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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

EBioMedicine
Published

Detecting amyloid-β pathology in subjective cognitive decline using plasma and CSF biomarkers

Authors
José Contador, Federico Emanuele Pozzi, Gonzalo Sánchez-Benavides, Ana Fernández-Arcos, Juan Lantero-Rodríguez, Laia Montoliu-Gaya, Carolina Minguillon, Karine Fauria, Armand González-Escalante, Paula Ortiz-Romero, Helena Blasco-Forniés, Marina de Diego-Osaba, Esther Jiménez Moyano, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Nathalie Le Bastard, Alicia Nadal, Eugeen Vanmechelen, Andreas Jeromin, Javier Torres-Torronteras, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, José Luis Molinuevo, Marta Del Campo, Oriol Grau-Rivera, Marc Suárez-Calvet, β-AARC Study collaborators
Detecting amyloid-β pathology in subjective cognitive decline using plasma and CSF biomarkers
Intensive care medicine
Published

Current knowledge and challenges of sepsis-associated encephalopathy

Authors
Manu Shankar-Hari, Sarah Benghanem, Lena Bourhy, Colm Cunningham, Johannes Ehler, Timothy D Girard, Teneille E Gofton, Bertrand Hermann, Zoeb Jiwaji, Aurelien Mazeraud, Ed Neeham, Regis G Rosa, Mervyn Singer, Arjen J C Slooter, Romain Sonneville, Robert D Stevens, Fabio Silvio Taccone, Tarek Sharshar
Current knowledge and challenges of sepsis-associated encephalopathy
Nature medicine
Published

Plasma proteomic signatures of cellular aging predict human disease

Authors
Daisy Yi Ding, Veronica Augustina Bot, Kenneth L Chen, James W Groves, Róbert Pálovics, Daisuke Masuda, Amelia Farinas, Hamilton Se-Hwee Oh, Viktoria Wagner, Nannan Lu, Global Neurodegeneration Proteomics Consortium (GNPC), Carlos Cruchaga, Alina Isakova, Jonathan M Schott, Tony Wyss-Coray
Plasma proteomic signatures of cellular aging predict human disease
Acta neuropathologica
Published

Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants

Authors
Nurun N Fancy, Nanet Willumsen, Vicky M N Chau, Samuel L Boulger, Harry J Whitwell, Wenhao Wang, Baptiste Avot, Michael Thomas, Jonathan Talbot-Martin, Stergios Tsartsalis, Combiz Khozoie, Aisling McGarry, Eleonore Schneegans, Riad Yagoubi, To Ka Dorcas Cheung, Marianna Papageorgopoulou, Emily Adair, Benjamin Cooper, Karen Davey, Amy M Smith, William Scotton, John Hardy, Paul M Matthews, Johanna S Jackson
Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants
Brain and neuroscience advances
Published

Alzheimer's Research UK Research Conference 2026

Authors
Elizabeth M Simzer, Jamie A Elliott, Soraya Meftah, Sowmya Sekizar, Lauren F P Young, James H Catterson
Alzheimer's Research UK Research Conference 2026
Alzheimer's research & therapy
Published

Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts

Authors
Brooke D Conway Kleven, Lung-Chang Chien, Dana Surwill, Michael L Alosco, Jennifer V Wethe, Yorghos Tripodis, Charles H Adler, Martha E Shenton, Ofer Pasternak, Douglas I Katz, Elaine Peskind, Laura J Balcer, Inga K Koerte, Jesse Mez, Eric M Reiman, Robert C Cantu, Robert A Stern, Henrik Zetterberg, Charles Bernick, Jeffrey L Cummings
Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts
Experimental neurology
Published

Infarct-associated oligoclonal T cell expansion in chronic experimental stroke across age, sex, and models

Authors
Sangeetha Senthil Kumar, Erin D Chapman, Danielle A Becktel, Susan A Whitman, Rachel Crumpacker, Jacob C Zbesko, Daniel Berchtold, Claudia Dames, María I Cuartero, Alicia Garcia-Culebras, Lizi M Hegarty, Gaia Brezzo, Jennifer E Goertz, Kristy Zera, Craig J Smith, Stuart M Allan, Christian Meisel, Andreas Meisel, María Ángeles Moro, Barry W McColl, Josef Anrather, Marion S Buckwalter, Helena W Morrison, Rick G Schnellmann, Kristian P Doyle
Infarct-associated oligoclonal T cell expansion in chronic experimental stroke across age, sex, and models
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state

Authors
Michael C B David, Emma-Jane Mallas, Magdalena A Kolanko, Martina Del Giovane, Danielle L Kurtin, Ramin Nilforooshan, Karl A Zimmerman, Cristina Bonet Olivares, Peter J Lally, CR&T Group of UKDRI, David J Sharp, Paresh A Malhotra, Gregory Scott
Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort

Authors
Rosalie J Cottez, Clémence Peyrot, Hélèna L Denis, Cyntia Tremblay, Andréanne Loiselle, Caroline Dallaire-Théroux, Ali Filali-Mouhim, Sébastien S Hébert, Nicole Leclerc, Kaj Blennow, Henrik Zetterberg, Consortium for the Early Identification of Alzheimer's Disease – Quebec (CIMA‐Q), Marie-Jeanne Kergoat, Frédéric Calon, Alexa Pichet Binette
Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort
GigaScience
Published

A large dataset of brain imaging linked to health systems data: curation and access to a whole system national cohort from NHS Scotland

Authors
Michael P J Camilleri, Dorian Gouzou, Salim Al-Wasity, Muthu R K Mookiah, María Valdes Hernandez, Bea Alex, Sotirios A Tsaftaris, Andrew Brooks, Ruairidh MacLeod, Honghan Wu, Brenda Bauer, Claire Grover, Parminder Reel, Susan Krueger, Richard Tobin, J Douglas Steele, Grant Mair, Joanna Wardlaw, Alexander Doney, Emanuele Trucco, William Whiteley
A large dataset of brain imaging linked to health systems data: curation and access to a whole system national cohort from NHS Scotland
Nature human behaviour
Published

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry

Authors
Megan Skelton, Brittany L Mitchell, Elham Assary, Danyang Li, Genevieve Morneau-Vaillancourt, Alan E Murphy, Abigail R Ter Kuile, Rujia Wang, Mark J Adams, Enda M Byrne, Elizabeth C Corfield, Poppy Z Grimes, Laurie J Hannigan, Jihua Hu, Kadri Kõiv, Alex S F Kwong, Sergi Papiol, Johanne H Pettersen, Giorgio Pistis, Enrique Castelao, Nora I Strom, Peter J van der Most, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, GLAD+ authors, Lifelines Cohort Study, NIHR BioResource, PROTECT-AD Consortium, Ole A Andreassen, Angelika Erhardt-Lehmann, Alexandra Havdahl, Nathan Skene, Brad Verhulst, Heike Weber, Chérie Armour, Helga Ask, William E Copeland, Udo Dannlowski, Jürgen Deckert, Katharina Domschke, Ian B Hickie, Kelli Lehto, Tina B Lonsdorf, Ulrike Lueken, Michelle K Lupton, Sarah E Medland, Andrew M McIntosh, Albertine J Oldehinkel, Martin Preisig, Andreas Reif, Harold Snieder, James T R Walters, Naomi R Wray, Catharina A Hartman, Nicholas G Martin, John M Hettema, Gerome Breen, Jonathan R I Coleman, Thalia C Eley
Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry
The journal of prevention of Alzheimer's disease
Published

Multimodal biomarker characterization of amnestic objective subtle cognitive decline in aging and preclinical Alzheimer's disease

Authors
David López-Martos, Raffaele Cacciaglia, Marc Suárez-Calvet, Gemma Salvadó, Mahnaz Shekari, Armand González-Escalante, Marta Milà-Alomà, Anna Brugulat-Serrat, Carolina Minguillon, Matteo Tonietto, Edilio Borroni, Gregory Klein, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, ALFA study
Multimodal biomarker characterization of amnestic objective subtle cognitive decline in aging and preclinical Alzheimer's disease
The lancet. Psychiatry
Published

Comparative effectiveness and safety of pharmacological treatments for rapid tranquilisation in emergency settings: a systematic review and individual participant data network meta-analysis

Authors
Spyridon Siafis, Frederik Philipona, Nobuyuki Nomura, Filip Milosavljević, Konstantina Chalkou, Johannes Schneider-Thoma, Irene Bighelli, Carolin Lorenz, Joseph E Dib, Prathap Tharyan, Esther Wy Chan, Jonathan C Knott, Celene Yl Yap, Célia Mantovani, Marc L Martel, William G Honer, Elfriede Scheuring, Gisele Huf, Jacob Alexander, Nirmal S Raveendran, Evandro Sf Coutinho, Josef Priller, Clive E Adams, Georgia Salanti, Stefan Leucht
Comparative effectiveness and safety of pharmacological treatments for rapid tranquilisation in emergency settings: a systematic review and individual participant data network meta-analysis