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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain communications
Published

Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease

Authors
Michalis Kassinopoulos, Paula Montesinos, Carles Falcon, Jordi Huguet, Carolina Minguillon, Karine Fauria, Gwendlyn Kollmorgen, Clara Quijano-Rubio, José Luis Molinuevo, Oriol Grau-Rivera, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Javier Sanchez-Gonzalez, Juan Domingo Gispert, ALFA study
Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease
Brain communications
Published

<em>C9orf72</em> poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia

Authors
Carmelo Milioto, Mireia Carcolé, Matteo Zanovello, Mhoriam Ahmed, Raja S Nirujogi, Daniel Biggs, Martha J Roberts, Kyra Schweers, Alexander J Cammack, Paolo M Marchi, Eszter Katona, Idoia Glaria, Almudena Santos, Anny Devoy, Pietro Fratta, Dario R Alessi, Ben Davies, Linda Greensmith, Elizabeth M C Fisher, Adrian M Isaacs
<em>C9orf72</em> poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia
Neurobiology of aging
Published

Relevance of the diffusion tensor imaging along the perivascular space (DTI-ALPS) index in small vessel disease - A study in patients with mild ischaemic stroke

Authors
Debora Mucida Alvim, Maria Del C Valdés Hernández, Mark E Bastin, Una Clancy, Carmen Arteaga-Reyes, Stewart Wiseman, Angela C C Jochems, Daniela Jaime Garcia, Olivia K L Hamilton, Ellen V Backhouse, Yajun Cheng, Michael J Thrippleton, Michael S Stringer, Francesca M Chappell, Fergus N Doubal, Susana Muñoz Maniega, Joanna M Wardlaw
Relevance of the diffusion tensor imaging along the perivascular space (DTI-ALPS) index in small vessel disease - A study in patients with mild ischaemic stroke
Brain communications
Published

Ventricular enlargement is associated with early Alzheimer's disease pathophysiology

Authors
Seyyed Ali Hosseini, Etienne Aumont, Nesrine Rahmouni, Marcel S Woo, Arthur C Macedo, Brandon Hall, Lydia Trudel, Tevy Chan, Jaime Fernandez Arias, Yi-Ting Wang, Stijn Servaes, Joseph Therriault, Yansheng Zheng, Kely Quispialaya Socualaya, Gleb Bezgin, Cécile Tissot, Delphine Oliva-Lopez, Robert Hopewell, Chris Hung-Hsin Hsiao, Catherine Saleh, Jenna Stevenson, Firoza Lussier, Liyong Wu, Min Chu, Sanjeev Chawla, Vladimir Fonov, Gassan Massarweh, Yasser Iturria-Medina, Jean-Paul Soucy, David A Rudko, Serge Gauthier, Thomas Karikari, Andréa Lessa Benedet, Nicholas J Ashton, Henrik Zetterberg, Maxime Montembeault, Paolo Vitali, Kaj Blennow, D Louis Collins, Jesse Klostranec, Tharick A Pascoal, Pedro Rosa-Neto
Ventricular enlargement is associated with early Alzheimer's disease pathophysiology
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Herpesvirus genome integration in whole-genome sequences of dementia and control cohorts

Authors
Stacey L Piotrowski, Mary Alice Allnutt, Kory Johnson, Toshiko Tanaka, Luigi Ferrucci, Huw Morris, John Hardy, PROSPECT Consortium, Mina Ryten, United Kingdom Brain Expression Consortium (UKBEC), Giancarlo Logroscino, Juan Troncoso, Thomas G Beach, Geidy E Serrano, Carlos Cruchaga, Dennis W Dickson, Owen A Ross, Adriano Chiò, International LBD Genomics Consortium, International ALS Genomics Consortium, Henry Houlden, American Genome Center, Clifton L Dalgard, Jinhui Ding, J Raphael Gibbs, Bryan J Traynor, Sonja W Scholz, Steven Jacobson
Herpesvirus genome integration in whole-genome sequences of dementia and control cohorts
Alzheimer's research & therapy
Published

Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer's disease using the Lumipulse platform

Authors
Andrea Valera-Barrero, Francisco Martínez-Dubarbie, Armando Guerra, Sara López-García, Carmen Lage, María Rivera-Sánchez, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Guglielmo Di Molfetta, Kaj Blennow, Nicholas J Ashton, Henrik Zetterberg, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Marta Fernández-Matarrubia
Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer's disease using the Lumipulse platform
Mammalian genome : official journal of the International Mammalian Genome Society
Published

Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory

Authors
Mehwish Anwer, Tetiana Poliakova, Ricardo D'Oliveira Albanus, Mohammad Iqbal H Bhuiyan, Adam M Brickman, Soumilee Chaudhuri, Leah Cuddy, Maxwell Eisenbaum, Kate Foley, Douglas B Gould, Catherine Hall, Costantino Iadecola, Olivia Marola, Christopher M Norris, Alaina Reagan, Julie Schneider, Donna Wilcock, Isabella Xu, Andrew Yang, Gareth Howell, Cheryl L Wellington
Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe

Authors
Francesco Bax, Jan Oltmer, Corinne A Auger, Anna Bonkhoff, Gillian T Coughlan, Alexandra Melloni, Methasit Jaisa-Aad, Jean Augustinack, Alberto Serrano-Pozo, Matthew P Frosch, Steven M Greenberg, Teresa Gomez-Isla, Bradley T Hyman, Susanne J van Veluw, Valentina Perosa
APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe
Journal of neurology, neurosurgery, and psychiatry
Published

Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 367 988 people using natural language processing

Authors
Matthew Henry Iveson, Mome Mukherjee, Emma M Davidson, Huayu Zhang, Laura Sherlock, Emily L Ball, Grant Mair, Alice Hosking, Heather Whalley, Michael T C Poon, Joanna M Wardlaw, David Kent, Richard Tobin, Claire Grover, Beatrice Alex, William Whiteley
Clinically reported covert cerebrovascular disease and risk of neurological disease: a whole-population cohort of 367 988 people using natural language processing
medRxiv : the preprint server for health sciences
Published

Location patterns and longitudinal progression of white matter hyperintensities

Authors
Xin Zhao, Ian B Malone, Thomas M Brown, Andrew Wong, David M Cash, Nish Chaturvedi, Alun D Hughes, Jonathan M Schott, Frederik Barkhof, Josephine Barnes, Carole H Sudre, Alzheimer’s Disease Neuroimaging Initiative
Location patterns and longitudinal progression of white matter hyperintensities