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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Stem cell reports
Published

Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource

Authors
Emily Maguire, Jincy Winston, Sarah H Ellwood, Rachel O'Donoghue, Bethany Shaw, Atahualpa Castillo Morales, Samuel Keat, Alexandra Evans, Rachel Marshall, Lauren Luckcuck, Laura Brown, Elisa Salis, Ganna Leonenko, Nicola Denning, EADB consortium, Nicholas D Allen, Valentina Escott-Price, Caleb Webber, Philip R Taylor, Rebecca Sims, Sally A Cowley, Julie Williams, Sarah M Carpanini, Hazel Hall-Roberts
Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource
Journal of Alzheimer's disease : JAD
Published

Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders

Authors
Ella Liu, Sherri Lee Jones, Victoria Light, Charlotte Teunissen, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Chris R Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Henrik Zetterberg, Jonathan D Rohrer, Simon Ducharme, Genetic Frontotemporal Dementia Initiative (GENFI) and Banque Signature (BbS)
Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference

Authors
Neus Falgàs, Lucia Maure-Blesa, Beau Ances, Lisi Flores-Aguilar, Sigan Hartley, Jason Hassenstab, M Florencia Iulita, Matthew Janicki, Katherine Koenig, Patrick Lao, Johannes Levin, Eric McDade, Laurent Meijer, Michael S Rafii, Heather M Snyder, Raquel Sánchez-Valle, Juan Fortea, DSAD‐ADAD conference group, Jose Arriola Infante, Mirea Balasa, Isabel Barroeta, Nicolas Barthelemy R, Alexandre Bejanin, Bessy Benejam, Beatriz Bosch, Angela Bradshaw, Maria Carmona-Iragui, Ann Cohen, Aina Comas Albertí, Lajos Csincsik, A Claudio Cuello, Laura Del Hoyo Soriano, Janna Dijkstra, Natalie Edwards, Sandra Giménez, Fernando Gonzalez-Ortiz, Brian Gordon, Sara Gutiérrez Fernández, Benjamin Handen, Charlotte Jacob, Erik Johnson, Charlotte Johansson, Albert Lladó, Alberto Lleó, Samuel Morabito, Alejandra O Morcillo-Nieto, Laia Montoliu-Gaya, Michael Okafor, Agnes Pérez-Millan, Marie Claude Potier, John Ringman, Íñigo Rodríguez-Baz, Eric Rubenstein, Natalie S Ryan, André Strydom, Lidia Vaqué-Alcázar, Lisa Vermunt, Laura Videla Toro, Shahid Zaman
Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Gut microbiome compositional and functional features associate with Alzheimer's disease pathology

Authors
Jea Woo Kang, Lora A Khatib, Margo B Heston, Amanda H Dilmore, Jennifer S Labus, Yuetiva Deming, Leyla Schimmel, Colette Blach, Daniel McDonald, Antonio Gonzalez, MacKenzie Bryant, Tyler K Ulland, Sterling C Johnson, Sanjay Asthana, Cynthia M Carlsson, Nathaniel A Chin, Kaj Blennow, Henrik Zetterberg, Federico E Rey, Alzheimer Gut Microbiome Project Consortium, Rima Kaddurah-Daouk, Rob Knight, Barbara B Bendlin
Gut microbiome compositional and functional features associate with Alzheimer's disease pathology
Lancet Healthy Longev
Published

Associations between life course exposure to ambient air pollution with cognition and later-life brain structure: a population-based study of the 1946 British Birth Cohort.

Authors
Thomas Canning, Jorge Arias-de la Torre, Helen L Fisher, John Gulliver, Anna L Hansell, Rebecca Hardy, Stephani L Hatch, Ian S Mudway, Amy Ronaldson, Molly Cartlidge, Sarah-Naomi James, Sarah E Keuss, Jonathan M Schott, Marcus Richards, Ioannis Bakolis
Associations between life course exposure to ambient air pollution with cognition and later-life brain structure: a population-based study of the 1946 British Birth Cohort.
The Journal of frailty & aging..
Published

Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study

Authors
Kelly Virecoulon Giudici, Philipe de Souto Barreto, Christelle Cantet, Henrik Zetterberg, Kaj Blennow, Bruno Vellas, MAPT/DSA group
Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study
Brain : a journal of neurology
Published

Brain health concerns in former rugby players: clinical and cognitive phenotypes

Authors
Thomas D Parker, Jessica A Hain, Erin J Rooney, Karl A Zimmerman, Ying Lee, Martina Del Giovane, Neil S N Graham, Maneesh Patel, Adam Hampshire, Mathew G Wilson, Daniel Friedland, David J Sharp, Richard J Sylvester
Brain health concerns in former rugby players: clinical and cognitive phenotypes
Nature communications
Published

Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications

Authors
Haseong Kim, Nathan J Hillson, Byung-Kwan Cho, Bong Hyun Sung, Dae-Hee Lee, Dong-Myung Kim, Min-Kyu Oh, Matthew Wook Chang, Yong-Su Jin, Susan J Rosser, Peter Vegh, Rennos Fragkoudis, Rosalind Le Feuvre, Nigel S Scrutton, Marko Storch, Wonjae Seong, Paul S Freemont, Seung-Goo Lee
Abstraction hierarchy to define biofoundry workflows and operations for interoperable synthetic biology research and applications
Brain : a journal of neurology
Published

Biomarker evidence of neurodegeneration in mid-life former rugby players

Authors
Neil S N Graham, Karl A Zimmerman, Jessica Hain, Erin Rooney, Ying Lee, Martina Del Giovane, Thomas Parker, Mathew G Wilson, Paresh Malhotra, Michael C B David, Magdalena Kolanko, Maneesh Patel, Elena Veleva, Owen Swann, Amanda Heslegrave, Henrik Zetterberg, Daniel Friedland, Richard Sylvester, David J Sharp
Biomarker evidence of neurodegeneration in mid-life former rugby players
Nature communications
Published

Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease

Authors
Laia Montoliu-Gaya, Shijia Bian, Eric B Dammer, Daniel Alcolea, Mathias Sauer, Mitchell Martá-Ariza, Nicholas J Ashton, Olivia Belbin, Johannes Fuchs, Caroline M Watson, Lingyan Ping, Duc M Duong, Johanna Nilsson, Isabel Barroeta, Juan Lantero-Rodriguez, Laura Videla, Bessy Benejam, Blaine R Roberts, Kaj Blennow, Nicholas T Seyfried, Allan I Levey, María Carmona-Iragui, Johan Gobom, Alberto Lleó, Thomas Wisniewski, Henrik Zetterberg, Juan Fortea, Erik C B Johnson
Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease
Nature communications
Published

Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease

Authors
Francieli Rohden, Pamela C L Ferreira, Bruna Bellaver, João Pedro Ferrari-Souza, Cristiano S Aguzzoli, Carolina Soares, Sarah Abbas, Hussein Zalzale, Guilherme Povala, Firoza Z Lussier, Douglas T Leffa, Guilherme Bauer-Negrini, Nesrine Rahmouni, Cécile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Dana L Tudorascu, Henrik Zetterberg, Kaj Blennow, Eduardo R Zimmer, Diogo Souza, Pedro Rosa-Neto, Tharick A Pascoal
Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study

Authors
Vincent Malotaux, Nicholas J Ashton, Annika Öhrfelt, Yinghua Chen, Yi Su, Gloria Garcia-Ospina, Claudia Guzman-Martínez, Andres Villegas-Lanau, Johana Gómez-Ramirez, Margarita Giraldo-Chica, David Aguillon, Victoria Tirado, Ana Baena, Claudia Munoz, Natalia Acosta-Baena, Jeremy J Pruzin, Valentina Ghisays, Silvia Rios-Romenets, Clara Vila-Castelar, Jairo E Martínez, Averi Giudicessi, Pierre N Tariot, Henrik Zetterberg, Kaj Blennow, Eric M Reiman, Yakeel T Quiroz
Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study
Resuscitation
Published

Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients

Authors
Christel Pussinen, Mikko Anttonen, Lauri Wihersaari, Marjaana Tiainen, Matti Reinikainen, Johanna Hästbacka, Henrik Zetterberg, Kaj Blennow, Kari Pulkki, Markus B Skrifvars
Neurofilament light chain evaluated with a new automated commercially available method for outcome prediction in out-of-hospital cardiac arrest patients