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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature communications
Published

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Authors
Kanta Chechi, Rima Chakaroun, Antonis Myridakis, Sofia K Forslund-Startceva, Sebastien Fromentin, Trine Nielsen, Judith Aron-Wisneswky, Eugeni Belda, Edi Prifti, Pierre Bel Lassen, Gwen Falony, Sara Vieira-Silva, Julien Chilloux, Kazuhiro Sonomura, Lesley Hoyles, Laura Martinez-Gili, Francesco Pallotti, Petros Andrikopoulos, Francesc Puig-Castellví, Romina Pacheco Tapia, Inés Castro-Dionicio, Hugo Roume, Nicolas Pons, Emmanuelle Le Chatelier, Benoit Quinquis, Nathalie Galleron, Magali Berland, Michael T Olanipekun, Manyi Jia, Angelos Manolias, Bridget Holmes, Solia Adriouch, Matthias Blüher, Luis Pedro Coelho, Kévin Da Silva, Pilar Galan, Boyang Ji, Ana Luisa Neves, Christine Rouault, Joe-Elie Salem, Valentina Tremaroli, Tue H Hansen, Nadja B Søndertoft, Christian Lewinter, Helle K Pedersen, MetaCardis Consortium, Peter D Mark, Jens P Goetze, Lars Køber, Henrik Vestergaard, Torben Hansen, Jean-Daniel Zucker, Taka-Aki Sato, Serge Hercberg, Fredrik Bäckhed, Ivica Letunic, Jean-Michel Oppert, Jens Nielsen, Jeroen Raes, Ioanna Tzoulaki, Abbas Dehghan, Verena Zuber, Emmanuelle Bouzigon, Mark Lathrop, Parminder Raina, Philippe Froguel, Fumihiko Matsuda, Florence Demenais, Dominique Gauguier, Michael Stumvoll, Peer Bork, Oluf Pedersen, S Dusko Ehrlich, Karine Clément, Marc-Emmanuel Dumas
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases
Brain communications
Published

Peripheral and CSF protein quantification in Parkinson's disease and multiple system atrophy-the nucleic acid-linked immuno-sandwich assay

Authors
Nirosen Vijiaratnam, Christine Girges, Arthur Mitchell, Dilan Athauda, Riona Fumi, Jennifer Hay, Nicola O'Reilly, Huw Morris, Camille Carroll, Michele T M Hu, Monty A Silverdale, Gordon Duncan, Amanda Heslegrave, Eliza Chai, Sonia Gandhi, Thomas Foltynie
Peripheral and CSF protein quantification in Parkinson's disease and multiple system atrophy-the nucleic acid-linked immuno-sandwich assay
Journal of the American Heart Association
Published

Different Characteristics of Incidental Diffusion-Weighted Imaging-Positive Lesions and Recent Small Subcortical Infarct in Patients With Cerebral Small Vessel Disease

Authors
Zi-Ang Pan, Ming Yao, Zi-Yue Liu, Xing-Qi Pan, Yan-Yan Wang, Cheng-Qian Li, Mei-Jun Shu, Tain-Qi Bao, Si-Han Tang, Ding-Ding Zhang, Li-Xin Zhou, Jun Ni, Joanna M Wardlaw, Fei Han, Yi-Cheng Zhu, CSVD Disability and Outcome Cohort Study Investigators †
Different Characteristics of Incidental Diffusion-Weighted Imaging-Positive Lesions and Recent Small Subcortical Infarct in Patients With Cerebral Small Vessel Disease
Scientific reports
Published

Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation-a controlled study

Authors
Roald Omdal, Ole Bernt Lenning, Grete Jonsson, Jan Terje Kvaløy, Guglielmo Di Molfetta, Kubra Tan, Andrea L Benedet, Nicholas J Ashton, Geir Sverre Braut, Henrik Zetterberg, Tore Grimstad
Long-COVID: assessment of circulating markers suggests no cerebral neuronal damage, neuroinflammation or systemic inflammation-a controlled study
Proceedings of the National Academy of Sciences of the United States of America
Published

Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification

Authors
Yuanbing Jiang, Wenyue Zheng, Zengjie Xia, Wan Wa Wong, Lily K W Cheng, Fanny C Ip, Siu Man Choi, Andrew L T Chan, Ching Yu Lam, Ka Shing Ho, Chun Keung Shum, Jacqueline K Y Yuen, Yat Fung Shea, Hok Man Wai, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, Hiu Yi Wong, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip
Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Patient and public involvement and engagement in clinical trials at scale: Analysis of the first 3250 responses on the POrtal for Patient and Public Engagement in Dementia (POPPED)

Authors
Hongyi Qin, Linda Pointon, James Carpenter, Vanessa Raymont, Ross Dunne, Suzanne Reeves, Shabinah Ali, Sabahat Iqbal, Cristina Bonet-Olivares, Joanne Whittle, Laura Rizzo, Paresh Malhotra, Benjamin R Underwood, AD‐SMART team
Patient and public involvement and engagement in clinical trials at scale: Analysis of the first 3250 responses on the POrtal for Patient and Public Engagement in Dementia (POPPED)
bioRxiv : the preprint server for biology
Published

Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity

Authors
Noah Wake, Juan Alcalde, Daniel Jutzi, Anjali Bajaj, Sukhleen Kour, Mayur Barai, Shuo-Lin Weng, Samara Cummings, Tongyin Zheng, Eric N Anderson, Szu-Huan Wang, Ryan Puterbaugh, Daryl A Bosco, Benjamin S Schuster, Jeetain Mittal, Udai Bhan Pandey, Marc-David Ruepp, Nicolas L Fawzi
Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity
Brain communications
Published

Increased cerebrospinal fluid YKL-40 concentration in hip fracture patients with delirium

Authors
Thea Berntsen, Kaj Blennow, Henrik Zetterberg, Ingrid Fæhn Brekke, Mathias Nikolai Petersen Hella, Tom Tarjei Lian, Lene B Solberg, Christian Thomas Pollmann, Adi Karabeg, Olav Tobias Ødegaard, Marius Myrstad, Kristian Sydnes, Roy Bjørkholt Olsen, Torgeir Bruun Wyller, Leiv Otto Watne, Bjørn Erik Neerland
Increased cerebrospinal fluid YKL-40 concentration in hip fracture patients with delirium
Brain communications
Published

Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers

Authors
Oriol Perera-Cruz, Cristina Solé-Padullés, Lídia Mulet-Pons, María Cabello-Toscano, Rachel M Morse, Kilian Abellaneda-Pérez, Rubén Perellón-Alfonso, Gabriele Cattaneo, Javier Solana-Sánchez, Vanessa Alviarez-Schulze, Nuria Bargalló, Juan Fortea, Josep M Tormos, Alvaro Pascual-Leone, Henrik Zetterberg, Lídia Vaqué-Alcázar, David Bartrés-Faz
Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Authors
Elisa M Cruz, Luana C Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo-Kolodner, Mona Barkat, Roslyn M Bill, Edward Mann, Linna Zhou, Mootaz M Salman, Hagan Bayley, Zoltán Molnár, Francis G Szele
Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair
Brain communications
Published

CSF protein clearance impairment revealed using stable isotope kinetics in normal pressure hydrocephalus

Authors
Claire A Leckey, Tatiana A Giovannucci, Eimear C Murphy, Eleanor M Moncur, Kanza Tariq, Aram Aslanyan, Michael Schöll, Meera Srikrishna, William Coath, Suzanne Barker, Dylan Esguerra, Ahmed K Toma, Laurence D Watkins, Lewis Thorne, Sylvain Lehmann, Jerome Vialaret, Selina Wray, Randall J Bateman, Kevin Mills, Donald L Elbert, Laura Pellegrini, Ross W Paterson
CSF protein clearance impairment revealed using stable isotope kinetics in normal pressure hydrocephalus
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease

Authors
Seyyed Ali Hosseini, Etienne Aumont, Nesrine Rahmouni, Marcel S Woo, Arthur C Macedo, Brandon Hall, Tevy Chan, Joseph Therriault, Lydia Trudel, Yansheng Zheng, Gleb Bezgin, Aurélie Lebrun, Jaime Fernandez Arias, Kely Quispialaya Socualaya, Cécile Tissot, Stijn Servaes, Yi-Ting Wang, Delphine Oliva-Lopez, Stuart Mitchell, Robert Hopewell, Chris Hung-Hsin Hsiao, Catherine Saleh, Jenna Stevenson, Firoza Lussier, Liyong Wu, Min Chu, Sanjeev Chawla, Vladimir Fonov, Gassan Massarweh, Yasser Iturria Medina, Jean-Paul Soucy, Karine Provost, David A Rudko, Thomas Karikari, Andréa Lessa Benedet, Nicholas J Ashton, Henrik Zetterberg, Maxime Montembeault, Paolo Vitali, Kaj Blennow, Serge Gauthier, D Louis Collins, Jesse Klostranec, Tharick A Pascoal, Pedro Rosa-Neto
Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease