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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

European heart journal
Published
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study
Authors
Devendra Meena, Jingxian Huang, Alexander Smith, James Yarmolinsky, Siwei Wu, Fotios Koskeridis, Yi-Hsuan Ko, Marie-Joe Dib, Charalabos Antonatos, Yiannis Vasilopoulos, Xinzhu Yu, Georg W Otto, Dipender Gill, Manuel Mayr, Paul Elliott, Abbas Dehghan, Ioanna Tzoulaki
Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study
Movement disorders : official journal of the Movement Disorder Society
Published
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Authors
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha-Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne-Claire Richard, Olivier Quenez, Camilo Toro, Steven J Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M Riboldi
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Proceedings of the National Academy of Sciences of the United States of America
Published
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
Authors
Berta Anuncibay Soto, Ying Ma, Mathieu Nollet, Sara Wong, Giulia Miracca, Daniel Rastinejad, Raquel Yustos, Alexei L Vyssotski, Nicholas P Franks, William Wisden
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
Acta pharmaceutica Sinica. B
Published
Artificial intelligence in drug development for delirium and Alzheimer's disease
Authors
Ruixue Ai, Xianglu Xiao, Shenglong Deng, Nan Yang, Xiaodan Xing, Leiv Otto Watne, Geir Selbæk, Yehani Wedatilake, Chenglong Xie, David C Rubinsztein, Jennifer E Palmer, Bjørn Erik Neerland, Hongming Chen, Zhangming Niu, Guang Yang, Evandro Fei Fang
Artificial intelligence in drug development for delirium and Alzheimer's disease
Journal of neurology, neurosurgery, and psychiatry
Published
Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players
Authors
Neil Graham, Karl Zimmerman, Jessica Hain, Erin Rooney, Ying Lee, Martina Del Giovane, Thomas Parker, Mathew Wilson, Maneesh Patel, Elena Veleva, Owen Swann, Amanda J Heslegrave, Lucia M Li, Henrik Zetterberg, Daniel Friedland, Richard Sylvester, David Sharp
Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players
bioRxiv : the preprint server for biology
Published
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
Authors
Noé Quittot, Dhanush Sivasankaran, Dorothea Boeken, Yu Chen, Joshua E Chun, Anne Wiedmer, Victoria Derosla, Mariana B M S Martins, Forest A Brooks, Georg Meisl, Matthew Cotton, Durga G Arumuganainar, Theresa Connors, Alexandra Melloni, Mathew Frosch, Derek Oakley, Lee Makowski, Meni Wanunu, David Klenerman, Bradley T Hyman
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
Nature biomedical engineering
Published
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Authors
Rebecca Andrews, Bin Fu, Christina E Toomey, Jonathan C Breiter, Joanne Lachica, Joseph S Beckwith, Ru Tian, Emma E Brock, Lisa-Maria Needham, Gregory J Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, Yen Goh, Begüm Kurt, Lenart Senicar, Marisa Edmonds, Tim Bartels, Nora Bengoa-Vergniory, Peter J Magill, Zane Jaunmuktane, Oliver J Freeman, Benjamin J M Taylor, John Hardy, Tammaryn Lashley, Mina Ryten, Michele Vendruscolo, Nicholas W Wood, Lucien E Weiss, Sonia Gandhi, Steven F Lee
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
bioRxiv : the preprint server for biology
Published
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD
Authors
Rachel Coneys, Alexander J Cammack, Remya R Nair, David Thompson, Jonas Mechtersheimer, Mireia Carcolé, Yashica Gupta, Gabriel E Rech, Michael Flower, Niamh O'Brien, Marc-David Ruepp, Sarah Mizielinska, Fiona Ducotterd, Sarah J Tabrizi, Elizabeth M C Fisher, Thomas J Cunningham, Michael Ward, William C Skarnes, Adrian M Isaacs
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD
Acta neuropathologica
Published
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Authors
Wagner S Brum, Laia Montoliu-Gaya, Gunnar Brinkmalm, Diana Piotrowska, Elena Camporesi, Carsten Jäger, Helena S Isaksson, Sven Martin, Jonas Kindberg, Juan Lantero-Rodriguez, João Pedro Ferrari-Souza, Alexis Moscoso, Andrea L Benedet, Shorena Janelidze, Johan Gobom, Henrik Zetterberg, Oskar Hansson, Eduardo R Zimmer, Nicholas J Ashton, Thomas Arendt, Tammaryn Lashley, Jens T Stieler, Max Holzer, Ole Fröbert, Kaj Blennow
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Plasma p-tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic
Authors
Dhamidhu Eratne, Matthew Kang, Charles B Malpas, Christa Dang, Courtney Lewis, Oneil G Bhalala, Qiao-Xin Li, Steven Collins, Colin L Masters, Samantha M Loi, Alexander F Santillo, Kaj Blennow, Henrik Zetterberg, Dennis Velakoulis, And The MiND Study Group
Plasma p-tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression
Authors
Michael C B David, Magdalena A Kolanko, Thomas D Parker, Ramin Nilforooshan, Karl A Zimmerman, Cristina Bonet Olivares, Karen Hoang, Johanna Brandt, Charikleia Triantafyllou, Peter J Lally, Gregory Scott, CR&T Group of UKDRI, David J Sharp, Paresh A Malhotra
Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium
Authors
Inge M W Verberk, Mariam Gouda, Daniel Antwi-Berko, Mardou van Leeuwenstijn, Bram Bongers, Isabel M Houtkamp, Wiesje M van der Flier, Shorena Janelidze, Oskar Hansson, Nathalie Le Bastard, Manu Vandijck, Jacob Hunter, Lee Honigberg, Kristopher M Kirmess, Philip B Verghese, Kaj Blennow, Henrik Zetterberg, Emily A Meyers, Rebecca M Edelmayer, Charlotte Teunissen
Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium