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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

medRxiv : the preprint server for health sciences
Published

DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation

Authors
Luna Bitar, Mario Díaz, Roberto Duarte Coello, Maria D C Valdés-Hernández, Hendrik Mattern, Katja Neumann, Malte Pfister, Carolin Beck, Huy Trong Mai, Erelle Fuchs, Serena Tang, Duygu Tosun, Bianca Besteher, Tonia Rocktäschel, Philipp A Reuken, Andreas Stallmach, Nils Opel, Christian Gaser, Martin Walter, Marc Dörner, Philipp Arndt, Daniel Behme, Christiane Piechowiak, Yves Lading, Patrick Müller, Rüdiger Braun-Dullaeus, Sven G Meuth, Joanna M Wardlaw, Stefanie Schreiber, Maria Trujillo, Emrah Düzel, Gabriel Ziegler, Jose Bernal
DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation
bioRxiv : the preprint server for biology
Published

A clinical grade neurostimulation implant for hierarchical control of physiological activity

Authors
Moaad Benjaber, Mayela Zamora, Robert Toth, John E Fleming, Kei Landin, Victoria S Marks, Rachel A Crockett, Jae-Wook Ryou, Alceste Deli, Alexander L Green, Rory J Piper, Martin M Tisdall, Derk-Jan Dijk, Nicholas D Schiff, Andrew Sharott, Keith P Purpura, Jonathan L Baker, Joram J van Rheede, Timothy J Denison
A clinical grade neurostimulation implant for hierarchical control of physiological activity
medRxiv : the preprint server for health sciences
Published

Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics

Authors
Sihao Xiao, Pallavi Kaushik, Gaoyu Du, Bowen Liu, Salman B Hosawi, Benoit Hastoy, M Austin Argentieri, Laura M Winchester, Alejo J Nevado-Holgado, Rima Kaddurah-Daouk, Najaf Amin, Cornelia van Duijn
Ticking Differently: Elucidating Sexual Dimorphism in Human Aging through Metabolomics, Proteomics and Genomics
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Fecal short-chain fatty acids vary by sex and amyloid status

Authors
Jessamine F Kuehn, Qijun Zhang, Margo B Heston, Jea Woo Kang, Sandra J Harding, Nancy J Davenport-Sis, Darby C Peter, Robert L Kerby, Vaibhav Vemuganti, Emma C Schiffmann, Michael M Tallon, Joseph Harpt, Arun Hajra, J L Wheeler, Sushma Shankar, Alissa Mickol, Justus Zemberi, Hana Chow, Eric Zhang, Eleanor Clements, Hanna Noughani, Allison Forst, Grace Everitt, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Bradley T Christian, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Tyler K Ulland, Federico E Rey, Barbara B Bendlin
Fecal short-chain fatty acids vary by sex and amyloid status
BMJ open
Published

Immune Profiling in Early Cognitive Disorders (IMPRINT) study protocol: a longitudinal cohort study exploring biomarkers of inflammation in early dementia with Lewy bodies and Alzheimer's disease, as part of the Dementias Platform UK

Authors
Harry Crook, Peter Swann, Haddy Fye, Stacey Kigar, George Savulich, Anna Mckeever, Elena Herrero, Lordina Turner, Lina Aimola, Gabrielle D Grey, Dan Blackburn, Paul M Matthews, Li Su, Leonidas Chouliaras, James B Rowe, Paresh Malhotra, John T O'Brien
Immune Profiling in Early Cognitive Disorders (IMPRINT) study protocol: a longitudinal cohort study exploring biomarkers of inflammation in early dementia with Lewy bodies and Alzheimer's disease, as part of the Dementias Platform UK
Communications medicine
Published

APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer's disease

Authors
Lydia Trudel, Joseph Therriault, Arthur C Macedo, Marcel S Woo, Nesrine Rahmouni, Étienne Aumont, Stijn Servaes, Seyyed Ali Hosseini, João Pedro Ferrari-Souza, Bruna Bellaver, Pamela L Ferreira, Tevy Chan, Yi-Ting Wang, Jaime Fernandez-Arias, Yansheng Zheng, Brandon Hall, Jenna Stevenson, Robert Hopewell, Chris Hung-Hsin Hsiao, Maxime Montembeault, Jesse Klostranec, Yasser Iturria-Medina, Paolo Vitali, Thomas K Karikari, Andrea L Benedet, Nicholas J Ashton, Eduardo Zimmer, Serge Gauthier, Tharick A Pascoal, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer's disease
Nature aging
Published

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

Authors
Ilana Caro, Daniel Western, Shinichi Namba, Na Sun, Shuji Kawaguchi, Yunye He, Masashi Fujita, Gennady Roshchupkin, Tim D'Aoust, Marie-Gabrielle Duperron, Muralidharan Sargurupremraj, Ami Tsuchida, Masaru Koido, Marziehsadat Ahmadi, Chengran Yang, Jigyasha Timsina, Laura Ibanez, Koichi Matsuda, Yutaka Suzuki, Yoshiya Oda, Akinori Kanai, Pouria Jandaghi, Markus Munter, Daniel Auld, Iana Astafeva, Raquel Puerta, Jerome I Rotter, Bruce M Psaty, Joshua C Bis, W T Longstreth, Thierry Couffinhal, Pablo García-González, Vanesa Pytel, Marta Marquié, Amanda Cano, Mercè Boada, Marc Joliot, Mark Lathrop, Quentin Le Grand, Lenore J Launer, Joanna M Wardlaw, Myriam Heiman, Agustin Ruiz, Paul M Matthews, Sudha Seshadri, Myriam Fornage, Hieab Adams, Aniket Mishra, David-Alexandre Trégouët, Yukinori Okada, Manolis Kellis, Philip L De Jager, Christophe Tzourio, Yoichiro Kamatani, Fumihiko Matsuda, Carlos Cruchaga, Stéphanie Debette
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
The Journal of infectious diseases
Published

Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy

Authors
Phillip Chan, Carlo Sacdalan, Suteeraporn Pinyakorn, Eugène Kroon, Donn Colby, Pathariya Promsena, Somchai Sriplienchan, Nittaya Phanuphak, Sandhya Vasan, Victor Valcour, Robert Paul, Magnus Gisslén, Henrik Zetterberg, Lydie Trautmann, Serena Spudich
Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy
Brain communications
Published

Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study

Authors
Sonja Soskic, Henry F J Tregidgo, Emily G Todd, Arabella Bouzigues, David M Cash, Lucy L Russell, David L Thomas, Ian B Malone, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Simon Ducharme, Christopher R Butler, Isabelle Le Ber, Elizabeth C Finger, Maria Carmela Tartaglia, Mario Masellis, James B Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Daniel C Alexander, Juan Eugenio Iglesias, Jonathan D Rohrer, Martina Bocchetta, GENetic Frontotemporal dementia Initiative (GENFI)
Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study
Journal of Alzheimer's disease : JAD
Published

Associations of lifestyle factors with amyloid pathology in persons without dementia

Authors
Julie E Oomens, Stephanie Jb Vos, Nancy N Maserejian, Mercè Boada, Mira Didic, Sebastiaan Engelborghs, Tormod Fladby, Wiesje M van der Flier, Giovanni B Frisoni, Lutz Fröhlich, Kiran Dip Gill, Timo Grimmer, Jakub Hort, Yoshiaki Itoh, Takeshi Iwatsubo, Aleksandra Klimkowicz-Mrowiec, Susan M Landau, Dong Young Lee, Alberto Lleó, Pablo Martinez-Lage, Alexandre de Mendonça, Philipp T Meyer, Piero Parchi, Matteo Pardini, Lucilla Parnetti, Julius Popp, Lorena Rami, Eric M Reiman, Juha O Rinne, Karen M Rodrigue, Pascual Sánchez-Juan, Isabel Santana, Nikolaos Scarmeas, Philip Scheltens, Ingmar Skoog, Reisa A Sperling, Yaakov Stern, Sylvia Villeneuve, Gunhild Waldemar, Jens Wiltfang, Henrik Zetterberg, Daniel Alcolea, Ricardo F Allegri, Daniele Altomare, Randall J Bateman, Simone Baiardi, Ines Baldeiras, Kaj Blennow, Anouk den Braber, Mark A van Buchem, Min Soo Byun, Jiří Cerman, Kewei Chen, Elena Chipi, Gregory S Day, Alexander Drzezga, Laura L Ekblad, Stefan Förster, Juan Fortea, Yvonne Freund-Levi, Lars Frings, Eric Guedj, Christian G Habeck, Ron Handels, Lucrezia Hausner, Sabine Hellwig, Julio F Jiménez-Bonilla, Ane Iriondo Juaristi, Ramesh Kandimalla, Silke Kern, Bjørn-Eivind S Bordewick Kirsebom, Johannes Kornhuber, Nienke Legdeur, Johannes Levin, Wolfgang Maier, Marta Marquié, Shinobu Minatani, Silvia Daniela Morbelli, Barbara Mroczko, Eva Ntanasi, Catarina Resende de Oliveira, Adelina Orellana, Oliver Peters, Sudesh Prabhakar, Inez H Ramakers, Eloy Rodríguez-Rodriguez, Agustín Ruiz, Eckart Rüther, Jayant Sakhardande, Per Selnes, Dina Silva, Hilkka Soininen, Luiza Spiru, Akitoshi Takeda, Charlotte E Teunissen, Betty M Tijms, Lisa Vermunt, Åsa K Wallin, Wietse Wiels, Mary Yannakoulia, Dahyun Yi, Anna Zettergren, Alzheimer's Disease Neuroimaging Initiative (ADNI), A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE), Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group, Rik Ossenkoppele, Frans Rj Verhey, Pieter Jelle Visser, Willemijn J Jansen
Associations of lifestyle factors with amyloid pathology in persons without dementia
International journal of epidemiology
Published

Investigating the association between anthropometry and colorectal cancer survival: a two-sample Mendelian randomization analysis

Authors
Afroditi Kanellopoulou, Emmanouil Bouras, Andrew T Chan, Loïc Le Marchand, Alicja Wolk, Anna H Wu, Marc J Gunter, Katharina Nimptsch, Philip Haycock, Sarah J Lewis, Richard M Martin, Verena Zuber, Amanda I Phipps, Ulrike Peters, Fränzel J B Van Duijnhoven, Konstantinos K Tsilidis
Investigating the association between anthropometry and colorectal cancer survival: a two-sample Mendelian randomization analysis
Alzheimer's research & therapy
Published

Prognostic value of plasma biomarkers in early Alzheimer's disease: a longitudinal clinical and neuroimaging study

Authors
Frederikke Kragh Clemmensen, Mathias Holsey Gramkow, Fernando Gonzalez-Ortiz, Andréa Lessa Benedet, Kübra Tan, Wiebke Traichel, Ulrich Lindberg, Otto Mølby Henriksen, Henrik Zetterberg, Kaj Blennow, Ian Law, Anja Hviid Simonsen, Kristian Steen Frederiksen, Steen Gregers Hasselbalch
Prognostic value of plasma biomarkers in early Alzheimer's disease: a longitudinal clinical and neuroimaging study