Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
BMC biology
Published

Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Authors
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M Chakrabarti, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
Correction: Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Authors
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J Devine, Edgar R Gomes, Joseph Chambers, Elena Koslover, Edward Avezov
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability
medRxiv : the preprint server for health sciences
Published

Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated with All-Cause Mortality

Authors
Maira Pyrgioti, Ines Mesa Eguiagaray, Paul Redmond, Janie Corley, Mark E Bastin, Maria Valdés Hernández, Tom C Russ, Joanna M Wardlaw, Eilis Hannon, Ian J Deary, Keenan A Walker, Elliot M Tucker-Drob, Simon R Cox, Riccardo E Marioni, Sarah E Harris
Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated with All-Cause Mortality
Alzheimer's research & therapy
Published

Independent and interactive contributions of white matter hyperintensities and Alzheimer's disease imaging and plasma biomarkers to cognitive decline in older adults without dementia

Authors
Dario Bachmann, Christoph Gericke, Maha Wybitul, Antje Saake, Sandro Studer, Katrin Rauen, Esmeralda Gruber, Andreas Buchmann, Martin Hüllner, Kaj Blennow, Henrik Zetterberg, Roger M Nitsch, Christoph Hock, Valerie Treyer, Anton Gietl
Independent and interactive contributions of white matter hyperintensities and Alzheimer's disease imaging and plasma biomarkers to cognitive decline in older adults without dementia
The European journal of neuroscience
Published

Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease

Authors
Francesco Gobbo, Declan King, Jane Tulloch, Davide Gobbo, Calum Bonthron, Soraya Meftah, Caleb Stoddart-Campbelton, Arisa Tamura, Jamie Rose, Colin Smith, Claire Durrant, Tara L Spires-Jones
Astrocyte Proximity Protects Synapses From Human Amyloid-Beta Induced Degeneration in a Mouse Ex Vivo Model of Early Alzheimer's Disease
medRxiv : the preprint server for health sciences
Published

OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery

Authors
Kaleigh F Roberts, Zachary B Abrams, Luca Cappelletti, Mahdi Moqri, Nicholas Heugel, J Harry Caufield, Mathieu Bourdenx, Yan Li, Jineta Banerjee, Luca Foschini, Diego Galeano, Nomi L Harris, Melody Li, Kejun Ying, Justin A Melendez, Nicolas R Barthélemy, James G Bollinger, Yingxin He, Vitaliy Ovod, Tammie L S Benzinger, Shaney Flores, Brian A Gordon, Adegoke A Ojewole, Mukta Phatak, Donald L Elbert, Sarah Biber, Eric C Landsness, Christopher J Mungall, Randall J Bateman, Justin T Reese
OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery
Research square
Published

Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness

Authors
Konstanze Tan, Sarah E Harris, Jane Maddock, Darwin Tay, Pritesh R Jain, HELIOS Study Team, Shi Qi Mok, Maxime Herbrard, Ulf Schminke, Can Can Xue, Liuh Ling Goh, Theresia H Mina, Alexander Teumer, Weng Khong Lim, Khai Pang Leong, Khung Keong Yeo, Ching-Yu Cheng, Xueling Sim, Lee Eng Sing, Joanna M Wardlaw, Henry Völzke, Andrew Wong, Simon R Cox, Rinkoo Dalan, Abbas Dehghan, Marie Loh
Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness
Brain : a journal of neurology
Published

Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease

Authors
Hemanth R Nelvagal, Nancy Chiraki, Toby Curless, Patrick W Cullinane, Alice Rockliffe, Samarth Pimparkar, Haruka Kawamura, Sophie Ollerenshaw, Isha Elahi, Sebastian Brandner, Lesley Wu, Raquel Real, Mina Ryten, John Hardy, Eduardo De Pablo Fernandez, Thomas T Warner, Huw R Morris, Yau Mun Lim, Zane Jaunmuktane
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease
Journal of Alzheimer's disease : JAD
Published

Generalizability of blood-based biomarkers of Alzheimer's disease and related dementias in a multicultural cohort of older adults: The effect of adjustment for kidney function

Authors
Ángel García de la Garza, Cuiling Wang, Carol A Derby, Qi Gao, Kenny Q Ye, Henrik Zetterberg, Christopher G Engeland, Richard B Lipton, Mindy J Katz
Generalizability of blood-based biomarkers of Alzheimer's disease and related dementias in a multicultural cohort of older adults: The effect of adjustment for kidney function
Brain communications
Published

Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease

Authors
Michalis Kassinopoulos, Paula Montesinos, Carles Falcon, Jordi Huguet, Carolina Minguillon, Karine Fauria, Gwendlyn Kollmorgen, Clara Quijano-Rubio, José Luis Molinuevo, Oriol Grau-Rivera, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Javier Sanchez-Gonzalez, Juan Domingo Gispert, ALFA study
Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease
Brain communications
Published

<em>C9orf72</em> poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia

Authors
Carmelo Milioto, Mireia Carcolé, Matteo Zanovello, Mhoriam Ahmed, Raja S Nirujogi, Daniel Biggs, Martha J Roberts, Kyra Schweers, Alexander J Cammack, Paolo M Marchi, Eszter Katona, Idoia Glaria, Almudena Santos, Anny Devoy, Pietro Fratta, Dario R Alessi, Ben Davies, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
<em>C9orf72</em> poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia
Neurobiology of aging
Published

Relevance of the diffusion tensor imaging along the perivascular space (DTI-ALPS) index in small vessel disease - A study in patients with mild ischaemic stroke

Authors
Debora Mucida Alvim, Maria Del C Valdés Hernández, Mark E Bastin, Una Clancy, Carmen Arteaga-Reyes, Stewart Wiseman, Angela C C Jochems, Daniela Jaime Garcia, Olivia K L Hamilton, Ellen V Backhouse, Yajun Cheng, Michael J Thrippleton, Michael S Stringer, Francesca M Chappell, Fergus N Doubal, Susana Muñoz Maniega, Joanna M Wardlaw
Relevance of the diffusion tensor imaging along the perivascular space (DTI-ALPS) index in small vessel disease - A study in patients with mild ischaemic stroke