Skip to main content
Search
Main content

Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein
Authors
Yuliya Patsyuk, Maxime Van Egroo, Elise Beckers, Elouise A Koops, Nicholas J Ashton, Shorena Janelidze, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Benedikt A Poser, Heidi I L Jacobs
Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Increased neuroplastic activity in the pathogenesis of Alzheimer's disease
Authors
Corey J Bolton, Panpan Zhang, Sydney R Wilhoite, Elizabeth E Moore, Michelle L Houston, Kimberly R Pechman, Logan Dumitrescu, Amalia Peterson, Omair A Khan, Dandan Liu, Katherine A Gifford, Kaj Blennow, Timothy J Hohman, Henrik Zetterberg, Angela L Jefferson
Increased neuroplastic activity in the pathogenesis of Alzheimer's disease
Molecular therapy. Methods & clinical development
Published
Intrathalamic delivery of adeno-associated viral vector expressing progranulin as gene therapy for GRN-related frontotemporal dementia
Authors
Youn Bok Lee, Do Young Lee, Zoe Walker, Joseph Allison, Aleksandra Kaliszewska, Alinda Fernandes, Katharine Y Zhang, Yalem Bekele, Paniz Hosseini, Romain Joubert, Joana Furtado, McQuinn Gumus, Olivier Brock, Ali Bienemann, Steven Gill, Samantha Murray, Nadia Mitchell, Page Bouchard, Alex Bloom, John Isaac, Carlos J Miranda, Christopher E Shaw
Intrathalamic delivery of adeno-associated viral vector expressing progranulin as gene therapy for GRN-related frontotemporal dementia
Brain, behavior, & immunity - health
Published
Plasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance
Authors
Martí Llaurador-Coll, Itziar Montalvo, Francesc Estrada, Vanessa Sánchez-Gistau, Henrik Zetterberg, Javier Labad, Andrea L Benedet, Elisabet Vilella
Plasma profiles of neurology-related proteins in at-risk mental state and first-episode psychosis: Associations with psychotic symptoms and cognitive performance
Journal of neurochemistry
Published
Development and Validation of an ICP-MS/MS Method for the Multielemental Analysis of Cerebrospinal Fluid, Examination of Alzheimer's Disease Samples
Authors
Rebeca Pérez-Ramírez, Inmaculada Cuchillo-Ibáñez, Raquel Sánchez-Romero, Ana Beltrán-Sanahuja, Sergio Escamilla, Ricardo Molina-Gasset, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero, José-Luis Todolí-Torró
Development and Validation of an ICP-MS/MS Method for the Multielemental Analysis of Cerebrospinal Fluid, Examination of Alzheimer's Disease Samples
Nature communications
Published
Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies
Authors
Sébastien Küry, Janelle E Stanton, Geeske M van Woerden, Amélie Bosc-Rosati, Tzung-Chien Hsieh, Lise Bray, Marielle Oloudé, Cory Rosenfelt, Marie Pier Scott-Boyer, Victoria Most, Tianyun Wang, Jonas J Papendorf, Charlotte de Konink, Wallid Deb, Virginie Vignard, Maja Studencka-Turski, Thomas Besnard, Anna M Hajdukowicz, Franziska G Thiel, Sophie Wolfgramm, Laëtitia Florenceau, Silvestre Cuinat, Sylvain Marsac, Yann Verrès, Audrey Dangoumau, Léa Poirier, Ingrid M Wentzensen, Annabelle Tuttle, Cara Forster, Johanna Striesow, Richard Golnik, Damara Ortiz, Laura Jenkins, Jill A Rosenfeld, Alban Ziegler, Clara Houdayer, Dominique Bonneau, Erin Torti, Amber Begtrup, Kristin G Monaghan, Sureni V Mullegama, Catharina M L Nienke Volker-Touw, Koen L I van Gassen, Renske Oegema, Mirjam S de Pagter, Katharina Steindl, Anita Rauch, Ivan Ivanovski, Kimberly McDonald, Emily Boothe, Andrew Dauber, Janice Baker, Noelle Andrea V Fabie, Raphael A Bernier, Tychele N Turner, Siddharth Srivastava, Kira A Dies, Lindsay C Swanson, Carrie Costin, Alali Abdulrazak, Rebekah K Jobling, John Pappas, Rachel Rabin, Dmitriy Niyazov, Anne Chun-Hui Tsai, Karen Kovak, David B Beck, May Christine V Malicdan, David R Adams, Lynne Wolfe, Rebecca D Ganetzky, Colleen C Muraresku, Davit Babikyan, Zdeněk Sedláček, Miroslava Hančárová, Andrew T Timberlake, Hind Al Saif, Berkley Nestler, Kayla King, M J Hajianpour, Gregory Costain, D'Arcy Prendergast, Chumei Li, David Geneviève, Antonio Vitobello, Arthur Sorlin, Christophe Philippe, Tamar Harel, Ori Toker, Ataf Sabir, Derek Lim, Mark J Hamilton, Lisa J Bryson, Elaine Cleary, Sacha Weber, Trevor L Hoffman, Anna M Cueto-González, Eduardo F Tizzano, David Gómez-Andrés, Marta Codina-Solà, Athina Ververi, Efterpi Pavlidou, Alexandros Lambropoulos, Kyriakos Garganis, Marlène Rio, Jonathan Levy, Sarah J Langas, Anne M McRae, Mathieu K Lessard, Maria Daniela D'Agostino, Isabelle De Bie, Meret Wegler, Rami Abou Jamra, Susanne B Kamphausen, Viktoria Bothe, Lorraine Potocki, Eric Olinger, Yves Sznajer, Elsa Wiame, Michelle L Thompson, Molly C Schroeder, Catherine Gooch, Raphael A Smith, Arti Pandya, Larissa M Busch, Uwe Völker, Elke Hammer, Kristian Wende, Benjamin Cogné, Bertrand Isidor, Jens Meiler, Clémentine Ripoll, Stéphanie Bigou, Frédéric Laumonnier, Peter W Hildebrand, Evan E Eichler, Kirsty McWalter, Peter M Krawitz, Florence Roux-Dalvai, Ype Elgersma, Julien Marcoux, Marie-Pierre Bousquet, Arnaud Droit, Jeremie Poschmann, Andreas M Grabrucker, Francois V Bolduc, Stéphane Bézieau, Frédéric Ebstein, Elke Krüger
Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies
Nature neuroscience
Published
The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
Authors
Giulia Albertini, Magdalena Zielonka, Marie-Lynn Cuypers, An Snellinx, Ciana Xu, Suresh Poovathingal, Marta Wojno, Kristofer Davie, Veerle van Lieshout, Katleen Craessaerts, Leen Wolfs, Emanuela Pasciuto, Tom Jaspers, Katrien Horré, Lurgarde Serneels, Mark Fiers, Maarten Dewilde, Bart De Strooper
The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
Nature communications
Published
Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain
Authors
Jenny Hällqvist, Christina E Toomey, Rui Pinto, Tomas Baldwin, Ivan Doykov, Anna Wernick, Mesfer Al Shahrani, James R Evans, Joanne Lachica, Simon Pope, Simon Heales, Simon Eaton, Kevin Mills, Sonia Gandhi, Wendy E Heywood
Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain
medRxiv : the preprint server for health sciences
Published
DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation
Authors
Luna Bitar, Mario Díaz, Roberto Duarte Coello, Maria D C Valdés-Hernández, Hendrik Mattern, Katja Neumann, Malte Pfister, Carolin Beck, Huy Trong Mai, Erelle Fuchs, Serena Tang, Duygu Tosun, Bianca Besteher, Tonia Rocktäschel, Philipp A Reuken, Andreas Stallmach, Nils Opel, Christian Gaser, Martin Walter, Marc Dörner, Philipp Arndt, Daniel Behme, Christiane Piechowiak, Yves Lading, Patrick Müller, Rüdiger Braun-Dullaeus, Sven G Meuth, Joanna M Wardlaw, Stefanie Schreiber, Maria Trujillo, Emrah Düzel, Gabriel Ziegler, Jose Bernal
DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation
bioRxiv : the preprint server for biology
Published
Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
Authors
Bernard Mulvey, Heena R Divecha, Madhavi Tippani, Svitlana V Bach, Rahul Bharadwaj, Ishbel Del Rosario, Sarah E Maguire, Ryan A Miller, Aaron J Salisbury, Atharv Chandra, Beau A Oster, Kelsey D Montgomery, Sang Ho Kwon, Haya A Algrain, Alexis R Papariello, Louise A Huuki-Myers, Joel E Kleinman, Leonardo Collado-Torres, Thomas M Hyde, Shizhong Han, Stephanie C Hicks, Daniel R Weinberger, Stephanie C Page, Kristen R Maynard, Keri Martinowich
Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
bioRxiv : the preprint server for biology
Published
A clinical grade neurostimulation implant for hierarchical control of physiological activity
Authors
Moaad Benjaber, Mayela Zamora, Robert Toth, John E Fleming, Kei Landin, Victoria S Marks, Rachel A Crockett, Jae-Wook Ryou, Alceste Deli, Alexander L Green, Rory J Piper, Martin M Tisdall, Derk-Jan Dijk, Nicholas D Schiff, Andrew Sharott, Keith P Purpura, Jonathan L Baker, Joram J van Rheede, Timothy J Denison
A clinical grade neurostimulation implant for hierarchical control of physiological activity
medRxiv : the preprint server for health sciences
Published
Gene-Pseudogene Inversions as a Hidden Source of Missing Heritability
Authors
Ilaria Quartesan, Stefano Facchini, Arianna Manini, Ricardo Parolin Schnekenberg, Chiara Pisciotta, Stefania Magri, Sara Negri, Carlo Gaetano, Adriana Rebelo, Jacquelyn Schatzman Raposo, Radim Mazanec, Riccardo Curro, Natalia Dominik, Stephanie Efthymiou, Matilde Laurà, Tiffany Grider, Shawna Me Feely, Vera Fridman, Alessandro Bertini, Gustavo Maximiano Alves, Lucia Ferullo, Arianna Ghia, Claudio Caccia, Francesca Balistreri, Paola Saveri, Luca Crivellari, Isabella Moroni, Federica Rachele Danti, Tiziana Mongini, Franco Taroni, Michaela Auer-Grumbach, Enrico Bugiardini, James N Sleigh, Arianna Tucci, Henry Houlden, Petra Laššuthová, Pavel Seeman, Anna Basile, Elisa Giorgio, Michael E Shy, Stephan Zuchner, Mary M Reilly, Davide Pareyson, Andrea Cortese
Gene-Pseudogene Inversions as a Hidden Source of Missing Heritability
medRxiv : the preprint server for health sciences
Published
Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics
Authors
Sihao Xiao, Pallavi Kaushik, Gaoyu Du, Bowen Liu, Salman B Hosawi, Benoit Hastoy, M Austin Argentieri, Laura M Winchester, Alejo J Nevado-Holgado, Rima Kaddurah-Daouk, Najaf Amin, Cornelia van Duijn
Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics