Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Nature neuroscience
Published
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Authors
Ashling Giblin, Alexander J Cammack, Niek Blomberg, Sharifah Anoar, Alla Mikheenko, Mireia Carcolé, Magda L Atilano, Alex Hull, Dunxin Shen, Xiaoya Wei, Rachel Coneys, Lele Zhou, Yassene Mohammed, Damien Olivier-Jimenez, Lian Y Wang, Kerri J Kinghorn, Teresa Niccoli, Alyssa N Coyne, Rik van der Kant, Tammaryn Lashley, Martin Giera, Linda Partridge, Adrian M Isaacs
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic
Authors
Federica Anastasi, Aida Fernández-Lebrero, Nicholas J Ashton, Paula Ortiz-Romero, Javier Torres-Torronteras, Armand González-Escalante, Marta Milà-Alomà, José Contador, Greta García-Escobar, Rosa María Manero-Borràs, Irene Navalpotro-Gómez, Esther Jiménez-Moyano, Aparna Sahajan, Qinyu Hao, Bingqing Zhang, Andreas Jeromin, Nathalie Le Bastard, Alicia Nadal, Tahmine Mousavi, Gwendlyn Kollmorgen, Margherita Carboni, Oriol Grau-Rivera, Henrik Zetterberg, Marta Del Campo, Kaj Blennow, Albert Puig-Pijoan, Marc Suárez-Calvet
A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic
Nature communications
Published
Author Correction: On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies
Authors
Kambiz Nanbakhsh, Ahmad Shah Idil, Callum Lamont, Csaba Dücső, Ömer Can Akgun, Domonkos Horváth, Kinga Tóth, Domokos Meszéna, István Ulbert, Federico Mazza, Timothy G Constandinou, Wouter Serdijn, Anne Vanhoestenberghe, Nick Donaldson, Vasiliki Giagka
Author Correction: On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Evaluation of two plasma-based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies
Authors
Anna Dittrich, Kaj Blennow, Kübra Tan, Andrea L Benedet, Ingmar Skoog, Kina Höglund, Nicholas J Ashton, Henrik Zetterberg, Silke Kern
Evaluation of two plasma-based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data
Authors
Linda Karlsson, Jacob Vogel, Ida Arvidsson, Kalle Åström, Olof Strandberg, Jakob Seidlitz, Richard A I Bethlehem, Erik Stomrud, Rik Ossenkoppele, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Ruben Smith, Shorena Janelidze, Renaud La Joie, Gil D Rabinovici, Alexa Pichet Binette, Niklas Mattsson-Carlgren, Oskar Hansson
Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data
Cell reports
Published
Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates
Authors
Philip Hasel, Melissa L Cooper, Anne E Marchildon, Uriel Rufen-Blanchette, Rachel D Kim, Thong C Ma, Adam M R Groh, Emily J Hill, Eleanor M Lewis, Michał Januszewski, Sarah E W Light, Cody J Smith, Jo Anne Stratton, Steven A Sloan, Un Jung Kang, Moses V Chao, Shane A Liddelow
Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates
Research square
Published
Isotope Encoded Spatial Biology Identifies Amyloid Plaque-Age-Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity
Authors
Jack I Wood, Maciej Dulewicz, Junyue Ge, Katie Stringer, Alicja Szadziewska, Sneha Desai, Srinivas Koutarapu, Haady B Hajar, Lydia Fenson, Kaj Blennow, Henrik Zetterberg, Damian M Cummings, Jeffrey N Savas, Frances A Edwards, Jörg Hanrieder
Isotope Encoded Spatial Biology Identifies Amyloid Plaque-Age-Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity
medRxiv : the preprint server for health sciences
Published
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial
Authors
Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford, Alireza Atri, Susan L Mills, Anna M Santacruz, Guoqiao Wang, Charlene Supnet, Tammie L S Benzinger, Brian A Gordon, Laura Ibanez, Gregory Klein, Monika Baudler, Rachelle S Doody, Paul Delmar, Geoffrey A Kerchner, Tobias Bittner, Jakub Wojtowicz, Azad Bonni, Paulo Fontoura, Carsten Hofmann, Luka Kulic, Jason Hassenstab, Andrew J Aschenbrenner, Richard J Perrin, Carlos Cruchaga, Alan E Renton, Chengjie Xiong, Alison A Goate, John C Morris, David M Holtzman, B Joy Snider, Catherine Mummery, William S Brooks, David Wallon, Sarah B Berman, Erik Roberson, Colin L Masters, Douglas R Galasko, Suman Jayadev, Rachel Sanchez-Valle, Jeremie Pariente, Justin Kinsella, Christopher H van Dyck, Serge Gauthier, Ging-Yuek Robin Hsiung, Mario Masellis, Bruno Dubois, Lawrence S Honig, Clifford R Jack, Alisha Daniels, David Aguillón, Ricardo Allegri, Jasmeer Chhatwal, Gregory Day, Nick Fox, Edward Huey, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Allan I Levey, Johannes Levin, Francisco Lopera, JeeHoon Roh, Pedro Rosa-Neto, Peter R Schofield, Dominantly Inherited Alzheimer’s Disease-Trials Unit
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial
medRxiv : the preprint server for health sciences
Published
Progression of biological markers in spinocerebellar ataxia type 3: analysis of longitudinal data from the ESMI cohort
Authors
Moritz Berger, Hector Garcia-Moreno, Monica Ferreira, Jeannette Hubener-Schmid, Tamara Schaprian, Philipp Wegner, Tim Elter, Kennet Teichmann, Magda M Santana, Marcus Grobe-Einsler, Demet Onder, Berkan Koyak, Sarah Bernsen, Luís Pereira de Almeida, Patrick Silva, Joana Afonso Ribeiro, Inês Cunha, Cristina Gonzalez-Robles, Shamsher Khan, Amanda Heslegrave, Henrik Zetterberg, Manuela Lima, Mafalda Raposo, Ana F Ferreira, João Vasconcelos, Bart P van de Warrenburg, Judith van Gaalen, Teije H van Prooije, Jeroen de Vries, Ludger Schols, Olaf Riess, Matthis Synofzik, Dagmar Timmann, Andreas Thieme, Friedrich Erdlenbruch, Jon Infante, Ana Lara Pelayo, Leire Manrique, Kathrin Reetz, Imis Dogan, Gulin Oz, James M Joers, Khalaf Bushara, Chiadikaobi Onyike, Michal Povazan, Heike Jacobi, Jeremy D Schmahmann, Eva-Maria Ratai, Matthias Schmid, Paola Giunti, Thomas Klockgether, Jennifer Faber
Progression of biological markers in spinocerebellar ataxia type 3: analysis of longitudinal data from the ESMI cohort
Journal of Huntington's disease
Published
Study protocol for the iMarkHD study in individuals with Huntington's disease
Authors
Daniel J van Wamelen, Naomi H Martin, Orsolya Makos, James Badenoch, Jose Manuel Valera-Bermejo, Monika Hartmann, Alay Rangel Cristales, Tobias C Wood, Mattia Veronese, Manuela Moretto, Fernando Zelaya, Flavio dell'Acqua, Owen O'Daly, David J Lythgoe, Cedric Ginestet, Federico Turkheimer, Nikki Palasits, Ladislav Mrzljak, John H Warner, Eugenii A Rabiner, Roger Gunn, Sarah J Tabrizi, Cristina Sampaio, Andrew Wood, Steven Cr Williams
Study protocol for the iMarkHD study in individuals with Huntington's disease
Brain and behavior
Published
The Role of the VWF/ADAMTS13 Axis in the Thromboinflammatory Response in Ischemic Stroke After SARS-CoV2 Infection
Authors
Nadim Luka, Kieron South, Rachel Jones, Amanda J Unsworth, Graham Coutts, Ioana-Emilia Mosneag, Mehwish Younas, Amy Bradley, Siew Yan Wong, Ellen Collins, Chloe Quigley, Sean B Knight, Barry W McColl, Laura McCulloch, John R Grainger, Craig J Smith, Stuart M Allan
The Role of the VWF/ADAMTS13 Axis in the Thromboinflammatory Response in Ischemic Stroke After SARS-CoV2 Infection
medRxiv : the preprint server for health sciences
Published
The association of umbilical cord blood neurofilament light with non-reassuring fetal status: a prospective observational study
Authors
David Zalcberg, Kaitlin Kramer, Emma Payne, Thomas Payne, Shreeya Marathe, Neha Mahajan, Ashly Liu, Jessica Barry, Andrew Duckworth, Mitchell Brookes, Bradley de Vries, Fernando Gonzalez-Ortiz, Kaj Blennow, Henrik Zetterberg, Adrienne Gordon, Benjamin Moran, Helen Manning, Robert D Sanders
The association of umbilical cord blood neurofilament light with non-reassuring fetal status: a prospective observational study
medRxiv : the preprint server for health sciences
Published
Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson's disease
Authors
Manuela Mx Tan, Hirotaka Iwaki, Sara Bandres-Ciga, Yuri Sosero, Maryam Shoai, Kathrin Brockmann, Nigel M Williams, Roy N Alcalay, Jodi Maple-Grødem, Guido Alves, Ole-Bjørn Tysnes, Peggy Auinger, Shirley Eberly, Peter Heutink, David K Simon, Karl Kieburtz, John Hardy, Caroline H Williams-Gray, Donald G Grosset, Jean-Christophe Corvol, Ziv Gan-Or, Mathias Toft, Lasse Pihlstrøm
Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson's disease
Alzheimer's research & therapy
Published
The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-β positivity
Authors
Burak Arslan, Wagner S Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault, Jesse Klostranec, Arthur C Macedo, Cecile Tissot, Serge Gauthier, Juan Lantero-Rodriguez, Eduardo R Zimmer, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L Benedet, Nicholas J Ashton
The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-β positivity