Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
BMJ open
Published

Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study

Authors
Mathias N P Hella, Nathalie B Halaas, Hogne Soennesyn, Anne K Bergland, Hanne B Hetland, Kaj Blennow, Henrik Zetterberg, Audun O Vik-Mo, Ane-Victoria Idland, Christian T Pollmann, Marius Myrstad, Bjørn E Neerland, Dag Aarsland, Leiv O Watne
Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study
Nature communications
Published

Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome

Authors
Hanna Huber, Javier Arranz, Burak Arslan, Antoine Leuzy, Oscar Kittel, Guglielmo di Molfetta, Bessy Benejam, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Lucía Maure-Blesa, Íñigo Rodríguez-Baz, José Enrique Arriola Infante, Ignacio Illán-Gala, Alexandre Bejanin, Laia Montoliu-Gaya, Alberto Lleó, María Carmona-Iragui, Daniel Alcolea, Kaj Blennow, Henrik Zetterberg, Juan Fortea, Nicholas J Ashton
Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome
Nature neuroscience
Published

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease

Authors
João Pedro Ferrari-Souza, Guilherme Povala, Nesrine Rahmouni, Bruna Bellaver, Pamela C L Ferreira, Marco Antônio De Bastiani, Douglas T Leffa, Firoza Z Lussier, Cristiano S Aguzzoli, Wagner S Brum, Giovanna Carello-Collar, Wyllians V Borelli, Joseph Therriault, Arthur C Macedo, Stijn Servaes, Jenna Stevenson, Ilaria Pola, Serge Gauthier, Diogo O Souza, Lucas Porcello Schilling, Mychael V Lourenco, Gallen Triana-Baltzer, Hartmuth C Kolb, Andréa L Benedet, Nicholas J Ashton, Dana L Tudorascu, Henrik Zetterberg, Kaj Blennow, Sterling C Johnson, Tharick A Pascoal, Pedro Rosa-Neto, Eduardo R Zimmer
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease
Nature communications
Published

Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human

Authors
Steven A Hill, Isabel Bravo-Ferrer, Austėja Čiulkinytė, Noelia Pérez Ramos, Ilaria Rossetti, Chiara Colvin, Paula Beltran-Lobo, Carlos Parra-Pérez, Katie Emelianova, Owen Dando, Beth Geary, Raja S Nirujogi, Dario R Alessi, Do-Young Lee, Youn-Bok Lee, Blanca Díaz Castro
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
Journal of internal medicine
Published

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

Authors
Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo, Pete A Williams, Patricia Rodriguez-Rodriguez, Luana Naia
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
The Journal of biological chemistry
Published

Cellular and functional insights into FIH-mediated hydroxylation of TRPA1

Authors
Tao Guo, Dianne Marquez Lopez, Siyuan Wang, Liudi Yao, Xi Li, Elizabeth R Davies, Mariana Vargas-Caballero, Nullin Divecha, Christopher J Schofield, Katrin Deinhardt, Yihua Wang
Cellular and functional insights into FIH-mediated hydroxylation of TRPA1
Neurology
Published

In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy: An Exploratory Study

Authors
Hilde van den Brink, Mariel G Kozberg, Nazanin Makkinejad, John E Kirsch, Michael J Thrippleton, Thijs W van Harten, Sabine Voigt, Whitney M Freeze, Matthias J P Van Osch, Anand Viswanathan, Susanne J van Veluw
In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy: An Exploratory Study
Multiple sclerosis (Houndmills, Basingstoke, England)
Published

Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity

Authors
Sofia Sandgren, Aleksandra Maleska Maceski, Pascal Benkert, Maximilian Einsiedler, Sabine Schaedelin, Johanna Oechtering, Lutz Achtnichts, Patrice H Lalive, Stefanie Müller, Caroline Pot, Amanda Heslegrave, David Hunt, Jan Lycke, Robert Hoepner, Patrick Roth, Claudio Gobbi, Manuel Comabella, Tobias Derfuss, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline Aj Willemse, Henrik Zetterberg, Jens Kuhle
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Molecular medicine (Cambridge, Mass.)
Published

Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model

Authors
Andrea Salzinger, Esra Özkan, Vidya Ramesh, Jyoti Nanda, Karen Burr, David Story, Nhan T Pham, Siddharthan Chandran, Bhuvaneish T Selvaraj
Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model
Brain : a journal of neurology
Published

Estimating the time course of biomarker changes in Alzheimer's disease

Authors
Lars Lau Raket, Alexa Pichet Binette, Niklas Mattsson-Carlgren, Shorena Janelidze, Henrik Zetterberg, Nicholas J Ashton, Kaj Blennow, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson
Estimating the time course of biomarker changes in Alzheimer's disease
Translational psychiatry
Published

Interplay between age, APOE Ɛ4 and the metabolome in plasma and brain in Alzheimer's disease

Authors
Najaf Amin, Jun Liu, William Sproviero, Matthias Arnold, Richa Batra, Bruno Bonnechere, Yu-Jie Chiou, Marco Fernandes, Jan Krumsiek, Danielle Newby, Kwangsik Nho, Jun Pyo Kim, Andrew J Saykin, Liu Shi, Laura M Winchester, Yang Yang, Alejo J Nevado-Holgado, Gabi Kastenmüller, Rima Kaddurah-Daouk, Cornelia M van Duijn
Interplay between age, APOE Ɛ4 and the metabolome in plasma and brain in Alzheimer's disease
Translational psychiatry
Published

Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures

Authors
Joanna E Moodie, Colin R Buchanan, Anna E Fürtjes, Eleanor L S Conole, Aleks Stolicyn, Janie Corley, Karen Ferguson, Maria Valdés Hernández, Susana Muñoz Maniega, Tom C Russ, Michelle Luciano, Heather Whalley, Mark E Bastin, Joanna Wardlaw, Ian J Deary, Simon R Cox
Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures
Neuron
Published

The brain neurovascular epigenome and its association with dementia

Authors
Kevin Chris Ziegler, Aydan Askarova, Charbel Gergian, Reuben M Yaa, Janna D van Dalen, Janis Lisa Transfeld, Filippo Zoppi, Jia Du, Daniel Clode, Fatemeh Rahbar, Rebecca E Graham, Muralidharan Sargurupremraj, Stéphanie Debette, David D Gonda, Michael L Levy, Siddharthan Chandran, Sven Falk, Marisa Karow, Paul M Matthews, Nicole G Coufal, Alexi Nott
The brain neurovascular epigenome and its association with dementia