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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Neurology
Published

Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study

Authors
Emilie Sleight, Michael S Stringer, Una Clancy, Carmen Arteaga-Reyes, Daniela Jaime Garcia, Angela C C Jochems, Stewart Wiseman, Maria Valdes Hernandez, Francesca M Chappell, Fergus N Doubal, Ian Marshall, Michael J Thrippleton, Joanna M Wardlaw
Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study
Neurology
Published

Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease

Authors
Michelle Safransky, Jenna R Groh, Kaj Blennow, Henrik Zetterberg, Yorghos Tripodis, Brett Martin, Jason Weller, Breton M Asken, Gil D Rabinovici, Wendy Wei Qiao Qiu, Ann C McKee, Thor D Stein, Jesse Mez, Rachel L Henson, Justin Long, John C Morris, Richard J Perrin, Suzanne E Schindler, Michael L Alosco
Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnoea

Authors
Ylenia Giarratano, Elizabeth A Hill, Charlene Hamid, Stewart Wiseman, Calum Gray, Francesca M Chappell, Roberto Duarte Coello, Maria C Valdés-Hernández, Lucia Ballerini, Michael S Stringer, Michael J Thrippleton, Daniela Jaime Garcia, Xiaodi Liu, William Hewins, Yajun Cheng, Sandra E Black, Andrew Lim, Rosa Sommer, Joel Ramirez, Bradley J MacIntosh, Rosalind Brown, Fergus Doubal, Tom MacGillivray, Joanna M Wardlaw, Renata Riha, Miguel O Bernabeu
Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnoea
Alzheimer's research & therapy
Published

Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study

Authors
Inga Menze, Jose Bernal, Pinar Kaya, Çağla Aki, Malte Pfister, Jonas Geisendörfer, Renat Yakupov, Roberto Duarte Coello, Maria D C Valdés-Hernández, Michael T Heneka, Frederic Brosseron, Matthias C Schmid, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Ayda Rostamzadeh, Dix Meiberth, Oliver Peters, Lukas Preis, Dominik Lammerding, Daria Gref, Josef Priller, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Stefan Hetzer, Anja Schneider, Klaus Fliessbach, Okka Kimmich, Ina R Vogt, Jens Wiltfang, Claudia Bartels, Björn H Schott, Niels Hansen, Peter Dechent, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Carolin Sanzenbacher, Petra Hinderer, Klaus Scheffler, Annika Spottke, Nina Roy-Kluth, Falk Lüsebrink, Katja Neumann, Joanna Wardlaw, Frank Jessen, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler
Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study
Molecular psychiatry
Published

Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival

Authors
Alexandra Strauss, Peter Swann, Stacey L Kigar, Rafailia Christou, Natalia Savinykh Yarkoni, Lorinda Turner, Alexander G Murley, Leonidas Chouliaras, Noah Shapiro, Nicholas J Ashton, George Savulich, W Richard Bevan-Jones, Ajenthan Surendranthan, Kaj Blennow, Henrik Zetterberg, John T O'Brien, James B Rowe, Maura Malpetti
Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival
Journal of neurochemistry
Published

Circulating medium- and long-chain acylcarnitines are associated with plasma P-tau181 in cognitively normal older adults

Authors
Tahmida Sharmin, Pratishtha Chatterjee, James D Doecke, Nicholas J Ashton, Kevin Huynh, Steve Pedrini, Hamid R Sohrabi, Benjamin Heng, Shaun Eslick, Henrik Zetterberg, Kaj Blennow, Manohar Garg, Ralph N Martins
Circulating medium- and long-chain acylcarnitines are associated with plasma P-tau181 in cognitively normal older adults
Frontiers in aging neuroscience
Published

Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants

Authors
Ann-Kathrin Schalkamp, Stefanie Lerche, Isabel Wurster, Benjamin Roeben, Milan Zimmermann, Franca Fries, Anna-Katharina von Thaler, Gerhard Eschweiler, Walter Maetzler, Daniela Berg, Fabian H Sinz, Kathrin Brockmann
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
Brain : a journal of neurology
Published

A comprehensive head-to-head comparison of key plasma phosphorylated tau 217 biomarker tests

Authors
Noëlle Warmenhoven, Gemma Salvadó, Shorena Janelidze, Niklas Mattsson-Carlgren, Divya Bali, Anna Orduña Dolado, Hartmuth Kolb, Gallen Triana-Baltzer, Nicolas R Barthélemy, Suzanne E Schindler, Andrew J Aschenbrenner, Cyrus A Raji, Tammie L S Benzinger, John C Morris, Laura Ibanez, Jigyasha Timsina, Carlos Cruchaga, Randall J Bateman, Nicholas Ashton, Burak Arslan, Henrik Zetterberg, Kaj Blennow, Alexa Pichet Binette, Oskar Hansson
A comprehensive head-to-head comparison of key plasma phosphorylated tau 217 biomarker tests
Alzheimer's research & therapy
Published

Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults

Authors
Jose Bernal, Inga Menze, Renat Yakupov, Oliver Peters, Julian Hellmann-Regen, Silka Dawn Freiesleben, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H Schott, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Sebastian Sodenkamp, Annika Spottke, Anna Esser, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler
Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults