By joining the UK DRI you’ll belong to a team of fantastic researchers, technical specialists and professional support staff passionate about accelerating the discovery, development and delivery of interventions that will help diagnose, treat and ultimately prevent dementia, directly benefitting people affected by dementia, their carers, families and the community.
We’re looking for brilliant people with diverse perspectives. Together our unique contributions will transform the range and pace of research on dementia. You’ll be supported by the very best tools and resources and join a culture that encourages high risk/reward science and sharing of ideas.
We are a vibrant, ambitious and interactive community. We offer opportunities at all career levels for scientists and support staff in our seven centres across the UK, as well as in our London-based HQ team.
We’re always interested in hearing from people as passionate about our mission as we are. To find out more about working at the UK DRI or our current opportunities, please contact us at email@example.com.
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UK DRI at UCL
Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test.
- Specialisms at UCL
- Mechanistic understanding of dysfunction in cells and neural systems
- Gene expression and biological pathways in single cells related to the progression of Alzheimer’s disease
- New biomarkers to monitor disease progression
- Deficits in axonal transport in early neurodegeneration
- Wnt signalling in synapses to discover new targets for future dementia therapies
Read more about UCL
From lab bench to bedside, and back again
UCL was selected as the hub of the UK DRI in 2016 because of its strength to bring together excellent clinical and basic neuroscience research to advance our understanding of neurodegeneration and identify novel targets and therapeutic approaches for dementia. As the hub, it has a larger research programme and also is the location for the national headquarters team who connect the whole institute together.
Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test. The groups believe in intervening earlier in disease in order to change the trajectory.
We need to better understand the diversity and complexity of neurodegenerative diseases, like Alzheimer's disease, in order to understand the mechanisms involved, and ultimately how we can alter them to improve people's lives.
We must find treatments quicker, and that's why the UK DRI at UCL is taking a novel approach by integrating diverse expertise for efficiency, from genetics to diagnostics.
This work is enhanced by incredible clinical resources. Researchers have access to unique clinical cohorts, where comprehensive data has been collected throughout disease progression including memory assessments and brain tissue. The UK DRI at UCL provides a clinical arm to the whole of the UK DRI.
The future iconic home of the UK DRI at UCL will be alongside UCL's Queen Square Institute of Neurology in a new building on Gray's Inn Road.
Visit the UK DRI at UCL local website for up-to-date news.
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Research Associate, UK DRI at Cardiff & UK DRI at UCL (Cross Centre)
The UK DRI’s Cross-Centre Postdoctoral Programme is designed to simultaneously fund exciting emerging science and to foster intra-UK DRI collaboration through support of a postdoctoral position based across two UK DRI sites. This position offers a unique opportunity to leverage the UK DRI’s cross-institutional strengths. Applications are invited for a Research Associate in Neuroinflammation/Complement Biology to work on an exciting biomarkers study entitled ‘Profiling complement markers in blood using neuronal-derived extracellular vesicles in FTD.’ In this comprehensive study we will measure several complement biomarkers and markers of neuroinflammation and cell origin in plasma, CSF and neuronal-derived extracellular vesicles (EVs) extracted from plasma samples. EVs represent a compartment in the blood reflecting changes in the brain enabling assessment of brain changes in inflammatory markers such as complement proteins. The primary aim is to deliver a comprehensive data package on the roles of the complement pathway in frontotemporal dementia (FTD) using these biomarkers approaches. The data will help identify mechanisms and therapeutic strategies to modulate complement dysregulation in the disease. The post-holder will be based in the UK DRI at Cardiff in the labs of Prof B. Paul Morgan and Dr Wioleta Zelek, but will spend up to 6 months in year 1 at UK DRI at UCL with Dr Aitana Sogorb-Esteve optimising methods for extracellular vesicle (EV) extraction. Subsequently, they will undertake regular visits to perform specific analyses at UCL during the three-year period. Ref: 15481BR, Closing date: 27 November 2022Apply to centre