Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations

Authors
Corey J Bolton, Omair A Khan, Dandan Liu, Kimberly R Pechman, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Combining plasma p-tau<sub>231</sub> and glial fibrillary acidic protein produces higher discriminative accuracy for amyloid positivity than other blood-based biomarker combinations
Movement disorders : official journal of the Movement Disorder Society
Published

RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications

Authors
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha-Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne-Claire Richard, Olivier Quenez, Camilo Toro, Steven J Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M Riboldi
RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications
Proceedings of the National Academy of Sciences of the United States of America
Published

The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation

Authors
Berta Anuncibay Soto, Ying Ma, Mathieu Nollet, Sara Wong, Giulia Miracca, Daniel Rastinejad, Raquel Yustos, Alexei L Vyssotski, Nicholas P Franks, William Wisden
The locus coeruleus maintains core body temperature and protects against hypothermia during dexmedetomidine-induced sedation
Acta pharmaceutica Sinica. B
Published

Artificial intelligence in drug development for delirium and Alzheimer's disease

Authors
Ruixue Ai, Xianglu Xiao, Shenglong Deng, Nan Yang, Xiaodan Xing, Leiv Otto Watne, Geir Selbæk, Yehani Wedatilake, Chenglong Xie, David C Rubinsztein, Jennifer E Palmer, Bjørn Erik Neerland, Hongming Chen, Zhangming Niu, Guang Yang, Evandro Fei Fang
Artificial intelligence in drug development for delirium and Alzheimer's disease
Journal of neurology, neurosurgery, and psychiatry
Published

Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players

Authors
Neil Graham, Karl Zimmerman, Jessica Hain, Erin Rooney, Ying Lee, Martina Del Giovane, Thomas Parker, Mathew Wilson, Maneesh Patel, Elena Veleva, Owen Swann, Amanda J Heslegrave, Lucia M Li, Henrik Zetterberg, Daniel Friedland, Richard Sylvester, David Sharp
Midlife plasma proteomic profiles indicate altered amyloid and tau processing in former elite rugby players
bioRxiv : the preprint server for biology
Published

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation

Authors
Noé Quittot, Dhanush Sivasankaran, Dorothea Boeken, Yu Chen, Joshua E Chun, Anne Wiedmer, Victoria Derosla, Mariana B M S Martins, Forest A Brooks, Georg Meisl, Matthew Cotton, Durga G Arumuganainar, Theresa Connors, Alexandra Melloni, Mathew Frosch, Derek Oakley, Lee Makowski, Meni Wanunu, David Klenerman, Bradley T Hyman
Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
bioRxiv : the preprint server for biology
Published

Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD

Authors
Rachel Coneys, Alexander J Cammack, Remya R Nair, David Thompson, Jonas Mechtersheimer, Mireia Carcolé, Yashica Gupta, Gabriel E Rech, Michael Flower, Niamh O'Brien, Marc-David Ruepp, Sarah Mizielinska, Fiona Ducotterd, Sarah J Tabrizi, Elizabeth M C Fisher, Thomas J Cunningham, Michael Ward, William C Skarnes, Adrian M Isaacs
Generation of <em>C9orf72</em> repeat knock-in iPSC lines for modelling ALS and FTD
Nature biomedical engineering
Published

Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue

Authors
Rebecca Andrews, Bin Fu, Christina E Toomey, Jonathan C Breiter, Joanne Lachica, Joseph S Beckwith, Ru Tian, Emma E Brock, Lisa-Maria Needham, Gregory J Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, Yen Goh, Begüm Kurt, Lenart Senicar, Marisa Edmonds, Tim Bartels, Nora Bengoa-Vergniory, Peter J Magill, Zane Jaunmuktane, Oliver J Freeman, Benjamin J M Taylor, John Hardy, Tammaryn Lashley, Mina Ryten, Michele Vendruscolo, Nicholas W Wood, Lucien E Weiss, Sonia Gandhi, Steven F Lee
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Acta neuropathologica
Published

Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study

Authors
Wagner S Brum, Laia Montoliu-Gaya, Gunnar Brinkmalm, Diana Piotrowska, Elena Camporesi, Carsten Jäger, Helena S Isaksson, Sven Martin, Jonas Kindberg, Juan Lantero-Rodriguez, João Pedro Ferrari-Souza, Alexis Moscoso, Andrea L Benedet, Shorena Janelidze, Johan Gobom, Henrik Zetterberg, Oskar Hansson, Eduardo R Zimmer, Nicholas J Ashton, Thomas Arendt, Tammaryn Lashley, Jens T Stieler, Max Holzer, Ole Fröbert, Kaj Blennow
Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression

Authors
Michael C B David, Magdalena A Kolanko, Thomas D Parker, Ramin Nilforooshan, Karl A Zimmerman, Cristina Bonet Olivares, Karen Hoang, Johanna Brandt, Charikleia Triantafyllou, Peter J Lally, Gregory Scott, CR&T Group of UKDRI, David J Sharp, Paresh A Malhotra
Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium

Authors
Inge M W Verberk, Mariam Gouda, Daniel Antwi-Berko, Mardou van Leeuwenstijn, Bram Bongers, Isabel M Houtkamp, Wiesje M van der Flier, Shorena Janelidze, Oskar Hansson, Nathalie Le Bastard, Manu Vandijck, Jacob Hunter, Lee Honigberg, Kristopher M Kirmess, Philip B Verghese, Kaj Blennow, Henrik Zetterberg, Emily A Meyers, Rebecca M Edelmayer, Charlotte Teunissen
Evidence-based standardized sample handling protocol for accurate blood-based Alzheimer's disease biomarker measurement: Results and consensus of the Global Biomarker Standardization Consortium
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic

Authors
Dhamidhu Eratne, Matthew Kang, Charles B Malpas, Christa Dang, Courtney Lewis, Oneil G Bhalala, Qiao-Xin Li, Steven Collins, Colin L Masters, Samantha M Loi, Alexander F Santillo, Kaj Blennow, Henrik Zetterberg, Dennis Velakoulis, And The MiND Study Group
Plasma p-tau217, NfL, GFAP diagnostic performance and biomarker profiles in Alzheimer's disease, frontotemporal dementia, and psychiatric disorders, in a prospective unselected neuropsychiatry memory clinic