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Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Emerging directions in tauopathy research

Authors

Luc Buée, Kristin R Wildsmith, Suvarna Alladi, Taylor Bertucci, Delphine Boche, Kathryn R Bowles, Adam Boxer, Jennifer Brummet, Sarah L DeVos, Kristophe Diaz, Anna Jane Dreyer, Karen Duff, Claudia Duran-Aniotz, Claire S Durrant, Kurt Farrell, Igor C Fontana, Nicolai Franzmeier, Bess Frost, Kanta Horie, Petr Kaňovský, Aimee W Kao, Simin Mahinrad, Maura Malpetti, Huw R Morris, Carla Palleis, Leonard Petrucelli, Jessica Rexach, Larisa Reyderman, Amy Rommel, James B Rowe, Sandra M Sanabria Bohórquez, Chihiro Sato, Michael Schöll, Anja Schneider, Rohan de Silva, Heather M Snyder, Lawren VandeVrede, Andrew W Varga, Jacob W Vogel, Felix L Yeh, Andrew S Yoo, Maria C Carrillo

Abstract

Alzheimers Dement. 2026 Jun;22(6):e71431. doi: 10.1002/alz.71431.

ABSTRACT

The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of tau regulation, degradation, and propagation; advances in biomarker development for the diagnosis and staging of tauopathies; and evolving therapeutic strategies targeting diverse aspects of tau pathophysiology. Discussions also emphasized the importance of cross-sector collaboration, and global initiatives to address disparities in tau research. This report synthesizes key insights from the conference and underscores the critical role of interdisciplinary, biomarker-driven, and globally inclusive approaches in accelerating the translation of tau research into effective clinical applications.

PMID:42324487 | DOI:10.1002/alz.71431

UK DRI Authors

Prof Karen Duff

Centre Director

Revealing the molecular causes and consequences of tauopathy in Alzheimer's disease and frontotemporal dementia

Prof Karen Duff

Dr Maura Malpetti

Emerging Leader

Using specialist brain scans and novel blood tests to measure inflammation and accelerate the development of new treatments

Dr Maura Malpetti