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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Journal of the American Heart Association
Published
Stroke, Small-Vessel Disease, and Occupation: Systematic Review and Data Analysis
Authors
Thomas Zhang, Una Clancy, Ayush Singh, Stephen Makin, Caroline McHutchison, Vera Cvoro, Carmen Arteaga-Reyes, Daniela Jaime Garcia, Will Hewins, Michael Stringer, Michael Thrippleton, Maria C Valdes-Hernandez, Stewart Wiseman, Francesca Chappell, Rosalind Brown, Fergus Doubal, Joanna M Wardlaw
Stroke, Small-Vessel Disease, and Occupation: Systematic Review and Data Analysis
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Authors
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K W Cheng, Elaine Y L Cheng, Bonnie W Y Wong, Ronnie M N Lo, Siu Ki Leung, Fanny C Ip, Jacqueline K Y Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip
Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging
Brain, behavior, and immunity
Published
Higher CSF sTREM2 is related to slower hippocampal atrophy and cognitive decline independently of pTau181 levels
Authors
Henry Gilreath Stephenson, Tobey J Betthauser, Erin Jonaitis, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Michael Ewers, Jannis Denecke, Tyler K Ulland, Nathaniel A Chin, Ozioma C Okonkwo, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin
Higher CSF sTREM2 is related to slower hippocampal atrophy and cognitive decline independently of pTau181 levels
Nature
Published
Intestinal macrophages modulate synucleinopathy along the gut-brain axis
Authors
Sebastiaan De Schepper, Viktoras Konstantellos, James A Conway, Dimitra Sokolova, Ludovica Zaccagnini, Matthew V Cowley, Annerieke Sierksma, Maria Yudina, Marisa Edmonds, Daria Gavriouchkina, Bethany Geary, Amber Wallis, Meral Celikag, Zeynep Baykam, Mónica Vara-Pérez, Gerard Crowley, Fabian Tobias Hager, Mitchell Bijnen, David Posner, Kelvin Luk, Vuk Cerovic, Menna Clatworthy, Elizabeth J Videlock, Zane Jaunmuktane, Kiavash Movahedi, Melanie Greter, Benny Chain, Dario R Alessi, Soyon Hong, Tim Bartels
Intestinal macrophages modulate synucleinopathy along the gut-brain axis
Immunology
Published
Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID
Authors
Samuel B K Keat, Priyanka Khatri, Youssif M Ali, Chanuka H Arachchilage, Gregory Demopulos, Kirsten Baillie, Kelly L Miners, Kristin Ladell, Samantha A Jones, Helen E Davies, David A Price, Wioleta M Zelek, B Paul Morgan, Wilhelm J Schwaeble, Nicholas J Lynch
Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published
The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis
Authors
Shu-Qin Cao, Juan Ignacio Jiménez-Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E Smith, Junjie Huang, Jun-Ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F Fang
The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis
The journal of prevention of Alzheimer's disease
Published
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease
Authors
Claude M Wischik, Richard Stefanacci, Peter Bentham, Serge Gauthier, Henrik Zetterberg, Gordon K Wilcock, Lutz Froelich, Alistair Burns, Emer MacSweeney, Clive Ballard, Jin-Tai Yu, Tay Siew Choon, Vahe Asvatourian, Natalia Muehlemann, Jan Priel, Karin Kook, Tenecia Sullivan, Diane Downie, Sonya Miller, Carol Pringle, John M D Storey, Tom Baddeley, Charles R Harrington, Lewis K Penny, Mohammad Arastoo, Roger Staff, Anca-Larisa Sandu, Helen Shiells, Serena Lo, Nafeesa Nazlee, Emily Evans, Claire Hull, Bjoern O Schelter
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease
BMC research notes
Published
Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort
Authors
Sarah E Keuss, Kirsty Lu, Sarah-Naomi James, Jennifer M Nicholas, William Coath, Ashvini Keshavan, David M Cash, Carole H Sudre, Josephine Barnes, Heidi Murray-Smith, Andrew Wong, Rebecca Street, Marcus Richards, Jonathan M Schott
Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort
Computer methods and programs in biomedicine
Published
Shape matters: Predicting Huntington's disease using progression modelling
Authors
Mohsen Ghofrani-Jahromi, Susmita Saha, Adeel Razi, Pubu M Abeyasinghe, Govinda R Poudel, Jane S Paulsen, Sarah J Tabrizi, Nellie Georgiou-Karistianis
Shape matters: Predicting Huntington's disease using progression modelling