Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick collection

Authors
Hanna Huber, Valentina Cantoni, Daniele Altomare, Lana Grötschel, Laia Montoliu-Gaya, Francisco Meda, Hlin Kvartsberg, Ilenia Libri, Maria Sofia Cotelli, Henrik Zetterberg, Kaj Blennow, Barbara Borroni, Nicholas J Ashton
The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick collection
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset

Authors
Cassandra M Joynes, Murat Bilgel, Yang An, Abhay R Moghekar, Nicholas J Ashton, Przemysław R Kac, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Madhav Thambisetty, Luigi Ferrucci, Susan M Resnick, Keenan A Walker
Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset
medRxiv : the preprint server for health sciences
Published

Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease

Authors
David M Cash, Katy E Morgan, Antoinette O'Connor, Thomas D Veale, Ian B Malone, Teresa Poole, Tammie Ls Benzinger, Brian A Gordon, Laura Ibanez, Yan Li, Jorge J Llibre-Guerra, Eric McDade, Guoqiao Wang, Jasmeer P Chhatwal, Gregory S Day, Edward Huey, Mathias Jucker, Johannes Levin, Yoshiki Niimi, James M Noble, Jee Hoon Roh, Racquel Sánchez-Valle, Peter R Schofield, Randall J Bateman, Chris Frost, Nick C Fox, Dominantly Inherited Alzheimer Network (DIAN)
Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease
Cell reports
Published

Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes

Authors
Kathryn R Bowles, Chiara Pedicone, Derian A Pugh, Laura-Maria Oja, Filipa H Sousa, Lois K Keavey, Brian Fulton-Howard, Sarah A Weitzman, Yiyuan Liu, Jonathan L Chen, Matthew D Disney, Alison M Goate
Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes
Neurobiology of aging
Published

Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals

Authors
Floor A S de Kort, Elisabeth J Vinke, Ewoud J van der Lelij, Devasuda Anblagan, Mark E Bastin, Alexa Beiser, Henry Brodaty, Nishi Chaturvedi, Bastian Cheng, Simon R Cox, Charles DeCarli, Christian Enzinger, Evan Fletcher, Richard Frayne, Marius de Groot, Felicia Huang, M Arfan Ikram, Jiyang Jiang, Bonnie Y K Lam, Pauline Maillard, Carola Mayer, Cheryl R McCreary, Vincent Mok, Susana Muñoz Maniega, Marvin Petersen, Genady Roshchupkin, Perminder S Sachdev, Reinhold Schmidt, Stephan Seiler, Sudha Seshadri, Carole H Sudre, Götz Thomalla, Raphael Twerenbold, Maria Valdés Hernández, Meike W Vernooij, Joanna M Wardlaw, Wei Wen, Hugo J Kuijf, Geert Jan Biessels, J Matthijs Biesbroek
Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals
Alzheimer's research & therapy
Published

Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans

Authors
Miray Budak, Bernadette A Fausto, Zuzanna Osiecka, Mustafa Sheikh, Robert Perna, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Patricia Fitzgerald-Bocarsly, Mark A Gluck
Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans
British journal of cancer
Published

Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study

Authors
Wing Ching Chan, Lili Liu, Emmanouil Bouras, Verena Zuber, Wanqing Wen, Jirong Long, Dipender Gill, Neil Murphy, Marc J Gunter, Themistocles L Assimes, Luis Bujanda, Stephen B Gruber, Sébastien Küry, Brigid M Lynch, Conghui Qu, Minta Thomas, Emily White, Michael O Woods, Ulrike Peters, Christopher I Li, Andrew T Chan, Hermann Brenner, Konstantinos K Tsilidis, Wei Zheng
Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study
bioRxiv : the preprint server for biology
Published

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

Authors
Anna E Fürtjes, Isabelle F Foote, Charley Xia, Gail Davies, Joanna Moodie, Adele Taylor, David C Liewald, Paul Redmond, Janie Corley, Andrew M McIntosh, Heather C Whalley, Susana Muñoz Maniega, Maria Valdés Hernández, Ellen Backhouse, Karen Ferguson, Mark E Bastin, Joanna Wardlaw, Javier de la Fuente, Andrew D Grotzinger, Michelle Luciano, W David Hill, Ian J Deary, Elliot M Tucker-Drob, Simon R Cox
Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates
The Lancet. Neurology
Published

Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study

Authors
Yihua Ma, Carly M Farris, Sandrina Weber, Sebastian Schade, Hieu Nguyen, Alexandra Pérez-Soriano, Darly M Giraldo, Manel Fernández, Marta Soto, Ana Cámara, Celia Painous, Esteban Muñoz, Francesc Valldeoriola, Maria J Martí, Jordi Clarimon, Pekka Kallunki, Thong Chi Ma, Roy N Alcalay, Bárbara Fernandez Gomes, Kaj Blennow, Henrik Zetterberg, Julius Constantinescu, David Mengel, Vaibhavi Kadam, Piero Parchi, Kathrin Brockmann, Thomas F Tropea, Andrew Siderowf, Matthis Synofzik, Un Jung Kang, Yaroslau Compta, Per Svenningsson, Brit Mollenhauer, Luis Concha-Marambio
Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study
Journal of the neurological sciences
Published

Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders

Authors
Dhamidhu Eratne, Matthew J Y Kang, Courtney Lewis, Christa Dang, Charles Malpas, Suyi Ooi, Amy Brodtmann, David Darby, Henrik Zetterberg, Kaj Blennow, Michael Berk, Olivia Dean, Chad Bousman, Naveen Thomas, Ian Everall, Chris Pantelis, Cassandra Wannan, Claudia Cicognola, Oskar Hansson, Shorena Janelidze, Alexander F Santillo, Dennis Velakoulis, MiND Study Group
Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders
bioRxiv : the preprint server for biology
Published

Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>

Authors
Sneha Desai, Elena Camporesi, Gunnar Brinkmalm, Argyro Alatza, Jack I Wood, Takshashila Tripathi, Sumi Bez, Nazar Stasyuk, Haady B Hajar, Takashi Saito, Takaomi C Saido, John Hardy, Damian M Cummings, Jörg Hanrieder, Frances A Edwards
Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: an improved mouse model of Alzheimer's disease without mutations in <em>MAPT</em>