Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Nature communications
Published

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Authors
Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Eric R McGregor, James R Hilser, Ruben Aquino-Martinez, Sandra Harding, Joseph Lawrence Harpt, Katharina R Beck, Hailey Bussan, Jessamine F Kuehn, Yuetiva Deming, Rachel Studer, Sterling C Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Corinne D Engelman, Hooman Allayee, Rozalyn M Anderson, Tyler K Ulland, Fredrik Bäckhed, Barbara B Bendlin, Federico E Rey
Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Analytical chemistry
Published

Profiling Protein Aggregate Size Using Single-Molecule Array Technology

Authors
Dorothea Böken, Yunzhao Wu, Jianli Zhang, Zengjie Xia, Paula Beltran-Lobo, Cara L Croft, Savinu Weerasekera, Amanda Heslegrave, Henrik Zetterberg, Ashvini Keshavan, Jonathan M Schott, Maria Jimenez-Sanchez, David C Duffy, David Klenerman
Profiling Protein Aggregate Size Using Single-Molecule Array Technology
Stem cell reports
Published

A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells

Authors
Galbha Duggal, Xinyu Li, Philippa Pettingill, Tatjana Lalic, Shailesh Kumar Gupta, Christine Flodgaard Høgsbro, Viola Volpato, Caleb Webber, Rory Bowden, Despoina Charou, Kanisa Arunasalam, Marcello Maresca, Ryan Hicks, Satyan Chintawar, M Zameel Cader
A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Nature communications
Published

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress

Authors
Rebecca Casterton, Aitana Martinez-Cotrina, Jodi Barnard, Eleanor Wycherley, Yanling Hu, Rhys Anderson, Sebastien Janel, Jiin Byun, Olivia Houghton, Daniel A Solomon, Juan Alcalde, Frank Lafont, Marc-David Ruepp, Frank Hirth, Bart Tummers, Yong-Yeon Cho, Gian De Nicola, Sarah Mizielinska, Manolis Fanto
Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress
Acta neuropathologica
Published

Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP

Authors
Przemysław R Kac, Katheryn A Q Cousins, Alicja Szadziewska, Leslie M Shaw, Michael Turton, Vivianna M Van Deerlin, Peter Harrison, Henrik Zetterberg, David A Wolk, Corey T McMillan, Douglas Galasko, Jörg Hanrieder, Edward B Lee, Hlin Kvartsberg, David J Irwin, Kaj Blennow
Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP
Alzheimer's & dementia (New York, N. Y.)
Published

Aβ- and tau-associated neuroinflammatory signatures in Alzheimer's disease

Authors
Bruna Bellaver, Guilherme Povala, Marco Antônio De Bastiani, Ilaria Pola, Pamela C L Ferreira, Guilherme Bauer-Negrini, João Pedro Ferrari-Souza, Douglas T Leffa, Firoza Z Lussier, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Riddhi Patira, Serge Gauthier, Dana L Tudorascu, Thomas K Karikari, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Eduardo R Zimmer, Andrea L Benedet, Pedro Rosa-Neto, Tharick A Pascoal
Aβ- and tau-associated neuroinflammatory signatures in Alzheimer's disease
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases

Authors
Bárbara Fernandes Gomes, Mathias Sauer, Laia Montoliu-Gaya, Maria Franquesa-Mullerat, Alexandre Bejanin, Daniel Alcolea, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Kaj Blennow, Henrik Zetterberg, Johanna Nilsson, Olivia Belbin, Nicholas J Ashton
Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases