Publications

Featured

Oct 31, 2024 - Research

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein...

Learn more Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

Two people sit in wheelchairs next to one another

Sep 19, 2024 - Research

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

The first results from the innovative platform trial, MND-SMART, have been published in the journal The Lancet Neurology today. Led by Prof Siddharthan Chandran (UK...

Learn more First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Illustration of the inside of a blood vessel

Sep 18, 2024 - Research

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

A new mouse study led by Prof David Attwell (BHF-UK DRI Centre for Vascular Dementia Research) has found that a repurposed drug could reverse the...

Learn more Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Cell Rep

Published Jul 25, 2023

Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells.

Authors

Prannoy Chaudhuri-Vayalambrone, Michael Everett Rule, Marius Bauza, Marino Krstulovic, Pauline Kerekes, Stephen Burton, Timothy O'Leary, Julija Krupic

Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells.

Cell Rep Methods

Published Jul 24, 2023

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.

Authors

Hinze Ho, Nejc Kejzar, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Bart De Strooper, Marius Bauza, Julija Krupic

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.

J Neuroinflammation

Published Jul 21, 2023

Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.

Authors

Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M Zelek, Sarah M Carpanini, Bryan Paul Morgan

Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.

EMBO J

Published Jul 17, 2023

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Authors

Julie Qiaojin Lin, Deepak Khuperkar, Sofia Pavlou, Stanislaw Makarchuk, Nikolaos Patikas, Flora Cy Lee, Julia M Zbiegly, Jianning Kang, Sarah F Field, David Md Bailey, Joshua L Freeman, Jernej Ule, Emmanouil Metzakopian, Marc-David Ruepp, Giovanna R Mallucci

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Annu Int Conf IEEE Eng Med Biol Soc

Published Jul 16, 2023

Hearables: Automatic Sleep Scoring from Single-Channel Ear-EEG in Older Adults.

Authors

Ghena Hammour, Giuseppe Atzori, Ciro Della Monica, Kiran K G Ravindran, Victoria Revell, Derk-Jan Dijk, Danilo P Mandic

Hearables: Automatic Sleep Scoring from Single-Channel Ear-EEG in Older Adults.

bioRxiv

Published Jul 11, 2023

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.

Authors

Taylor Bertucci, Kathryn R Bowles, Steven Lotz, Le Qi, Katherine Stevens, Susan K Goderie, Susan Borden, Laura Maria Oja, Keith Lane, Ryan Lotz, Hailey Lotz, Rebecca Chowdhury, Shona Joy, Brigitte L Arduini, David C Butler, Michael Miller, Heide Baron, Carl Alexander Sandhof, M Catarina Silva, Stephen J Haggarty, Celeste M Karch, Daniel H Geschwind, Alison M Goate, Sally Temple

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.

Annu Rev Neurosci

Published Jul 10, 2023

Astrocyte Endfeet in Brain Function and Pathology: Open Questions.

Authors

Blanca Díaz-Castro, Stefanie Robel, Anusha Mishra

Astrocyte Endfeet in Brain Function and Pathology: Open Questions.

Neuron

Published Jul 05, 2023

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.

Authors

Beatrice Paola Festa, Farah H Siddiqi, Maria Jimenez-Sanchez, Hyeran Won, Matea Rob, Alvin Djajadikerta, Eleanna Stamatakou, David C Rubinsztein

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.

Wellcome Open Res

Published Jul 04, 2023

nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis.

Authors

Charlotte West, Charlotte Capitanchik, Chris Cheshire, Nicholas M Luscombe, Anob Chakrabarti, Jernej Ule

nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis.

Brain

Published Jul 03, 2023

Functional genomics provide key insights to improve the diagnostic yield of hereditary ataxia.

Authors

Zhongbo Chen, Arianna Tucci, Valentina Cipriani, Emil K Gustavsson, Kristina Ibañez, Regina H Reynolds, David Zhang, Letizia Vestito, Alejandro Cisterna García, Siddharth Sethi, Jonathan W Brenton, Sonia García-Ruiz, Aine Fairbrother-Browne, Ana-Luisa Gil-Martinez, , Nick Wood, John A Hardy, Damian Smedley, Henry Houlden, Juan Botía, Mina Ryten

Functional genomics provide key insights to improve the diagnostic yield of hereditary ataxia.

Neuroimage

Published Jul 01, 2023

Higher order diffusion imaging as a putative index of human sleep-related microstructural changes and glymphatic clearance.

Authors

Balázs Örzsik, Marco Palombo, Iris Asllani, Derk-Jan Dijk, Neil A Harrison, Mara Cercignani

Higher order diffusion imaging as a putative index of human sleep-related microstructural changes and glymphatic clearance.

JAMA Neurol

Published Jul 01, 2023

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.

Authors

Joanna M Wardlaw, Lisa J Woodhouse, Iris I Mhlanga, Katherine Oatey, Anna K Heye, John Bamford, Vera Cvoro, Fergus N Doubal, Timothy England, Ahamad Hassan, Alan Montgomery, John T O'Brien, Christine Roffe, Nikola Sprigg, David J Werring, Philip M Bath,

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.

Nat Commun

Published Jun 08, 2023

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Authors

Irene Molina-Gonzalez, Rebecca K Holloway, Zoeb Jiwaji, Owen Dando, Sarah A Kent, Katie Emelianova, Amy F Lloyd, Lindsey H Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A Febery, Jeffrey A Johnson, Jill H Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J M Howden, Giles E Hardingham, Veronique E Miron

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

bioRxiv

Published Jun 05, 2023

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Authors

K R Bowles, D A Pugh, C Pedicone, L Oja, S A Weitzman, Y Liu, J L Chen, M D Disney, A M Goate

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Toxicon

Published Jun 01, 2023

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Authors

Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiavo

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Int J Mol Sci

Published May 17, 2023

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Authors

Yoel Hirsch, Wendy K Chung, Sergey Novoselov, Louis H Weimer, Alexander Rossor, Charles A LeDuc, Amanda J McPartland, Ernesto Cabrera, Josef Ekstein, Sholem Scher, Rick F Nelson, Giampietro Schiavo, Lindsay B Henderson, Kevin T A Booth

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

JCI Insight

Published May 08, 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors

James N Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L Simkin, Jose Norberto S Vargas, Elena R Rhymes, Andrew P Tosolini, Steven J West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Semin Cell Dev Biol

Published Apr 30, 2023

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

Authors

Leire Melgosa-Ecenarro, Nazanin Doostdar, Carola I Radulescu, Johanna S Jackson, Samuel J Barnes

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

Shaping the future of dementia research: Meet the UK DRI’s newest Emerging Leaders

Why partner with the UK DRI?

Why join the UK DRI?

Publications

Featured

Glaucoma drug shows promise against neurodegenerative diseases, animal studies suggest

First results published from innovative platform trial, MND-SMART, aiming to speed up delivery of treatments for motor neuron disease

Effects of reduced blood flow in early Alzheimer’s reversed by repurposed drug

Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells.

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.

Alzheimer's disease-associated complement gene variants influence plasma complement protein levels.

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Hearables: Automatic Sleep Scoring from Single-Channel Ear-EEG in Older Adults.

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.

Astrocyte Endfeet in Brain Function and Pathology: Open Questions.

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration.

nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis.

Functional genomics provide key insights to improve the diagnostic yield of hereditary ataxia.

Higher order diffusion imaging as a putative index of human sleep-related microstructural changes and glymphatic clearance.

Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.