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By joining the UK DRI you’ll belong to a team of fantastic researchers, technical specialists and professional support staff passionate about accelerating the discovery, development and delivery of interventions that will help diagnose, treat and ultimately prevent dementia, directly benefitting people affected by dementia, their carers, families and the community.

We’re looking for brilliant people with diverse perspectives. Together our unique contributions will transform the range and pace of research on dementia. You’ll be supported by the very best tools and resources and join a culture that encourages high risk/reward science and sharing of ideas.

We are a vibrant, ambitious and interactive community. We offer opportunities at all career levels for scientists and support staff in our seven centres across the UK, as well as in our London-based HQ team.

We’re always interested in hearing from people as passionate about our mission as we are. To find out more about working at the UK DRI or our current opportunities, please contact us at enquiries@ukdri.ac.uk.

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​UK DRI at UCL

Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test.

  • Specialisms at UCL
  • Mechanistic understanding of dysfunction in cells and neural systems
  • Gene expression and biological pathways in single cells related to the progression of Alzheimer’s disease
  • New biomarkers to monitor disease progression
  • Deficits in axonal transport in early neurodegeneration
  • Wnt signalling in synapses to discover new targets for future dementia therapies
  • Read more about UCL

    From lab bench to bedside, and back again

    UCL was selected as the hub of the UK DRI in 2016 because of its strength to bring together excellent clinical and basic neuroscience research to advance our understanding of neurodegeneration and identify novel targets and therapeutic approaches for dementia. As the hub, it has a larger research programme and also is the location for the national headquarters team who connect the whole institute together.

    Research at the UK DRI at UCL covers the journey from the person living with dementia to the laboratory and back again - with improved diagnosis and potential therapies put to the test. The groups believe in intervening earlier in disease in order to change the trajectory.

    We need to better understand the diversity and complexity of neurodegenerative diseases, like Alzheimer's disease, in order to understand the mechanisms involved, and ultimately how we can alter them to improve people's lives.

    We must find treatments quicker, and that's why the UK DRI at UCL is taking a novel approach by integrating diverse expertise for efficiency, from genetics to diagnostics.

    This work is enhanced by incredible clinical resources. Researchers have access to unique clinical cohorts, where comprehensive data has been collected throughout disease progression including memory assessments and brain tissue. The UK DRI at UCL provides a clinical arm to the whole of the UK DRI.

    The future iconic home of the UK DRI at UCL will be alongside UCL's Queen Square Institute of Neurology in a new building on Gray's Inn Road.

    Visit the UK DRI at UCL local website for up-to-date news.

Apply for latest jobs at UCL

  • Research Fellow, UK DRI at UCL - Krupic lab

    The UK DRI at UCL is looking for a highly motivated, experienced, and self-driven Postdoctoral Research Fellow to join the Krupic Lab to help investigate the role of disrupted deep brain circuitry in diminished spatial memory function in Alzheimer’s disease. The Krupic laboratory employs neural recordings using multi-tetrodes, Neuropixels, and two-photon imaging in head-fixed mice navigating in virtual enclosures as well as comprehensive monitoring of mouse behaviour in the smart-Kages (the home monitoring system that was recently developed in the lab). One of your main tasks will be to help implement the long-term neural recordings in the smart Kages. You will hold a PhD in neuroscience or a related subject and have significant experience with in vivo electrophysiological recordings and data analysis in behaving mice, and good proven programming skills with MATLAB or Python as well as good knowledge of statistics and complex neural data analysis. Excellent experience performing in vivo surgeries, such as chronic implantation of multi-tetrodes, Neuropixels, or similar, along with maintaining mice during the chronic experience, pre- and post-surgery is also essential. Ref: B02-06902, Closing date: Sunday 2 June 2024

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  • Research Fellow, UK DRI at UCL - Krupic lab

    The UK DRI at UCL is looking for a highly motivated, experienced, and self-driven Postdoctoral Research Fellow to join the Krupic Lab and study how spatial memory and the ability to navigate to the goal are affected in the Tau- and amyloid-beta- Alzheimer’s disease mouse models and how these changes correlate with neural and synaptic functions of the medial entorhinal-hippocampal neurons. The lab is especially keen to develop a stronger analytical and theoretical background for understanding the changes in neural dynamics related to the progression of Tau and/or Amyloid pathology. You will hold a PhD in neuroscience or a related subject, with strong experience with complex neural and behavioural data analysis, including writing your analysis functions, and excellent programming skills in either MATLAB or Python, combined with knowledge of statistics and complex neural data analysis. Experience of working on hippocampal and/or medial entorhinal datasets and in in vivo electrophysiological recordings, two-photon imaging, and mouse behaviour is desirable. Ref: B02-06901, Closing date: Sunday 2 June 2024

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