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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature communications
Published

ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases

Authors
Evgeniia Lobanova, Yu P Zhang, Derya Emin, Jack Brelstaff, Lakmini Kahanawita, Maura Malpetti, Annelies Quaegebeur, Kathy Triantafilou, Martha Triantafilou, Henrik Zetterberg, James B Rowe, Caroline H Williams-Gray, Clare Elizabeth Bryant, David Klenerman
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
Neurology
Published

Association of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia

Authors
P Tristin Best, John C Van Swieten, Lize Corrine Jiskoot, Fermin Moreno, Raquel Sánchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Carmela Tartaglia, James B Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Christopher Butler, Alexander Gerhard, Isabelle Le Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Harro Seelaar, Arabella Bouzigues, David M Cash, Lucy Louise Russell, Martina Bocchetta, Jonathan Daniel Rohrer, Gabriel A Devenyi, Mallar Chakravarty, Simon Ducharme, Genetic Frontotemporal Dementia Initiative (GENFI)
Association of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia
Molecular cell
Published

VPS4A is the selective receptor for lipophagy in mice and humans

Authors
Debajyoti Das, Mridul Sharma, Deepanshi Gahlot, Shervin S Nia, Chandrima Gain, Matthew Mecklenburg, Z Hong Zhou, Mathieu Bourdenx, Lipi Thukral, Nuria Martinez-Lopez, Rajat Singh
VPS4A is the selective receptor for lipophagy in mice and humans
BMC biology
Published

Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

Authors
Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M Chakrabarti, Andrew M Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R Sibley, Aida Martinez-Sanchez, Boris Lenhard
Widespread 3'UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project)

Authors
Chinedu T Udeh-Momoh, Rachel Maina, Udunna C Anazodo, Rufus Akinyemi, Lukoye Atwoli, Laura Baker, Darina Bassil, Karen Blackmon, Edna Bosire, Gloria Chemutai, Lucia Crivelli, Laz U Eze, Agustin Ibanez, Dimitra Kafetsouli, Thomas K Karikari, Linda Khakali, Manasi Kumar, Imre Lengyel, Celeste A de Jager Loots, Francesca Mangialasche, Sylvia Mbugua, Zul Merali, Michelle Mielke, Cyprian Mostert, Eunice Muthoni, Olivera Nesic-Taylor, Anthony Ngugi, Samuel Nguku, Adesola Ogunniyi, Adedoyin Ogunyemi, Ozioma C Okonkwo, Njideka Okubadejo, Robert Perneczky, Tunde Peto, Roselyter M Riang'a, Mansoor Saleh, Shaheen Sayed, Jasmit Shah, Sheena Shah, Alina Solomon, Thomas Thesen, Dominic Trepel, Valentine Ucheagwu, Victor Valcour, Sheila Waa, Tamlyn Watermeyer, Jennifer Yokoyama, Henrik Zetterberg, Miia Kivipelto, Africa‐FINGERS Study Team
Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project)
Neurology
Published

Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study

Authors
Emilie Sleight, Michael S Stringer, Una Clancy, Carmen Arteaga-Reyes, Daniela Jaime Garcia, Angela C C Jochems, Stewart Wiseman, Maria Valdes Hernandez, Francesca M Chappell, Fergus N Doubal, Ian Marshall, Michael J Thrippleton, Joanna M Wardlaw
Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study
Scientific reports
Published

Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease

Authors
Beth Whittington, Evangelos Tzolos, Shruti Joshi, Rong Bing, Jack Andrews, Krithika Loganath, Neil Craig, Craig Balmforth, Laura Clark, Christophe Lucatelli, Mark G MacAskill, Adriana A S Tavares, Tim Clark, Nicholas L Mills, Jennifer Nash, Damini Dey, Piotr J Slomka, Norman Koglin, Andrew W Stephens, Marc R Dweck, Michelle C Williams, William Whiteley, Edwin J R van Beek, Joanna M Wardlaw, David E Newby
Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease
EBioMedicine
Published

Identification of late-stage tau accumulation using plasma phospho-tau217

Authors
Marcel S Woo, Joseph Therriault, Erin M Jonaitis, Rachael Wilson, Rebecca E Langhough, Nesrine Rahmouni, Andrea Lessa Benedet, Nicholas J Ashton, Cécile Tissot, Juan Lantero-Rodriguez, Arthur C Macedo, Stijn Servaes, Yi-Ting Wang, Jaime Fernandez Arias, Seyyed Ali Hosseini, Tobey J Betthauser, Firoza Z Lussier, Robert Hopewell, Gallen Triana-Baltzer, Hartmuth C Kolb, Andreas Jeromin, Eliane Kobayashi, Gassan Massarweh, Manuel A Friese, Jesse Klostranec, Paolo Vilali, Tharick A Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Sterling C Johnson, Pedro Rosa-Neto
Identification of late-stage tau accumulation using plasma phospho-tau217
Neurology
Published

Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease

Authors
Michelle Safransky, Jenna R Groh, Kaj Blennow, Henrik Zetterberg, Yorghos Tripodis, Brett Martin, Jason Weller, Breton M Asken, Gil D Rabinovici, Wendy Wei Qiao Qiu, Ann C McKee, Thor D Stein, Jesse Mez, Rachel L Henson, Justin Long, John C Morris, Richard J Perrin, Suzanne E Schindler, Michael L Alosco
Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnoea

Authors
Ylenia Giarratano, Elizabeth A Hill, Charlene Hamid, Stewart Wiseman, Calum Gray, Francesca M Chappell, Roberto Duarte Coello, Maria C Valdés-Hernández, Lucia Ballerini, Michael S Stringer, Michael J Thrippleton, Daniela Jaime Garcia, Xiaodi Liu, William Hewins, Yajun Cheng, Sandra E Black, Andrew Lim, Rosa Sommer, Joel Ramirez, Bradley J MacIntosh, Rosalind Brown, Fergus Doubal, Tom MacGillivray, Joanna M Wardlaw, Renata Riha, Miguel O Bernabeu
Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnoea
Alzheimer's research & therapy
Published

Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study

Authors
Inga Menze, Jose Bernal, Pinar Kaya, Çağla Aki, Malte Pfister, Jonas Geisendörfer, Renat Yakupov, Roberto Duarte Coello, Maria D C Valdés-Hernández, Michael T Heneka, Frederic Brosseron, Matthias C Schmid, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Ayda Rostamzadeh, Dix Meiberth, Oliver Peters, Lukas Preis, Dominik Lammerding, Daria Gref, Josef Priller, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Stefan Hetzer, Anja Schneider, Klaus Fliessbach, Okka Kimmich, Ina R Vogt, Jens Wiltfang, Claudia Bartels, Björn H Schott, Niels Hansen, Peter Dechent, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Carolin Sanzenbacher, Petra Hinderer, Klaus Scheffler, Annika Spottke, Nina Roy-Kluth, Falk Lüsebrink, Katja Neumann, Joanna Wardlaw, Frank Jessen, Stefanie Schreiber, Emrah Düzel, Gabriel Ziegler
Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study