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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's research & therapy
Published

Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly

Authors
Mikko Koivumäki, Laura Ekblad, Juan Lantero-Rodriguez, Nicholas J Ashton, Thomas K Karikari, Semi Helin, Riitta Parkkola, Jyrki Lötjönen, Henrik Zetterberg, Kaj Blennow, Juha O Rinne, Anniina Snellman
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly
Computers in biology and medicine
Published

Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease

Authors
Alicia Gómez-Pascual, Talel Naccache, Jin Xu, Kourosh Hooshmand, Asger Wretlind, Martina Gabrielli, Marta Tiffany Lombardo, Liu Shi, Noel J Buckley, Betty M Tijms, Stephanie J B Vos, Mara Ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez-Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J Nevado-Holgado, Alice Gualerzi, Silvia Picciolini, Petroula Proitsi, Claudia Verderio, Juan A Botía, Cristina Legido-Quigley
Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease
Molecular neurodegeneration
Published

Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology

Authors
Rebecca L Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A Gifford, Kimberly R Pechman, Mabel Seto, Vladislav A Petyuk, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohman, Alzheimer’s Disease Neuroimaging Initiative*
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Immunity & ageing : I & A
Published

The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people

Authors
Tovia Jacobs, Sean R Jacobson, Juan Fortea, Jeffrey S Berger, Alok Vedvyas, Karyn Marsh, Tianshe He, Eugenio Gutierrez-Jimenez, Nathanael R Fillmore, Moses Gonzalez, Luisa Figueredo, Naomi L Gaggi, Chelsea Reichert Plaska, Nunzio Pomara, Esther Blessing, Rebecca Betensky, Henry Rusinek, Henrik Zetterberg, Kaj Blennow, Lidia Glodzik, Thomas M Wisniweski, Mony J de Leon, Ricardo S Osorio, Jaime Ramos-Cejudo, Alzheimer’s Disease Neuroimaging Initiative
The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
NPJ Parkinson's disease
Published

Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson's disease

Authors
Michael Bartl, Johanna Nilsson, Mohammed Dakna, Sandrina Weber, Sebastian Schade, Mary Xylaki, Bárbara Fernandes Gomes, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudia Trenkwalder, Henrik Zetterberg, Ann Brinkmalm, Brit Mollenhauer
Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson's disease
The Lancet. Neurology
Published

Climate change and disorders of the nervous system

Authors
Sanjay M Sisodiya, Medine I Gulcebi, Francesco Fortunato, James D Mills, Ethan Haynes, Elvira Bramon, Paul Chadwick, Olga Ciccarelli, Anthony S David, Kris De Meyer, Nick C Fox, Joanna Davan Wetton, Martin Koltzenburg, Dimitri M Kullmann, Manju A Kurian, Hadi Manji, Mark A Maslin, Manjit Matharu, Hugh Montgomery, Marina Romanello, David J Werring, Lisa Zhang, Karl J Friston, Michael G Hanna
Climate change and disorders of the nervous system
Annals of clinical and translational neurology
Published

Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure

Authors
Mario Tranfa, Luigi Lorenzini, Lyduine E Collij, David Vállez García, Silvia Ingala, Giuseppe Pontillo, Leonard Pieperhoff, Alessio Maranzano, Robin Wolz, Sven Haller, Kaj Blennow, Giovanni Frisoni, Carole H Sudre, Gael Chételat, Michael Ewers, Pierre Payoux, Adam Waldman, Pablo Martinez-Lage, Adam J Schwarz, Craig W Ritchie, Joanna M Wardlaw, Juan Domingo Gispert, Arturo Brunetti, Henk J M M Mutsaerts, Alle Meije Wink, Frederik Barkhof
Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
BMJ neurology open
Published

Recreational nitrous oxide and thrombotic events: a case series

Authors
Marta Patyjewicz, Devan Mair, Safiya A Zaloum, Barbara Onen, Joseph Walton, Ruth Dobson, Christine Joerres, Apeksha Madhusudan Shah, Peter MacCallum, Thomas H Massey, Tadbir Bariana, Veronica White, Sarah A De Freitas, Alastair Noyce
Recreational nitrous oxide and thrombotic events: a case series
Molecular neurodegeneration
Published

Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting

Authors
Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K Lafferty, Julia Kofler, Sarah B Berman, Robert A Sweet, Dana L Tudorascu, William E Klunk, Milos D Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E Snitz, Anne D Cohen, Victor L Villemagne, Tharick A Pascoal, M Llyas Kamboh, Oscar I Lopez, Kaj Blennow, Thomas K Karikari
Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Nature neuroscience
Published

Brain clearance is reduced during sleep and anesthesia

Authors
Andawei Miao, Tianyuan Luo, Bryan Hsieh, Christopher J Edge, Morgan Gridley, Ryan Tak Chun Wong, Timothy G Constandinou, William Wisden, Nicholas P Franks
Brain clearance is reduced during sleep and anesthesia
Diagnostics (Basel, Switzerland)
Published

Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age-Results from the Multicentre Observational DELCODE Study

Authors
Marc Dörner, Katharina Seebach, Michael T Heneka, Inga Menze, Roland von Känel, Sebastian Euler, Frank Schreiber, Philipp Arndt, Katja Neumann, Annkatrin Hildebrand, Anna-Charlotte John, Anthony Tyndall, Johannes Kirchebner, Pawel Tacik, Robin Jansen, Alexander Grimm, Solveig Henneicke, Valentina Perosa, Sven G Meuth, Oliver Peters, Julian Hellmann-Regen, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Jan Ben Schulze, Sarah Lavinia Florence Schiebler, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy-Kluth, Michael Wagner, Ingo Frommann, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Melina Stark, Matthias Schmid, Ersin Ersözlü, Frederic Brosseron, Michael Ewers, Björn H Schott, Emrah Düzel, Gabriel Ziegler, Hendrik Mattern, Stefanie Schreiber, Jose Bernal
Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age-Results from the Multicentre Observational DELCODE Study
International journal of molecular sciences
Published

A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1

Authors
Gustaf Gadd, Daniel Åberg, Alexander Wall, Henrik Zetterberg, Kaj Blennow, Katarina Jood, Christina Jern, Jörgen Isgaard, Johan Svensson, N David Åberg
A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1