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By joining the UK DRI you’ll belong to a team of fantastic researchers, technical specialists and professional support staff passionate about accelerating the discovery, development and delivery of interventions that will help diagnose, treat and ultimately prevent dementia, directly benefitting people affected by dementia, their carers, families and the community.

We’re looking for brilliant people with diverse perspectives. Together our unique contributions will transform the range and pace of research on dementia. You’ll be supported by the very best tools and resources and join a culture that encourages high risk/reward science and sharing of ideas.

We are a vibrant, ambitious and interactive community. We offer opportunities at all career levels for scientists and support staff in our seven centres across the UK, as well as in our London-based HQ team.

We’re always interested in hearing from people as passionate about our mission as we are. To find out more about working at the UK DRI or our current opportunities, please contact us at

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Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test.

  • Specialisms at UCL
  • Mechanistic understanding of dysfunction in cells and neural systems
  • Gene expression and biological pathways in single cells related to the progression of Alzheimer’s disease
  • New biomarkers to monitor disease progression
  • Deficits in axonal transport in early neurodegeneration
  • Wnt signalling in synapses to discover new targets for future dementia therapies
  • Read more about UCL

    From lab bench to bedside, and back again

    UCL was selected as the hub of the UK DRI in 2016 because of its strength to bring together excellent clinical and basic neuroscience research to advance our understanding of neurodegeneration and identify novel targets and therapeutic approaches for dementia. As the hub, it has a larger research programme and also is the location for the national headquarters team who connect the whole institute together.

    Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test. The groups believe in intervening earlier in disease in order to change the trajectory.

    We need to better understand the diversity and complexity of neurodegenerative diseases, like Alzheimer's disease, in order to understand the mechanisms involved, and ultimately how we can alter them to improve people's lives.

    We must find treatments quicker, and that's why the UK DRI at UCL is taking a novel approach by integrating diverse expertise for efficiency, from genetics to diagnostics.

    This work is enhanced by incredible clinical resources. Researchers have access to unique clinical cohorts, where comprehensive data has been collected throughout disease progression including memory assessments and brain tissue. The UK DRI at UCL provides a clinical arm to the whole of the UK DRI.

    The future iconic home of the UK DRI at UCL will be alongside UCL's Queen Square Institute of Neurology in a new building on Gray's Inn Road.

    Visit the UK DRI at UCL local website for up-to-date news.

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  • Centre Colony Manager, UK DRI at UCL

    UK DRI is seeking a Centre Colony Manager to join the Department of School of Life & Medical Sciences within UCL. The Centre Colony Manager is based in the UK DRI at UCL’s core services team, located at the Cruciform building. The UK DRI at UCL is currently comprised of c100 researchers and support staff at all levels and is still growing. The role is primarily focused on the management and maintenance of the UK DRI at UCL’s animal colonies and will also involve other duties related to animal research at the UK DRI. You will interact with research staff at all levels daily and will help facilitate research at the UK DRI. You will be the main point of contact between the UCL biological services and the UK DRI at UCL’s researchers and will be expected to manage multiple transgenic mouse lines and to maintain suitable records. You will also assist in the day-to-day running of the laboratory and will be involved in ensuring that health and safety policies are followed and updated accordingly. You will also have a central role in planning and implementing the phased transition of animal activities from the Bloomsbury Campus to the ION-DRI Grays Inn Road Hub over the next two years. You’ll have a BSc in Biological Sciences (or a related subject) and a Home Office personal licence. Experience of maintaining transgenic mouse lines, of genotyping mice, and of using animal-based project tracking software is essential for this role. You’ll also have excellent communication skills, an organised and methodical approach to your work, and the ability to build strong working relationships and work collaboratively. Ref: B02-06014, Closing date: 10 March 2024

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