Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Nature
Published

Caspase activation precedes and leads to tangles

Authors
Alix de Calignon, Leora M. Fox, Rose Pitstick, George A. Carlson, Brian J. Bacskai, Tara L. Spires-Jones, Bradley T. Hyman
Caspase activation precedes and leads to tangles
Proceedings of the National Academy of Sciences of the United States of America
Published

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

Authors
Robert M. Koffie, Melanie Meyer-Luehmann, Tadafumi Hashimoto, Kenneth W. Adams, Matthew L. Mielke, Monica Garcia-Alloza, Kristina D. Micheva, Stephen J. Smith, M. Leo Kim, Virginia M. Lee, Bradley T. Hyman, Tara L. Spires-Jones
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
Nature Protocols
Published

Studying synapses in human brain with array tomography and electron microscopy

Authors
Kevin R Kay, Colin Smith, Ann K Wright, Alberto Serrano-Pozo, Amy M Pooler, Robert Koffie, Mark E Bastin, Thomas H Bak, Sharon Abrahams, Katherine J Kopeikina, Declan McGuone, Matthew P Frosch, Thomas H Gillingwater, Bradley T Hyman, Tara L Spires-Jones
Studying synapses in human brain with array tomography and electron microscopy
Cell Reports Medicine
Published

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

Authors
Makis Tzioras, Michael J.D. Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay, Balazs Varga, Karla Popovic, Madison Hernandez, Anna J. Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K. Holloway, Jane Tulloch, Jonathan Moss, Clare Latta, Jothy Kandasamy, Drahoslav Sokol, Colin Smith, Veronique E. Miron, Ragnhildur Thóra Káradóttir, Giles E. Hardingham, Christopher M. Henstridge, Paul M. Brennan, Barry W. McColl, Tara L. Spires-Jones
Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8
Cell Reports
Published

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease

Authors
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease
Acta Neuropathologica Communications
Published

Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype

Authors
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype
Brain Communications
Published

Predictive blood biomarkers and brain changes associated with age-related cognitive decline

Authors
Tyler S Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I. McGeachan, Maxwell P Spires-Jones, Sarah E Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J Deary, Simon R Cox, Henrik Zetterberg, Tara L. Spires-Jones
Predictive blood biomarkers and brain changes associated with age-related cognitive decline
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Published

COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects

Authors
Isabella Canavero, Benedetta Storti, Giulia Marinoni, Diana Aguiar De Souza, Elena Moro, Laura Gatti, Simona Sacco, Svetlana Lorenzano, Else C Sandset, Anna Poggesi, Tatiana Carrozzini, Giuliana Pollaci, Antonella Potenza, Gemma Gorla, Joanna M Wardlaw, Maria Luisa Zedde, Anna Bersano
COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects
Frontiers in neuroscience
Published

Methodological challenges of measuring brain volumes and cortical thickness in idiopathic normal pressure hydrocephalus with a surface-based approach

Authors
Martina Del Giovane, Michael C B David, Magdalena A Kolanko, Anastasia Gontsarova, Thomas Parker, Adam Hampshire, David J Sharp, Paresh A Malhotra, Christopher Carswell
Methodological challenges of measuring brain volumes and cortical thickness in idiopathic normal pressure hydrocephalus with a surface-based approach
Curr Biol
Published

A REM-active basal ganglia circuit that regulates anxiety.

Authors
Wei Ba, Mathieu Nollet, Chunyu Yin, Xiao Yu, Sara Wong, Andawei Miao, Esteban J Beckwith, Edward C Harding, Ying Ma, Raquel Yustos, Alexei L Vyssotski, William Wisden, Nicholas P Franks
A REM-active basal ganglia circuit that regulates anxiety.