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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Aging-related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline, and age at onset in Alzheimer's disease
Authors
Bryan Ng, Eleftheria Kodosaki, Elena Veleva, Ashvini Keshavan, Jonathan M Schott, Amanda J Heslegrave, Nick C Fox, Henrik Zetterberg
Aging-related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline, and age at onset in Alzheimer's disease
Nature
Published
Focal white matter lesions drive grey matter inflammation and synapse loss
Authors
Omar de Faria, Stavros Vagionitis, Andrea Lopez-Lopez, Michael Perry, Joseph Jo Yin Wong, Leslie Rodríguez-Kirby, Bastien Hervé, Balazs Viktor Varga, Eneritz Agirre, Sabrina Ghosh, Sebastian Timmler, Mert Yucel, Andrew T Setley, Kimberley Anne Evans, Tanja Mist Birgisdóttir, Sindri Gíslason, Yan Ting Ng, Courtney Kremler, Helene O B Gautier, Yasmine Kamen, Helena Pivonkova, Katrin Volbracht, Felix Hildebrand, Christian A Cepeda, Javier Rueda-Carrasco, Soyon Hong, George Malliaras, Sabine Dietmann, Gonçalo Castelo-Branco, Ragnhildur Thóra Káradóttir
Focal white matter lesions drive grey matter inflammation and synapse loss
Nature communications
Published
GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy
Authors
Jigyasha Timsina, Chenyang Jiang, Daniel L McCartney, Feifei Tao, Maria Carolina Dalmasso, Jenna Najar, Federica Anastasi, Olena Ohlei, Raquel Puerta Fuentes, Chenyu Yang, Joseph Bradley, Daniel Western, Muhammad Ali, Ciyang Wang, Chengran Yang, Ying Wu, Menghan Liu, John Budde, Julie Williams, Rebecca Mahoney, Atahualpa Castillo Morales, Timothy J Hohman, Logan Dumitrescu, Ting-Chen Wang, Niccolo' Tesi, Silke Kern, Margda Waern, Ingmar Skoog, Argonde van Harten, Yolande A L Pijnenburg, Wiesje M van der Flier, Pascual Sánchez-Juan, Eloy Rodriguez-Rodriguez, Luca Kleineidam, Oliver Peters, Anja Schneider, Fahri Küçükali, Céline Bellenguez, Benjamin Grenier-Boley, Sami Heikkinen, Itziar de Rojas, Dan Rujescu, Norbert Scherbaum, Lucrezia Hausner, Emrah Düzel, Timo Grimmer, Jens Wiltfang, Rik Vandenberghe, Sebastiaan Engelborghs, Stefanie Heilmann-Heimbach, Matthias Schmid, Thomas Tegos, Nikolaos Scarmeas, Oriol Dols-Icardo, Fermin Moreno, Jordi Pérez-Tur, María J Bullido, Raquel Sánchez-Valle, Victoria Álvarez, Pablo García-González, Pablo Mir, Luis M Real, Gerard Piñol-Ripoll, Jose María García-Alberca, Harro Seelaar, Inez Ramakers, Janne Papma, Marc Hulsman, Christoph Laske, Stefan Teipel, Josef Priller, Robert Perneczky, Katharina Buerger, Markus M Nöthen, Piotr Lewczuk, Johannes Kornhuber, Harald Hampel, Ina Giegling, Oliver Goldhardt, Janine Diehl-Schmid, Victor Andrade, Michael Mt Heneka, Lutz Frölich, Jonathan Vogelgsang, Caroline Graff, Hakan Thonberg, Abbe Ullgren, Goran Papenberg, Jean-François Deleuze, Carole Dufouil, Michael Wagner, Frank Jessen, Henne Holstege, Cornelia van Duijn, Thibaud Lebouvier, Olivier Hannon, Ville Leinonen, Hilkka Soininen, Sanna-Kaisa Herukka, Vilmantas Giedraitis, Malin Löwenmark, Lena Kilander, Patricia Genius, Blanca Rodríguez, Emma S Luckett, Arcadi Navarro, Amanda Cano, Marta Marquié, Kaj Blennow, Henrik Zetterberg, Alberto Lleo, Mercè Boada, Agustin Ruiz, Virginia Man-Yee Lee, Vivianna M Van Deerlin, Yuetiva Deming, Sterling C Johnson, Corinne D Engelman, Pau Pastor, Ignacio Alvarez, Elaine R Peskind, Amanda J Heslegrave, Andrew J Saykin, Kwangsik Nho, Suzanne E Schindler, John C Morris, David M Holtzman, Eric McDade, Alan E Renton, Alison Goate, Laura Ibanez, Matthias Riemenschneider, Marilyn S Albert, Simon M Laws, Tenielle Porter, Eleanor K O'Brien, Leslie M Shaw, Betty M Tijms, Martin Ingelsson, Pieter Jelle Visser, Mikko Hiltunen, Kristel Sleegers, Craig W Ritchie, Rebecca Sims, Michael Belloy, Jean-Charles Lambert, Natalia Vilor-Tejedor, Maria Victoria Fernández, Qingqin S Li, Michael W Nagle, Riccardo E Marioni, Alfredo Ramirez, Lars Bertram, Sven J van der Lee, Carlos Cruchaga
GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy
Molecular neurobiology
Published
Blood-Brain Barrier Permeability in Cases of Post-operative Delirium Is Associated with Central Nervous System Phosphatidylcholine Imbalances
Authors
Mijin Jung, Xiaobei Pan, Aoife Sweeney, Anthony P Passmore, Bernadette McGuinness, Daniel F McAuley, David Beverland, Amanda J Heslegrave, Jonathan Schott, Henrik Zetterberg, Emma L Cunningham, Brian D Green
Blood-Brain Barrier Permeability in Cases of Post-operative Delirium Is Associated with Central Nervous System Phosphatidylcholine Imbalances
The Journal of experimental medicine
Published
CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β
Authors
Vignesh Jayaraman, Ian E Prise, Verena Kästele, Sabrina Tamburrano, Kelly Wemyss, Hayley M Bridgeman, Rufus H Daw, Patrick Strangward, Alfie Sanderson, Sheena M Cruickshank, Joanne E Konkel, Christine Chew, Chengcan Yao, C J Anderson, Josef Priller, Barry McColl, David A D Munro, Liesbet Martens, Charlotte L Scott, Martin Guilliams, Antony D Adamson, John R Grainger, Tovah N Shaw
CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Imaging the later-life white matter pathologies of repetitive head impacts: A novel pattern revealed through T2 FLAIR MRI
Authors
Jenna R Groh, Annalise E Miner, Mohamad J Alshikho, Chad Farris, Anna Cui, Erika Pettway, Jacob Labonte, Sydney Mosaheb, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Robert C Cantu, Michael J Coleman, David W Dodick, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind, Christopher Nowinski, Monica Ly, Caroline Altaras, Steven Lenio, Gil D Rabinovici, Breton Asken, Howard Rosen, Yann Cobigo, Jan Krzysztof Blusztajn, Andrew E Budson, Katherine Turk, Wei Qiao Qiu, Lee Goldstein, Brett Martin, Joseph N Palmisano, Diane Dixon, Greta Schneider, Eric G Steinberg, Yi Su, Hillary Protas, Ofer Pasternak, Inga Koerte, Sylvain Bouix, Jeffrey L Cummings, Eric M Reiman, Martha E Shenton, Robert A Stern, Ann C McKee, Thor D Stein, Adam M Brickman, Jesse Mez, Michael L Alosco
Imaging the later-life white matter pathologies of repetitive head impacts: A novel pattern revealed through T2 FLAIR MRI
The journal of prevention of Alzheimer's disease
Published
Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer's disease with hydromethylthionine mesylate using external control data
Authors
Bjoern O Schelter, Helen Shiells, Serena Lo, Nafeesa Nazlee, Emily Evans, Peter Bentham, Serge Gauthier, Henrik Zetterberg, Gordon K Wilcock, Lutz Froelich, Alistair Burns, Emer MacSweeney, Clive Ballard, Jin-Tai Yu, Tay Siew Choon, Vahe Asvatourian, Natalia Muehlemann, Jan Priel, Karin Kook, Tenecia Sullivan, Diane Downie, Sonya Miller, Carol Pringle, John M D Storey, Tom Baddeley, Charles R Harrington, Roger Staff, Anca-Larisa Sandu, Claire Hull, Richard Stefanacci, Claude M Wischik, Alzheimer's Disease Neuroimaging Initiative
Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer's disease with hydromethylthionine mesylate using external control data
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Associations of <sup>18</sup>F-RO-948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum
Authors
Mahnaz Shekari, Armand González Escalante, Marta Milà-Alomà, Carles Falcon, David López-Martos, Gonzalo Sánchez-Benavides, Anna Brugulat-Serrat, Aida Niñerola-Baizán, Nicholas J Ashton, Thomas K Karikari, Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Anniina Snellman, Theresa A Day, Jeffrey L Dage, Paula Ortiz-Romero, Matteo Tonietto, Edilio Borroni, Gregory Klein, Gwendlyn Kollmorgen, Margherita Carboni, Clara Quijano-Rubio, Eugeen Vanmechelen, Carolina Minguillón, Karine Fauria, Andrés Perissinotti, José Luis Molinuevo, Henrik Zetterberg, Kaj Blennow, Oriol Grau-Rivera, Marc Suárez-Calvet, Juan Domingo Gispert, ALFA Study
Associations of <sup>18</sup>F-RO-948 tau PET with fluid AD biomarkers, Centiloid, and cognition in early AD continuum
HIV medicine
Published
Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART
Authors
Merle Henderson, Peter Dutey-Magni, Carolina Herrera, Wolfgang Stöhr, Alejandro Arenas-Pinto, Owen Swann, Amanda Heslegrave, Henrik Zetterberg, John Tregoning, Sarah Fidler, François Raffi, Andrea Calcagno, Ab Babiker, Alan Winston
Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART
Science signaling
Published
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons
Authors
Jose Norberto S Vargas, Anna-Leigh Brown, Kai Sun, Cathleen Hagemann, Bethany Geary, David Villarroel-Campos, Sam Bryce-Smith, Matteo Zanovello, Madeline Lombardo, Stan Majewski, Andrew Tosolini, Maria Secrier, Matthew J Keuss, Andrea Serio, James N Sleigh, Pietro Fratta, Giampietro Schiavo
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons
Nature reviews. Neurology
Published
UK Biobank at 20 - a growing, global resource for dementia research
Authors
Paul M Matthews, Naomi E Allen, Stephanie Debette, Aiden Doherty, Gwenaëlle Douaud, Eugene P Duff, Paul Elliott, Evelynne S Fulda, Anastasia Illina, Quentin Le Grand, Adam J Lewandowski, Rebecca Mahoney, Karla Miller, Cecilia Rodriguez, Martin K Rutter, Cynthia Sandor, Rebecca Sims, Stephen M Smith, Chaoyue Wang
UK Biobank at 20 - a growing, global resource for dementia research