L Dage, Clifford R Jack, Charlotte E Teunissen, Leslie M Shaw, Henrik Zetterberg, Ibanez Laura, Jigyasha Timsina, Cruchaga Carlos, DIAN-TU Study Team, Randall J Bateman
The CentiMarker Project: Standardizing Quantitative Alzheimer's disease Fluid Biomarkers for Biologic Interpretation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Clinical Manifestations

Authors
Emma-Jane Mallas, Michael Cb David, Hanim Karakoc, Chris Ml Tsoi, Paresh A Malhotra, Gregory Scott, David J Sharp
Clinical Manifestations
Science
Published

Tau suppression in a neurodegenerative mouse model improves memory function

Authors
K. SantaCruz*, J. Lewis*, T. Spires*, J. Paulson, L. Kotilinek, M. Ingelsson, A. Guimaraes, M. DeTure, M. Ramsden, E. McGowan, C. Forster, M. Yue, J. Orne, C. Janus, A. Mariash, M. Kuskowski, B. Hyman, M. Hutton, K. H. Ashe
Tau suppression in a neurodegenerative mouse model improves memory function