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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

bioRxiv : the preprint server for biology
Published
Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease
Authors
Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen, James Groves, Róbert Pálovics, Daisuke Masuda, Amelia Farinas, Hamilton Se-Hwee Oh, Viktoria Wagner, Nannan Lu, Global Neurodegeneration Proteomics Consortium (GNPC), Carlos Cruchaga, Alina Isakova, Jonathan M Schott, Tony Wyss-Coray
Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease
The Lancet. Neurology
Published
A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA
Authors
Eric M Reiman, Robert C Alexander, Jessica B Langbaum, Paul S Aisen, Nicholas Ashton, Alireza Atri, Paola Barbarino, Goldie S Byrd, Howard H Feldman, Nicole R Fowler, Valentina Ghisays, Joshua D Grill, Jason Hassenstab, George R Heaton, William L Herring, Clifford R Jack, Sterling C Johnson, Jason Karlawish, Nancy L Keach, Miia Kivipelto, Harlan M Krumholz, Emily A Largent, Tamiko MaGee-Rodgers, Eric McDade, Michelle M Mielke, Doris Molina-Henry, Ronald C Petersen, Gil D Rabinovici, Craig Ritchie, Suzanne E Schindler, Reisa A Sperling, Marc Suárez-Calvet, George Vradenburg, Michael W Weiner, Kathleen A Welsh-Bohmer, Henrik Zetterberg, Michael T Zuendel, Soeren Mattke, Jeffrey L Cummings
A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA
npj aging
Published
Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential
Authors
Nazia Saiyed, Vaibhav Pandya, Xiaobei Pan, Miroslava Cuperlovic-Culf, Nadia Ashrafi, Shiva Kant, Marie Migaud, Jyothi Dhuguru, Henrik Zetterberg, Bernadette McGuinness, Anthony P Passmore, Leiv Otto Watne, Brian D Green, Emma L Cunningham, Stewart F Graham
Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential
NPJ dementia
Published
15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN
Authors
Alisha J Daniels, Eric McDade, Jorge J Llibre-Guerra, Chengjie Xiong, Richard J Perrin, Laura Ibanez, Charlene Supnet-Bell, Carlos Cruchaga, Alison Goate, Alan E Renton, Tammie L S Benzinger, Brian A Gordon, Jason Hassenstab, Celeste Karch, Allan Levey, John C Morris, Virginia Buckles, Ricardo F Allegri, Patricio Chrem, Sarah B Berman, Jasmeer P Chhatwal, Martin R Farlow, Nick C Fox, Gregory S Day, Takeshi Ikeuchi, Mathias Jucker, Johannes Levin, Jae-Hong Lee, David Aguillon, Leonel Takada, Ana Luisa Sosa, Ralph Martins, Hiroshi Mori, James M Noble, Stephen Salloway, Edward Huey, Raquel Sánchez-Valle, Peter R Schofield, Jee Hoon Roh, Randall J Bateman, Dominantly Inherited Alzheimer Network
15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
The Alzheimer's Disease Diagnosis and Plasma Phospho-Tau217 (ADAPT) study stage 1: Validating clinical cut-points against CSF and amyloid PET
Authors
Ashvini Keshavan, Katharine Wiltshire, Ryan Wee, Irene Gorostiaga Belio, Katie Tucker, Melanie Hart, Michael P Lunn, Michael C B David, Laura Rizzo, Omid Sadeghi-Alavijeh, Patricia Wilson, Daniel P Gale, Amanda J Heslegrave, Henrik Zetterberg, Nick C Fox, Paresh Malhotra, Jonathan M Schott
The Alzheimer's Disease Diagnosis and Plasma Phospho-Tau217 (ADAPT) study stage 1: Validating clinical cut-points against CSF and amyloid PET
Nature medicine
Published
Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks
Authors
Kellen K Petersen, Marta Milà-Alomà, Yan Li, Lianlian Du, Chengjie Xiong, Duygu Tosun, Benjamin Saef, Ziad S Saad, Lei Du-Cuny, Janaky Coomaraswamy, Yulia Mordashova, Carrie E Rubel, Emily A Meyers, Leslie M Shaw, Jeffrey L Dage, Nicholas J Ashton, Henrik Zetterberg, Kyle Ferber, Gallen Triana-Baltzer, Michael Baratta, Erin G Rosenbaugh, Carlos Cruchaga, Eric McDade, David M Holtzman, John C Morris, J Martin Sabandal, Randall J Bateman, Anthony W Bannon, William Z Potter, Suzanne E Schindler, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer’s Disease Project Team
Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks
Scientific reports
Published
GluN2A-mediated currents and calcium signal in human iPSC-derived neurons
Authors
Sergio Escamilla, Carlos Avilés-Granados, Francisco Andrés Peralta, Ana V Paternain, María-Ángeles Cortés-Gómez, Henrik Zetterberg, Elvira de la Peña, Federico Salas-Lucia, Javier Sáez-Valero, Inmaculada Cuchillo-Ibáñez
GluN2A-mediated currents and calcium signal in human iPSC-derived neurons
Frontiers in neuroscience
Published
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations
Authors
Claudio Villegas-Llerena, Solange R Paredes-Moscosso, María Luisa Guevara-Fujita, Daisy Obispo, Nilton Custodio, Rosa Montesinos, José F Parodi, Oscar Flores-Flores, John Hardy, Ricardo Fujita
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations
Nature communications
Published
Structural defects in amyloid-β fibrils drive secondary nucleation
Authors
Jing Hu, Tom Scheidt, Dev Thacker, Emil Axell, Elin Stemme, Urszula Łapińska, Stefan Wennmalm, Georg Meisl, Samo Curk, Maria Andreasen, Michele Vendruscolo, Paolo Arosio, Anđela Šarić, Jeremy D Schmit, Tuomas P J Knowles, Emma Sparr, Sara Linse, Thomas C T Michaels, Alexander J Dear
Structural defects in amyloid-β fibrils drive secondary nucleation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population
Authors
Han Cao, Ziyu Zheng, Xiaopu Zhou, Masataka Kikuchi, Hiu Yi Wong, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Maryam Shoai, Joyce R Chong, Andrew L T Chan, Christopher Chen, Linda C W Lam, Vincent C T Mok, Timothy C Y Kwok, Japanese Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Neuroimaging Initiative, Yu Chen, Fanny C F Ip, Kin Y Mok, Akinori Miyashita, Takeshi Ikeuchi, John Hardy, Amy K Y Fu, Nancy Y Ip
Ethnic-specific effects of the LILRB2-LILRB5 locus and newly identified risk loci for Alzheimer's disease in the East Asian population
Nature neuroscience
Published
Author Correction: Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Authors
Sebastiaan De Schepper, Judy Z Ge, Annerieke Sierksma, Gerard Crowley, Laís S S Ferreira, Dylan Garceau, Christina E Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong
Author Correction: Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Nature communications
Published
Characterising processing conditions that artifactually bias human brain tissue transcriptomes
Authors
Moein Yaqubi, Michael Thomas, Jonathan Talbot-Martin, Abdulshakour Mohammadnia, Alexis Allot, Adam M R Groh, Nurun Fancy, Marianna Papageorgopoulou, Xiaowen Zhang, Aisling McGarry, Paul M Matthews, Kevin Petrecca, Johanna S Jackson, Jo Anne Stratton
Characterising processing conditions that artifactually bias human brain tissue transcriptomes