Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Molecular neurodegeneration
Published
Targeting tau in Alzheimer's Disease: rationale, approach and challenges
Authors
Aram Aslanyan, Martha S Foiani, Tatiana A Giovannucci, Eric McDade, Karen E Duff, Catherine J Mummery, Michael Schöll, Kristin R Wildsmith, Ross W Paterson
Targeting tau in Alzheimer's Disease: rationale, approach and challenges
Human brain mapping
Published
segcsvd<sub>PVS</sub>: A Convolutional Neural Network-Based Tool for Quantification of Enlarged Perivascular Spaces (PVS) on T<sub>1</sub>-Weighted Images
Authors
Erin Gibson, Joel Ramirez, Lauren Abby Woods, Stephanie Berberian, Julie Ottoy, Christopher J M Scott, Vanessa Yhap, Fuqiang Gao, Roberto Duarte Coello, Maria Valdes Hernandez, Anthony E Lang, Carmela M Tartaglia, Sanjeev Kumar, Malcolm A Binns, Robert Bartha, Sean Symons, Richard H Swartz, Mario Masellis, Navneet Singh, Bradley J MacIntosh, Joanna M Wardlaw, Sandra E Black, ONDRI Investigators, ADNI, CAHHM Investigators, CAIN Investigators, colleagues from the Foundation Leducq Transatlantic Network of Excellence, Andrew S P Lim, Maged Goubran
segcsvd<sub>PVS</sub>: A Convolutional Neural Network-Based Tool for Quantification of Enlarged Perivascular Spaces (PVS) on T<sub>1</sub>-Weighted Images
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published
Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF-21), and insulin-like growth factor binding protein 2 (IGFBP-2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum
Authors
Caroline Dallaire-Théroux, Helena L Denis, Rosalie Cottez, Cyntia Tremblay, Amélie Provencher, Josue Valentin-Escalera, Manon Leclerc, Andreanne Loiselle, Marine Tournissac, Olivier Potvin, Sylvie Belleville, Anne Gangloff, Frederic Picard, Henrik Zetterberg, Consortium for the Early Identification of Alzheimer's Disease – Quebec (CIMA‐Q), Frédéric Calon
Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF-21), and insulin-like growth factor binding protein 2 (IGFBP-2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum
Neurology. Genetics
Published
Pilot Study of Fingolimod Treatment in Neuronal Ceroid Lipofuscinosis Type 1
Authors
Martina Messina, Rebecca Whiteley, Chin Gan, Wendy E Heywood, Amanda J Heslegrave, Megan Keating, Sophie Taylor, Emma Footitt, Philippa Mills, Cheryl Hemingway, Paul Gissen, Katy Vecchiato
Pilot Study of Fingolimod Treatment in Neuronal Ceroid Lipofuscinosis Type 1
Cerebral circulation - cognition and behavior
Published
Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease
Authors
Michael S Stringer, Xingfeng Shao, Hedok Lee, Antoine Vallatos, Carmen Arteaga-Reyes, Una Clancy, Francesca Chappell, Cameron Manning, Maria Valdes-Hernandez, Daniela Jaime Garcia, Rosalind Brown, Fergus N Doubal, Helene Benveniste, Michael J Thrippleton, Danny Jj Wang, Joanna M Wardlaw, Mild Stroke Study 3 study group
Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease
Mammalian genome : official journal of the International Mammalian Genome Society
Published
Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities
Authors
Nikoleta Daskoulidou, Jacqui Nimmo, Matthew Bright, Zhizhong Yang, Laura Elisabeth Nicholls, Bryan Paul Morgan, Nikoleta Daskoulidou, Wioleta Milena Zelek
Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities
JAMA neurology
Published
Plasma Phosphorylated Tau 217 Cutoffs for Amyloid Pathology and Kidney Function, Body Mass Index, and Anemia
Authors
Jihwan Yun, Jungah Lee, Daeun Shin, Eun Hye Lee, Jun Pyo Kim, Hongki Ham, Yuna Gu, Min Young Chun, Sung Hoon Kang, Hee Jin Kim, Duk L Na, Ko Woon Kim, Si Eun Kim, Yeshin Kim, Jaeho Kim, Na-Yeon Jung, Yeo Jin Kim, Soo Hyun Cho, Jin San Lee, Seonghyeon Kim, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Joel B Braunstein, Philip B Verghese, Tim West, Matthew R Meyer, Sang Won Seo, Hyemin Jang, K-ROAD Study Groups
Plasma Phosphorylated Tau 217 Cutoffs for Amyloid Pathology and Kidney Function, Body Mass Index, and Anemia
Nature communications
Published
Biomarker-integrated prognostic stagings for Alzheimer's Disease
Authors
Daeun Shin, Sungjoo Lee, Jun Pyo Kim, Hyemin Jang, Jihwan Yun, Min Young Chun, Jehyun Ahn, Seongmi Kim, Kyoungmin Kim, Soyeon Yoon, Hee Jin Kim, Heekyoung Kang, Sohyun Yim, Hee Kyung Park, Seonghyeon Kim, Duk L Na, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Michael W Weiner, Sang Won Seo, Kyunga Kim
Biomarker-integrated prognostic stagings for Alzheimer's Disease
Alzheimer's research & therapy
Published
Glymphatic dysfunction links vascular pathology to Alzheimer's biomarkers and cognitive decline
Authors
Sung Hoon Kang, Seongmi Kim, Young Ju Kim, Heejin Yoo, Eun Hye Lee, Hyemin Jang, Daeun Shin, Jihwan Yun, Jun Pyo Kim, Hee Jin Kim, Duk L Na, Henrick Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Theresa A Day, Marco Duering, Seong-Beom Koh, Sang-Young Kim, Eung Yeop Kim, Sung Tae Kim, Beomseok Sohn, Sang Won Seo
Glymphatic dysfunction links vascular pathology to Alzheimer's biomarkers and cognitive decline