By joining the UK DRI you’ll belong to a team of fantastic researchers, technical specialists and professional support staff passionate about accelerating the discovery, development and delivery of interventions that will help diagnose, treat and ultimately prevent dementia, directly benefitting people affected by dementia, their carers, families and the community.
We’re looking for brilliant people with diverse perspectives. Together our unique contributions will transform the range and pace of research on dementia. You’ll be supported by the very best tools and resources and join a culture that encourages high risk/reward science and sharing of ideas.
We are a vibrant, ambitious and interactive community. We offer opportunities at all career levels for scientists and support staff in our seven centres across the UK, as well as in our London-based HQ team.
We’re always interested in hearing from people as passionate about our mission as we are. To find out more about working at the UK DRI or our current opportunities, please contact us at email@example.com.
King's College London
Group Leader in RNA Biology, UK DRI at King's
As part of the continued growth of the UK DRI at King’s College London, the Department of Basic and Clinical Neuroscience is seeking a clinical or nonclinical academic to initiate a novel programme of research into neurodegeneration. We welcome applications from clinical and nonclinical academics with any research interest that will contribute to the aim of our centre to characterise the mechanisms of protein-RNA complexes and their impairments in ALS and develop new therapeutics with AAV- and antisense RNA-based delivery. You will be responsible for building and providing research leadership to a group of research scientists, comprising postdoctoral fellows, PhD students and technical support staff. Applicants should have well-established expertise, reputation, and a proven portfolio of research, including a record of publications that initiated new research directions and impacted the research of other teams. Ref: 047645, Closing date: 1 September 2022Apply to centre
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UK DRI at UCL
Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test.
- Specialisms at UCL
- Mechanistic understanding of dysfunction in cells and neural systems
- Gene expression and biological pathways in single cells related to the progression of Alzheimer’s disease
- New biomarkers to monitor disease progression
- Deficits in axonal transport in early neurodegeneration
- Wnt signalling in synapses to discover new targets for future dementia therapies
Read more about UCL
From lab bench to bedside, and back again
UCL was selected as the hub of the UK DRI in 2016 because of its strength to bring together excellent clinical and basic neuroscience research to advance our understanding of neurodegeneration and identify novel targets and therapeutic approaches for dementia. As the hub, it has a larger research programme and also is the location for the national headquarters team who connect the whole institute together.
Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test. The groups believe in intervening earlier in disease in order to change the trajectory.
We need to better understand the diversity and complexity of neurodegenerative diseases, like Alzheimer's disease, in order to understand the mechanisms involved, and ultimately how we can alter them to improve people's lives.
We must find treatments quicker, and that's why the UK DRI at UCL is taking a novel approach by integrating diverse expertise for efficiency, from genetics to diagnostics.
This work is enhanced by incredible clinical resources. Researchers have access to unique clinical cohorts, where comprehensive data has been collected throughout disease progression including memory assessments and brain tissue. The UK DRI at UCL provides a clinical arm to the whole of the UK DRI.
The future iconic home of the UK DRI at UCL will be alongside UCL's Queen Square Institute of Neurology in a new building on Gray's Inn Road.
Visit the UK DRI at UCL local website for up-to-date news.
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Research Fellow, UK DRI at UCL - Bartels lab
The UK DRI at UCL is seeking a Research Fellow to join the lab of Dr Tim Bartels. Tim Bartels first discovered disease resistant forms of the α-synuclein protein and their destabilisation in Parkinson’s Disease. His lab is interested in identifying the different factors that destabilise α-synuclein and that lead to neurotoxicity. The lab is now looking for a Research Fellow to join them and work on one of the current projects on offer. One project will involve developing antibodies against specific species of α-Synuclein, a protein involved in neurodegeneration, and developing an ELISA or Quanterix detection assay to detect α-Synuclein in different human biofluids (blood, CSF) and establishing a fluid biomarker for Parkinson’s Disease and Dementia with Lewy Bodies. This project will offer the opportunity o work in collaboration with Zetterberg lab at the UK DRI at UCL and Rimona Weil at the National Hospital for Neurology and Neurosurgery. The second project involves investigating the gut-brain axis in PD using mouse models and human synucleinopathy tissue in collaboration with the Soyon Hong lab at the UK DRI. Candidates interested in this project should be familiar with one (or more) of the following: Protein biochemistry (Western, ELISA, IHC), biophysical structure work, protein purification, immune cell signalling. Ref: 1879783, Closing date: 31 July 2022Apply to centre