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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

European stroke journal
Published
Randomised, controlled Trial of CT perfusion and angiography compared to CT alone in thrombolysis-eligible acute ischaemic stroke patients: The penumbra and recanalisation acute computed tomography in ischaemic stroke evaluation (PRACTISE) trial
Authors
Keith W Muir, Salwa El Tawil, Alex McConnachie, Ian Ford, Grant Mair, Jattinder Khaira, Kausik Chatterjee, Laszlo Sztriha, Omid Halse, Ibrahim Balogun, Sanjeev Nayak, Phil White, Elizabeth A Warburton, Joanna Wardlaw
Randomised, controlled Trial of CT perfusion and angiography compared to CT alone in thrombolysis-eligible acute ischaemic stroke patients: The penumbra and recanalisation acute computed tomography in ischaemic stroke evaluation (PRACTISE) trial
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Mild kidney dysfunction affects the predictive accuracy of blood-based biomarkers for neuropsychological and neuroimaging outcomes over a 9 year follow-up period
Authors
Corey J Bolton, Panpan Zhang, Devika Nair, Dandan Liu, L Taylor Davis, Kimberly R Pechman, Niranjana Shashikumar, Sydney Wilhoite, Dominic Roby, Carlie Beeson, Haley Komorowski, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Mild kidney dysfunction affects the predictive accuracy of blood-based biomarkers for neuropsychological and neuroimaging outcomes over a 9 year follow-up period
Brain : a journal of neurology
Published
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer's disease
Authors
Julia Pescoller, Anna Dewenter, Amir Dehsarvi, Anna Steward, Lukas Frontzkowski, Zeyu Zhu, Sebastian N Roemer-Cassiano, Carla Palleis, Fabian Hirsch, Fabian Wagner, Hannah de Bruin, Boris Rauchmann, Robert Perneczky, Johannes Gnörich, Maura Malpetti, Rik Ossenkoppele, Michael Schöll, Johannes Levin, Günter Höglinger, Matthias Brendel, Nicolai Franzmeier
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer's disease
medRxiv : the preprint server for health sciences
Published
Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity
Authors
James W Groves, Veronica Augustina Bot, Daisy Yi Ding, Jennifer Nicholas, Amelia Farinas, Hamilton See-Oh, Sarah-Naomi James, Andrew Wong, Dylan M Williams, Josh King-Robson, Nishi Chaturvedi, Marcus Richards, Tony Wyss-Coray, Jonathan M Schott
Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity
Clinical chemistry and laboratory medicine
Published
Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays
Authors
Udit Sheth, Rebecca Harrison, Kyle Ferber, Erin G Rosenbaugh, Amanda Bevis, Rohini Khillan, Michael Benatar, Nicole L Bjorklund, Elena Di Daniel, Glenn A Harris, Olga I Kahn, Yongge Liu, Henrik Zetterberg, Laura L Mitic, Danielle Graham, Tania F Gendron
Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease
Authors
Mieke Nuytten, Marieke Voets, Eveline Debroux, Katrien Princen, Lentel Pringels, Marc Fivaz, Eline Byl, Steven Ramael, Koen De Witte, Mercé Boada, Xavier Morató, Juan Pablo Tartari, Asunción Lafuente, Emilio Franco Macias, Jordi A Matias-Guiu, Everard Vijverberg, Charlotte E Teunissen, Peter Anderer, Vincent Staggs, Vincent Hayman, Anne Corbett, Clive Ballard, John E Harrison, Manfred Windisch, Ann Brinkmalm Westman, Henrik Zetterberg, Sam Dickson, Craig Mallinckrodt, Suzanne Hendrix, Jeffrey Cummings, Gerard Griffioen
Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease
Alzheimer's & dementia (Amsterdam, Netherlands)
Published
Preclinical dementia rating scores are associated with plasma phosphorylated tau-217
Authors
Qi Huang, Erin M Jonaitis, Rachel L Studer, Rachael Wilson, Ramiro Eduardo Rea Reyes, Henrik Zetterberg, Lianlian Du, Bruce P Hermann, Sterling C Johnson, Rebecca E Langhough
Preclinical dementia rating scores are associated with plasma phosphorylated tau-217
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Recent advances in neuroimaging of Alzheimer's disease and related dementias
Authors
Julie Ottoy, Nicole Owsicki, Murat Bilgel, Alexa Pichet Binette, Gemma Salvadó, Min Su Kang, David M Cash, Michael Ewers, Renaud La Joie, Laura E M Wisse, Maged Goubran, Tobey Betthauser
Recent advances in neuroimaging of Alzheimer's disease and related dementias
Clinical nuclear medicine
Published
Prognostic Value of A/T/N Biomarkers: Comparing Plasma and Imaging Modalities in Alzheimer Disease
Authors
Sohyun Yim, Yuna Gu, Heekyung Kang, Daeun Shin, Hyemin Jang, Heejin Yoo, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Michael W Weiner, Theresa A Day, Eun Hye Lee, Duk L Na, Hee Jin Kim, Sung Hoon Kang, Ko Woon Kim, Yeo Jin Kim, Yeshin Kim, Jaeho Kim, Min Young Chun, Na Yeon Jung, Soo Hyun Cho, Jun Pyo Kim, Jihwan Yun, Sang Won Seo, K-ROAD study groups
Prognostic Value of A/T/N Biomarkers: Comparing Plasma and Imaging Modalities in Alzheimer Disease
Science (New York, N.Y.)
Published
Lewy body dementia promotion by air pollutants
Authors
Xiaodi Zhang, Haiqing Liu, Xiao Wu, Longgang Jia, Kundlik Gadhave, Lena Wang, Kevin Zhang, Hanyu Li, Rong Chen, Ramhari Kumbhar, Ning Wang, Chantelle E Terrillion, Bong Gu Kang, Bin Bai, Minhan Park, Ma Cristine Faye Denna, Shu Zhang, Wenqiang Zheng, Denghui Ye, Xiaoli Rong, Liu Yang, Lili Niu, Han Seok Ko, Weiyi Peng, Lingtao Jin, Mingyao Ying, Liana S Rosenthal, David W Nauen, Alex Pantelyat, Mahima Kaur, Kezia Irene, Liuhua Shi, Rahel Feleke, Sonia García-Ruiz, Mina Ryten, Valina L Dawson, Francesca Dominici, Rodney J Weber, Xuan Zhang, Pengfei Liu, Ted M Dawson, Shizhong Han, Xiaobo Mao
Lewy body dementia promotion by air pollutants
Molecular psychiatry
Published
Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review
Authors
Luiza S Machado, Pedro Vidor, Lavínia Perquim, Christian Limberger, Leonardo Machado, Andréia Rocha, Carolina Soares, Nesrine Rahmouni, Wagner S Brum, Bruna Bellaver, Pamela C L Ferreira, Wyllians V Borelli, Jaderson C da Costa, Maura Malpetti, Tharick A Pascoal, Diogo O Souza, Paul Edison, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Andrea L Benedet, Alberto Serrano-Pozo, Pedro Rosa-Neto, Eduardo R Zimmer
Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers
Authors
Timo Kaleck, Rafael Campos-Martin, Amanda Cano, Maria Victoria Fernández, Pamela Martino-Adami, Luca Kleineidam, Victor M Andrade Fuentes, Kumar P Tripathi, Kayenat Parveen, Raquel Puerta, Itziar de Rojas, Kishore A Ravichandran, Oliver Peters, Julian Hellmann-Regen, Josef Priller, Maria Gemenetzi, Anja Schneider, Jens Wiltfang, Emrah Düzel, Katharina Buerger, Robert Perneczky, Stefan Teipel, Christoph Laske, Frederic Brosseron, Marta Marquié, Daniel LA van den Hove, Mercè Boada, Michael T Heneka, Michael Wagner, Natalie Marchant, Jean-Charles Lambert, Ruth Frikke-Schmidt, Frank Jessen, Agustín Ruiz, Alfredo Ramirez
Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers