Philip Hasel

Dr Philip Hasel

Group Leader

Deciphering the role of astrocytes at brain borders in neurodegeneration

Condition

Alzheimer's disease, Motor neuron disease/ALS, Vascular dementia

Topics

Cell biology of neurons & glia, Molecular mechanisms, Vascular system

Techniques

Advanced microscopy & imaging, Bioinformatics, CRISPR, Flow cytometry, Mouse in vivo imaging, Next generation sequencing, Single cell / nucleus transcriptomics, Spatial transcriptomics, Viral-mediated expression

Biography

Philip Hasel completed his PhD in Giles Hardingham’s lab at the University of Edinburgh, exploring neuron-to-astrocyte signalling, before moving to New York for his postdoc at NYU. There, he worked with Prof Shane Liddelow to uncover new subtypes of healthy and reactive astrocytes. He is now a Group Leader and Wellcome Trust Career Development Fellow at the UK DRI at Edinburgh. Philip’s group works on astrocyte subtypes and their contribution to brain function and dysfunction. The lab is applying a mix of computational and wet lab approaches to study the role of astrocytes at the borders of the central nervous system.

News

Key publications

Cell reports
Published
Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates
Authors
Philip Hasel, Melissa L Cooper, Anne E Marchildon, Uriel Rufen-Blanchette, Rachel D Kim, Thong C Ma, Adam M R Groh, Emily J Hill, Eleanor M Lewis, Michał Januszewski, Sarah E W Light, Cody J Smith, Jo Anne Stratton, Steven A Sloan, Un Jung Kang, Moses V Chao, Shane A Liddelow
Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates

Hasel Lab

Explore the work of the Hasel Lab focused on uncovering the role of astrocyte subtypes in neurodegeneration.

Hasel Lab
Astrocytes on the brain surface