Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Cell reports
Published

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Authors
Samuel S Harris, Rikesh M Rajani, Jana Zünkler, Robert Ellingford, Mengke Yang, James M Rowland, Alexander Schmidt, Byung Il Lee, Marten Kehring, Mariam Hellmuth, Francesca Kar Wey Lam, Dominique Fässler, Susanne Erdinger, David P Wolfer, Carlo Sala Frigerio, Fred Wolf, Bradley T Hyman, Ulrike C Müller, Marc Aurel Busche
The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo
bioRxiv : the preprint server for biology
Published

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Authors
Vaibhav Vemuganti, Jea Woo Kang, Qijun Zhang, Ruben Aquino-Martinez, Sandra Harding, Joseph Lawrence Harpt, Yuetiva Deming, Sterling Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Corinne D Engelman, Tyler K Ulland, Fredrik Bäckhed, Barbara B Bendlin, Federico E Rey
Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Online46: Online cognitive assessments in elderly cohorts-The British 1946 birth cohort case study

Authors
Ziyuan Cai, Valentina Giunchiglia, Rebecca Street, Martina Del Giovane, Kirsty Lu, Maria Popham, Andrew Wong, Heidi Murray-Smith, Marcus Richards, Sebastian Crutch, Peter J Hellyer, Jonathan M Schott, Adam Hampshire
Online46: Online cognitive assessments in elderly cohorts-The British 1946 birth cohort case study
Infectious diseases (London, England)
Published

Increased immune activation in people living with HIV on antiretroviral therapy but not when compared with persons on HIV preexposure prophylaxis

Authors
Josefina Robertson, Arvid Edén, Aylin Yilmaz, Lars-Magnus Andersson, Lars Hagberg, Kristina Nyström, Staffan Nilsson, Carl-Johan Treutiger, Petra Tunbäck, Johanna M Gostner, Henrik Zetterberg, Magnus Gisslén
Increased immune activation in people living with HIV on antiretroviral therapy but not when compared with persons on HIV preexposure prophylaxis
Med (New York, N.Y.)
Published

Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer's disease

Authors
Vijay R Varma, Yang An, Przemek R Kac, Murat Bilgel, Abhay Moghekar, Tina Loeffler, David Amschl, Magdalena Daurer, Manuela Prokesch, Juan Troncoso, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Luigi Ferrucci, Susan M Resnick, Madhav Thambisetty
Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease

Authors
Adam P Mecca, Nicholas J Ashton, Ming-Kai Chen, Ryan S O'Dell, Takaya Toyonaga, Wenzhen Zhao, Juan J Young, Elaheh Salardini, Kara A Bates, Jocelyn Ra, Sam Goodcase, Jason A Silva-Rudberg, Nabeel B Nabulsi, Ann Brinkmalm, Hlin Kvartsberg, Michael Schöll, Johanna Nilsson, Amy F T Arnsten, Yiyun Huang, Oskar Hansson, Henrik Zetterberg, Richard E Carson, Kaj Blennow, Christopher H van Dyck
Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease
Movement disorders : official journal of the Movement Disorder Society
Published

Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy

Authors
Carla Palleis, Andrea Quattrone, Amir Dehsarvi, Sebastian N Roemer-Cassiano, Alexander M Bernhardt, AL‐108‐231 Investigators, the PASSPORT Study Group, Hans-Jürgen Huppertz, Maura Malpetti, Adam L Boxer, Johannes Gnörich, Lukas Frontzkowski, Johannes Levin, Matthias Brendel, Günter U Höglinger, Nicolai Franzmeier
Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy
Brain : a journal of neurology
Published

Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease

Authors
Sarah McGlasson, Katy Reid, Anna Klingseisen, Bastien Rioux, Samuel Chauvin, Cathrine A Miner, Joe Holley, Deborah Forbes, Bethany Geary, Jeffrey Kimber, Katrina Wood, Candice Roufosse, Colin Smith, David Kavanagh, Jonathan Miner, David P J Hunt
Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease
bioRxiv : the preprint server for biology
Published

Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

Authors
G Brezzo, K A Zera, D Straus, J E Goertz, S H Loppi, R Crumpacker, J B Frye, D A Becktel, M I Cuartero, A García Culebras, C Dames, D Berchtold, J H Fowler, A Meisel, J Anrather, M A Moro, S M Allan, K P Doyle, M S Buckwalter, B W McColl
Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study
Nature neuroscience
Published

Author Correction: Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus

Authors
Kyoko Tossell, Xiao Yu, Panagiotis Giannos, Berta Anuncibay Soto, Mathieu Nollet, Raquel Yustos, Giulia Miracca, Mikal Vicente, Andawei Miao, Bryan Hsieh, Ying Ma, Alexei L Vyssotski, Tim Constandinou, Nicholas P Franks, William Wisden
Author Correction: Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus