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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Cell Rep
Published

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Authors
Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Biosens Bioelectron
Published

Multiplexed immunosensors for point-of-care diagnostic applications.

Authors
Bruno Gil Rosa, Oluwatomi E Akingbade, Xiaotong Guo, Laura Gonzalez-Macia, Michael A Crone, Loren P Cameron, Paul Freemont, Kwang-Leong Choy, Firat Güder, Eric Yeatman, David J Sharp, Bing Li
Multiplexed immunosensors for point-of-care diagnostic applications.
J Neurosci
Published

Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.

Authors
Paula de Oliveira, Claire Cella, Nicolas Locker, Kiran K G Ravindran, Agampodi Mendis, Keith Wafford, Gary Gilmour, Derk-Jan Dijk, Raphaelle Winsky-Sommerer
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
Acta Neuropathol
Published

Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Authors
Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Amber Wallis, Kristina Zhelcheska, Nora Kim, John Sanderson, Haiyang Jiang, Elodie Martin, Adam Cantlon, Matteo Rovere, Lei Liu, Marc Sylvester, Tammaryn Lashley, Ulf Dettmer, Zane Jaunmuktane, Tim Bartels
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Nat Neurosci
Published

Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.

Authors
Branduff McAllister, Jasmine Donaldson, Caroline S Binda, Sophie Powell, Uroosa Chughtai, Gareth Edwards, Joseph Stone, Sergey Lobanov, Linda Elliston, Laura-Nadine Schuhmacher, Elliott Rees, Georgina Menzies, Marc Ciosi, Alastair Maxwell, Michael J Chao, Eun Pyo Hong, Diane Lucente, Vanessa Wheeler, Jong-Min Lee, Marcy E MacDonald, Jeffrey D Long, Elizabeth H Aylward, G Bernhard Landwehrmeyer, Anne E Rosser, Jane S Paulsen, Nigel M Williams, James F Gusella, Darren G Monckton, Nicholas D Allen, Peter Holmans, Lesley Jones, Thomas H Massey
Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.
Nat Commun
Published

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

Authors
Zoeb Jiwaji, Sachin S Tiwari, Rolando X Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M Smith, Peta Greer, Matthew Ball, Peter C Kind, Paul M Matthews, Colin Smith, Owen Dando, Tara L Spires-Jones, Jeffrey A Johnson, Siddharthan Chandran, Giles E Hardingham
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
Dev Cell
Published

iPSC-derived myelinoids to study myelin biology of humans.

Authors
Owen G James, Bhuvaneish T Selvaraj, Dario Magnani, Karen Burr, Peter Connick, Samantha K Barton, Navneet A Vasistha, David W Hampton, David Story, Robert Smigiel, Rafal Ploski, Peter J Brophy, Charles Ffrench-Constant, David A Lyons, Siddharthan Chandran
iPSC-derived myelinoids to study myelin biology of humans.
Brain
Published

Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype.

Authors
Antoinette O'Connor, Josef Pannee, Teresa Poole, Charles Arber, Erik Portelius, Imogen J Swift, Amanda J Heslegrave, Emily Abel, Nanet Willumsen, Helen Rice, Philip S J Weston, Natalie S Ryan, James M Polke, Jennifer M Nicholas, Simon Mead, Selina Wray, Lucía Chávez-Gutiérrez, Chris Frost, Kaj Blennow, Henrik Zetterberg, Nick C Fox
Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype.
Sci Adv
Published

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.

Authors
Georg Meisl, Eric Hidari, Kieren Allinson, Timothy Rittman, Sarah L DeVos, Justin S Sanchez, Catherine K Xu, Karen E Duff, Keith A Johnson, James B Rowe, Bradley T Hyman, Tuomas P J Knowles, David Klenerman
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.
Cell Stem Cell
Published

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Authors
Hannah Walgrave, Sriram Balusu, Sarah Snoeck, Elke Vanden Eynden, Katleen Craessaerts, Nicky Thrupp, Leen Wolfs, Katrien Horré, Yannick Fourne, Alicja Ronisz, Edina Silajdžić, Amber Penning, Giorgia Tosoni, Zsuzsanna Callaerts-Vegh, Rudi D'Hooge, Dietmar Rudolf Thal, Henrik Zetterberg, Sandrine Thuret, Mark Fiers, Carlo Sala Frigerio, Bart De Strooper, Evgenia Salta
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.