Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
HIV medicine
Published

Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART

Authors
Merle Henderson, Peter Dutey-Magni, Carolina Herrera, Wolfgang Stöhr, Alejandro Arenas-Pinto, Owen Swann, Amanda Heslegrave, Henrik Zetterberg, John Tregoning, Sarah Fidler, François Raffi, Andrea Calcagno, Ab Babiker, Alan Winston
Longitudinal changes in plasma biomarkers of immune activation, neuronal inflammation and injury in persons with HIV initiating ART
Nature reviews. Neurology
Published

UK Biobank at 20 - a growing, global resource for dementia research

Authors
Paul M Matthews, Naomi E Allen, Stephanie Debette, Aiden Doherty, Gwenaëlle Douaud, Eugene P Duff, Paul Elliott, Evelynne S Fulda, Anastasia Illina, Quentin Le Grand, Adam J Lewandowski, Rebecca Mahoney, Karla Miller, Cecilia Rodriguez, Martin K Rutter, Cynthia Sandor, Rebecca Sims, Stephen M Smith, Chaoyue Wang
UK Biobank at 20 - a growing, global resource for dementia research
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation

Authors
Burak Arslan, Johan Gobom, Ulf Andreasson, Laia Montoliu-Gaya, Andrea L Benedet, Anna Dittrich, Silke Kern, Ingmar Skoog, Nicholas J Ashton, Tevy Chan, Nesrine Rahmouni, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg
Analytical and clinical validation of the Lumipulse G plasma p-tau217 assay for clinical implementation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Traumatic brain injury and risk of early-onset dementia: A population-based cohort study

Authors
Aishwarya Saravanan, Katherine Giorgio, Natalia Lakomski, Andrea L C Schneider, Barbara A Olson-Bullis, Behnam Sabayan, James S Pankow, Paul S de Vries, Kristine Yaffe, Alexa Beiser, Abbas Dehghan, Elizabeth A Peterson, Rachel Zmora, John J Stephen, Denise Scholtens, Maxwell Mansolf, Lenore J Launer, Richard F MacLehose, Pamela L Lutsey, Norrina B Allen, Sanaz Sedaghat
Traumatic brain injury and risk of early-onset dementia: A population-based cohort study
Science signaling
Published

Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

Authors
Jose Norberto S Vargas, Anna-Leigh Brown, Kai Sun, Cathleen Hagemann, Bethany Geary, David Villarroel-Campos, Sam Bryce-Smith, Matteo Zanovello, Madeline Lombardo, Stan Majewski, Andrew Tosolini, Maria Secrier, Matthew J Keuss, Andrea Serio, James N Sleigh, Pietro Fratta, Giampietro Schiavo
Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons
EBioMedicine
Published

Biomarkers of Alzheimer's disease pathophysiology and delirium

Authors
Kristi Henjum, Bjørn Erik Neerland, Kaj Blennow, Henrik Zetterberg, Christian Thomas Pollmann, Roy Bjørkholt Olsen, Lene Solberg, Marius Myrstad, Olav Tobias Ødegaard, Adi Karabeg, Alan Gulestøl, Ane Victoria Idland, Leiv Otto Watne
Biomarkers of Alzheimer's disease pathophysiology and delirium
European journal of clinical investigation
Published

Prognostic Added Value of GFAP in Patients With Minor Ischemic Stroke

Authors
Andrea Morotti, Mathias Sauer, Francesco Berinato, Marcello Catania, Andrea L Benedet, Chiara Tolassi, Guglielmo Di Molfetta, Ilaria Pola, Henrik Zetterberg, Nicholas J Ashton, Andrea Pilotto, Alessandro Padovani
Prognostic Added Value of GFAP in Patients With Minor Ischemic Stroke
medRxiv : the preprint server for health sciences
Published

Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing

Authors
Christopher R S Belder, Amanda J Heslegrave, Owen Swann, Emily Abel, Millie Beament, Moneeb Nasir, Helen Rice, Philip S J Weston, Natalie S Ryan, Lyle J Palmer, Amy Brodtmann, Timothy Kleinig, Henrik Zetterberg, Nick C Fox
Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing
bioRxiv : the preprint server for biology
Published

General cognitive function and the brain's structural connectome

Authors
Colin R Buchanan, Joanna E Moodie, Venia Batziou, Eleanor L S Conole, Susana Muñoz Maniega, Mathew A Harris, Hon Wah Yeung, Janie Corley, David C Liewald, Paul Redmond, J Douglas Steele, Gordon D Waiter, Heather C Whalley, Andrew M McIntosh, Joanna M Wardlaw, Mark E Bastin, Ian J Deary, Elliot M Tucker-Drob, Simon R Cox
General cognitive function and the brain's structural connectome
medRxiv : the preprint server for health sciences
Published

Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer's Disease

Authors
Wenjing Lin, Aleksandra Beric, Julie K Wisch, Bryce Baker, Gina Jerome, Matthew Minton, Sam Preminger, Jennifer Stauber, Suzanne E Schindler, Jeffrey L Dage, Ricardo Allegri, David Aguillon, Tammie Benzinger, Jasmeer Chhatwal, Alisha Daniels, Gregory S Day, Emma Devenney, Nick C Fox, Alison Goate, Brian A Gordon, Nicolas R Barthélemy, Jason Hassenstab, Edward Huey, Takeshi Ikeuchi, Suman Jayadev, Mathias Jucker, Takanobu Ishiguro, Jae-Hong Lee, Allan I Levey, Johannes Levin, John C Morris, Richard J Perrin, Alan Renton, Jee Hoon Roh, Chengjie Xiong, Randall J Bateman, Beau M Ances, Carlos Cruchaga, Celeste M Karch, Charlene Supnet-Bell, Jorge Llibre-Guerra, Eric McDade, Dominantly Inherited Alzheimer Network, Laura Ibanez
Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer's Disease
NPJ Parkinson's disease
Published

Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease

Authors
Alena M Smith, Sara A Lorkiewicz, Burak Arslan, Laia Montoliu-Gaya, Nicholas J Ashton, Edward N Wilson, Daniel Alcolea, Íñigo Rodríguez-Baz, Juan Fortea, Christina B Young, Joseph R Winer, Marian Shahid-Besanti, Hillary Vossler, Melanie J Plastini, Tianyu Pan, Elena Vera-Campuzano, Isabel Sala, Justin H Mendiola, Veronica Ramirez, Geoffrey A Kerchner, Katrin I Andreasson, Victor W Henderson, Thomas J Montine, Lu Tian, Elizabeth C Mormino, Henrik Zetterberg, Kathleen L Poston, Carla Abdelnour
Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease
Acta neuropathologica communications
Published

Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease

Authors
Carlos Avilés-Granados, Adriana Gea-González, Jorge Sáez-Leyva, Sylvia E Perez, Elliott J Mufson, Ann-Charlotte Granholm, María Carmona-Iragui, Henrik Zetterberg, Kaj Blennow, Juan Fortea, María-Salud García-Ayllón, Javier Sáez-Valero
Cerebrospinal fluid and frontal cortex TMPRSS2 and ACE2 protein levels differ in Down syndrome and Alzheimer's disease