Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Trials
Published

Digital endpoints in clinical trials: emerging themes from a multi-stakeholder Knowledge Exchange event

Authors
Mia S Tackney, Amber Steele, Joseph Newman, Marie-Christine Fritzsche, Federica Lucivero, Zarnie Khadjesari, Jennifer Lynch, Rosemary A Abbott, Vicki S Barber, James R Carpenter, Bethan Copsey, Elin H Davies, William G Dixon, Lisa Fox, Javier González, Jessica Griffiths, Chloe H L Hinchliffe, Magdalena A Kolanko, Dylan McGagh, Aryelly Rodriguez, George Roussos, Karen B E So, Louise Stanton, Mark Toshner, Frances Varian, Paula R Williamson, Belay B Yimer, Sofía S Villar
Digital endpoints in clinical trials: emerging themes from a multi-stakeholder Knowledge Exchange event
Neuron
Published

Synaptic oligomeric tau in Alzheimer’s disease - A potential culprit in the spread of tau pathology through the brain.

Authors
Martí Colom-Cadena, Caitlin Davies , Sònia Sirisi, Ji-Eun Lee, Elizabeth M. Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kristjan Holt, Robert I. McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H. Horrocks, Alberto Lleó, Tara L. Spires-Jones
Synaptic oligomeric tau in Alzheimer’s disease - A potential culprit in the spread of tau pathology through the brain.
Molecular cell
Published

The V-ATPase/ATG16L1 axis is controlled by the V<sub>1</sub>H subunit

Authors
Lewis Timimi, Antoni G Wrobel, George N Chiduza, Sarah L Maslen, Antonio Torres-Méndez, Beatriz Montaner, Colin Davis, Taylor Minckley, Katriona L Hole, Andrea Serio, Michael J Devine, J Mark Skehel, John L Rubinstein, Anne Schreiber, Rupert Beale
The V-ATPase/ATG16L1 axis is controlled by the V<sub>1</sub>H subunit
The EMBO journal
Published

Author Correction: Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models

Authors
Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hong
Author Correction: Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer's disease

Authors
Marc James Quesnel, Anne Labonté, Cynthia Picard, Daniel C Bowie, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, Sylvia Villeneuve, Judes Poirier, Alzheimer's Disease Neuroimaging Initiative, PREVENT‐AD Research Group
Osteopontin: A novel marker of pre-symptomatic sporadic Alzheimer's disease
Cortex; a journal devoted to the study of the nervous system and behavior
Published

Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study

Authors
Danielle Page, Colin R Buchanan, Joanna E Moodie, Mathew A Harris, Adele Taylor, Maria Valdés Hernández, Susana Muñoz Maniega, Janie Corley, Mark E Bastin, Joanna M Wardlaw, Tom C Russ, Ian J Deary, Simon R Cox
Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study
NPJ Parkinson's disease
Published

Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing

Authors
Pilar Alvarez Jerez, Kensuke Daida, Francis P Grenn, Laksh Malik, Abigail Miano-Burkhardt, Mary B Makarious, Jinhui Ding, J Raphael Gibbs, Anni Moore, Xylena Reed, Mike A Nalls, Syed Shah, Medhat Mahmoud, Fritz J Sedlazeck, Egor Dolzhenko, Morgan Park, Hirotaka Iwaki, Bradford Casey, Mina Ryten, Cornelis Blauwendraat, Andrew B Singleton, Kimberley J Billingsley
Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing
The Lancet. Neurology
Published

Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study

Authors
Leonard H van den Berg, Jeffrey D Rothstein, Pamela J Shaw, Suma Babu, Michael Benatar, Robert C Bucelli, Angela Genge, Jonathan D Glass, Orla Hardiman, Vincenzo Libri, Theodore Mobach, Björn Oskarsson, Gary L Pattee, John Ravits, Christopher E Shaw, Markus Weber, Lorne Zinman, Paymaan Jafar-Nejad, Frank Rigo, Luan Lin, Toby A Ferguson, Anthony L Gotter, Danielle Graham, Michael Monine, Jennifer Inra, Susie Sinks, Satish Eraly, Steve Garafalo, Stephanie Fradette
Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
NPJ Parkinsons Dis
Published

Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing.

Authors
Pilar Alvarez Jerez, Kensuke Daida, Francis P Grenn, Laksh Malik, Abigail Miano-Burkhardt, Mary B Makarious, Jinhui Ding, J Raphael Gibbs, Anni Moore, Xylena Reed, Mike A Nalls, Syed Shah, Medhat Mahmoud, Fritz J Sedlazeck, Egor Dolzhenko, Morgan Park, Hirotaka Iwaki, Bradford Casey, Mina Ryten, Cornelis Blauwendraat, Andrew B Singleton, Kimberley J Billingsley
Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing.
Alzheimer's research & therapy
Published

Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression

Authors
Miriam Rabl, Leonardo Zullo, Piotr Lewczuk, Johannes Kornhuber, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Francesco Bavato, Boris B Quednow, Erich Seifritz, Armin von Gunten, Christopher Clark, Julius Popp
Plasma neurofilament light, glial fibrillary acid protein, and phosphorylated tau 181 as biomarkers for neuropsychiatric symptoms and related clinical disease progression
Nature structural & molecular biology
Published

Poised PABP-RNA hubs implement signal-dependent mRNA decay in development

Authors
Miha Modic, Klara Kuret, Sebastian Steinhauser, Rupert Faraway, Emiel van Genderen, Igor Ruiz de Los Mozos, Jona Novljan, Žiga Vičič, Flora C Y Lee, Derk Ten Berge, Nicholas M Luscombe, Jernej Ule
Poised PABP-RNA hubs implement signal-dependent mRNA decay in development
Stroke
Published

Plasma Brain-Derived Tau in Prognosis of Large Vessel Occlusion Ischemic Stroke

Authors
Ricardo Varela, Fernando Gonzalez-Ortiz, Alexandre Dias, Nicoló Luca Knuth, Joana Fonte, Beatriz Pinto, Idil Yuksekel, Vasco Abreu, Isabel Silva, Liliana Igreja, Joana Lopes, José Silva, Rafael Dias, João Pedro Filipe, Maria João Malaquias, Ana Moutinho, Denis Gabriel, Ana Aires, Rui Antunes, José Pedro Rocha, Rui Felgueiras, Ricardo Almendra, Pedro Castro, Henrik Zetterberg, Rui Magalhães, Thomas K Karikari, Manuel Correia, Kaj Blennow, Luís F Maia
Plasma Brain-Derived Tau in Prognosis of Large Vessel Occlusion Ischemic Stroke
Brain communications
Published

Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET

Authors
Steffi De Meyer, Jolien M Schaeverbeke, Emma S Luckett, Mariska Reinartz, Elena R Blujdea, Isabelle Cleynen, Patrick Dupont, Koen Van Laere, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Guglielmo di Molfetta, Henrik Zetterberg, Nicholas J Ashton, Charlotte E Teunissen, Koen Poesen, Rik Vandenberghe
Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET