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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature communications
Published

Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain

Authors
Jenny Hällqvist, Christina E Toomey, Rui Pinto, Tomas Baldwin, Ivan Doykov, Anna Wernick, Mesfer Al Shahrani, James R Evans, Joanne Lachica, Simon Pope, Simon Heales, Simon Eaton, Kevin Mills, Sonia Gandhi, Wendy E Heywood
Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain
bioRxiv : the preprint server for biology
Published

A clinical grade neurostimulation implant for hierarchical control of physiological activity

Authors
Moaad Benjaber, Mayela Zamora, Robert Toth, John E Fleming, Kei Landin, Victoria S Marks, Rachel A Crockett, Jae-Wook Ryou, Alceste Deli, Alexander L Green, Rory J Piper, Martin M Tisdall, Derk-Jan Dijk, Nicholas D Schiff, Andrew Sharott, Keith P Purpura, Jonathan L Baker, Joram J van Rheede, Timothy J Denison
A clinical grade neurostimulation implant for hierarchical control of physiological activity
medRxiv : the preprint server for health sciences
Published

P-TAU205 IS A BIOMARKER LINKED TO TAU-PET ABNORMALITY: A CROSS-SECTIONAL AND LONGITUDINAL STUDY

Authors
Juan Lantero-Rodriguez, Shorena Janelidze, Sebastian Palmqvist, Luisa Sophie Braun-Wohlfahrt, Jakub Vavra, Divya Bali, Anna Orduña Dolado, Niklas Mattsson-Carlgren, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Oskar Hansson, Laia Montoliu-Gaya, Gemma Salvadó
P-TAU205 IS A BIOMARKER LINKED TO TAU-PET ABNORMALITY: A CROSS-SECTIONAL AND LONGITUDINAL STUDY
bioRxiv : the preprint server for biology
Published

Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

Authors
Bernard Mulvey, Heena R Divecha, Madhavi Tippani, Svitlana V Bach, Rahul Bharadwaj, Ishbel Del Rosario, Sarah E Maguire, Ryan A Miller, Aaron J Salisbury, Atharv Chandra, Beau A Oster, Kelsey D Montgomery, Sang Ho Kwon, Haya A Algrain, Alexis R Papariello, Louise A Huuki-Myers, Joel E Kleinman, Leonardo Collado-Torres, Thomas M Hyde, Shizhong Han, Stephanie C Hicks, Daniel R Weinberger, Stephanie C Page, Kristen R Maynard, Keri Martinowich
Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
medRxiv : the preprint server for health sciences
Published

Gene-Pseudogene Inversions as a Hidden Source of Missing Heritability

Authors
Ilaria Quartesan, Stefano Facchini, Arianna Manini, Ricardo Parolin Schnekenberg, Chiara Pisciotta, Stefania Magri, Sara Negri, Carlo Gaetano, Adriana Rebelo, Jacquelyn Schatzman Raposo, Radim Mazanec, Riccardo Curro, Natalia Dominik, Stephanie Efthymiou, Matilde Laurà, Tiffany Grider, Shawna Me Feely, Vera Fridman, Alessandro Bertini, Gustavo Maximiano Alves, Lucia Ferullo, Arianna Ghia, Claudio Caccia, Francesca Balistreri, Paola Saveri, Luca Crivellari, Isabella Moroni, Federica Rachele Danti, Tiziana Mongini, Franco Taroni, Michaela Auer-Grumbach, Enrico Bugiardini, James N Sleigh, Arianna Tucci, Henry Houlden, Petra Laššuthová, Pavel Seeman, Anna Basile, Elisa Giorgio, Michael E Shy, Stephan Zuchner, Mary M Reilly, Davide Pareyson, Andrea Cortese
Gene-Pseudogene Inversions as a Hidden Source of Missing Heritability
medRxiv : the preprint server for health sciences
Published

Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics

Authors
Sihao Xiao, Pallavi Kaushik, Gaoyu Du, Bowen Liu, Salman B Hosawi, Benoit Hastoy, M Austin Argentieri, Laura M Winchester, Alejo J Nevado-Holgado, Rima Kaddurah-Daouk, Najaf Amin, Cornelia van Duijn
Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics
Brain : a journal of neurology
Published

Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia

Authors
Kamen A Tsvetanov, Maura Malpetti, P Simon Jones, Timothy Rittman, David J Whiteside, Alexander G Murley, Richard Bethlehem, Casey Paquola, Enrico Premi, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Sandro Sorbi, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Simon Ducharme, Chris R Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D Rohrer, James B Rowe, Genetic FTD Initiative, GENFI
Cellular signatures underlying functional resilience in presymptomatic frontotemporal dementia
medRxiv : the preprint server for health sciences
Published

DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation

Authors
Luna Bitar, Mario Díaz, Roberto Duarte Coello, Maria D C Valdés-Hernández, Hendrik Mattern, Katja Neumann, Malte Pfister, Carolin Beck, Huy Trong Mai, Erelle Fuchs, Serena Tang, Duygu Tosun, Bianca Besteher, Tonia Rocktäschel, Philipp A Reuken, Andreas Stallmach, Nils Opel, Christian Gaser, Martin Walter, Marc Dörner, Philipp Arndt, Daniel Behme, Christiane Piechowiak, Yves Lading, Patrick Müller, Rüdiger Braun-Dullaeus, Sven G Meuth, Joanna M Wardlaw, Stefanie Schreiber, Maria Trujillo, Emrah Düzel, Gabriel Ziegler, Jose Bernal
DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Fecal short-chain fatty acids vary by sex and amyloid status

Authors
Jessamine F Kuehn, Qijun Zhang, Margo B Heston, Jea Woo Kang, Sandra J Harding, Nancy J Davenport-Sis, Darby C Peter, Robert L Kerby, Vaibhav Vemuganti, Emma C Schiffmann, Michael M Tallon, Joseph Harpt, Arun Hajra, J L Wheeler, Sushma Shankar, Alissa Mickol, Justus Zemberi, Hana Chow, Eric Zhang, Eleanor Clements, Hanna Noughani, Allison Forst, Grace Everitt, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Bradley T Christian, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Tyler K Ulland, Federico E Rey, Barbara B Bendlin
Fecal short-chain fatty acids vary by sex and amyloid status
BMJ open
Published

Immune Profiling in Early Cognitive Disorders (IMPRINT) study protocol: a longitudinal cohort study exploring biomarkers of inflammation in early dementia with Lewy bodies and Alzheimer's disease, as part of the Dementias Platform UK

Authors
Harry Crook, Peter Swann, Haddy Fye, Stacey Kigar, George Savulich, Anna Mckeever, Elena Herrero, Lordina Turner, Lina Aimola, Gabrielle D Grey, Dan Blackburn, Paul M Matthews, Li Su, Leonidas Chouliaras, James B Rowe, Paresh Malhotra, John T O'Brien
Immune Profiling in Early Cognitive Disorders (IMPRINT) study protocol: a longitudinal cohort study exploring biomarkers of inflammation in early dementia with Lewy bodies and Alzheimer's disease, as part of the Dementias Platform UK
Nature aging
Published

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

Authors
Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Muralidharan Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Markus Munter, Daniel Auld, Iana Astafeva, Raquel Puerta, Jerome I Rotter, Bruce M Psaty, Joshua C Bis, W T Longstreth, Thierry Couffinhal, Pablo García-González, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore J Launer, Joanna M Wardlaw, Myriam Heiman, Agustin Ruiz, Paul M Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip L De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga, Stéphanie Debette
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
Communications medicine
Published

APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer's disease

Authors
Lydia Trudel, Joseph Therriault, Arthur C Macedo, Marcel S Woo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Seyyed Ali Hosseini, João Pedro Ferrari-Souza, Bruna Bellaver, Pamela L Ferreira, Tevy Chan, Yi-Ting Wang, Jaime Fernandez-Arias, Yansheng Zheng, Brandon Hall, Jenna Stevenson, Robert Hopewell, Chris Hung-Hsin Hsiao, Maxime Montembeault, Jesse Klostranec, Yasser Iturria-Medina, Paolo Vitali, Thomas K Karikari, Andrea L Benedet, Nicholas J Ashton, Eduardo Zimmer, Serge Gauthier, Tharick A Pascoal, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer's disease
The Journal of infectious diseases
Published

Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy

Authors
Phillip Chan, Carlo Sacdalan, Suteeraporn Pinyakorn, Eugène Kroon, Donn Colby, Pathariya Promsena, Somchai Sriplienchan, Nittaya Phanuphak, Sandhya Vasan, Victor Valcour, Robert Paul, Magnus Gisslén, Henrik Zetterberg, Lydie Trautmann, Serena Spudich
Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy