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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

BMJ open
Published

Carbon footprint of a sample of clinical trials for people with neurological disorders: cross-sectional analysis

Authors
Denise Cranley, Sarah Dunn, John-Paul Taylor, Michael Jr Desborough, Jennifer Craig, Nikola Sprigg, Rachel McComish, Thomas Foltynie, Joanna Wardlaw, Katherine Oatey, Anna Heye, Philip Bath, Karen Innes, Lynn Dinsmore, Jessica Griffiths, Lisa Fox, Paula R Williamson, Rustam Al-Shahi Salman
Carbon footprint of a sample of clinical trials for people with neurological disorders: cross-sectional analysis
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

Authors
Mathias Sauer, Bárbara Fernandes Gomes, Parasto Shahrouki, Juan Lantero-Rodriguez, Laia Montoliu-Gaya, Elena Camporesi, Olivia Belbin, Daniel Alcolea, Ashish Kumar, Mitu Sharma, Sangeeta Singh, Gunnar Brinkmalm, Johan Gobom, María Carmona-Iragui, Michael Schöll, Shorena Janelidze, Gagan Deep, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm, Alberto Lleó, Juan Fortea, Oskar Hansson, Nicholas J Ashton, Johanna Nilsson
Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome
Nature nanotechnology
Published

Nanoneedles enable spatiotemporal lipidomics of living tissues

Authors
Chenlei Gu, Davide Alessandro Martella, Leor Ariel Rose, Nadia Rouatbi, Cong Wang, Alaa Zam, Valeria Caprettini, Magnus Jensen, Shiyue Liu, Cathleen Hagemann, Siham Memdouh, Andrea Serio, Vincenzo Abbate, Khuloud T Al-Jamal, Maddy Parsons, Mads S Bergholt, Paul M Brennan, Assaf Zaritsky, Ciro Chiappini
Nanoneedles enable spatiotemporal lipidomics of living tissues
JAMA
Published

Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity

Authors
Alexis Moscoso, Fiona Heeman, Sheelakumari Raghavan, Alejandro Costoya-Sánchez, Martijn van Essen, Ismini Mainta, Valle Camacho, Omar Rodríguez-Fonseca, Jesús Silva-Rodríguez, Andrés Perissinotti, Yuna Gu, Jihwan Yun, Debora Peretti, Federica Ribaldi, Emma M Coomans, Wagner S Brum, Michel J Grothe, Pablo Aguiar, Gérard N Bischof, Alexander Drzezga, Sang Won Seo, Sylvia Villeneuve, Maura Malpetti, John T O'Brien, James B Rowe, Elsmarieke M van de Giessen, Rik Ossenkoppele, William J Jagust, Ruben Smith, Oskar Hansson, Giovanni B Frisoni, Valentina Garibotto, David N Soleimani-Meigooni, Maria Carrillo, Bradford C Dickerson, Renaud La Joie, Gil D Rabinovici, Liana G Apostolova, Pamela J LaMontagne, Michael J Pontecorvo, Keith A Johnson, Reisa A Sperling, Michael W Weiner, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri, Michael Schöll, PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer’s Disease Neuroimaging Initiative
Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity
Cell reports
Published

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Authors
Samuel S Harris, Rikesh M Rajani, Jana Zünkler, Robert Ellingford, Mengke Yang, James M Rowland, Alexander Schmidt, Byung Il Lee, Marten Kehring, Mariam Hellmuth, Francesca Kar Wey Lam, Dominique Fässler, Susanne Erdinger, David P Wolfer, Carlo Sala Frigerio, Fred Wolf, Bradley T Hyman, Ulrike C Müller, Marc Aurel Busche
The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo
bioRxiv : the preprint server for biology
Published

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Authors
Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Ruben Aquino-Martinez, Sandra Harding, Joseph Lawrence Harpt, Yuetiva Deming, Sterling Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Corinne D Engelman, Tyler K Ulland, Fredrik Bäckhed, Barbara B Bendlin, Federico E Rey
Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Infectious diseases (London, England)
Published

Increased immune activation in people living with HIV on antiretroviral therapy but not when compared with persons on HIV preexposure prophylaxis

Authors
Josefina Robertson, Arvid Edén, Aylin Yilmaz, Lars-Magnus Andersson, Lars Hagberg, Kristina Nyström, Staffan Nilsson, Carl-Johan Treutiger, Petra Tunbäck, Johanna M Gostner, Henrik Zetterberg, Magnus Gisslén
Increased immune activation in people living with HIV on antiretroviral therapy but not when compared with persons on HIV preexposure prophylaxis
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Online46: Online cognitive assessments in elderly cohorts-The British 1946 birth cohort case study

Authors
Ziyuan Cai, Valentina Giunchiglia, Rebecca Street, Martina Del Giovane, Kirsty Lu, Maria Popham, Andrew Wong, Heidi Murray-Smith, Marcus Richards, Sebastian Crutch, Peter J Hellyer, Jonathan M Schott, Adam Hampshire
Online46: Online cognitive assessments in elderly cohorts-The British 1946 birth cohort case study
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease

Authors
Adam P Mecca, Nicholas J Ashton, Ming-Kai Chen, Ryan S O'Dell, Takaya Toyonaga, Wenzhen Zhao, Juan J Young, Elaheh Salardini, Kara A Bates, Jocelyn Ra, Sam Goodcase, Jason A Silva-Rudberg, Nabeel B Nabulsi, Ann Brinkmalm, Hlin Kvartsberg, Michael Schöll, Johanna Nilsson, Amy F T Arnsten, Yiyun Huang, Oskar Hansson, Henrik Zetterberg, Richard E Carson, Kaj Blennow, Christopher H van Dyck
Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease
Med (New York, N.Y.)
Published

Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer's disease

Authors
Vijay R Varma, Yang An, Przemek R Kac, Murat Bilgel, Abhay Moghekar, Tina Loeffler, David Amschl, Magdalena Daurer, Manuela Prokesch, Juan Troncoso, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Luigi Ferrucci, Susan M Resnick, Madhav Thambisetty
Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer's disease
Movement disorders : official journal of the Movement Disorder Society
Published

Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy

Authors
Carla Palleis, Andrea Quattrone, Amir Dehsarvi, Sebastian N Roemer-Cassiano, Alexander M Bernhardt, AL‐108‐231 Investigators, the PASSPORT Study Group, Hans-Jürgen Huppertz, Maura Malpetti, Adam L Boxer, Johannes Gnörich, Lukas Frontzkowski, Johannes Levin, Matthias Brendel, Günter U Höglinger, Nicolai Franzmeier
Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy