Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Nature reviews. Neurology
Published
The potential of low-field MRI for global dementia care
Authors
Tavia E Evans, Joshua Harper, Aram Salehi, Andrew G Webb, James H Cole, Ana Correa, Hieab H H Adams, David M Cash, Derek K Jones
The potential of low-field MRI for global dementia care
Alzheimer's research & therapy
Published
Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease
Authors
Valentina Di Caro, Eunah Cho, Jill Thiel, Britney N Lizama, Marleen J A Koel-Simmelink, Kiran Pandey, Duc Duong, Nicholas T Seyfried, Michael Grundman, Charlotte E Teunissen, Henrik Zetterberg, Kaj Blennow, Anthony O Caggiano, Mary E Hamby
Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteomic molecular correlates in plasma of participants from a phase 2 clinical trial in Alzheimer's disease
Communications medicine
Published
Author Correction: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans
Authors
Bryan J Neth, Kevin Huynh, Corey Giles, Tingting Wang, Natalie A Mellett, Thy Duong, Colette Blach, Leyla Schimmel, Thomas C Register, Kaj Blennow, Henrik Zetterberg, Richa Batra, Annalise Schweickart, Amanda Hazel Dilmore, Cameron Martino, Matthias Arnold, Jan Krumsiek, Xianlin Han, Pieter C Dorrestein, Rob Knight, Peter J Meikle, Suzanne Craft, Rima Kaddurah-Daouk
Author Correction: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans
The lancet. Healthy longevity
Published
Risk factors for early-onset and late-onset dementia: a prospective cohort study
Authors
Katherine Giorgio, John J Stephen, Maxwell Mansolf, Elizabeth A Peterson, Alden L Gross, Emily M Briceño, Deborah A Levine, Catherine Helmer, Stéphanie Debette, Aïcha Soumaré, M Arfan Ikram, Frank J Wolters, Sudha Seshadri, Claudia L Satizabal, Jayandra Jung Himali, Lenore J Launer, David Li, Djass Mbangdadji, Donald M Lloyd-Jones, Farzaneh A Sorond, Lihui Zhao, Oscar L Lopez, Suzanne E Judd, Timothy M Hughes, Vilmundur Guðnason, Allison E Aiello, Alison Fohner, Archana Singh-Manoux, Behnam Sabayan, James S Pankow, Paul S de Vries, Kristine Yaffe, Alexa Beiser, Abbas Dehghan, Rachel Zmora, Denise Scholtens, Pamela L Lutsey, Norrina B Allen, Richard MacLehose, Sanaz Sedaghat
Risk factors for early-onset and late-onset dementia: a prospective cohort study
International journal of stroke : official journal of the International Stroke Society
Published
Global burden of cerebral small vessel disease determined from large MRI studies - a systematic review and meta-analysis
Authors
Bonnie Yk Lam, Yuan Cai, Huijing Zheng, Jize Wei, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Lh Chen, Marco Duering, Deborah Gustafson, Saima Hilal, Vincent Hui, Raj Kalaria, SangYun Kim, Maggie Li Man Lam, Frank-Erik de Leeuw, Ami Sm Li, Hugh Stephen Markus, Anna Marseglia, John O'brien, Leonardo Pantoni, Perminder S Sachdev, Eric Edward Smith, Joanna Wardlaw, Adrian Wong, Ho Ko, Vincent Ct Mok
Global burden of cerebral small vessel disease determined from large MRI studies - a systematic review and meta-analysis
JAMA network open
Published
Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial
Authors
Noah J Timko, Mary Cooter Wright, Melody R Smith, Piper C Boykin, Jacqueline M Emerson, Marty G Woldorff, Sarada Eleswarpu, J Taylor Herbert, Eugene W Moretti, Michael J Devinney, Chakib M Ayoub, Frank W Rockhold, David Ryu, Ayesha Syed, Keith W VanDusen, Thomas Bunning, Bethany J Hsia, Michael P Bolognesi, William A Jiranek, Henrik Zetterberg, Kaj Blennow, Janet L Huebner, Zhong Li, Tyler H Reekes, Jeffrey N Browndyke, Daniel T Laskowitz, Miles Berger, MARBLE Study Investigators
Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial
EBioMedicine
Published
Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study
Authors
Chenhao Yang, Yongxin Xu, Yichao Du, Xiaonan Shen, Tingting Li, Nan Chen, Yulian Zhu, Lingyan Huang, Jiaojiao Lü, Lu Li, Zhenyu Qian, Zhen Wang, Ulf Ziemann, Nir Grossman, Alvaro Pascual-Leone, Brad Manor, Chencheng Zhang, Junhong Zhou, Yu Liu
Transcranial temporal interference stimulation targeting the subthalamic region for motor symptoms in Parkinson's disease: a pilot, randomised, double-blind, sham-controlled crossover study
Neurology
Published
Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling
Authors
Jake Mitchell, Stuart J McDonald, Meng Law, Terence J O'Brien, Lars T Westlye, Karen Caeyenberghs, Virginia Newcombe, David J Sharp, Abdalla Z Mohamed, Erin D Bigler, Houshang Amiri, Andrei Irimia, Stefania Mondello, Sophia I Thomopoulos, John Darrell Van Horn, David F Tate, Elisabeth A Wilde, Asta K Håberg, Martin M Monti, Rachel Edelstein, Maheen M Adamson, William C Walker, Kristen Dams-O'Connor, Evelyn M Deutscher, Ekaterina Dobryakova, Torgeir Hellstrøm, Emily L Dennis, Paul M Thompson, Frank G Hillary, Alexander Olsen, Jennie L Ponsford, Sandy R Shultz, Gershon Spitz
Characterizing Heterogeneity in Brain Morphology in Traumatic Brain Injury Using Normative Modeling
medRxiv : the preprint server for health sciences
Published
Plasma pTau217 as a Prognostic, Monitoring, and Risk-Stratification Biomarker of Clinical Progression in Lewy Body Disease
Authors
S A Lorkiewicz, C Abdelnour, M Bolen, A M Smith, M Shahid-Besanti, D Hemachandra, E M Müller-Oehring, N Siddiqui, L Montoliu-Gaya, B Arslan, N J Ashton, E N Wilson, L Tian, K I Andreasson, E C Mormino, V W Henderson, H Zetterberg, K L Poston
Plasma pTau217 as a Prognostic, Monitoring, and Risk-Stratification Biomarker of Clinical Progression in Lewy Body Disease
bioRxiv : the preprint server for biology
Published
Non-microglial downregulation of <em>PLCG2</em> impairs synaptic function and elicits Alzheimer disease-related hallmarks
Authors
Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki-Wullich, Nina Lannette-Weimann, Nad'a Majerníková, Arthur Grenon, Vance Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, Pauline Walle, Tiago Mendes, Karine Guyot, Célia Lemeu, Lukas-Iohan Carvalho, Ana Raquel Melo de Farias, Marc Hulsman, Chloé Najdek, Alejandra Freire-Regatillo, Orthis Saha, Philippe Amouyel, Camille Charbonnier, Jean-François Deleuze, Orio Dols-Icardo, Heli Jeskanen, Roosa-Maria Willman, Teemu Kuulasmaa, Mitja Kurki, John Hardy, Sami Heikkinen, Henne Holstege, Petra Mäkinen, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Tuomas Rauramaa, Aarno Palotie, Rebecca Sims, Hilkka Soininen, John van Swieten, Julie Williams, Céline Bellenguez, Carla Gelle, Erwan Lambert, Marcos R Costa, Julia Tcw, Enrico Glaab, Anne-Marie Ayral, Florie Demiautte, Benjamin Grenier-Boley, Manon Muntaner, Delphine Eberlé, Séverine Deforges, Joel Haas, Devrim Kilinc, Christophe Mulle, Julien Chapuis, Mikko Hiltunen, Julie Dumont, Jean-Charles Lambert
Non-microglial downregulation of <em>PLCG2</em> impairs synaptic function and elicits Alzheimer disease-related hallmarks
Nature
Published
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
Authors
Laura Morcom, Wenlong Xia, Zhaoyang Xu, Yashika Awasthi, Celine Geywitz, Matthew O Ellis, Tomas Noli, Amel Zulji, Daniel Yamamoto, Gemma C Girdler, Li Kai, Keying Zhu, Mingming Wei, Xiao-Yan Tang, Kimberly K Hoi, Julio Gonzalez-Maya, Greg J Duncan, Adrien M Vaquie, Diana Gold Diaz, Riki Kawaguchi, Erdong Liu, Yu Sun, Denny Yang, Gregory D Jordan, I-Ling Lu, Staffan Holmqvist, Theresa Bartels, Katherine Ridley, Jennifer Ja-Yoon Choi, Santos J Franco, Eric J Huang, Ben Emery, Daniel Geschwind, Lucas Schirmer, Gabriel Balmus, Brian Popko, Stephen P J Fancy, David H Rowitch
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
BMC biology
Published
Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Authors
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M Chakrabarti, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Neuron
Published
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
Authors
Robert Ellingford, Samuel S Harris, Marten Kehring, Rikesh M Rajani, Francesca Kar Wey Lam, David Graykowski, Dorothea Bӧken, Lindsay A Welikovitch, Anita Khasnavis, Rhiannon Laban, Amanda Heslegrave, Umran Yaman, Anastasie Mate de Gerando, Suraya A Bond, Selina Wray, Dervis A Salih, David Dupret, Raymond J Dolan, David Klenerman, Henrik Zetterberg, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits