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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

BMJ open
Published

Protocol for a double-blind placebo-controlled randomised controlled trial assessing the impact of oral semaglutide in amyloid positivity (ISAP) in community dwelling UK adults

Authors
Ivan Koychev, Amanda I Adler, Paul Edison, Brian Tom, Joanne E Milton, Joe Butchart, Adam Hampshire, Charles Marshall, Elizabeth Coulthard, Henrik Zetterberg, Peter Hellyer, Francesca Cormack, Benjamin R Underwood, Catherine J Mummery, Rury R Holman
Protocol for a double-blind placebo-controlled randomised controlled trial assessing the impact of oral semaglutide in amyloid positivity (ISAP) in community dwelling UK adults
Cerebral cortex (New York, N.Y. : 1991)
Published

Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study

Authors
Elise Beckers, Maxime Van Egroo, Nicholas J Ashton, Kaj Blennow, Gilles Vandewalle, Henrik Zetterberg, Benedikt A Poser, Heidi I L Jacobs
Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study
Biology of sex differences
Published

Sex-specific differences in the mechanisms for enhanced thromboxane A<sub>2</sub>-mediated vasoconstriction in adult offspring exposed to prenatal hypoxia

Authors
Murilo E Graton, Floor Spaans, Rose He, Paulami Chatterjee, Raven Kirschenman, Anita Quon, Tom J Phillips, C Patrick Case, Sandra T Davidge
Sex-specific differences in the mechanisms for enhanced thromboxane A<sub>2</sub>-mediated vasoconstriction in adult offspring exposed to prenatal hypoxia
Neuron
Published

Microglia protect against age-associated brain pathologies

Authors
David A D Munro, Nadine Bestard-Cuche, Conor McQuaid, Audrey Chagnot, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Upasana Maheshwari, Stefan Szymkowiak, Kim Morris, Mehreen Mohammad, Andrea Corsinotti, Barry Bradford, Neil Mabbott, Ross J Lennen, Maurits A Jansen, Clare Pridans, Barry W McColl, Annika Keller, Mathew Blurton-Jones, Axel Montagne, Anna Williams, Josef Priller
Microglia protect against age-associated brain pathologies
bioRxiv : the preprint server for biology
Published

The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma

Authors
Marla E Tharp, Claudia Z Han, Chris D Balak, Conor Fitzpatrick, Carolyn O'Connor, Sebastian Preissl, Justin Buchanan, Alexi Nott, Laure Escoubet, Konstantinos Mavrommatis, Mihir Gupta, Marc S Schwartz, U Hoi Sang, Pamela S Jones, Michael L Levy, David D Gonda, Sharona Ben-Haim, Joseph Ciacci, David Barba, Alexander Khalessi, Nicole G Coufal, Clark C Chen, Christopher K Glass, David C Page
The inactive X chromosome drives sex differences in microglial inflammatory activity in human glioblastoma
bioRxiv : the preprint server for biology
Published

Chemical signatures delineate heterogeneous amyloid plaque populations across the Alzheimer's disease spectrum

Authors
Srinivas Koutarapu, Junyue Ge, Maciej Dulewicz, Meera Srikrishna, Alicja Szadziewska, Jack Wood, Kaj Blennow, Henrik Zetterberg, Wojciech Michno, Natalie S Ryan, Tammaryn Lashley, Jeffrey Savas, Michael Schöll, Jörg Hanrieder
Chemical signatures delineate heterogeneous amyloid plaque populations across the Alzheimer's disease spectrum
Nature
Published

Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Authors
Anna-Leigh Brown, Oscar G Wilkins, Matthew J Keuss, Sarah E Hill, Matteo Zanovello, Weaverly Colleen Lee, Alexander Bampton, Flora C Y Lee, Laura Masino, Yue A Qi, Sam Bryce-Smith, Ariana Gatt, Martina Hallegger, Delphine Fagegaltier, Hemali Phatnani, NYGC ALS Consortium, Jia Newcombe, Emil K Gustavsson, Sahba Seddighi, Joel F Reyes, Steven L Coon, Daniel Ramos, Giampietro Schiavo, Elizabeth M C Fisher, Towfique Raj, Maria Secrier, Tammaryn Lashley, Jernej Ule, Emanuele Buratti, Jack Humphrey, Michael E Ward, Pietro Fratta
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
American journal of human genetics
Published

Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia

Authors
Claudia Manzoni, Demis A Kia, Raffaele Ferrari, Ganna Leonenko, Beatrice Costa, Valentina Saba, Edwin Jabbari, Manuela Mx Tan, Diego Albani, Victoria Alvarez, Ignacio Alvarez, Ole A Andreassen, Antonella Angiolillo, Andrea Arighi, Matt Baker, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Daniel J Blackburn, Merce Boada, Bradley F Boeve, Sergi Borrego-Ecija, Barbara Borroni, Geir Bråthen, William S Brooks, Amalia C Bruni, Paola Caroppo, Sara Bandres-Ciga, Jordi Clarimon, Rosanna Colao, Carlos Cruchaga, Adrian Danek, Sterre Cm de Boer, Itziar de Rojas, Alfonso di Costanzo, Dennis W Dickson, Janine Diehl-Schmid, Carol Dobson-Stone, Oriol Dols-Icardo, Aldo Donizetti, Elise Dopper, Elisabetta Durante, Camilla Ferrari, Gianluigi Forloni, Francesca Frangipane, Laura Fratiglioni, Milica G Kramberger, Daniela Galimberti, Maurizio Gallucci, Pablo García-González, Roberta Ghidoni, Giorgio Giaccone, Caroline Graff, Neill R Graff-Radford, Jordan Grafman, Glenda M Halliday, Dena G Hernandez, Lena E Hjermind, John R Hodges, Guy Holloway, Edward D Huey, Ignacio Illán-Gala, Keith A Josephs, David S Knopman, Mark Kristiansen, John B Kwok, Isabelle Leber, Hampton L Leonard, Ilenia Libri, Alberto Lleo, Ian R Mackenzie, Gaganjit K Madhan, Raffaele Maletta, Marta Marquié, Ales Maver, Manuel Menendez-Gonzalez, Graziella Milan, Bruce L Miller, Christopher M Morris, Huw R Morris, Benedetta Nacmias, Judith Newton, Jørgen E Nielsen, Christer Nilsson, Valeria Novelli, Alessandro Padovani, Suvankar Pal, Florence Pasquier, Pau Pastor, Robert Perneczky, Borut Peterlin, Ronald C Petersen, Olivier Piguet, Yolande Al Pijnenburg, Annibale A Puca, Rosa Rademakers, Innocenzo Rainero, Lianne M Reus, Anna Mt Richardson, Matthias Riemenschneider, Ekaterina Rogaeva, Boris Rogelj, Sara Rollinson, Howard Rosen, Giacomina Rossi, James B Rowe, Elisa Rubino, Agustin Ruiz, Erika Salvi, Raquel Sanchez-Valle, Sigrid Botne Sando, Alexander F Santillo, Jennifer A Saxon, Johannes Cm Schlachetzki, Sonja W Scholz, Harro Seelaar, William W Seeley, Maria Serpente, Sandro Sorbi, Sabrina Sordon, Peter St George-Hyslop, Jennifer C Thompson, Christine Van Broeckhoven, Vivianna M Van Deerlin, Sven J Van der Lee, John Van Swieten, Fabrizio Tagliavini, Julie van der Zee, Arianna Veronesi, Emilia Vitale, Maria Landqvist Waldo, Jennifer S Yokoyama, Mike A Nalls, Parastoo Momeni, Andrew B Singleton, John Hardy, Valentina Escott-Price
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia
Aging cell
Published

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

Authors
James N Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I Emilie Steinmark, Iveta Ivanova, István L Darabán, Parth P Joshi, Elena R Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni
Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons