Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Stroke
Published

Plasma Brain-Derived Tau in Prognosis of Large Vessel Occlusion Ischemic Stroke

Authors
Ricardo Varela, Fernando Gonzalez-Ortiz, Alexandre Dias, Nicoló Luca Knuth, Joana Fonte, Beatriz Pinto, Idil Yuksekel, Vasco Abreu, Isabel Silva, Liliana Igreja, Joana Lopes, José Silva, Rafael Dias, João Pedro Filipe, Maria João Malaquias, Ana Moutinho, Denis Gabriel, Ana Aires, Rui Antunes, José Pedro Rocha, Rui Felgueiras, Ricardo Almendra, Pedro Castro, Henrik Zetterberg, Rui Magalhães, Thomas K Karikari, Manuel Correia, Kaj Blennow, Luís F Maia
Plasma Brain-Derived Tau in Prognosis of Large Vessel Occlusion Ischemic Stroke
Brain communications
Published

Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET

Authors
Steffi De Meyer, Jolien M Schaeverbeke, Emma S Luckett, Mariska Reinartz, Elena R Blujdea, Isabelle Cleynen, Patrick Dupont, Koen Van Laere, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Guglielmo di Molfetta, Henrik Zetterberg, Nicholas J Ashton, Charlotte E Teunissen, Koen Poesen, Rik Vandenberghe
Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study

Authors
Mingqing Zhao, Yuanjing Li, Xiaodong Han, Chunyan Li, Pin Wang, Jiafeng Wang, Tingting Hou, Yongxiang Wang, Lin Cong, Joanna M Wardlaw, Lenore J Launer, Lin Song, Yifeng Du, Chengxuan Qiu
Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study
PLoS biology
Published

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease

Authors
Rikesh M Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S Harris, Orjona S Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S H Danial, Matthew Swire, Marcus Lloyd, Tatiana A Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease
PLoS Biol
Published

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.

Authors
Rikesh M Rajani, Robert Ellingford, Mariam Hellmuth, Samuel S Harris, Orjona S Taso, David Graykowski, Francesca Kar Wey Lam, Charles Arber, Emre Fertan, John S H Danial, Matthew Swire, Marcus Lloyd, Tatiana A Giovannucci, Mathieu Bourdenx, David Klenerman, Robert Vassar, Selina Wray, Carlo Sala Frigerio, Marc Aurel Busche
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
Journal of neurology
Published

18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes

Authors
Anna Vasilevskaya, Chloe Anastassiadis, Simrika Thapa, Foad Taghdiri, Mozhgan Khodadadi, Namita Multani, Pablo Rusjan, Miracle Ozzoude, Apameh Tarazi, Asma Mushtaque, Richard Wennberg, Sylvain Houle, Robin Green, Brenda Colella, Neil Vasdev, Kaj Blennow, Henrik Zetterberg, Thomas Karikari, Christine Sato, Danielle Moreno, Ekaterina Rogaeva, David Mikulis, Karen Deborah Davis, Charles Tator, Maria Carmela Tartaglia
18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes
Alzheimer's research & therapy
Published

Hormone therapy is associated with lower Alzheimer's disease tau biomarkers in post-menopausal females -evidence from two independent cohorts

Authors
Yi-Ting Wang, Joseph Therriault, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Jaime Fernandez-Arias, Sulantha S Mathotaarachchi, Jenna Stevenson, Firoza Z Lussier, Andréa L Benedet, Tharick A Pascoal, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Pedro Rosa-Neto
Hormone therapy is associated with lower Alzheimer's disease tau biomarkers in post-menopausal females -evidence from two independent cohorts
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease

Authors
Noëlle Warmenhoven, Gonzalo Sánchez-Benavides, Armand González-Escalante, Marta Milà-Alomà, Mahnaz Shekari, David López-Martos, Paula Ortiz-Romero, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Carolina Minguillón, Juan Domingo Gispert, Natalia Vilor-Tejedor, Eider Arenaza-Urquijo, Eleni Palpatzis, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Oriol Grau-Rivera, ALFA Study
CSF glial biomarkers are associated with cognition in individuals at risk of Alzheimer's disease
Epilepsia
Published

Elevated plasma neurofilament light and glial fibrillary acidic protein in epilepsy versus nonepileptic seizures and nonepileptic disorders

Authors
Hannah Dobson, Said Al Maawali, Charles Malpas, Alexander F Santillo, Matthew Kang, Marian Todaro, Rosie Watson, Nawaf Yassi, Kaj Blennow, Henrik Zetterberg, Emma Foster, Andrew Neal, Dennis Velakoulis, Terence John O'Brien, Dhamidhu Eratne, Patrick Kwan
Elevated plasma neurofilament light and glial fibrillary acidic protein in epilepsy versus nonepileptic seizures and nonepileptic disorders
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults

Authors
Ira Frahmand Driscoll, Sarah Lose, Yue Ma, Barbara B Bendlin, Catherine Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dena Dubal, Ozioma C Okonkwo
KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults
J Neurochem
Published

Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains.

Authors
Helen Xuexia Huang, Paolo Inglese, Jiabin Tang, Riad Yagoubi, Gonçalo D S Correia, Verena M Horneffer-van der Sluis, Stephane Camuzeaux, Vincen Wu, Maksym V Kopanitsa, Nanet Willumsen, Johanna S Jackson, Anna M Barron, Takashi Saito, Takaomi C Saido, Steve Gentlemen, Zoltan Takats, Paul M Matthews
Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains.
Molecular neurodegeneration
Published

Tau protein profiling in tauopathies: a human brain study

Authors
Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M Burmann, Michael Perkinton, Nicholas J Ashton, Nick C Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
Tau protein profiling in tauopathies: a human brain study
Acta neuropathologica
Published

Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down syndrome

Authors
Amal Kasri, Elena Camporesi, Eleni Gkanatsiou, Susana Boluda, Gunnar Brinkmalm, Lev Stimmer, Junyue Ge, Jörg Hanrieder, Nicolas Villain, Charles Duyckaerts, Yannick Vermeiren, Sarah E Pape, Gaël Nicolas, Annie Laquerrière, Peter Paul De Deyn, David Wallon, Kaj Blennow, Andre Strydom, Henrik Zetterberg, Marie-Claude Potier
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down syndrome
Fluids and barriers of the CNS
Published

Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies

Authors
Aurore Delvenne, Charysse Vandendriessche, Johan Gobom, Marlies Burgelman, Pieter Dujardin, Clint De Nolf, Betty M Tijms, Charlotte E Teunissen, Suzanne E Schindler, Frans Verhey, Inez Ramakers, Pablo Martinez-Lage, Mikel Tainta, Rik Vandenberghe, Jolien Schaeverbeke, Sebastiaan Engelborghs, Ellen De Roeck, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Roosmarijn E Vandenbroucke, Stephanie J B Vos
Involvement of the choroid plexus in Alzheimer's disease pathophysiology: findings from mouse and human proteomic studies