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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

bioRxiv : the preprint server for biology
Published

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
bioRxiv : the preprint server for biology
Published

Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models

Authors
Dimitra Sokolova, Shari Addington Ghansah, Francesca Puletti, Tatiana Georgiades, Sebastiaan De Schepper, Yongjing Zheng, Gerard Crowley, Ling Wu, Javier Rueda-Carrasco, Angeliki Koutsiouroumpa, Philip Muckett, Oliver J Freeman, Baljit S Khakh, Soyon Hong
Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Overview of ADNI MRI

Authors
Clifford R Jack, Arvin Arani, Bret J Borowski, Dave M Cash, Karen Crawford, Sandhitsu R Das, Charles DeCarli, Evan Fletcher, Nick C Fox, Jeffrey L Gunter, Ranjit Ittyerah, Danielle J Harvey, Neda Jahanshad, Pauline Maillard, Ian B Malone, Talia M Nir, Robert I Reid, Denise A Reyes, Christopher G Schwarz, Matthew L Senjem, David L Thomas, Paul M Thompson, Duygu Tosun, Paul A Yushkevich, Chadwick P Ward, Michael W Weiner, Alzheimer's Disease Neuroimaging Initiative
Overview of ADNI MRI
Clinical epigenetics
Published

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

Authors
Danni A Gadd, Hannah M Smith, Donncha Mullin, Ola Chybowska, Robert F Hillary, Dorien M Kimenai, Elena Bernabeu, Yipeng Cheng, Chloe Fawns-Ritchie, Archie Campbell, Danielle Page, Adele Taylor, Janie Corley, Maria Del C Valdés-Hernández, Susana Muñoz Maniega, Mark E Bastin, Joanna M Wardlaw, Rosie M Walker, Kathryn L Evans, Andrew M McIntosh, Caroline Hayward, Tom C Russ, Sarah E Harris, Paul Welsh, Naveed Sattar, Simon R Cox, Daniel L McCartney, Riccardo E Marioni
DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain
Journal of neurology
Published

GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)

Authors
Sabrina Katzdobler, Georg Nübling, Martin Klietz, Urban M Fietzek, Carla Palleis, Alexander M Bernhardt, Florian Wegner, Meret Huber, Sophia Rogozinski, Luisa-Sophie Schneider, Eike Jakob Spruth, Aline Beyle, Ina R Vogt, Moritz Brandt, Niels Hansen, Wenzel Glanz, Kathrin Brockmann, Annika Spottke, Daniel C Hoffmann, Oliver Peters, Josef Priller, Jens Wiltfang, Emrah Düzel, Anja Schneider, Björn Falkenburger, Thomas Klockgether, Thomas Gasser, Brigitte Nuscher, Christian Haass, Günter Höglinger, Johannes Levin
GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)
The Lancet regional health. Europe
Published

Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study

Authors
Pamela V Martino-Adami, Madhurima Chatterjee, Luca Kleineidam, Siegfried Weyerer, Horst Bickel, Birgitt Wiese, Steffi G Riedel-Heller, Martin Scherer, Kaj Blennow, Henrik Zetterberg, Michael Wagner, Anja Schneider, Alfredo Ramirez
Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study
Translational psychiatry
Published

Neuroinflammation, cerebrovascular dysfunction and diurnal cortisol biomarkers in a memory clinic cohort: Findings from the Co-STAR study

Authors
Makrina Daniilidou, Jasper Holleman, Göran Hagman, Ingemar Kåreholt, Malin Aspö, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Alina Solomon, Miia Kivipelto, Shireen Sindi, Anna Matton
Neuroinflammation, cerebrovascular dysfunction and diurnal cortisol biomarkers in a memory clinic cohort: Findings from the Co-STAR study
Journal of neurology
Published

Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson's disease

Authors
Andrea Pilotto, Nicholas J Ashton, Alessandro Lupini, Beatrice Battaglio, Cinzia Zatti, Chiara Trasciatti, Stefano Gipponi, Elisabetta Cottini, Ilaria Grossi, Alessandro Salvi, Giuseppina de Petro, Marina Pizzi, Antonio Canale, Kaj Blennow, Henrik Zetterberg, Alessandro Padovani
Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson's disease
medRxiv : the preprint server for health sciences
Published

The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study

Authors
Nicholas J Ashton, Ashvini Keshavan, Wagner S Brum, Ulf Andreasson, Burak Arslan, Mathias Droescher, Stefan Barghorn, Jeroen Vanbrabant, Charlotte Lambrechts, Maxime Van Loo, Erik Stoops, Shweta Iyengar, HaYeun Ji, Xiaomei Xu, Alex Forrest-Hay, Bingqing Zhang, Yuling Luo, Andreas Jeromin, Manu Vandijck, Nathalie Le Bastard, Hartmuth Kolb, Gallen Triana-Baltzer, Divya Bali, Shorena Janelidze, Shieh-Yueh Yang, Catherine Demos, Daniel Romero, George Sigal, Jacob Wohlstadter, Kishore Malyavantham, Meenakshi Khare, Alexander Jethwa, Laura Stoeckl, Johan Gobom, Przemysław R Kac, Fernando Gonzalez-Ortiz, Laia Montoliu-Gaya, Oskar Hansson, Robert A Rissman, Maria C Carillo, Leslie M Shaw, Kaj Blennow, Jonathan M Schott, Henrik Zetterberg
The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study
Neuron
Published

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.

Authors
Isabel Lam, Alain Ndayisaba, Amanda J Lewis, YuHong Fu, Giselle T Sagredo, Anastasia Kuzkina, Ludovica Zaccagnini, Meral Celikag, Jackson Sandoe, Ricardo L Sanz, Aazam Vahdatshoar, Timothy D Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, Nagendran Ramalingam, Charlotte Oettgen-Suazo, Theresa Bartels, Manel Boussouf, Max Schäbinger, Erinc Hallacli, Xin Jiang, Amrita Verma, Challana Tea, Zichen Wang, Hiroyuki Hakozaki, Xiao Yu, Kelly Hyles, Chansaem Park, Xinyuan Wang, Thorold W Theunissen, Haoyi Wang, Rudolf Jaenisch, Susan Lindquist, Beth Stevens, Nadia Stefanova, Gregor Wenning, Wilma D J van de Berg, Kelvin C Luk, Rosario Sanchez-Pernaute, Juan Carlos Gómez-Esteban, Daniel Felsky, Yasujiro Kiyota, Nidhi Sahni, S Stephen Yi, Chee Yeun Chung, Henning Stahlberg, Isidro Ferrer, Johannes Schöneberg, Stephen J Elledge, Ulf Dettmer, Glenda M Halliday, Tim Bartels, Vikram Khurana
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
Experimental gerontology
Published

A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions

Authors
Miguel German Borda, George E Barreto, Jonathan Patricio Baldera, Chiara de Lucia, Khadija Khalifa, Anne Katrine Bergland, Ilaria Pola, Felipe Botero-Rodríguez, Richard Siow, Miia Kivipelto, Henrik Zetterberg, Nicholas J Ashton, Clive Ballard, Dag Aarsland, NJ FINGER
A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions
Advanced healthcare materials
Published

An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein

Authors
Yixuan Li, Liuxiong Luo, Lenart Senicar, Rica Asrosa, Burcu Kizilates, Kaizhong Xing, Elias Torres, Lizhou Xu, Danyang Li, Neil Graham, Amanda Heslegrave, Henrik Zetterberg, David J Sharp, Bing Li
An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein
Science (New York, N.Y.)
Published

Aggregate-selective removal of pathological tau by clustering-activated degraders

Authors
Jonathan Benn, Shi Cheng, Sophie Keeling, Annabel E Smith, Marina J Vaysburd, Dorothea Böken, Lauren V C Miller, Taxiarchis Katsinelos, Catarina Franco, Elian Dupré, Clément Danis, Isabelle Landrieu, Luc Buée, David Klenerman, Leo C James, William A McEwan
Aggregate-selective removal of pathological tau by clustering-activated degraders