By joining the UK DRI you’ll belong to a team of fantastic researchers, technical specialists and professional support staff passionate about accelerating the discovery, development and delivery of interventions that will help diagnose, treat and ultimately prevent dementia, directly benefitting people affected by dementia, their carers, families and the community.
We’re looking for brilliant people with diverse perspectives. Together our unique contributions will transform the range and pace of research on dementia. You’ll be supported by the very best tools and resources and join a culture that encourages high risk/reward science and sharing of ideas.
We are a vibrant, ambitious and interactive community. We offer opportunities at all career levels for scientists and support staff in our seven centres across the UK, as well as in our London-based HQ team.
We’re always interested in hearing from people as passionate about our mission as we are. To find out more about working at the UK DRI or our current opportunities, please contact us at email@example.com.
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UK DRI at The University of Edinburgh
From brain vasculature to microglia: elucidating the interactions within the brain and with the body which control the trajectory of neurodegenerative disorders.
- Specialisms at Edinburgh
- Cellular interplay maintaining brain homeostasis and its disruption in dementia
- Mechanisms of synapse-, neuron- and circuit-level dysfunction leading to cognitive decline
- Macroglial and microglial roles in neuroprotection and neurodegeneration
- Biology of cerebrovascular, blood-brain-barrier and metabolic dysfunction in neurodegenerative disease
Read more about Edinburgh
Studies are increasingly highlighting the important role of immune, vascular and metabolic factors in the development of neurodegenerative diseases but the interplay between these components in disease progression is poorly understood. The UK DRI at Edinburgh broadens out the traditional view of neurodegenerative disease as a disorder of misfolded proteins to encompass the multicellular environment surrounding degenerating neurons.
The research team lead by Professor Giles Hardingham examines the complex interactions between cells of the brain, immune system and blood vessels that make up the ‘neurogliovascular unit’. They bring together strengths in metabolism, inflammation, blood vessel biology and stem cell medicine to explore how interactions at the neurogliovascular unit control the trajectory of neurodegenerative diseases leading to dementia.
By describing interactions at the neurogliovascular unit that help to maintain cognitive function for several decades in a healthy, ageing brain, the team aim to identify biological regulators that can inform the development of new therapies.
UK DRI at The University of Edinburgh is located on the BioQuarter, Edinburgh's new multidisciplinary research institute and teaching hospital with access to superb multimodal neuroimaging and clinical research facilities.
Apply for latest jobs at Edinburgh
Postdoctoral Research Fellow, UK DRI at Edinburgh - Bowles' Lab
The project is focused on understanding the function of the LRRC37A2 gene in astrocytes, and how this modifies inflammation and neuronal health to modulate risk for Parkinson’s disease. You will use iPSC-derived monocultures and co-cultures to investigate this mechanism in both neurons and glial cells, using a combination of approaches including transcriptomics, electrophysiology and basic molecular biology techniques. The successful candidate will contribute to all aspects of this project, resulting in the generation of a novel ‘omics dataset and new information about an understudied gene. The post-holder will be expected to work with a high degree of independence in day-to-day work, and encouraged to contribute their own ideas to the project direction. You will hold a PhD or other higher level degree (e.g MD/PhD) in a relevant discipline (neuroscience, neurodegeneration, molecular and cellular biology), have experience in either iPSC culture OR electrophysiology and with a range of basic biochemical techniques, excellent written and oral communication skills and willingness to learn a variety of new skills. Ref: 8379, Closing date: 25 September 2023Apply to centre
Postdoctoral Research Fellow, UK DRI at Edinburgh - Hardingham Lab
UK DRI is seeking a Postdoctoral Research Fellow to join the Centre Manager Prof Giles Hardingham's Lab in the Centre for Discovery Brain Sciences within University of Edinburgh. The successful candidate will drive a project centred on the functional interplay between neurons, astrocytes and microglia in the context of Aß and tau pathology. The project will involve the use of established in vivo disease models of ß-amyloidopathy and tauopathy, mice lacking microglia (with and without microglial replacement therapy) and also viral manipulation of cell types (e.g. using chemogenetics). Approaches will be tailored to the questions being asked, but may involve single-cell and spatial transcriptomics/proteomics, in vivo optical imaging, electrophysiology, behavioural testing, and cell biological/primary culture approaches. All relevant training will be given and career development actively encouraged. You will have a strong track record of research publications commensurate with career stage, a high level of technical and theoretical knowledge in your current subject area, an ambition to develop a project and contribute intellectually to its direction, experience in a subset of relevant techniques and good interpersonal, time management and team-working skills. Ref: 7561, Closing date 17 October 2023Apply to centre