Jian Gan

Dr Jian Gan

Group Leader

Understanding why and how neurons and brain circuits become dysfunctional in vivo

Condition

Alzheimer's disease, Vascular dementia, Frontotemporal dementia, Mild cognitive impairment

Topics

Ageing, Cell biology of neurons & glia, Immune system, Sleep & Circadian rhythms, Synapse & Circuitry, Vascular system, Biomarkers & diagnostics, Treatments & Interventions

Techniques

Advanced microscopy & imaging, Electrophysiology, Mouse behaviour, Mouse in vivo imaging, Optogenetics, Single cell / nucleus transcriptomics, Viral-mediated expression

Biography

Dr Jian Gan is a cellular/systems neuroscientist. After obtaining his PhD from the University of Glasgow, supported by a Synergy Postgraduate Award and an Overseas Research Student Award, he went on to work in the lab of Prof. Peter Jonas at the University of Freiburg, Germany and later Institute of Science and Technology Austria near Vienna, where he employed and optimised in vivo high-resolution patch-clamp recording technique to elucidate synaptic mechanism of hippocampal oscillations that are essential for spatial coding and memory consolidation. He went on to gain further experience in cognitive and behavioural neurobiology using high-density population recording and virtual reality in the lab of Prof. Thomas Klausberger at the Medical University of Vienna, before setting up his own lab at the University of Edinburgh.

News

Key publications

Nature neuroscience
Published
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Authors
Mary O'Keeffe, Sam A Booker, Darren Walsh, Mosi Li, Chloe Henley, Laura Simões de Oliveira, Mingshan Liu, Xingran Wang, Maria Banqueri, Katherine Ridley, Kosala N Dissanayake, Cristina Martinez-Gonzalez, Kirsty J Craigie, Deepali Vasoya, Tom Leah, Xin He, David A Hume, Ian Duguid, Matthew F Nolan, Jing Qiu, David J A Wyllie, Owen R Dando, Alfredo Gonzalez-Sulser, Jian Gan, Clare Pridans, Peter C Kind, Giles E Hardingham
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Cereb Circ Cogn Behav
Published
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Authors
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Barry W McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B Lawrence, Cheryl Hawkes, Chrysia-Maria Pegasiou-Davies, Claire Gibson, Colin L Crawford, Colin Smith, Denis Vivien, Fiona H McLean, Frances Wiseman, Gaia Brezzo, Giovanna Lalli, Harry A T Pritchard, Hugh S Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S Stringer, Mlj Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H Hainsworth, Joanna M Wardlaw
A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.

Gan Lab

Explore the work of the Gan Lab, aiming to understand why and how neurons and brain circuits become dysfunctional in vivo

Gan Lab
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