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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

EMBO molecular medicine
Published

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients

Authors
Laura de Boni, Amber Wallis, Aurelia Hays Watson, Alejandro Ruiz-Riquelme, Louise-Ann Leyland, Thomas Bourinaris, Naomi Hannaway, Ullrich Wüllner, Oliver Peters, Josef Priller, Björn H Falkenburger, Jens Wiltfang, Mathias Bähr, Inga Zerr, Katharina Bürger, Robert Perneczky, Stefan Teipel, Matthias Löhle, Wiebke Hermann, Björn-Hendrik Schott, Kathrin Brockmann, Annika Spottke, Katrin Haustein, Peter Breuer, Henry Houlden, Rimona S Weil, Tim Bartels
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients
Neurology
Published

Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies

Authors
Katharina Bolsewig, Annemartijn A J M van Unnik, Elena R Blujdea, Maria C Gonzalez, Nicholas J Ashton, Dag Aarsland, Henrik Zetterberg, Alessandro Padovani, Laura Bonanni, Brit Mollenhauer, Sebastian Schade, Rik Vandenberghe, Koen Poesen, Milica G Kramberger, Claire Paquet, Olivier Bousiges, Benjamin Cretin, Eline A J Willemse, Charlotte E Teunissen, Afina W Lemstra, European-Dementia With Lewy Bodies (E-DLB) Consortium
Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations

Authors
Charles Arber, Christopher R S Belder, Filip Tomczuk, Rebecca Gabriele, Yazead Buhidma, Clíona Farrell, Antoinette O'Connor, Helen Rice, Tammaryn Lashley, Nick C Fox, Natalie S Ryan, Selina Wray
The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations
Nature communications
Published

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

Authors
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease
Nat Commun
Published

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.

Authors
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.
Brain : a journal of neurology
Published

Towards cascading genetic risk in Alzheimer's disease

Authors
Andre Altmann, Leon M Aksman, Neil P Oxtoby, Alexandra Young, ADNI, Daniel C Alexander, Frederik Barkhof, Maryam Shoai, John Hardy, Jonathan M Schott
Towards cascading genetic risk in Alzheimer's disease
Cell reports
Published

Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics

Authors
Anna Mallach, Magdalena Zielonka, Veerle van Lieshout, Yanru An, Jia Hui Khoo, Marisa Vanheusden, Wei-Ting Chen, Daan Moechars, I Lorena Arancibia-Carcamo, Mark Fiers, Bart De Strooper
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics
Science (New York, N.Y.)
Published

Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

Authors
Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease
Molecular psychiatry
Published

Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease

Authors
Quentin Le Grand, Ami Tsuchida, Alexandra Koch, Mohammed-Aslam Imtiaz, N Ahmad Aziz, Chloé Vigneron, Laure Zago, Mark Lathrop, Alexandre Dubrac, Thierry Couffinhal, Fabrice Crivello, Paul M Matthews, Aniket Mishra, Monique M B Breteler, Christophe Tzourio, Stéphanie Debette
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3

Authors
Daniel J Panyard, Lianne M Reus, Muhammad Ali, Jihua Liu, Yuetiva K Deming, Qiongshi Lu, Gwendlyn Kollmorgen, Margherita Carboni, Norbert Wild, Pieter J Visser, Lars Bertram, Henrik Zetterberg, Kaj Blennow, Johan Gobom, Dan Western, Yun Ju Sung, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Carlos Cruchaga, Betty M Tijms, Corinne D Engelman, Michael P Snyder
Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3
PloS one
Published

Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)

Authors
Howard H Feldman, José A Luchsinger, Gabriel C Léger, Curtis Taylor, Diane M Jacobs, David P Salmon, Steven D Edland, Karen Messer, Carolyn Revta, Sarah A Flowers, Kerry S Jones, Albert Koulman, Kevin E Yarasheski, Philip B Verghese, Venky Venkatesh, Henrik Zetterberg, January Durant, Jody-Lynn Lupo, Gary E Gibson, ADCS BenfoTeam Study Group
Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects

Authors
Adrienne Biskaduros, Lidia Glodzik, Leslie A Saint Louis, Henry Rusinek, Elizabeth Pirraglia, Ricardo Osorio, Tracy Butler, Yi Li, Ke Xi, Emily Tanzi, Patrick Harvey, Henrik Zetterberg, Kaj Blennow, Mony J de Leon
Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects